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  1. Article ; Online: Eosinophile in der HNO-Heilkunde: Freund oder Feind?

    Laudien, Martin

    HNO

    2024  Volume 72, Issue 4, Page(s) 242–249

    Abstract: This article summarizes the essential aspects of current knowledge about eosinophils, classifies eosinophilia in terms of the dimensions healthy or harmful reaction, takes a specific look at eosinophils in the field of otorhinolaryngology, and gives ... ...

    Title translation Eosinophils in otorhinolaryngology: friend or foe?
    Abstract This article summarizes the essential aspects of current knowledge about eosinophils, classifies eosinophilia in terms of the dimensions healthy or harmful reaction, takes a specific look at eosinophils in the field of otorhinolaryngology, and gives recommendations for diagnostic workup and therapeutic intervention in case of proven eosinophilia, particularly as an adverse drug reaction. The thoughts are inspired by communications at the 29th Congress of the European Rhinologic Society in Sofia, Bulgaria, 2023.
    MeSH term(s) Humans ; Eosinophils ; Eosinophilia/diagnosis ; Eosinophilia/therapy ; Otolaryngology
    Language German
    Publishing date 2024-03-04
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 200040-4
    ISSN 1433-0458 ; 0017-6192
    ISSN (online) 1433-0458
    ISSN 0017-6192
    DOI 10.1007/s00106-024-01442-x
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  2. Article ; Online: Bioptische Diagnostik ANCA‑assoziierter Vaskulitiden im HNO‑Trakt.

    Laudien, Martin / Holl-Ulrich, Konstanze

    Zeitschrift fur Rheumatologie

    2022  Volume 82, Issue 1, Page(s) 53–55

    Title translation Biopsy diagnostics of ANCA-associated vasculitides in the ENT tract.
    MeSH term(s) Humans ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Antibodies, Antineutrophil Cytoplasmic/analysis ; Biopsy
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language German
    Publishing date 2022-12-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-022-01303-4
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  3. Article ; Online: Nasenmuscheloperation: Welche olfaktorischen Leistungen werden eingeschränkt.

    Laudien, Martin

    Laryngo- rhino- otologie

    2017  Volume 96, Issue 11, Page(s) 753–754

    MeSH term(s) Adult ; Case-Control Studies ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Nasal Obstruction/diagnosis ; Nasal Obstruction/etiology ; Nasal Septum/surgery ; Olfaction Disorders/diagnosis ; Olfaction Disorders/etiology ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Rhinoplasty/methods ; Syndrome ; Trigeminal Nerve Diseases/diagnosis ; Trigeminal Nerve Diseases/etiology ; Turbinates/surgery
    Language German
    Publishing date 2017-11-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0340-1588 ; 0935-8943
    ISSN (online) 1438-8685
    ISSN 0340-1588 ; 0935-8943
    DOI 10.1055/s-0043-119601
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  4. Article ; Online: Therapie der chronischen Rhinosinusitis mit Polyposis nasi (CRScNP) mit monoklonalen Antikörpern (Biologika): S2k-Leitlinie der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie (DGHNO-KHC) und der Deutschen Gesellschaft für Allgemeinmedizin und Familienmedizin (DEGAM).

    Pfaar, Oliver / Beule, Achim Georg / Laudien, Martin / Stuck, Boris A

    HNO

    2023  Volume 71, Issue 4, Page(s) 256–263

    Abstract: Monoclonal antibodies (so-called biologics) can be prescribed for chronic rhinosinusitis with nasal polyps (CRSwNP) within the scope of their market authorization. However, their prescription is limited to severe CRSwNP without disease control, whereby ... ...

    Title translation Treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) with monoclonal antibodies (biologics): S2k guideline of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), and the German College of General Practitioners and Family Physicians (DEGAM).
    Abstract Monoclonal antibodies (so-called biologics) can be prescribed for chronic rhinosinusitis with nasal polyps (CRSwNP) within the scope of their market authorization. However, their prescription is limited to severe CRSwNP without disease control, whereby certain requirements must be met. Dupilumab, omalizumab, and mepolizumab have currently gained market authorization, with adequate evidence for their efficacy and safety available in the literature. It can be assumed that other biologics will be approved for this indication in the future. The severity of disease and the efficacy of treatment should be assessed objectively and subjectively before treatment initiation and after an appropriate duration, respectively. The documentation sheet proposed in this guideline chapter can be used for the assessments. In the presence of relative contraindications, a treatment should only be initiated after differentiated consideration by an experienced physician in the sense of a case-by-case decision. In summary, this guideline chapter aims to contribute to high-quality care of adult patients with these therapies in view of the increasing evidence for treatment with these substances and the increasing number of market authorizations of different biologics.
    MeSH term(s) Adult ; Humans ; Antibodies, Monoclonal/therapeutic use ; General Practitioners ; Physicians, Family ; Biological Products/therapeutic use ; Nasal Polyps/complications ; Nasal Polyps/drug therapy ; Nasal Polyps/surgery ; Sinusitis/complications ; Sinusitis/drug therapy ; Chronic Disease ; Rhinitis/drug therapy
    Chemical Substances Antibodies, Monoclonal ; Biological Products
    Language German
    Publishing date 2023-03-20
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 200040-4
    ISSN 1433-0458 ; 0017-6192
    ISSN (online) 1433-0458
    ISSN 0017-6192
    DOI 10.1007/s00106-023-01273-2
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  5. Article: Orphan diseases of the nose and paranasal sinuses: Pathogenesis - clinic - therapy.

    Laudien, Martin

    GMS current topics in otorhinolaryngology, head and neck surgery

    2015  Volume 14, Page(s) Doc04

    Abstract: Rare rhinological diseases are a diagnostic challenge. Sometimes it takes months or even years from the primary manifestation of the disease until the definitive diagnosis is establibshed. During these times the disease proceeds in an uncontrolled or ... ...

    Abstract Rare rhinological diseases are a diagnostic challenge. Sometimes it takes months or even years from the primary manifestation of the disease until the definitive diagnosis is establibshed. During these times the disease proceeds in an uncontrolled or insufficiently treated way. (Irreversible) damage results and sometimes life-threatening situations occur. The unexpected course of a (misdiagnosed) disease should lead to further diagnostic reflections and steps in order to detect also rare diseases as early as possible. The present paper discusses granulomatous diseases of the nose and paranasal sinuses caused by mycobacteria, treponema, Klebsiella, fungi, and protozoa as well as vasculitis, sarcoidosis, rosacea, cocaine-induced midline destruction, nasal extranodal NK/T cell lymphoma, and cholesterol granuloma. Furthermore, diseases with disorders of the mucociliary clearance such as primary ciliary dyskinesia and cystic fibrosis are presented, taking into consideration the current literature.
    Language English
    Publishing date 2015-12-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2178422-X
    ISSN 1865-1011
    ISSN 1865-1011
    DOI 10.3205/cto000119
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  6. Article: Nasenmuscheloperation: Welche olfaktorischen Leistungen werden eingeschränkt

    Laudien, Martin

    Laryngo-Rhino-Otologie

    2017  Volume 96, Issue 11, Page(s) 753–754

    Abstract: Konstantinidis I et al. Intranasal trigeminal function in patients with empty nose syndrome. Laryngoscope 2017;127: 1263–1267: Das trigeminale System vermittelt die Wahrnehmung des nasalen Luftflusses. Eine griechische Arbeitsgruppe hat nun in einer ... ...

    Abstract Konstantinidis I et al. Intranasal trigeminal function in patients with empty nose syndrome. Laryngoscope 2017;127: 1263–1267
    Das trigeminale System vermittelt die Wahrnehmung des nasalen Luftflusses. Eine griechische Arbeitsgruppe hat nun in einer Studie untersucht, inwieweit bei „Syndrom der leeren Nase“-Patienten (Empty Nose Syndrome, ENS) die geschädigte intranasale Trigeminusfunktion Teil einer paradoxen Nasenatmungsbehinderung ist.:
    Language German
    Publishing date 2017-11-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-119601
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  7. Article ; Conference proceedings: Erfolgreiche Therapie mit Tocilizumab bei einer Patientin mit therapierefraktärer rezidievierender polychondritis

    Karakitsos, Ilias / Zeuner, Rainald / Hoffmann, Markus / Laudien, Martin

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1766446
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  8. Article ; Conference proceedings: Successful therapy with tocilizumab in a patient with therapy-refractory relapsing polychondritis

    Karakitsos, Ilias / Zeuner, Rainald / Hoffmann, Markus / Laudien, Martin

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language English
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1767033
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  9. Article ; Online: COVID-19-induced olfactory loss.

    Stuck, Boris A / Menzel, Susanne / Laudien, Martin / Hintschich, Constantin A / Hummel, Thomas

    The Journal of allergy and clinical immunology

    2023  Volume 151, Issue 4, Page(s) 895–897

    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Olfaction Disorders/etiology ; Smell
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.02.007
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  10. Article ; Online: EGPA: Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) as a special presentation of chronic rhinosinusitis with nasal polyps (CRSwNP).

    Hagemann, Jan / Laudien, Martin / Becker, Sven / Cuevas, Mandy / Klimek, Felix / Kianfar, Roya / Casper, Ingrid / Klimek, Ludger

    Allergologie select

    2024  Volume 8, Page(s) 18–25

    Abstract: Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) was formerly known as Churg-Strauss syndrome. The condition is characterized by disseminated necrotizing vasculitis with extravascular granulomas associated with hypereosinophilia. The ... ...

    Abstract Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) was formerly known as Churg-Strauss syndrome. The condition is characterized by disseminated necrotizing vasculitis with extravascular granulomas associated with hypereosinophilia. The vasculitides affect small vessels and are associated with antineutrophil cytoplasmic antibodies (ANCAs) detectable in the blood. Distinguishing between type 2-mediated chronic airway inflammation such as chronic rhinosinusitis with nasal polyps (CRSwNP) without vasculitis can be clinically challenging and should be considered.
    Materials and methods: Immunological background, diagnosis, and therapy of EGPA were identified through literature searches in Medline, PubMed, as well as national and international studies (ClinicalTrials.gov) and the Cochrane Library. Human studies published up to and including 10/2023 on the topic were considered.
    Results: In cases of deteriorating general health with previously known eosinophilic inflammation of the upper and lower airways, EGPA and its interdisciplinary investigation should be considered. Various types of eosinophilic inflammation and syndromes must be considered differentially.
    Conclusion: Characterization of mucosal airway inflammation through biomarker determination is meaningful and occasionally makes the difference for targeted therapy.
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02475E
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