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  1. Article ; Online: Lumipulse G β-Amyloid Ratio Test for the Diagnosis of Alzheimer Disease.

    Lau, Kyle / Lin, Kenneth W

    American family physician

    2023  Volume 107, Issue 5, Page(s) 550–551

    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Amyloid beta-Peptides ; Peptide Fragments
    Chemical Substances Amyloid beta-Peptides ; Peptide Fragments
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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  2. Article ; Online: Improving Cryo-Electron Tomography Data Quality and Throughput by Streamlining the Workflow.

    Smeets, Marit / Lau, Katherine

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 29 Suppl 1, Page(s) 1054

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.540
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  3. Article ; Online: The multivariate interaction between Au and TiO

    Lau, Kinran / Giera, Brian / Barcikowski, Stephan / Reichenberger, Sven

    Nanoscale

    2024  Volume 16, Issue 5, Page(s) 2552–2564

    Abstract: The established DLVO theory explains colloidal stability by the electrostatic repulsion between electrical double layers. While the routinely measured zeta potential can estimate the charges of double layers, it is only an average surface property which ... ...

    Abstract The established DLVO theory explains colloidal stability by the electrostatic repulsion between electrical double layers. While the routinely measured zeta potential can estimate the charges of double layers, it is only an average surface property which might deviate from the local environment. Moreover, other factors such as the ionic strength and the presence of defects should also be considered. To investigate this multivariate problem, here we model the interaction between a negatively charged Au particle and a negatively charged TiO
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr06205h
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  4. Article ; Online: Experiences of motivational interviewing in virtual healthcare visits for adults with type 2 diabetes mellitus: A qualitative analysis.

    Lau, Kimberley / Escudero, Carlos / Lee, Irene / Yu, Catherine

    Canadian journal of diabetes

    2024  

    Abstract: Aims: The purpose of this qualitative study is to identify barriers minimizing the effectiveness of motivational interviewing during virtual clinic encounters for individuals with type 2 diabetes based on the Capability, Opportunity, Motivation- ... ...

    Abstract Aims: The purpose of this qualitative study is to identify barriers minimizing the effectiveness of motivational interviewing during virtual clinic encounters for individuals with type 2 diabetes based on the Capability, Opportunity, Motivation-Behaviour (COM-B) model.
    Methods: One-on-one semi-structured interviews were conducted from March to June 2023 with 17 adults with type 2 diabetes (64.7% female, median age 69 years with age range 47-83 years) followed at St. Michael's Hospital (Toronto, Canada). Themes from transcribed interviews were identified through descriptive analysis using a grounded theory approach.
    Results: The following main themes were identified: 1) Face-to-face appointments strengthen provider-patient rapport and collaboration, 2) virtual encounters reduce patient accountability and hinder health-seeking behaviour, 3) individuals with physical disabilities and/or low technological proficiency experience decreased provider accessibility. Protective factors that can mitigate these negative impacts include establishing rapport during in-person appointments prior to transitioning to virtual appointments and incorporating video component during virtual encounters.
    Conclusions: Several barriers of virtual appointments currently limit the effectiveness of motivational interviewing for individuals with type 2 diabetes and make it difficult to provide person-centered care, especially over telephone. However, there are protective factors that help to maintain healthy lifestyle behaviours even after transitioning to virtual settings and are areas for optimization moving forward.
    Language English
    Publishing date 2024-04-17
    Publishing country Canada
    Document type Journal Article
    ISSN 2352-3840
    ISSN (online) 2352-3840
    DOI 10.1016/j.jcjd.2024.04.008
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  5. Article ; Online: Pharyngeal pouch: comparison of surgical treatment with botulinum toxin injection to the cricopharyngeus.

    Lau, K / Watson, M G

    The Journal of laryngology and otology

    2019  Volume 133, Issue 2, Page(s) 125–128

    Abstract: Background: Pharyngeal pouch surgical treatments can be carried out via an endoscopic or open approach. Injection of botulinum toxin into the cricopharyngeus was first described as an alternative treatment to the more invasive surgical procedures ... ...

    Abstract Background: Pharyngeal pouch surgical treatments can be carried out via an endoscopic or open approach. Injection of botulinum toxin into the cricopharyngeus was first described as an alternative treatment to the more invasive surgical procedures performed for cricopharyngeal dysfunction. It has not been previously described as a treatment option for pharyngeal pouch.
    Objectives: To compare operative time, average stay, complication rates and symptom control between endoscopic laser diverticulotomy, botulinum toxin injection and open procedures for pharyngeal pouch patients.
    Methods: The medical records for 66 pharyngeal pouch procedures, carried out on 47 patients treated between 2011 and 2017, were identified and reviewed.
    Results: The mean operative time was 21 minutes for botulinum toxin injection, 38 for endoscopic laser diverticulotomy and 104 for open surgery. The mean hospital stay was 0.6 days for botulinum toxin injection, 4.7 for endoscopic laser diverticulotomy and 4 for open surgery. The improvement in Reflux Symptom Index scores was statistically significant for both endoscopic laser diverticulotomy and botulinum toxin injection. Botulinum toxin injection had a 0 per cent complication rate.
    Conclusion: Botulinum toxin injection is a safe and effective treatment for pharyngeal pouch.
    MeSH term(s) Aged ; Aged, 80 and over ; Botulinum Toxins/administration & dosage ; DiGeorge Syndrome/drug therapy ; DiGeorge Syndrome/surgery ; Endoscopy/methods ; Female ; Humans ; Injections ; Male ; Middle Aged ; Neurotoxins/administration & dosage ; Otorhinolaryngologic Surgical Procedures/methods ; Pharyngeal Muscles ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Neurotoxins ; Botulinum Toxins (EC 3.4.24.69)
    Language English
    Publishing date 2019-02-06
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215119000124
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    Ul II Zs.64: Show issues Location:
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  6. Article ; Online: Ophthalmic artery Doppler in women with hypertensive disorders of pregnancy: relationship to blood pressure control and renal dysfunction at 6-9 weeks postnatally.

    Gy Lau, K / Bednorz, M / Parisi, N / Nicolaides, K H / Kametas, N A

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

    2023  

    Abstract: Objective: To examine the postnatal course of the ophthalmic artery (OA) Doppler in women with hypertensive disorders of pregnancy (HDP) and evaluate the correlation between OA Dopplers and poor postnatal blood pressure control and renal dysfunction at ... ...

    Abstract Objective: To examine the postnatal course of the ophthalmic artery (OA) Doppler in women with hypertensive disorders of pregnancy (HDP) and evaluate the correlation between OA Dopplers and poor postnatal blood pressure control and renal dysfunction at 2-3 and 6-9 weeks postnatally.
    Methods: Prospective cohort study of women with singleton pregnancies with HDP in a tertiary Pregnancy Hypertension clinic. Three visits were included: 1) the last antenatal hypertension clinic visit within 2 weeks prior to delivery, 2) 2-3 weeks postnatally, 3) 6-9 weeks postnatally. At each visit, maternal demographics, medical history, blood pressure and maternal OA Dopplers were performed. In addition, antenatally, fetal growth and fetal Dopplers were examined and at 6-9 weeks postnatally, estimated glomerular filtration rate and proteinuria were quantified. Study participants were divided into four hypertension groups, according to the blood pressure changes with time during the three visits. For the postnatal visits, hypertension was defined as systolic blood pressure (SBP) ≥140 mmHg and / or diastolic(D) BP ≥ 90 mmHg or SBP ≥130 mmHg or DBP ≥ 80 mmHg whilst taking antihypertensives. Group 1 was hypertensive in all three visits, Group 2 was hypertensive in the first two visits but was normotensive in the third visit, Group 3 was hypertensive in visits one and three, but normotensive in visit two, and Group 4 was hypertensive in visit one but normotensive in visits two and three. The longitudinal changes of mean arterial pressure (MAP) and peak systolic velocity (PSV) 1, PSV2 and the ratio of PSV2 / PSV1 over the three time points were examined by a repeated measure, multilevel linear mixed-effects analysis, controlling for maternal age, booking weight and use of antihypertensives. In addition, we examined the longitudinal change of OA Dopplers in women with different degrees of postnatal blood pressure control and in those with and without renal dysfunction at 6-9 weeks' postnatally.
    Results: 108 women (86 new-onset and 22 chronic hypertension) were recruited into the study. When controlling for maternal age, booking weight and use of antihypertensive medication, a significant decline in Log
    Conclusions: In women with HDP, the OA-PSVR was significantly higher in those with labile or persistently raised blood pressure postnatally when compared to women whose blood pressure normalised. Similarly, the OA-PSVR at 6-9 weeks postnatally was significantly higher in women with renal dysfunction versus those without dysfunction. This article is protected by copyright. All rights reserved.
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1073183-0
    ISSN 1469-0705 ; 0960-7692
    ISSN (online) 1469-0705
    ISSN 0960-7692
    DOI 10.1002/uog.27563
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    Zs.A 3214: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Measuring Asymptomatic Growth of COVID-19; A Powerful Mechanism for Controlling the Disease Spread

    Lau, Keith

    Coronaviruses

    2020  Volume 01

    Abstract: Background: Coronavirus, dubbed as, "the worst public health crisis for a generation," is a malevolent silent kill-er. Objective: One of the main concerns is containing the disease and avoiding the second wave of the pandemic; likely to arise because of ... ...

    Abstract Background: Coronavirus, dubbed as, "the worst public health crisis for a generation," is a malevolent silent kill-er. Objective: One of the main concerns is containing the disease and avoiding the second wave of the pandemic; likely to arise because of the symptomatic patients while ensuring the safe execution of day to day tasks. Method: The indirect transmission of coronavirus from asymptomatic individuals during incubation time and the identifica-tion of the people who have accidentally and unknowingly come in contact with infected but asymptomatic patients pose a significant challenge to the health care providers. Result: Herein, for the first time, we have introduced a quantitative index; asymptomatic growth, to indicate whether COVID-19 community spread is under control and if economic activities can be resumed. Conclusion: More importantly, our system provides a feasible mechanism for improving the index to a level <1, a safety level at which normal economic activities can be conducted.
    Keywords covid19
    Language English
    Publisher Bentham Science Publishers Ltd.
    Publishing country nl
    Document type Article ; Online
    ISSN 2666-7967
    DOI 10.2174/2666796701999200821160307
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Promoting research in primary care.

    Lau, K T

    British dental journal

    2019  Volume 226, Issue 8, Page(s) 540

    MeSH term(s) Health Promotion ; Primary Health Care
    Language English
    Publishing date 2019-04-27
    Publishing country England
    Document type Letter
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-019-0285-8
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  9. Article: Shortcomings of Rapid Clinical Information Dissemination: Lessons From a Pandemic.

    Lau, K H Vincent / Anand, Pria

    Neurology. Clinical practice

    2021  Volume 11, Issue 3, Page(s) e337–e343

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic has led to an acceleration of clinical information dissemination to unprecedented speeds, a phenomenon only partially explained by formal efforts of the scientific community. These have ranged from the ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic has led to an acceleration of clinical information dissemination to unprecedented speeds, a phenomenon only partially explained by formal efforts of the scientific community. These have ranged from the establishment of open-source platforms for review of article preprints to the elimination of journal paywalls for COVID-19-related publications. In addition, informal efforts that rely on various modern media platforms that promote, repackage, and synthesize information have played substantial adjunctive roles, many of which did not exist during the severe acute respiratory syndrome pandemic of 2003. Although these latter efforts have greatly bolstered the speed of knowledge dissemination, their unregulated nature subjects them to risk for facilitating the spread of misinformation. In our opinion, the role of modern media in influencing clinical knowledge dissemination was not adequately examined even before the pandemic and therefore remains largely unchecked. In this article, we examine the spread of information in the field of COVID-19 and neurologic disorders, develop a simple model that maps various modern media tools on to the dissemination pipeline, and critically examine its components. Through this exercise, we identify opportunities for the scientific community to regulate and safeguard the clinical knowledge dissemination process, with implications both for the pandemic and beyond.
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000000915
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  10. Article ; Online: Model-based iterative reconstruction in CT of paranasal sinuses in cystic fibrosis.

    Lin, S / Lau, K K

    Clinical radiology

    2021  Volume 76, Issue 12, Page(s) 930–934

    Abstract: Aim: To assess image quality and dose-reduction efficacy of model-based iterative reconstruction (MBIR) in computed tomography (CT) of the paranasal sinus (CTPNS) compared with adaptive statistical iterative reconstruction (ASIR) in cystic fibrosis (CF) ...

    Abstract Aim: To assess image quality and dose-reduction efficacy of model-based iterative reconstruction (MBIR) in computed tomography (CT) of the paranasal sinus (CTPNS) compared with adaptive statistical iterative reconstruction (ASIR) in cystic fibrosis (CF) patients.
    Materials and methods: Unenhanced CTPNS studies performed in adult CF patients from 2014 to 2020 were included. MBIR and ASIR were used and compared. Two radiologists assessed the CT images blindly and randomly. Quantitative assessment of noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) was performed in the maxillary sinus, sphenoid body, temporalis, and background air. Qualitative assessment performed included image sharpness, noise and contrast.
    Results: Thirty-seven MBIR and 45 ASIR CT PNS studies were included. MBIR achieved a 74% effective median dose reduction (0.039 mSv) compared with ASIR (0.147 mSv). Measured noise was significantly lower in all regions using MBIR (p<0.001) with superior SNR (p<0.001). MBIR had higher CNR compared to ASIR (4.567 versus 2.03, p<0.001). MBIR images were sharper and less noisy, with equal contrast. Cohen's weighted kappa value was 0.824 for qualitative analysis, indicating good inter-rater agreement. Both methods had 100% diagnostic acceptability.
    Conclusion: MBIR produces high-quality CTPNS images at a significantly lower dose compared with ASIR. It is the preferred imaging surveillance method in CF patients and may have roles in other patient cohorts.
    MeSH term(s) Adult ; Cohort Studies ; Cystic Fibrosis/diagnostic imaging ; Female ; Humans ; Image Processing, Computer-Assisted ; Male ; Paranasal Sinuses/diagnostic imaging ; Radiation Dosage ; Radiographic Image Interpretation, Computer-Assisted ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; Young Adult
    Language English
    Publishing date 2021-09-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2021.09.008
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