LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 43

Search options

  1. Article ; Online: Innovation in surgery.

    Khoma, Oleksandr / Laurence, Jerome M / Sandroussi, Charbel / Wijnhoven, Bas P L

    The British journal of surgery

    2023  Volume 110, Issue 12, Page(s) 1611–1613

    MeSH term(s) Diffusion of Innovation ; Surgical Procedures, Operative
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad164
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Prospective evaluation of a closed-incision negative pressure wound therapy system in kidney transplantation and its association with wound complications.

    Lam, Susanna / Huynh, Annie / Ying, Tracey / Sandroussi, Charbel / Gracey, David / Pleass, Henry C / Chadban, Steve / Laurence, Jerome M

    Frontiers in nephrology

    2024  Volume 4, Page(s) 1352363

    Abstract: Introduction: Wound complications can cause considerable morbidity in kidney transplantation. Closed-incision negative pressure wound therapy (ciNPWT) systems have been efficacious in reducing wound complications across surgical specialties. The aims of ...

    Abstract Introduction: Wound complications can cause considerable morbidity in kidney transplantation. Closed-incision negative pressure wound therapy (ciNPWT) systems have been efficacious in reducing wound complications across surgical specialties. The aims of this study were to evaluate the use of ciNPWT, Prevena™, in kidney transplant recipients and to determine any association with wound complications.
    Material and methods: A single-center, prospective observational cohort study was performed in 2018. A total of 30 consecutive kidney transplant recipients deemed at high risk for wound complications received ciNPWT, and the results were compared to those of a historical cohort of subjects who received conventional dressings. Analysis for recipients with obesity and propensity score matching were performed.
    Results: In total, 127 subjects were included in the analysis. Of these, 30 received a ciNPWT dressing and were compared with 97 subjects from a non-study historical control group who had conventional dressing. The overall wound complication rate was 21.3% (27/127). There was no reduction in the rate of wound complications with ciNPWT when compared with conventional dressing [23.3% (7/30) and 20.6% (20/97), respectively,
    Conclusion: This is the first reported cohort study evaluating the use of ciNPWT in kidney transplantation. While ciNPWT is safe and well tolerated, it is not associated with a statistically significant reduction in wound complications when compared to conventional dressing. The findings from this study will be used to inform future studies associated with ciNPWT in kidney transplantation.
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2813-0626
    ISSN (online) 2813-0626
    DOI 10.3389/fneph.2024.1352363
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Splenic Artery Aneurysm Management in the Cirrhotic Patient Listed for Liver Transplantation: A Systematic Review.

    Phan, Du / Furtado, Ruelan / Laurence, Jerome M / Pleass, Henry

    Transplantation proceedings

    2022  Volume 54, Issue 3, Page(s) 706–714

    Abstract: Background: Splenic artery aneurysms (SAA), although rare in the general population, occur more commonly in liver transplant candidates owing to cirrhosis-induced portal hypertension. In this population, particularly in the perioperative period, SAAs ... ...

    Abstract Background: Splenic artery aneurysms (SAA), although rare in the general population, occur more commonly in liver transplant candidates owing to cirrhosis-induced portal hypertension. In this population, particularly in the perioperative period, SAAs are at heightened risks of rupture with potentially fatal consequences. There is no consensus regarding optimal management of asymptomatic SAA diagnosed before liver transplantation.
    Materials and methods: We performed a systematic review of the literature to investigate the management options and outcomes of asymptomatic SAAs in liver transplant candidates. The EMBASE and MEDLINE electronic databases were used to identify articles.
    Results: Eleven articles met the criteria for analysis and included 159 patients with SAAs, among whom 121 had asymptomatic aneurysms diagnosed pre transplant and subsequently underwent liver transplantation. The majority of SAAs were located distally or intrahilar (80%) and more than half of the patients had multiple SAAs. In 121 patients diagnosed pre transplant, 37 patients had treatment instigated (28 treated surgically and 8 treated radiologically). Post-transplant rupture was noted in 2 patients treated surgically (2/28) with no fatality. No rupture was observed in the radiologically treated group, although 1 patient died of splenic abscess and sepsis after embolization. In 86 untreated patients, 4 cases of post-transplant rupture were recorded (2/4 resulted in fatality).
    Conclusion: Asymptomatic SAAs are at risks of rupture post transplant and treatment should be considered, regardless of aneurysm size. Both surgical and radiological treatments offer adequate control, and choice of treatment is dependent on location and number of SAA present.
    MeSH term(s) Aneurysm, Ruptured/epidemiology ; Aneurysm, Ruptured/surgery ; Gastrointestinal Diseases ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/surgery ; Liver Transplantation/adverse effects ; Splenic Artery/surgery ; Splenic Diseases
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2022.01.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Kidney Transplantation Outcomes From Uncontrolled Donation After Circulatory Death: A Systematic Review and Meta-analysis.

    Vijayan, Keshini / Schroder, Hugh J / Hameed, Ahmer / Hitos, Kerry / Lo, Warren / Laurence, Jerome M / Yoon, Peter D / Nahm, Christopher / Lim, Wai H / Lee, Taina / Yuen, Lawrence / Wong, Germaine / Pleass, Henry

    Transplantation

    2024  

    Abstract: Background: Uncontrolled donation after circulatory death (uDCD) is a potential additional source of donor kidneys. This study reviewed uDCD kidney transplant outcomes to determine if these are comparable to controlled donation after circulatory death ( ... ...

    Abstract Background: Uncontrolled donation after circulatory death (uDCD) is a potential additional source of donor kidneys. This study reviewed uDCD kidney transplant outcomes to determine if these are comparable to controlled donation after circulatory death (cDCD).
    Methods: MEDLINE, Cochrane, and Embase databases were searched. Data on demographic information and transplant outcomes were extracted from included studies. Meta-analyses were performed, and risk ratios (RR) were estimated to compare transplant outcomes from uDCD to cDCD.
    Results: Nine cohort studies were included, from 2178 uDCD kidney transplants. There was a moderate degree of bias, as 4 studies did not account for potential confounding factors. The median incidence of primary nonfunction in uDCD was 12.3% versus 5.7% for cDCD (RR, 1.85; 95% confidence intervals, 1.06-3.23; P = 0.03, I2 = 75). The median rate of delayed graft function was 65.1% for uDCD and 52.0% for cDCD. The median 1-y graft survival for uDCD was 82.7% compared with 87.5% for cDCD (RR, 1.43; 95% confidence intervals, 1.02-2.01; P = 0.04; I2 = 71%). The median 5-y graft survival for uDCD and cDCD was 70% each. Notably, the use of normothermic regional perfusion improved primary nonfunction rates in uDCD grafts.
    Conclusions: Although uDCD outcomes may be inferior in the short-term, the long-term outcomes are comparable to cDCD.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004937
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Surgical mentorship in a new landscape.

    Laurence, Jerome M / Hong, Jonathan / Storey, David W

    ANZ journal of surgery

    2019  Volume 89, Issue 7-8, Page(s) 800–801

    MeSH term(s) Education, Medical, Graduate/methods ; Mentors ; Specialties, Surgical/education
    Language English
    Publishing date 2019-08-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.15165
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Techniques of pancreas graft salvage/indications for allograft pancreatectomy.

    Laurence, Jerome M / Cattral, Mark S

    Current opinion in organ transplantation

    2016  Volume 21, Issue 4, Page(s) 405–411

    Abstract: Purpose of review: Despite improvements in pancreas allograft outcome, graft complications remain a significant cause of morbidity and mortality. This review analyses the issues involved in the management of conditions that may require graft ... ...

    Abstract Purpose of review: Despite improvements in pancreas allograft outcome, graft complications remain a significant cause of morbidity and mortality. This review analyses the issues involved in the management of conditions that may require graft pancreatectomy, including the indications and techniques for graft salvage.
    Recent findings: With early recognition of graft complications, liberal use of radiological interventions, improved infection control, access to critical care and innovative surgical techniques, graft salvage is now feasible in many circumstances where graft pancreatectomy would previously have been necessary.
    Summary: The outcome of pancreas transplantation continues to improve with advances in the management of graft-threatening complications.
    MeSH term(s) Allografts/transplantation ; Graft Survival/physiology ; Humans ; Pancreas Transplantation/methods ; Pancreatectomy/methods ; Transplantation, Homologous/methods
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000318
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Combined Liver-Kidney Transplant for Juvenile Polycystic Kidney Disease and Concomitant Hereditary Factor V Deficiency.

    Yu, Victor / Ebrahimi, Nargus / Cachalia, Tariq / Jacques, Andrew / Wyburn, Kate / McCaughan, Geoffrey W / Dunkley, Scott / Crawford, Michael D / Pulitano, Carlo / Laurence, Jerome M

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2022  Volume 20, Issue 11, Page(s) 1043–1045

    Abstract: Factor V deficiency is a congenital bleeding diathesis that, in selected cases, may be managed with liver transplant. In this case, we describe the treatment of an adult patient with kidney failure secondary to juvenile onset polycystic kidney disease ... ...

    Abstract Factor V deficiency is a congenital bleeding diathesis that, in selected cases, may be managed with liver transplant. In this case, we describe the treatment of an adult patient with kidney failure secondary to juvenile onset polycystic kidney disease who received a combined liver-kidney transplant as a method to manage the risks associated with the need for a kidney transplantin the setting of factorV deficiency and high sensitization.
    MeSH term(s) Adult ; Humans ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Factor V Deficiency/complications ; Factor V Deficiency/diagnosis ; Factor V Deficiency/surgery ; Treatment Outcome ; Polycystic Kidney Diseases/complications ; Polycystic Kidney Diseases/diagnosis ; Polycystic Kidney Diseases/genetics ; Kidney ; Liver
    Language English
    Publishing date 2022-12-15
    Publishing country Turkey
    Document type Case Reports ; Journal Article
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.2022.0229
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Reply.

    Hameed, Ahmer M / Laurence, Jerome M / Lam, Vincent W T / Pleass, Henry C / Hawthorne, Wayne J

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2018  Volume 24, Issue 8, Page(s) 1144–1146

    MeSH term(s) Allografts ; Liver Transplantation
    Language English
    Publishing date 2018-05-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.25195
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Use of pre-operative steroids in liver resection: a systematic review and meta-analysis.

    Richardson, Arthur J / Laurence, Jerome M / Lam, Vincent W T

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2013  Volume 16, Issue 1, Page(s) 12–19

    Abstract: Background: By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications.: Methods: A systematic review was conducted to identify randomized controlled ... ...

    Abstract Background: By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications.
    Methods: A systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed.
    Results: Five RCTs were identified including a total of 379 patients. Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. There was a trend towards a lower incidence of post-operative complications and prothrombin time (PT), but this did not reach statistical significance.
    Conclusion: Pre-operative steroids may be associated with a clinically significant benefit in liver resection.
    MeSH term(s) Bilirubin/blood ; Biomarkers/blood ; Chi-Square Distribution ; Drug Administration Schedule ; Hepatectomy/adverse effects ; Humans ; Inflammation Mediators/blood ; Interleukin-6/blood ; Odds Ratio ; Preoperative Care ; Prothrombin Time ; Risk Factors ; Steroids/administration & dosage ; Systemic Inflammatory Response Syndrome/blood ; Systemic Inflammatory Response Syndrome/etiology ; Systemic Inflammatory Response Syndrome/prevention & control ; Treatment Outcome
    Chemical Substances Biomarkers ; IL6 protein, human ; Inflammation Mediators ; Interleukin-6 ; Steroids ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2013-03-06
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1111/hpb.12066
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Transarterial chemoembolization with irinotecan beads in the treatment of colorectal liver metastases: systematic review.

    Richardson, Arthur J / Laurence, Jerome M / Lam, Vincent W T

    Journal of vascular and interventional radiology : JVIR

    2013  Volume 24, Issue 8, Page(s) 1209–1217

    Abstract: Purpose: For patients with unresectable colorectal liver metastasis (CRLM), transarterial embolization with the use of drug-eluting beads with irinotecan (DEBIRI) represents a novel alternative to systemic chemotherapy or local treatments alone. The ... ...

    Abstract Purpose: For patients with unresectable colorectal liver metastasis (CRLM), transarterial embolization with the use of drug-eluting beads with irinotecan (DEBIRI) represents a novel alternative to systemic chemotherapy or local treatments alone. The present systematic review evaluates available data on the efficacy and safety of DEBIRI embolization.
    Materials and methods: A comprehensive search of medical literature identified studies describing the use of DEBIRI in the treatment of CRLM. Data describing adverse events, pharmacokinetics, tumor response, and overall survival were collected.
    Results: Five observational studies and one randomized controlled trial (RCT) were reviewed. A total of 235 patients were included in the descriptive analysis of observational studies. Postembolization syndrome was the most common adverse event. Peak plasma levels of irinotecan were observed at 1-2 hours after administration. Wide variations in tumor response were observed. The median survival time ranged from 15.2 months to 25 months. In the RCT, treatment with DEBIRI was superior to systemic chemotherapy with 5-fluorouracil/leucovorin/irinotecan in terms of quality of life and progression-free survival.
    Conclusions: For patients with unresectable CRLM, particularly after failure to respond to first-line regimens, DEBIRI represents a novel alternative to systemic chemotherapy alone, transarterial embolization with other agents, or other local treatments (eg, microwave or radiofrequency ablation). In these reports, DEBIRI was safe and effective in the in the treatment of unresectable CRLM. Further RCTs comparing DEBIRI with alternative management strategies are required to define the optimal role for this treatment.
    MeSH term(s) Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/adverse effects ; Antineoplastic Agents, Phytogenic/pharmacokinetics ; Camptothecin/administration & dosage ; Camptothecin/adverse effects ; Camptothecin/analogs & derivatives ; Camptothecin/pharmacokinetics ; Chemoembolization, Therapeutic/adverse effects ; Chemoembolization, Therapeutic/mortality ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Disease Progression ; Disease-Free Survival ; Drug Carriers ; Humans ; Liver Neoplasms/mortality ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Quality of Life ; Survival Analysis ; Time Factors ; Treatment Outcome
    Chemical Substances Antineoplastic Agents, Phytogenic ; Drug Carriers ; irinotecan (7673326042) ; Camptothecin (XT3Z54Z28A)
    Language English
    Publishing date 2013-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1137756-2
    ISSN 1535-7732 ; 1051-0443
    ISSN (online) 1535-7732
    ISSN 1051-0443
    DOI 10.1016/j.jvir.2013.05.055
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top