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  1. Article ; Online: Interrelationships among central insulin signalling, diabetes, and cognitive impairment.

    Launer, Lenore J

    The Lancet. Neurology

    2020  Volume 19, Issue 8, Page(s) 640–642

    MeSH term(s) Cognitive Dysfunction ; Diabetes Mellitus ; Eating ; Humans ; Insulin ; Signal Transduction
    Chemical Substances Insulin
    Language English
    Publishing date 2020-05-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(20)30172-1
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  2. Article ; Online: Blood pressure control as an intervention to prevent dementia.

    Launer, Lenore J

    The Lancet. Neurology

    2019  Volume 18, Issue 10, Page(s) 906–908

    MeSH term(s) Adult ; Blood Pressure ; Brain ; Dementia ; Epidemiologic Studies ; Humans ; Hypertension
    Language English
    Publishing date 2019-08-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(19)30288-1
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  3. Article ; Online: The magnitude and direction of the relationship between risk factor and cognition depends on age: a pooled analysis of 5 community-based studies.

    Meirelles, Osorio / Arnette, Anthony / Guðnason, Vilmundur / Launer, Lenore J

    European journal of epidemiology

    2024  Volume 39, Issue 2, Page(s) 161–169

    Abstract: The mixed evidence of the association between high levels of cardiovascular risk factors (CVRF) and the risk for cognitive impairment may be due to confounding of age across studies. We pooled and harmonized individual-level data (30,967 persons, age ... ...

    Abstract The mixed evidence of the association between high levels of cardiovascular risk factors (CVRF) and the risk for cognitive impairment may be due to confounding of age across studies. We pooled and harmonized individual-level data (30,967 persons, age range 42-96 years) from five prospective cohorts to investigate by 1 year age increments to investigate whether or not there is change in slope describing the association of CVRF to a cognitive outcome (Digit Symbol Substitution Test; DSST). The CVRF included: systolic and diastolic blood pressure, total cholesterol, fasting glucose and body mass index. Linear and quadratic piecewise regression models were fit to the trajectory patterns of these slopes (betas). The pattern of yearly slope changes showed higher CVRF were associated with lower DSST, but associations attenuated toward zero as age increased for all but DBP where 1 year slopes for DBP changed direction from negative to positive from mid- to late-age. Age is not only a driver of cognitive decline-age also modifies the direction and strength of the association of cognitive function to CVRF and cohort age may be one reason why the evidence for CVRF-CD association is mixed.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Prospective Studies ; Risk Factors ; Cognition ; Cognitive Dysfunction/epidemiology ; Body Mass Index
    Language English
    Publishing date 2024-01-05
    Publishing country Netherlands
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-023-01087-0
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  4. Book: Frequency and impact of neurologic diseases in the elderly of Europe

    Launer, Lenore J.

    (Neurology ; 54,11, Suppl. 5)

    2000  

    Author's details Lenore J. Launer, suppl. ed
    Series title Neurology ; 54,11, Suppl. 5
    Collection
    Language English
    Size S40 S. : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Hagerstown, Md
    Publishing country United States
    Document type Book
    HBZ-ID HT012755297
    Database Catalogue ZB MED Medicine, Health

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    Ui II Zs 153 -54,11,Suppl.5- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Statistics on the burden of dementia: need for stronger data.

    Launer, Lenore J

    The Lancet. Neurology

    2018  Volume 18, Issue 1, Page(s) 25–27

    MeSH term(s) Alzheimer Disease ; Caregivers ; Dementia ; Global Burden of Disease ; Humans
    Language English
    Publishing date 2018-11-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(18)30456-3
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  6. Article ; Online: Trajectories in depressive symptoms and midlife brain health.

    Dintica, Christina S / Habes, Mohamad / Schreiner, Pamela J / Launer, Lenore J / Yaffe, Kristine

    Translational psychiatry

    2024  Volume 14, Issue 1, Page(s) 169

    Abstract: Depressive symptoms may either be a risk factor or prodromal to dementia. Investigating this association in midlife may help clarify the role of depression in cognitive aging. We aimed to identify trajectories in depressive symptoms in early to mid-life ... ...

    Abstract Depressive symptoms may either be a risk factor or prodromal to dementia. Investigating this association in midlife may help clarify the role of depression in cognitive aging. We aimed to identify trajectories in depressive symptoms in early to mid-life and related cognitive and brain outcomes in midlife. This study includes 3944 Black and White participants (ages 26-45 years at baseline) from the Coronary Artery Risk Development in Young Adults (CARDIA) study with 20 years of follow-up. Depressive symptoms were assessed using the Center for Epidemiological Studies Depression scale at five time points over 20 years. Growth mixture modeling (GMM) was used to identify depressive symptom trajectories. Participants completed a neuropsychological battery 20 years after baseline, including the Digit Symbol Substitution Test (DSST), Rey-Auditory Verbal Learning Test (RAVLT), Stroop Test, Montreal Cognitive Assessment (MoCA), and category and letter fluency tests. A sub-sample of participants (n = 662) underwent brain magnetic resonance imaging (MRI) to characterize gray matter volumes and white matter hyperintensities (WMHs). We identified four classes of depressive symptom trajectories: a "declining" class (n = 286, 7.3%) with initially high symptoms and subsequent decline, a class with consistently high symptoms ("steady high"; n = 264, 6.7%), a class with late increases in symptoms ("increasing"; n = 277, 7%), and a class with consistently low symptoms ("steady low"; n = 3117, 79.0%). The steady high and the increasing classes had poorer performance on all cognitive tests, while the declining class had poorer performance on the DSST, verbal fluency, and MoCA. Compared to the steady low symptom class, the steady high class had lower volumes in the entorhinal cortex (β: -180.80, 95% CI: -336.69 to -24.91) and the amygdala (β: -40.97, 95% CI: -74.09 to -7.85), the increasing class had more WMHs (β: 0.55, 95% CI: 0.22 to 0.89), and the declining class was not significantly different in any brain measures. Trajectories in depressive symptoms in young to mid-adulthood show distinct cognitive and brain phenotypes in midlife. Steady high depressive symptoms may represent a group that is at risk for dementia, whereas increasing symptoms in midlife may be associated with white matter damage.
    MeSH term(s) Young Adult ; Humans ; Adult ; Depression ; Cognition ; Brain/diagnostic imaging ; Risk Factors ; Dementia
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-024-02883-2
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  7. Book ; Conference proceedings: European studies on the incidence of dementing diseases

    Launer, Lenore J.

    a report of the EURODEM research group ; [EURODEM incidence conferences, Bordeaux, France, 1989, Cambridge, UK, 1990] ; 44 tables

    (Neuroepidemiology ; 11, Suppl. 1)

    1992  

    Institution Europäische Zusammenarbeit auf dem Gebiet der Wissenschaftlichen und Technischen Forschung / Concerted Action Epidemiology of Dementia
    Author's details guest ed. L. J. Launer
    Series title Neuroepidemiology ; 11, Suppl. 1
    Neuroepidemiology
    Collection Neuroepidemiology
    Keywords Dementia / epidemiology / congresses ; Europa ; Demenz ; Epidemiologie
    Subject Krankheitsverbreitung ; Anoia ; Dementia ; Chronische Verwirrtheit
    Size VI, 122 S. : graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT004244698
    ISBN 3-8055-5593-8 ; 978-3-8055-5593-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1722 -11,Suppl.1- verfügbar in Königswinter Königswinter

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  8. Article ; Online: The role of population-level preventive care for brain health in ageing.

    Sabayan, Behnam / Doyle, Sara / Rost, Natalia S / Sorond, Farzaneh A / Lakshminarayan, Kamakshi / Launer, Lenore J

    The lancet. Healthy longevity

    2023  Volume 4, Issue 6, Page(s) e274–e283

    Abstract: Over the past several decades, a worldwide demographic transition has led to an increasing number of older adults with chronic neurological conditions. These conditions, which have a profound effect on the cognitive function and physical ability of older ...

    Abstract Over the past several decades, a worldwide demographic transition has led to an increasing number of older adults with chronic neurological conditions. These conditions, which have a profound effect on the cognitive function and physical ability of older adults, also have a long preclinical phase. This feature provides a unique opportunity to implement preventive measures for high-risk groups and the population as a whole, and therefore to reduce the burden of neurological diseases. The concept of brain health has emerged as the overarching theme to define overall brain function independently of underlying pathophysiological processes. We review the concept of brain health from the ageing and preventive care perspectives, discuss the mechanisms underpinning ageing and brain ageing, highlight the interplay of various forces resulting in deviation from brain health towards brain disease, and provide an overview of strategies to promote brain health with a life-course approach.
    MeSH term(s) Brain ; Cognition/physiology
    Language English
    Publishing date 2023-05-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ISSN 2666-7568
    ISSN (online) 2666-7568
    DOI 10.1016/S2666-7568(23)00051-X
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  9. Article ; Online: Preventing Alzheimer's disease is difficult.

    Launer, Lenore J

    The Lancet. Neurology

    2015  Volume 14, Issue 9, Page(s) 872–874

    MeSH term(s) Alzheimer Disease/prevention & control ; Alzheimer Disease/therapy ; Clinical Trials as Topic/trends ; Humans ; Learning ; Risk Reduction Behavior
    Language English
    Publishing date 2015-09
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(15)00193-3
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  10. Article ; Online: Associations of Polycystic Ovary Syndrome With Indicators of Brain Health at Midlife in the CARDIA Cohort.

    Huddleston, Heather G / Jaswa, Eleni G / Casaletto, Kaitlin B / Neuhaus, John / Kim, Catherine / Wellons, Melissa / Launer, Lenore J / Yaffe, Kristine

    Neurology

    2024  Volume 102, Issue 4, Page(s) e208104

    Abstract: Background and objectives: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with an adverse cardiometabolic profile early in life. Increasing evidence links cardiovascular risk factors, such as diabetes and hypertension, to ... ...

    Abstract Background and objectives: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with an adverse cardiometabolic profile early in life. Increasing evidence links cardiovascular risk factors, such as diabetes and hypertension, to accelerated cognitive aging. However, less is known about PCOS and its relationship to brain health, particularly at midlife. Our goal was to investigate possible associations between PCOS and midlife cognitive function and brain MRI findings in an ongoing prospective study.
    Methods: We used data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a geographically diverse prospective cohort study of individuals who were 18-30 years at baseline (1985-1986) and followed for 30 years. We identified women with PCOS from an ancillary study (CARDIA Women's study (CWS); n = 1,163) as those with elevated androgen levels and/or hirsutism in conjunction with symptoms of oligomenorrhea. At year 30, participants completed cognitive testing, including the Montreal Cognitive Assessment, Rey Auditory Verbal Learning Test (RAVLT) (verbal learning and memory), Digit Symbol Substitution Test (processing speed and executive function), Stroop test (attention and cognitive control), and category and letter fluency tests (semantics and attention). A subset completed brain MRI to assess brain structure and white matter integrity. Multivariable linear regression models estimated the association between PCOS and outcomes, adjusting for age, race, education, and study center.
    Results: Of the 1163 women in CWS, 907 completed cognitive testing, and of these, 66 (7.1%) met criteria for PCOS (age 54.7 years). Women with and without PCOS were similar for age, BMI, smoking/drinking status, and income. At year 30, participants with PCOS performed lower (mean z score; 95% CI) on Stroop (-0.323 (-0.69 to -7.37);
    Discussion: Our results suggest that women with PCOS have lower cognitive performance and lower white matter integrity at midlife. Additional research is needed to confirm these findings and to determine potential mechanistic pathways including potential modifiable factors.
    MeSH term(s) Young Adult ; Humans ; Female ; Middle Aged ; Prospective Studies ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/diagnostic imaging ; Polycystic Ovary Syndrome/epidemiology ; Coronary Vessels ; Brain/diagnostic imaging ; Executive Function ; Cognition
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000208104
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