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  1. Article: Intermittent hyperbaric oxygen therapy for reduction of mortality in experimental polymicrobial sepsis.

    Thom, S R / Lauermann, M W / Hart, G B

    The Journal of infectious diseases

    1986  Volume 154, Issue 3, Page(s) 504–510

    Abstract: Hyperbaric oxygen therapy has a marked beneficial effect in experimental intraabdominal sepsis. Two rat models involving implantation of either rat fecal material or a mixture of pure cultures of Escherichia coli, Streptococcus faecalis, and Bacteroides ... ...

    Abstract Hyperbaric oxygen therapy has a marked beneficial effect in experimental intraabdominal sepsis. Two rat models involving implantation of either rat fecal material or a mixture of pure cultures of Escherichia coli, Streptococcus faecalis, and Bacteroides fragilis were used in this study. A death rate of 100% was obtained in control animals implanted with fecal material; with intermittent hyperbaric oxygen treatment, a death rate of only 8% was observed (P less than .005). With a mixture of pure cultures of clinical pathogens, the death rate in control animals was 79%, and intermittent hyperbaric oxygen treatment reduced the rate to 23% (P less than .005). Data from cultures of blood indicated that the efficacy of hyperbaric oxygen was not related to antibacterial activity.
    MeSH term(s) Animals ; Bacterial Infections/mortality ; Bacterial Infections/therapy ; Bacteroides Infections/therapy ; Bacteroides fragilis ; Enterococcus faecalis ; Escherichia coli Infections/therapy ; Feces/microbiology ; Hyperbaric Oxygenation ; Male ; Rats ; Rats, Inbred Strains ; Streptococcal Infections/therapy
    Language English
    Publishing date 1986-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/154.3.504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Differences in susceptibilities of the lymphogranuloma venereum and trachoma biovars of Chlamydia trachomatis to neutralization by immune sera.

    Peterson, E M / Hoshiko, M / Markoff, B A / Lauermann, M W / de la Maza, L M

    Infection and immunity

    1990  Volume 58, Issue 4, Page(s) 938–943

    Abstract: Sera from seven patients from whom a C. trachomatis serovar L2 strain was isolated were tested in vitro for their ability to neutralize the infectivity of this organism. In one patient an inguinal lymph node was culture positive, whereas the remaining ... ...

    Abstract Sera from seven patients from whom a C. trachomatis serovar L2 strain was isolated were tested in vitro for their ability to neutralize the infectivity of this organism. In one patient an inguinal lymph node was culture positive, whereas the remaining six patients had positive rectal biopsies. Sera from four of the patients, including the patient with the lymph node isolate, failed to neutralize serovar L2(434). In addition, the homologous strain recovered from the inguinal lymph node was available and was resistant to neutralization by the homologous sera. However, the same sera effectively neutralized a trachoma serovar, E(Bour). All four sera had inclusion immunofluorescent-antibody titers to C. trachomatis serovar L2 of 2,048 to 16,384 and microimmunofluorescent-antibody titers to the lymphogranuloma venereum biovar were equal or higher in all cases than to the 12 serovars of the trachoma biovar. The three remaining sera, while neutralizing the infectivity of the L2 strains tested, neutralized serovar E to a greater extent. These sera had the same inclusion immunofluorescent antibody titers as the sera that failed to neutralize serovar L2. To see whether this difference in the sensitivity of the biovars toward neutralization could be characterized, sera were obtained from mice immunized with different doses of both serovars L2 and E. Sera obtained from mice immunized with serovar E were able to effectively neutralize the homologous strain. In contrast, neutralization of the immunizing strain, L2(UCI-20), was not seen with sera obtained on days 7, 14, and 21 after immunization from animals receiving 8 x 10(5) and 8 x 10(4) inclusion-forming units of L2(UCI-20); however, these same sera neutralized serovar E. However, with a higher immunizing dose of L2 (10(7) IFUs), both E and L2 were neutralized with sera obtained 7 and 14 days after immunization. Therefore, the relative resistance to neutralization by serovar L2 compared with that of serovar E in the mouse model was inoculum dependent.
    MeSH term(s) Animals ; Antibodies, Bacterial/analysis ; Chlamydia trachomatis/immunology ; Chlamydia trachomatis/pathogenicity ; Female ; Humans ; Immune Sera/immunology ; Immunization ; Lymphogranuloma Venereum/microbiology ; Mice ; Mice, Inbred BALB C ; Neutralization Tests ; Trachoma/microbiology ; Virulence
    Chemical Substances Antibodies, Bacterial ; Immune Sera
    Language English
    Publishing date 1990-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.58.4.938-943.1990
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Prospective, randomized trial of netilmicin and amikacin, with emphasis on eighth-nerve toxicity.

    Barza, M / Lauermann, M W / Tally, F P / Gorbach, S L

    Antimicrobial agents and chemotherapy

    1980  Volume 17, Issue 4, Page(s) 707–714

    Abstract: The toxicity of netilmicin was compared with that of amikacin in a randomized, prospective trial in 90 adults with a variety of serious gram-negative infections. There was no instance of antibiotic-related nephrotoxicity in the group given amikacin and ... ...

    Abstract The toxicity of netilmicin was compared with that of amikacin in a randomized, prospective trial in 90 adults with a variety of serious gram-negative infections. There was no instance of antibiotic-related nephrotoxicity in the group given amikacin and only one instance in the group given netilmicin. Cochlear toxicity, as measured by a change in audiogram, occurred in 4/14 (28.5%) of the amikacin recipients and 3/19 (15.8%) of the netilmicin recipients. Vestibular toxicity, as determined by a change in ice-water calorics, was noted in 3/16 (19%) of the amikacin-treated patients and 0/15 of the netilmicin-treated individuals. Despite the trend toward lesser ototoxicity with netilmicin, the differences between the drugs were not statistically significant. There was, however, a significant association between male sex and the development of ototoxicity. Although many patients could not be evaluated for efficacy, there did not appear to be any difference in the therapeutic activity of the two drugs.
    MeSH term(s) Aged ; Amikacin/toxicity ; Audiometry, Pure-Tone ; Bacterial Infections/drug therapy ; Caloric Tests ; Clinical Trials as Topic ; Creatinine/blood ; Female ; Gentamicins/toxicity ; Hearing/drug effects ; Humans ; Kanamycin/analogs & derivatives ; Kidney/drug effects ; Male ; Middle Aged ; Netilmicin/toxicity ; Random Allocation ; Sex Factors ; Vestibule, Labyrinth/drug effects ; Vestibulocochlear Nerve/drug effects
    Chemical Substances Gentamicins ; Netilmicin (4O5J85GJJB) ; Kanamycin (59-01-8) ; Amikacin (84319SGC3C) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 1980-04
    Publishing country United States
    Document type Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.17.4.707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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