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  1. Article ; Online: Publisher Correction

    Juhi K. Gupta / Angharad Care / Laura Goodfellow / Zarko Alfirevic / Bertram Müller‑Myhsok / Ana Alfirevic

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    Genome and transcriptome profiling of spontaneous preterm birth phenotypes

    2022  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Genome and transcriptome profiling of spontaneous preterm birth phenotypes

    Juhi K. Gupta / Angharad Care / Laura Goodfellow / Zarko Alfirevic / Bertram Müller-Myhsok / Ana Alfirevic

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 10

    Abstract: Abstract Preterm birth (PTB) occurs before 37 weeks of gestation. Risk factors include genetics and infection/inflammation. Different mechanisms have been reported for spontaneous preterm birth (SPTB) and preterm birth following preterm premature rupture ...

    Abstract Abstract Preterm birth (PTB) occurs before 37 weeks of gestation. Risk factors include genetics and infection/inflammation. Different mechanisms have been reported for spontaneous preterm birth (SPTB) and preterm birth following preterm premature rupture of membranes (PPROM). This study aimed to identify early pregnancy biomarkers of SPTB and PPROM from the maternal genome and transcriptome. Pregnant women were recruited at the Liverpool Women’s Hospital. Pregnancy outcomes were categorised as SPTB, PPROM (≤ 34 weeks gestation, n = 53), high-risk term (HTERM, ≥ 37 weeks, n = 126) or low-risk (no history of SPTB/PPROM) term (LTERM, ≥ 39 weeks, n = 188). Blood samples were collected at 16 and 20 weeks gestation from which, genome (UK Biobank Axiom array) and transcriptome (Clariom D Human assay) data were acquired. PLINK and R were used to perform genetic association and differential expression analyses and expression quantitative trait loci (eQTL) mapping. Several significant molecular signatures were identified across the analyses in preterm cases. Genome-wide significant SNP rs14675645 (ASTN1) was associated with SPTB whereas microRNA-142 transcript and PPARG1-FOXP3 gene set were associated with PPROM at week 20 of gestation and is related to inflammation and immune response. This study has determined genomic and transcriptomic candidate biomarkers of SPTB and PPROM that require validation in diverse populations.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Association of maternal prenatal selenium concentration and preterm birth

    Anisur Rahman / Ana Alfirevic / Kenneth Maleta / Ulla Ashorn / Per Ashorn / Kelli K Ryckman / Stephen H Kennedy / Monjur Rahman / Jesmin Pervin / Cathrine Hoyo / Rasheda Khanam / James A Litch / Aneeta Hotwani / Daniel E Roth / Ge Zhang / Abdullah Al Mahmud / Mikko Hallman / Huan Xu / Zarko Alfirevic /
    Jeffrey C Murray / Bellington Vwalika / Susan Murphy / Patrick Musonda / Nagendra Monangi / Angharad Care / Waqasuddin Khan / Joan T Price / Yuemei Fan / Thanh Q Le / Julio A Landero / Gerald F Combs / Elizabeth Belling / Joanne Chappell / Fansheng Kong / Criag Lacher / Nabidul Haque Chowdhury / Furqan Kabir / Imran Nisar / Ambreen Nizar / Javairia Khalid / Said Ali / Mohammed Hamad Juma / Md Munirul Islam / Laura Goodfellow / Juhi K Gupta / Larry Rand / Courtney Baruch-Gravett / Abdullah Baqui / Jane Hirst / Laura L Jelliffe-Pawlowski / Jeffrey Stringer / Louis Muglia

    BMJ Global Health, Vol 6, Iss

    a multicountry meta-analysis

    2021  Volume 9

    Keywords Medicine (General) ; R5-920 ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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