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  1. Article ; Online: The emergent relationship between temporoparietal junction and anosognosia in Alzheimer's disease.

    Lattanzio, Lucas / Seames, Alexander / Holden, Samantha K / Buard, Isabelle

    Journal of neuroscience research

    2021  Volume 99, Issue 9, Page(s) 2091–2096

    Abstract: Anosognosia and impairment of insight are characteristic features of Alzheimer's disease (AD), which can lead to delays in appropriate medical care and significant family discord. The default mode network (DMN), a distributed but highly connected network ...

    Abstract Anosognosia and impairment of insight are characteristic features of Alzheimer's disease (AD), which can lead to delays in appropriate medical care and significant family discord. The default mode network (DMN), a distributed but highly connected network of brain regions more active during rest than during task, is integrally involved in awareness. DMN dysfunction is common in AD, and disrupted communication between memory-related and self-related DMN networks is associated with anosognosia in AD patients. In addition, the temporoparietal junction (TPJ) is a key region of the "social brain" and also contributes to representations of the self. The exact classification of the TPJ within the DMN is unclear, though connections between the TPJ and DMN have been highlighted in multiple avenues of research. Here we discuss the relationship between the TPJ, DMN, and AD, as well as the potential involvement of the TPJ in anosognosia in AD. We review past and present findings to raise attention to the TPJ, with a specific emphasis on neuroimaging technologies which suggest a pivotal role of the TPJ within large-scale brain networks linked to anosognosia in AD.
    MeSH term(s) Agnosia/diagnostic imaging ; Agnosia/metabolism ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/metabolism ; Default Mode Network/diagnostic imaging ; Default Mode Network/metabolism ; Humans ; Nerve Net/diagnostic imaging ; Nerve Net/metabolism ; Neuroimaging/methods ; Neuroimaging/trends ; Parietal Lobe/diagnostic imaging ; Parietal Lobe/metabolism ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/metabolism
    Language English
    Publishing date 2021-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.24904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1232: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Finger dexterity measured by the Grooved Pegboard test indexes Parkinson's motor severity in a tremor-independent manner.

    Buard, Isabelle / Yang, Xinyi / Kaizer, Alexander / Lattanzio, Lucas / Kluger, Benzi / Enoka, Roger M

    Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology

    2022  Volume 66, Page(s) 102695

    Abstract: Fine motor impairments are frequent complaints in people with Parkinson's disease (PD). While they may develop at an early stage of the disease, they become more problematic as the disease progresses. Tremors and fine motor symptoms may seem related, but ...

    Abstract Fine motor impairments are frequent complaints in people with Parkinson's disease (PD). While they may develop at an early stage of the disease, they become more problematic as the disease progresses. Tremors and fine motor symptoms may seem related, but evidence suggests two distinct phenomena. The purpose of our study was to investigate the relationships between fine motor skills and clinical characteristics of PD patients. We hypothesized worse fine motor skills to be associated with greater motor severity that is independent of tremor. We measured fine motor abilities using the Grooved Pegboard test (GPT) in each hand separately and collected clinical and demographics data in a cohort of 82 persons with PD. We performed regression analyses between GPT scores and a range of outcomes: motor severity, time from diagnosis, age and tremors. We also explored similar associations using finger and hand dexterity scores from a standardized PD rating scale. Our results indicate that scores on the GPT for each hand, as measures of manual dexterity, are associated with motor severity and time from diagnosis. The presence of tremors was not a confounding factor, as hypothesized, but age was associated with GPT scores for the dominant hand. Motor severity was also associated with hand and finger dexterity as measured by single items from the clinical Parkinson's rating scale. These findings suggest that the GPT to be useful tool for motor severity assessments of people with PD.
    MeSH term(s) Fingers ; Humans ; Motor Skills/physiology ; Muscle, Skeletal ; Parkinson Disease/diagnosis ; Tremor/complications ; Tremor/diagnosis
    Language English
    Publishing date 2022-08-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1073161-1
    ISSN 1873-5711 ; 1050-6411
    ISSN (online) 1873-5711
    ISSN 1050-6411
    DOI 10.1016/j.jelekin.2022.102695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: A Study Protocol for an Open-Label Feasibility Treatment Trial of Visual Snow Syndrome With Transcranial Magnetic Stimulation.

    Grande, Marissa / Lattanzio, Lucas / Buard, Isabelle / McKendrick, Allison M / Chan, Yu Man / Pelak, Victoria S

    Frontiers in neurology

    2021  Volume 12, Page(s) 724081

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-09-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.724081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Randomized controlled trial of neurologic music therapy in Parkinson's disease: research rehabilitation protocols for mechanistic and clinical investigations.

    Buard, Isabelle / Lattanzio, Lucas / Stewart, Rebekah / Thompson, Sarah / Sjoberg, Kristin / Hookstadt, Karen / Morrow, Meghan / Holden, Samantha K / Sillau, Stefan / Thaut, Michael / Kluger, Benzi

    Trials

    2021  Volume 22, Issue 1, Page(s) 577

    Abstract: Background: Presently available medications and surgical treatments for Parkinson's disease have limited effects on fine motor problems and often leave patients with significant fine motor disability. Standard of care occupational therapy (OT) yields ... ...

    Abstract Background: Presently available medications and surgical treatments for Parkinson's disease have limited effects on fine motor problems and often leave patients with significant fine motor disability. Standard of care occupational therapy (OT) yields low efficacy, potentially due to a lack of standard protocols. Neurologic music therapy (NMT) techniques, especially rhythmic auditory stimulation which relies on interaction between rhythm and movement, have shown to be effective in PD gait rehabilitation possibly through their reliance on neural pathways that are not affected by PD. Therapeutic instrumental music performance (TIMP) is one other NMT technique that holds promise but which mode of action and efficacy has not been investigated in PD yet.
    Methods: One hundred PD participants will be randomly assigned to receive 15 sessions of either TIMP with rhythm or TIMP without rhythm, standard of care OT, or to be waitlisted (control) over 5 consecutive weeks. Brain oscillatory responses will be collected using magnetoencephalography during an auditory-motor task to understand the underlying mechanisms. The Grooved Pegboard, the UPDRS III finger tap, and the finger-thumb opposition will be assessed to investigate clinical changes related to fine motor function. This project will also serve to confirm or refute our pilot data findings suggesting NMT relies on compensatory brain networks utilized by the PD brain to bypass the dysfunctional basal ganglia.
    Discussion: This study aims to use standardized TIMP and OT research protocols for investigating the neuronal pathways utilized by each intervention and possibly study their efficacy with respect to fine motor rehabilitation via a randomized control trial in the PD population.
    Trial registration: ClinicalTrials.gov NCT03049033 . Registered on September 29, 2020.
    MeSH term(s) Disabled Persons ; Gait ; Humans ; Motor Disorders ; Music Therapy ; Parkinson Disease/diagnosis ; Parkinson Disease/therapy ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2021-08-28
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1468-6708
    ISSN (online) 1745-6215 ; 1468-6694
    ISSN 1468-6708
    DOI 10.1186/s13063-021-05560-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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