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Article ; Online: An in silico study of the effects of cardiovascular aging on carotid flow waveforms and indexes in a virtual population.

Suriani, Irene / Bouwman, R Arthur / Mischi, Massimo / Lau, Kevin D

American journal of physiology. Heart and circulatory physiology

2024 Volume 326, Issue 4, Page(s) H877–H899

Abstract: Cardiovascular aging is strongly associated with increased risk of cardiovascular disease and mortality. Moreover, health and lifestyle factors may accelerate age-induced alterations, such as increased arterial stiffness and wall dilation, beyond ... ...

Abstract	Cardiovascular aging is strongly associated with increased risk of cardiovascular disease and mortality. Moreover, health and lifestyle factors may accelerate age-induced alterations, such as increased arterial stiffness and wall dilation, beyond chronological age, making the clinical assessment of cardiovascular aging an important prompt for preventative action. Carotid flow waveforms contain information about age-dependent cardiovascular properties, and their ease of measurement via noninvasive Doppler ultrasound (US) makes their analysis a promising tool for the routine assessment of cardiovascular aging. In this work, the impact of different aging processes on carotid waveform morphology and derived indexes is studied in silico, with the aim of establishing the clinical potential of a carotid US-based assessment of cardiovascular aging. One-dimensional (1-D) hemodynamic modeling was employed to generate an age-specific virtual population (VP) of
MeSH term(s)	Humans ; Aged ; Aging ; Carotid Arteries/diagnostic imaging ; Hemodynamics ; Cardiovascular Diseases ; Ultrasonography
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00304.2023
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Article: Simulated late gadolinium enhanced cardiac magnetic resonance imaging dataset from mechanical XCAT phantom including a myocardial infarct

Kruithof, Evianne / Amirrajab, Sina / Lau, Kevin D. / Breeuwer, Marcel

Data in Brief. 2022 Feb., v. 40

2022

Abstract: The late enhanced magnetic resonance image dataset in this article is simulated using a mechanistic cardiac phantom that includes an myocardial infarct. Settings of the image simulation pipeline are adjusted such that high- and low-resolution images, ... ...

Abstract	The late enhanced magnetic resonance image dataset in this article is simulated using a mechanistic cardiac phantom that includes an myocardial infarct. Settings of the image simulation pipeline are adjusted such that high- and low-resolution images, with and without slice alignment artifacts, are simulated. Our article on the influence of image artifacts on image-based models of the cardiac electrophysiology is based on this data (Kruithof et al., 2021). This dataset provides image-analysis researchers a reference to perform validation of their methods using the included high-resolution ground truth image, a resource that is often unavailable clinically.
Keywords	data collection ; electrophysiology ; gadolinium ; image analysis ; magnetic resonance imaging ; magnetism ; myocardial infarction
Language	English
Dates of publication	2022-02
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2021.107691
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Article ; Online: Validation of an aging virtual population for the study of carotid hemodynamics.

Suriani, Irene / Bouwman, R Arthur / Mischi, Massimo / Lau, Kevin D

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2021 Volume 2021, Page(s) 4249–4252

Abstract: The analysis of carotid ultrasound (US) flow, velocity, and diameter waveforms provides important information about cardiovascular and circulatory health. These can be used to derive clinical indices of atherosclerosis, vascular aging, and hemodynamic ... ...

Abstract	The analysis of carotid ultrasound (US) flow, velocity, and diameter waveforms provides important information about cardiovascular and circulatory health. These can be used to derive clinical indices of atherosclerosis, vascular aging, and hemodynamic status. To derive clinical insight from carotid waveforms, it is essential to understand the relationship of the observed variability in morphology with the underlying hemodynamic status and cardiovascular properties. For this purpose, using a one-dimensional modeling approach, we have developed and validated a virtual population that is able to realistically simulate carotid waveforms of healthy subjects aged between 10 and 80 years old.Clinical Relevance-Our virtual population of carotid waveforms can support the interpretation of US patient data. It can be used, e.g., to investigate how waveform morphology and derived indices relate to individual arterial and cardiac properties.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging ; Carotid Arteries/diagnostic imaging ; Child ; Hemodynamics ; Humans ; Middle Aged ; Ultrasonography ; Young Adult
Language	English
Publishing date	2021-12-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC46164.2021.9630876
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Article ; Online: Simulated late gadolinium enhanced cardiac magnetic resonance imaging dataset from mechanical XCAT phantom including a myocardial infarct.

Kruithof, Evianne / Amirrajab, Sina / Lau, Kevin D / Breeuwer, Marcel

Data in brief

2021 Volume 40, Page(s) 107691

Abstract	The late enhanced magnetic resonance image dataset in this article is simulated using a mechanistic cardiac phantom that includes an myocardial infarct. Settings of the image simulation pipeline are adjusted such that high- and low-resolution images, with and without slice alignment artifacts, are simulated. Our article on the influence of image artifacts on image-based models of the cardiac electrophysiology is based on this data (Kruithof et al., 2021). This dataset provides image-analysis researchers a reference to perform validation of their methods using the included high-resolution ground truth image, a resource that is often unavailable clinically.
Language	English
Publishing date	2021-12-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2021.107691
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Article ; Online: Simulation of short-term pressure regulation during the tilt test in a coupled 3D-0D closed-loop model of the circulation.

Lau, Kevin D / Figueroa, C Alberto

Biomechanics and modeling in mechanobiology

2015 Volume 14, Issue 4, Page(s) 915–929

Abstract: Short-term fluctuations in arterial pressures arising from normal physiological function are buffered by a negative feedback system known as the arterial baroreflex. Initiated by altered biomechanical stretch in the vessel wall, the baroreflex ... ...

Abstract	Short-term fluctuations in arterial pressures arising from normal physiological function are buffered by a negative feedback system known as the arterial baroreflex. Initiated by altered biomechanical stretch in the vessel wall, the baroreflex coordinates a systemic response that alters heart rate, cardiac contractility and peripheral vessel vasoconstriction. In this work, a coupled 3D-0D formulation for the short-term pressure regulation of the systemic circulation is presented. Including the baroreflex feedback mechanisms, a patient-specific model of the large arteries is subjected to a simulated head up tilt test. Comparative simulations with and without baroreflex control highlight the critical role that the baroreflex has in regulating variations in pressures within the systemic circulation.
MeSH term(s)	Arteries/physiology ; Baroreflex/physiology ; Blood Circulation/physiology ; Blood Pressure/physiology ; Compliance ; Computer Simulation ; Heart Rate/physiology ; Hemodynamics ; Humans ; Models, Cardiovascular ; Supine Position ; Tilt-Table Test ; Vascular Resistance/physiology
Language	English
Publishing date	2015-01-08
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2093052-5
ISSN	1617-7940 ; 1617-7959
ISSN (online)	1617-7940
ISSN	1617-7959
DOI	10.1007/s10237-014-0645-x
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Article ; Online: A mathematical model of coronary blood flow control: simulation of patient-specific three-dimensional hemodynamics during exercise.

Arthurs, Christopher J / Lau, Kevin D / Asrress, Kaleab N / Redwood, Simon R / Figueroa, C Alberto

American journal of physiology. Heart and circulatory physiology

2016 Volume 310, Issue 9, Page(s) H1242–58

Abstract: This work presents a mathematical model of the metabolic feedback and adrenergic feedforward control of coronary blood flow that occur during variations in the cardiac workload. It is based on the physiological observations that coronary blood flow ... ...

Abstract	This work presents a mathematical model of the metabolic feedback and adrenergic feedforward control of coronary blood flow that occur during variations in the cardiac workload. It is based on the physiological observations that coronary blood flow closely follows myocardial oxygen demand, that myocardial oxygen debts are repaid, and that control oscillations occur when the system is perturbed and so are phenomenological in nature. Using clinical data, we demonstrate that the model can provide patient-specific estimates of coronary blood flow changes between rest and exercise, requiring only the patient's heart rate and peak aortic pressure as input. The model can be used in zero-dimensional lumped parameter network studies or as a boundary condition for three-dimensional multidomain Navier-Stokes blood flow simulations. For the first time, this model provides feedback control of the coronary vascular resistance, which can be used to enhance the physiological accuracy of any hemodynamic simulation, which includes both a heart model and coronary arteries. This has particular relevance to patient-specific simulation for which heart rate and aortic pressure recordings are available. In addition to providing a simulation tool, under our assumptions, the derivation of our model shows that β-feedforward control of the coronary microvascular resistance is a mathematical necessity and that the metabolic feedback control must be dependent on two error signals: the historical myocardial oxygen debt, and the instantaneous myocardial oxygen deficit.
MeSH term(s)	Adaptation, Physiological ; Arterial Pressure ; Autonomic Nervous System/physiology ; Computer Simulation ; Coronary Circulation ; Coronary Vessels/innervation ; Coronary Vessels/physiology ; Exercise ; Heart Rate ; Hemodynamics ; Humans ; Models, Cardiovascular ; Muscle Contraction ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiology ; Myocardium/metabolism ; Oxygen/blood ; Oxygen Consumption ; Time Factors ; Vascular Resistance
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2016-03-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00517.2015
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Article ; Online: Patient-Specific Modeling of Hemodynamics: Supporting Surgical Planning in a Fontan Circulation Correction.

van Bakel, Theodorus M J / Lau, Kevin D / Hirsch-Romano, Jennifer / Trimarchi, Santi / Dorfman, Adam L / Figueroa, C Alberto

Journal of cardiovascular translational research

2018 Volume 11, Issue 2, Page(s) 145–155

Abstract: Computational fluid dynamics (CFD) is a modeling technique that enables calculation of the behavior of fluid flows in complex geometries. In cardiovascular medicine, CFD methods are being used to calculate patient-specific hemodynamics for a variety of ... ...

Abstract	Computational fluid dynamics (CFD) is a modeling technique that enables calculation of the behavior of fluid flows in complex geometries. In cardiovascular medicine, CFD methods are being used to calculate patient-specific hemodynamics for a variety of applications, such as disease research, noninvasive diagnostics, medical device evaluation, and surgical planning. This paper provides a concise overview of the methods to perform patient-specific computational analyses using clinical data, followed by a case study where CFD-supported surgical planning is presented in a patient with Fontan circulation complicated by unilateral pulmonary arteriovenous malformations. In closing, the challenges for implementation and adoption of CFD modeling in clinical practice are discussed.
MeSH term(s)	Adolescent ; Clinical Decision-Making ; Computed Tomography Angiography ; Coronary Angiography/methods ; Female ; Fontan Procedure/adverse effects ; Fontan Procedure/methods ; Heart Defects, Congenital/diagnostic imaging ; Heart Defects, Congenital/pathology ; Heart Defects, Congenital/physiopathology ; Heart Defects, Congenital/surgery ; Hemodynamics ; Humans ; Models, Cardiovascular ; Patient Selection ; Patient-Centered Care/methods ; Patient-Specific Modeling ; Predictive Value of Tests ; Surgery, Computer-Assisted/adverse effects ; Surgery, Computer-Assisted/methods ; Time-to-Treatment ; Ventricular Function
Language	English
Publishing date	2018-01-08
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2422411-X
ISSN	1937-5395 ; 1937-5387
ISSN (online)	1937-5395
ISSN	1937-5387
DOI	10.1007/s12265-017-9781-x
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Article ; Online: Computational Fluid Dynamics and Aortic Thrombus Formation Following Thoracic Endovascular Aortic Repair.

Nauta, Foeke J H / Lau, Kevin D / Arthurs, Christopher J / Eagle, Kim A / Williams, David M / Trimarchi, Santi / Patel, Himanshu J / Figueroa, Carlos A

The Annals of thoracic surgery

2017 Volume 103, Issue 6, Page(s) 1914–1921

Abstract: Background: We present the possible utility of computational fluid dynamics in the assessment of thrombus formation and virtual surgical planning illustrated in a patient with aortic thrombus in a kinked ascending aortic graft following thoracic ... ...

Abstract	Background: We present the possible utility of computational fluid dynamics in the assessment of thrombus formation and virtual surgical planning illustrated in a patient with aortic thrombus in a kinked ascending aortic graft following thoracic endovascular aortic repair. Methods: A patient-specific three-dimensional model was built from computed tomography. Additionally, we modeled 3 virtual aortic interventions to assess their effect on thrombosis potential: (1) open surgical repair, (2) conformable endografting, and (3) single-branched endografting. Flow waveforms were extracted from echocardiography and used for the simulations. We used the computational index termed platelet activation potential (PLAP) representing accumulated shear rates of fluid particles within a fluid domain to assess thrombosis potential. Results: The baseline model revealed high PLAP in the entire arch (119.8 ± 42.5), with significantly larger PLAP at the thrombus location (125.4 ± 41.2, p < 0.001). Surgical repair showed a 37% PLAP reduction at the thrombus location (78.6 ± 25.3, p < 0.001) and a 24% reduction in the arch (91.6 ± 28.9, p < 0.001). Single-branched endografting reduced PLAP in the thrombus region by 20% (99.7 ± 24.6, p < 0.001) and by 14% in the arch (103.8 ± 26.1, p < 0.001), whereas a more conformable endograft did not have a profound effect, resulting in a modest 4% PLAP increase (130.6 ± 43.7, p < 0.001) in the thrombus region relative to the baseline case. Conclusions: Regions of high PLAP were associated with aortic thrombus. Aortic repair resolved pathologic flow patterns, reducing PLAP. Branched endografting also relieved complex flow patterns reducing PLAP. Computational fluid dynamics may assist in the prediction of aortic thrombus formation in hemodynamically complex cases and help guide repair strategies.
MeSH term(s)	Aged ; Aorta/anatomy & histology ; Aorta/diagnostic imaging ; Aorta/physiopathology ; Aorta/surgery ; Aortic Aneurysm/diagnostic imaging ; Aortic Aneurysm/physiopathology ; Aortic Aneurysm/surgery ; Endovascular Procedures/adverse effects ; Female ; Hemodynamics ; Humans ; Models, Cardiovascular ; Thrombosis/etiology ; Thrombosis/physiopathology ; Tomography, X-Ray Computed
Language	English
Publishing date	2017-06
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2016.09.067
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Article ; Online: Noninvasive detection of spatiotemporal activation-repolarization interactions that prime idiopathic ventricular fibrillation.

Science translational medicine

2021 Volume 13, Issue 620, Page(s) eabi9317

Abstract: A comprehensive understanding of the interaction between triggers and electrical substrates leading to ventricular fibrillation (VF) and sudden cardiac arrest is lacking, and electrical substrates are difficult to detect and localize with current ... ...

Abstract	A comprehensive understanding of the interaction between triggers and electrical substrates leading to ventricular fibrillation (VF) and sudden cardiac arrest is lacking, and electrical substrates are difficult to detect and localize with current clinical tools. Here, we created repolarization time (RT) dispersion by regional drug infusion in perfused explanted human (
MeSH term(s)	Animals ; Electrocardiography/methods ; Heart Arrest ; Heart Ventricles ; Humans ; Swine ; Ventricular Fibrillation/diagnosis
Language	English
Publishing date	2021-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.abi9317
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Article ; Online: CRIMSON: An open-source software framework for cardiovascular integrated modelling and simulation.

Arthurs, Christopher J / Khlebnikov, Rostislav / Melville, Alex / Marčan, Marija / Gomez, Alberto / Dillon-Murphy, Desmond / Cuomo, Federica / Silva Vieira, Miguel / Schollenberger, Jonas / Lynch, Sabrina R / Tossas-Betancourt, Christopher / Iyer, Kritika / Hopper, Sara / Livingston, Elizabeth / Youssefi, Pouya / Noorani, Alia / Ben Ahmed, Sabrina / Nauta, Foeke J H / van Bakel, Theodorus M J /

Ahmed, Yunus / van Bakel, Petrus A J / Mynard, Jonathan / Di Achille, Paolo / Gharahi, Hamid / Lau, Kevin D / Filonova, Vasilina / Aguirre, Miquel / Nama, Nitesh / Xiao, Nan / Baek, Seungik / Garikipati, Krishna / Sahni, Onkar / Nordsletten, David / Figueroa, C Alberto

PLoS computational biology

2021 Volume 17, Issue 5, Page(s) e1008881

Abstract: In this work, we describe the CRIMSON (CardiovasculaR Integrated Modelling and SimulatiON) software environment. CRIMSON provides a powerful, customizable and user-friendly system for performing three-dimensional and reduced-order computational ... ...

Abstract	In this work, we describe the CRIMSON (CardiovasculaR Integrated Modelling and SimulatiON) software environment. CRIMSON provides a powerful, customizable and user-friendly system for performing three-dimensional and reduced-order computational haemodynamics studies via a pipeline which involves: 1) segmenting vascular structures from medical images; 2) constructing analytic arterial and venous geometric models; 3) performing finite element mesh generation; 4) designing, and 5) applying boundary conditions; 6) running incompressible Navier-Stokes simulations of blood flow with fluid-structure interaction capabilities; and 7) post-processing and visualizing the results, including velocity, pressure and wall shear stress fields. A key aim of CRIMSON is to create a software environment that makes powerful computational haemodynamics tools accessible to a wide audience, including clinicians and students, both within our research laboratories and throughout the community. The overall philosophy is to leverage best-in-class open source standards for medical image processing, parallel flow computation, geometric solid modelling, data assimilation, and mesh generation. It is actively used by researchers in Europe, North and South America, Asia, and Australia. It has been applied to numerous clinical problems; we illustrate applications of CRIMSON to real-world problems using examples ranging from pre-operative surgical planning to medical device design optimization.
MeSH term(s)	Alagille Syndrome/physiopathology ; Alagille Syndrome/surgery ; Blood Vessels/anatomy & histology ; Blood Vessels/diagnostic imaging ; Blood Vessels/physiology ; Computational Biology ; Computer Simulation ; Finite Element Analysis ; Heart Disease Risk Factors ; Hemodynamics/physiology ; Humans ; Imaging, Three-Dimensional ; Liver Transplantation/adverse effects ; Magnetic Resonance Imaging/statistics & numerical data ; Models, Anatomic ; Models, Cardiovascular ; Patient-Specific Modeling ; Postoperative Complications/etiology ; Software ; User-Computer Interface
Language	English
Publishing date	2021-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1008881
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