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Article ; Online: Do short-term, reduced-volume methods accurately reflect chronic toxic effects in the cladoceran Ceriodaphnia dubia? A study with the reference toxicant hexavalent chromium

Fernando Martínez-Jerónimo / Laura Martínez-Jerónimo

Frontiers in Environmental Science, Vol

2023 Volume 11

Abstract: Cladocerans are frequently used as test organisms in aquatic toxicology studies. For practical reasons (bioethical and economic), efforts are currently made in search of alternative animal models and in defining short-lasting test methods that will allow ...

Abstract	Cladocerans are frequently used as test organisms in aquatic toxicology studies. For practical reasons (bioethical and economic), efforts are currently made in search of alternative animal models and in defining short-lasting test methods that will allow reliable evaluation of the chronic effect of chemical contaminants. The use of small-sized invertebrates, like the Ceriodaphnia dubia cladoceran, represents a good option and has been included in diverse testing protocols; however, the use of reduced volumes and shortened exposure times, as well as higher temperatures to accelerate their development could influence the results and lead to imprecise conclusions. The present study aimed to evaluate the effects of different test volumes, temperature, and exposure time on the toxicity of hexavalent chrome in C. dubia. In acute and chronic assays, three test volumes (5, 15, and 25 mL) were used. Once the LC50 was determined, four sublethal concentrations (0.01, 0.02, 0.04, and 0.08 mg L−1) of Cr(VI) were applied daily to each of the three test volumes for 21 days, evaluating the progeny and survival of adults. The LC50 values did not differ at 20°C, but at 25°C they were significantly lower in 5 mL. The chronic toxic effects varied depending on the test volume and exposure time. Significant effects were observed on day 7 of exposure (corresponding to the third reproduction) in the accumulated progeny only in the volume of 5 mL. Based on the aforementioned, it is necessary to revise whether the short-term and small-scale methods are not underestimating the detection of chronic effects.
Keywords	Cr(VI) ; cladocera ; Daphnia ; chronic toxicity ; aquatic toxicology ; aquatic toxicity guidelines ; Environmental sciences ; GE1-350
Subject code	150
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Víctimas, salvadores y el colapso de una ONG

Laura Martínez Apráez

Antípoda: Revista de Antropología y Arqueología, Vol 35, Pp 47-

beneficios y riesgos de la aplicación de metodologías participativas en el trabajo de organizaciones no gubernamentales

2019 Volume 67

Abstract: A reflection on the case of an NGO co-founded by the author, which had to be closed down following severe failures generated by the misuse of feminist and participative methodologies and the financing system for such organizations. This analysis takes ... ...

Abstract	A reflection on the case of an NGO co-founded by the author, which had to be closed down following severe failures generated by the misuse of feminist and participative methodologies and the financing system for such organizations. This analysis takes into account feminist and participative methodologies through which the organization was funded, it reviews the failures and proposes considerations with respect to the use of these methods. Methodology: This article considers the personal experience of the author as a researcher and co-founder of the NGO, and presents a bibliographic review of the subject, supporting the ideas presented. Conclusions: Participative methodologies emerge as a way to “give voice” to historically marginalized communities and seek approaches that are more closely committed to social justice. Nevertheless, from an NGO perspective, there are newer risks in practice, especially with financing. It is important to consider these risks and decide on the future growth and financing goals beforehand in order to avoid falling into these common traps. Originality: This reflection is relevant since it is an understudied subject that can have serious implications with regards the beneficiaries of NGOs and the researchers involved.
Keywords	Ethical implications ; feminist ethnographies ; human rights ; NGOs ; Participative Action Research (PAR) ; Anthropology ; GN1-890 ; Archaeology ; CC1-960
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	Universidad de los Andes (Bogotá)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cartas para la Historia en el mundo 2.0

Laura Martínez Martín / Guadalupe Adámez Castro

Historia Crítica, Vol 83, Pp 99-

la construcción y estudio de un corpus epistolar digital hispano-luso de la Edad Moderna

2022 Volume 123

Abstract: Objective/Context: The text proposes a journey through the methodology and work process followed in the Post Scriptum. A Digital Archive of Ordinary Writings (Early Modern in Spain and Portugal) project, which led to the formation of a digital epistolary ...

Abstract	Objective/Context: The text proposes a journey through the methodology and work process followed in the Post Scriptum. A Digital Archive of Ordinary Writings (Early Modern in Spain and Portugal) project, which led to the formation of a digital epistolary corpus—now available online—from funds preserved in judicial archives during the Modern Age in the Iberian Peninsula. Based on a practical case, the paper reflects on the reality of the fieldwork carried out in order to build a digital corpus, as well as on its strengths and weaknesses, which allows a first-hand insight of some changes and challenges of the digital revolution we are immersed in. Methodology: Advances in the field of Digital Humanities are taken as a starting point to examine the multidisciplinarity that characterizes both the corpus formation process and the possibilities for its analysis and study. Originality: The paper describes the complete work process involved in the transformation of primary sources into digital sources in an innovative project in the field of Digital Humanities; it also reflects on problems faced by historians in working with private letters produced by common people (sixteenth-nineteenth centuries), which range from the location of these sources to their selection, digitization, editing, treatment, and subsequent study. Conclusions: In addition to describing the process of transforming sources into a digital corpus and the possibilities of its analysis, the article evidences different analytical ways. Likewise, it addresses the wealth of archives as essential repositories for recovering private and ordinary epistolary sources while also reflecting on the future of their conservation in the digital environment.
Keywords	digital humanities ; historical corpus ; historiography ; iberian peninsula ; ordinary writing ; private correspondence ; History (General) and history of Europe ; D ; History (General) ; D1-2009
Subject code	302
Language	Spanish
Publishing date	2022-01-01T00:00:00Z
Publisher	Universidad de los Andes
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A clade of RHH proteins ubiquitous in Sulfolobales and their viruses regulates cell cycle progression.

Xuyang, Li / Cristina, Lozano-Madueño / Laura, Martínez-Alvarez / Xu, Peng

Nucleic acids research

2023 Volume 51, Issue 4, Page(s) 1724–1739

Abstract: Cell cycle regulation is crucial for all living organisms and is often targeted by viruses to facilitate their own propagation, yet cell cycle progression control is largely underexplored in archaea. In this work, we reveal a cell cycle regulator (aCcr1) ...

Abstract	Cell cycle regulation is crucial for all living organisms and is often targeted by viruses to facilitate their own propagation, yet cell cycle progression control is largely underexplored in archaea. In this work, we reveal a cell cycle regulator (aCcr1) carrying a ribbon-helix-helix (RHH) domain and ubiquitous in the Thermoproteota of the order Sulfolobales and their viruses. Overexpression of several aCcr1 members including gp21 of rudivirus SIRV2 and its host homolog SiL_0190 of Saccharolobus islandicus LAL14/1 results in impairment of cell division, evidenced by growth retardation, cell enlargement and an increase in cellular DNA content. Additionally, both gp21 and SiL_0190 can bind to the motif AGTATTA conserved in the promoter of several genes involved in cell division, DNA replication and cellular metabolism thereby repressing or inducing their transcription. Our results suggest that aCcr1 silences cell division and drives progression to the S-phase in Sulfolobales, a function exploited by viruses to facilitate viral propagation.
MeSH term(s)	Cell Cycle ; Cell Division ; DNA Replication ; Rudiviridae/genetics ; Rudiviridae/metabolism ; Sulfolobales/cytology ; Sulfolobales/virology ; Archaeal Proteins/metabolism
Chemical Substances	Archaeal Proteins
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparison of the Informed Health Choices Key Concepts Framework to other frameworks relevant to teaching and learning how to think critically about health claims and choices: a systematic review.

Oxman, Andrew D / García, Laura Martínez

F1000Research

2020 Volume 9, Page(s) 164

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Choice Behavior ; Curriculum ; Health Education ; Humans ; Learning ; Teaching ; Thinking
Language	English
Publishing date	2020-03-05
Publishing country	England
Document type	Comparative Study ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.21858.1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Guiding future research on psychological interventions in people with COVID-19 and post COVID syndrome and comorbid emotional disorders based on a systematic review

Verónica Martínez-Borba / Laura Martínez-García / Óscar Peris-Baquero / Jorge Osma / Esther del Corral-Beamonte

Frontiers in Public Health, Vol

2024 Volume 11

Abstract: ObjectiveThe COVID-19 pandemic has been emotionally challenging for the entire population and especially for people who contracted the illness. This systematic review summarizes psychological interventions implemented in COVID-19 and long COVID-19 ... ...

Abstract	ObjectiveThe COVID-19 pandemic has been emotionally challenging for the entire population and especially for people who contracted the illness. This systematic review summarizes psychological interventions implemented in COVID-19 and long COVID-19 patients who presented comorbid emotional disorders.Methods and measures3,839 articles were identified in 6 databases and 43 of them were included in this work. Two independent researchers selected the articles and assessed their quality.Results2,359 adults were included in this review. Severity of COVID-19 symptoms ranged from asymptomatic to hospitalized patients; only 3 studies included long COVID-19 populations. Similar number of randomized controlled studies (n = 15) and case studies (n = 14) were found. Emotional disorders were anxiety and/or depressive symptoms (n = 39) and the psychological intervention most represented had a cognitive behavioral approach (n = 10). Length of psychological programs ranged from 1–5 sessions (n = 6) to 16 appointments (n = 2). Some programs were distributed on a daily (n = 4) or weekly basis (n = 2), but other proposed several sessions a week (n = 4). Short (5–10 min, n = 4) and long sessions (60–90 min, n = 3) are proposed. Most interventions were supported by the use of technologies (n = 18). Important risk of bias was present in several studies.ConclusionPromising results in the reduction of depressive, anxiety and related disorders have been found. However, important limitations in current psychological interventions were detected (i.e., duration, format, length, and efficacy of interventions were not consistently established across investigations). The results derived from our work may help to understand clinical practices in the context of pandemics and could guide future efforts to manage emotional suffering in COVID-19 patients. A stepped model of care could help to determine the dosage, length and format of delivery for each patient.Systematic review registration: PROSPERO 2022 CRD42022367227. Available from: ...
Keywords	COVID-19 patients ; long COVID-19 conditions ; psychological interventions ; systematic review ; emotional disorders ; Public aspects of medicine ; RA1-1270
Subject code	150
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Detection of Plasmopara halstedii in sunflower seeds: A case study using molecular testing

Laura Martínez, Ana / José Quiroz, Facundo / Delia Carrera, Alicia

Journal of the Saudi Society of Agricultural Sciences. 2021 Apr. 19,

2021

Abstract: Plasmopara halstedii (Farl.) Berl. & De Toni causing downy mildew of sunflower is responsible for considerable economic losses worldwide. Because P. halstedii can be seed-transmitted, monitoring of seeds for pathogen contamination is important for the ... ...

Abstract	Plasmopara halstedii (Farl.) Berl. & De Toni causing downy mildew of sunflower is responsible for considerable economic losses worldwide. Because P. halstedii can be seed-transmitted, monitoring of seeds for pathogen contamination is important for the sunflower seed trade. The relevance of asymptomatic or latent infections as factors of disease spread have not been studied by molecular techniques. A molecular marker based on a putative effector gene of P. halstedii was used to examine the pathogen’s presence in asymptomatic sunflowers growing near patches of mildewed plants in naturally infected fields. The method based on conventional PCR was highly sensitive for detection of P. halstedii in DNA from whole seeds. By the application of this protocol, we found that all seed samples obtained from symptomatic plants amplified the expected fragment, whereas the diagnostic marker identified the presence of pathogen in one out of 21 asymptomatic plants. Possible uses of this marker to detect downy mildew in seed from asymptomatic plants or for race identification are discussed.
Keywords	DNA ; Helianthus annuus ; Plasmopara halstedii ; case studies ; downy mildew ; genes ; genetic markers ; pathogens ; sunflower seed ; trade
Language	English
Dates of publication	2021-0419
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean ; Pre-press version
ISSN	1658-077X
DOI	10.1016/j.jssas.2021.04.007
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: FleQ, FleN and c-di-GMP coordinately regulate cellulose production in Pseudomonas syringae pv. tomato DC3000

Laura Martínez-Rodríguez / Aroa López-Sánchez / Andrea García-Alcaide / Fernando Govantes / María-Trinidad Gallegos

Frontiers in Molecular Biosciences, Vol

2023 Volume 10

Abstract: The second messenger cyclic di-GMP (c-di-GMP) controls the transition between motility and sessility in many bacterial species by a variety of mechanisms, including the production of multiple exopolysaccharides. Pseudomonas syringae pv. tomato (Pto) ... ...

Abstract	The second messenger cyclic di-GMP (c-di-GMP) controls the transition between motility and sessility in many bacterial species by a variety of mechanisms, including the production of multiple exopolysaccharides. Pseudomonas syringae pv. tomato (Pto) DC3000 is a plant pathogenic bacteria able to synthesize acetylated cellulose under high c-di-GMP levels thanks to the expression of the wssABCDEFGHI operon. Increased cellulose production enhances air-liquid biofilm formation and generates a wrinkled colony phenotype on solid media. We previously showed that under low levels of c-di-GMP, the regulators FleQ and AmrZ bound to adjacent sequences at the wss promoter inhibiting its expression, but only FleQ responded to the presence of c-di-GMP by activating cellulose production. In the present work, we advance in the knowledge of this complex regulation in Pto DC3000 by shedding light over the role of FleN in this process. The distinctive features of this system are that FleN and FleQ are both required for repression and activation of the wss operon under low and high c-di-GMP levels, respectively. We have also identified three putative FleQ binding sites at the wss promoter and show that FleQ/FleN-ATP binds at those sites under low c-di-GMP levels, inducing a distortion of DNA, impairing RNA polymerase binding, and repressing wss transcription. However, binding of c-di-GMP induces a conformational change in the FleQ/FleN-ATP complex, which relieves the DNA distortion, allows promoter access to the RNA polymerase, and leads to activation of wss transcription. On the other hand, AmrZ is always bound at the wss promoter limiting its expression independently of FleQ, FleN and c-di-GMP levels.
Keywords	FleN ; FleQ ; c-di-GMP ; Pseudomonas syringae ; cellulose ; transcriptional regulation ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Esophageal blind sac fistula.

Luna-Abanto, Jorge / Laura Martínez, Jheff

Cirugia espanola

2018 Volume 97, Issue 6, Page(s) 344

Title translation	Fístula esofágica en saco ciego.
MeSH term(s)	Carcinoma, Squamous Cell/complications ; Carcinoma, Squamous Cell/diagnostic imaging ; Esophageal Fistula/diagnostic imaging ; Esophageal Fistula/etiology ; Esophageal Neoplasms/complications ; Esophageal Neoplasms/diagnostic imaging ; Female ; Humans ; Middle Aged ; Tomography, X-Ray Computed
Language	Spanish
Publishing date	2018-12-07
Publishing country	Spain
Document type	Case Reports ; Journal Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.ciresp.2018.10.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Seguridad alimentaria, autosuficiencia y disponibilidad del amaranto en México

Laura Martínez Salvador

Problemas del Desarrollo : Revista Latinoamericana de Economía, Vol 47, Iss 186, Pp 107-

2016 Volume 132

Abstract: En México la obesidad y la desnutrición son un grave problema de salud pública por lo que el rescate de cultivos nutritivos y superavitarios, como los es el del amaranto, surge como una alternativa para contribuir a mejorar la dieta alimenticia y ... ...

Abstract	En México la obesidad y la desnutrición son un grave problema de salud pública por lo que el rescate de cultivos nutritivos y superavitarios, como los es el del amaranto, surge como una alternativa para contribuir a mejorar la dieta alimenticia y favorecer la disminución de los problemas de malnutrición en el país. El amaranto, considerado como un cultivo con amplio potencial nutricional, tiene una baja importancia estadística como alimento, por lo que representa un claro ejemplo del potencial y la diversidad agrícola desaprovechada por las estrategias alimenticias. Es importante rescatar la producción local de amaranto, procurando que los actores de la dinámica agrícola de este cultivo posean las capacidades para impulsar su producción y consumo en aras de atender el problema de malnutrición (obesidad o desnutrición) y de seguridad alimentaria.
Keywords	Economic growth ; development ; planning ; HD72-88 ; Industries. Land use. Labor ; HD28-9999 ; Social Sciences ; H
Language	Spanish
Publishing date	2016-01-01T00:00:00Z
Publisher	Universidad Nacional Autónoma de México
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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