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  1. Book ; Online ; E-Book: Proteinkinase inhibitors

    Laufer, Stefan

    (Topics in medicinal chemistry ; 36)

    2021  

    Author's details Stefan Laufer editor
    Series title Topics in medicinal chemistry ; 36
    Collection
    Keywords Medicinal chemistry ; Proteins  ; Bioorganic chemistry ; Pharmaceutical technology
    Subject code 615.19
    Language English
    Size 1 Online-Ressource (vii, 256 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020916299
    ISBN 978-3-030-68180-7 ; 9783030681791 ; 3-030-68180-7 ; 3030681793
    DOI 10.1007/978-3-030-68180-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Inflammation and Rheumatic Diseases

    Bartsch, Volker / Laufer, Stefan

    the molecular basis of novel therapies ; 23 tables

    2003  

    Author's details Stefan Laufer ... With contr. by Volker Bartsch
    Keywords Rheumatismus ; Molekularbiologie ; Pharmakotherapie
    Subject Arzneimitteltherapie ; Arzneitherapie ; Medikamentöse Therapie ; Rheuma ; Rheumatische Krankheit ; Molekulare Biologie
    Language English
    Size VIII, 139 S. : Ill., graph. Darst.
    Edition 1., rev. and updated Engl. ed.
    Publisher Thieme
    Publishing place Stuttgart u.a.
    Publishing country Germany
    Document type Book
    Note Aus dem Dt. übers.
    HBZ-ID HT013754269
    ISBN 3-13-133091-0 ; 1-58890-205-6 ; 978-3-13-133091-8 ; 978-1-58890-205-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 2630 order for loan Magazin

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  3. Book: Rheumatische Erkrankungen und Entzündung

    Bartsch, Volker / Laufer, Stefan

    von den molekularen Grundlagen zur medikamentösen Therapie ; 26 Tabellen

    2002  

    Author's details Stefan Laufer ... Unter Mitarb. von Volker Bartsch
    Keywords Rheumatismus ; Molekularbiologie ; Pharmakotherapie
    Subject Rheuma ; Rheumatische Krankheit ; Arzneimitteltherapie ; Arzneitherapie ; Medikamentöse Therapie ; Molekulare Biologie
    Language German
    Size VIII, 134 S. : Ill., graph. Darst.
    Publisher Thieme
    Publishing place Stuttgart u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT013456334
    ISBN 3-13-132671-9 ; 978-3-13-132671-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 5225 order for loan Magazin

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  4. Article ; Online: Journal of Medicinal Chemistry

    Laufer, Stefan / Gehringer, Matthias / Titz, Alexander

    Journal of medicinal chemistry

    2024  Volume 67, Issue 4, Page(s) 2237

    MeSH term(s) Chemistry, Pharmaceutical ; Drug Discovery ; Germany
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.4c00122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Candidate drugs against SARS-CoV-2 and COVID-19

    Laufer, Stefan

    2020  

    Keywords 610 ; covid19
    Language English
    Publisher Academic Press Ltd - Elsevier Science Ltd
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Rapid Phenotypic Antibiotics Susceptibility Analysis by a 3D Printed Prototype.

    Riester, Oliver / Kaiser, Lars / Laufer, Stefan / Deigner, Hans-Peter

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  , Page(s) e2308806

    Abstract: One of the most important public health concerns is the increase in antibiotic-resistant pathogens and corresponding treatment of associated infections. Addressing this challenge requires more efficient use of antibiotics, achievable by the use of ... ...

    Abstract One of the most important public health concerns is the increase in antibiotic-resistant pathogens and corresponding treatment of associated infections. Addressing this challenge requires more efficient use of antibiotics, achievable by the use of evidence-based, effective antibiotics identified by antibiotic susceptibility testing (AST). However, the current standard method of phenotypic AST used for this purpose requires 48 h or more from sample collection to result. Until results are available, broad-spectrum antibiotics are used to avoid delaying treatment. The turnaround time must therefore be shortened in order for the results to be available before the second administration of antibiotics. The phenotypic electrochemical AST method presented here identifies effective antibiotics within 5-10 h after sampling. Spiked serum samples, including polymicrobial samples, with clinically relevant pathogens and respective concentrations commonly found in bloodstream infections (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa) are used. Direct loading of the test with diluted serum eliminates the need for a pre-culture, as required by existing methods. Furthermore, by combining several electrochemical measurement procedures with computational analysis, allowing the method to be used both online and offline, the AST achieves a sensitivity of 94.44% and a specificity of 95.83% considering each replicate individually.
    Language English
    Publishing date 2024-03-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202308806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: MKK4 Inhibitors-Recent Development Status and Therapeutic Potential.

    Katzengruber, Leon / Sander, Pascal / Laufer, Stefan

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: MKK4 (mitogen-activated protein kinase kinase 4; also referred to as MEK4) is a dual-specificity protein kinase that phosphorylates and regulates both JNK (c-Jun N-terminal kinase) and p38 MAPK (p38 mitogen-activated protein kinase) signaling pathways ... ...

    Abstract MKK4 (mitogen-activated protein kinase kinase 4; also referred to as MEK4) is a dual-specificity protein kinase that phosphorylates and regulates both JNK (c-Jun N-terminal kinase) and p38 MAPK (p38 mitogen-activated protein kinase) signaling pathways and therefore has a great impact on cell proliferation, differentiation and apoptosis. Overexpression of MKK4 has been associated with aggressive cancer types, including metastatic prostate and ovarian cancer and triple-negative breast cancer. In addition, MKK4 has been identified as a key regulator in liver regeneration. Therefore, MKK4 is a promising target both for cancer therapeutics and for the treatment of liver-associated diseases, offering an alternative to liver transplantation. The recent reports on new inhibitors, as well as the formation of a startup company investigating an inhibitor in clinical trials, show the importance and interest of MKK4 in drug discovery. In this review, we highlight the significance of MKK4 in cancer development and other diseases, as well as its unique role in liver regeneration. Furthermore, we present the most recent progress in MKK4 drug discovery and future challenges in the development of MKK4-targeting drugs.
    MeSH term(s) Female ; Humans ; Male ; JNK Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Kinase 4/metabolism ; Ovarian Neoplasms/pathology ; p38 Mitogen-Activated Protein Kinases/metabolism ; Phosphorylation
    Chemical Substances JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; MAP Kinase Kinase 4 (EC 2.7.12.2) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; MAP2K4 protein, human (EC 2.7.12.2)
    Language English
    Publishing date 2023-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease.

    Kronenberger, Thales / Laufer, Stefan A / Pillaiyar, Thanigaimalai

    Drug discovery today

    2023  Volume 28, Issue 6, Page(s) 103579

    Abstract: The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the causative factor behind the 2019 global coronavirus pandemic (COVID-19). The main protease, known as ... ...

    Abstract The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the causative factor behind the 2019 global coronavirus pandemic (COVID-19). The main protease, known as M
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2/metabolism ; Pandemics ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Antiviral Agents/chemistry ; Drug Development ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; Protease Inhibitors/chemistry ; Molecular Docking Simulation
    Chemical Substances 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Antiviral Agents ; Protease Inhibitors
    Language English
    Publishing date 2023-04-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2023.103579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4725: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Book ; Online ; Thesis: Identification and characterization of kinase-sparing aurora kinase A ligands for treatment of TP53-altered liver carcinomas

    Henning, Melanie [Verfasser] / Laufer, Stefan [Akademischer Betreuer]

    2024  

    Author's details Melanie Henning ; Gutachter: Stefan Laufer
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Article ; Online: Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy.

    Pillaiyar, Thanigaimalai / Laufer, Stefan

    Journal of medicinal chemistry

    2021  Volume 65, Issue 2, Page(s) 955–982

    Abstract: The global coronavirus disease-19 (COVID-19) has affected more than 140 million and killed more than 3 million people worldwide as of April 20, 2021. The novel human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been identified as an ... ...

    Abstract The global coronavirus disease-19 (COVID-19) has affected more than 140 million and killed more than 3 million people worldwide as of April 20, 2021. The novel human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been identified as an etiological agent for COVID-19. Several kinases have been proposed as possible mediators of multiple viral infections, including life-threatening coronaviruses like SARS-CoV-1, Middle East syndrome coronavirus (MERS-CoV), and SARS-CoV-2. Viral infections hijack abundant cell signaling pathways, resulting in drastic phosphorylation rewiring in the host and viral proteins. Some kinases play a significant role throughout the viral infection cycle (entry, replication, assembly, and egress), and several of them are involved in the virus-induced hyperinflammatory response that leads to cytokine storm, acute respiratory distress syndrome (ARDS), organ injury, and death. Here, we highlight kinases that are associated with coronavirus infections and their inhibitors with antiviral and potentially anti-inflammatory, cytokine-suppressive, or antifibrotic activity.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/virology ; Humans ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; SARS-CoV-2/drug effects ; SARS-CoV-2/isolation & purification ; Signal Transduction/drug effects ; Virus Replication/drug effects ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Protein Kinase Inhibitors
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.1c00335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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