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  1. Article ; Online: Physical Exercise or Activity and Energy Balance or Metabolism in the Context of Health and Diseases.

    Messonnier, Laurent A

    Nutrients

    2023  Volume 15, Issue 23

    Abstract: Regular long-lasting physical exercise demands a tremendous amount of metabolic energy [ ... ]. ...

    Abstract Regular long-lasting physical exercise demands a tremendous amount of metabolic energy [...].
    MeSH term(s) Humans ; Exercise ; Energy Metabolism ; Exercise Therapy
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15234909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Traumatisme des soignants de réanimation face à la crise sanitaire.

    Laurent, Alexandra

    Soins. Psychiatrie

    2022  Volume 43, Issue 338, Page(s) 29–32

    Abstract: The COVID-19 crisis has profoundly affected intensive care units. To protect themselves from the violence of the circumstances, the caregivers relied on their team membership, but it is in the aftermath that these situations seem to take their full ... ...

    Title translation Trauma of intensive care workers in the face of a health crisis: a two-step psychological support.
    Abstract The COVID-19 crisis has profoundly affected intensive care units. To protect themselves from the violence of the circumstances, the caregivers relied on their team membership, but it is in the aftermath that these situations seem to take their full traumatic dimension. A clinical case illustrates the two-step work of the psychologist with the caregivers and his role in the traumatic elaboration passing by an individual and collective reconquest of the caregiving function.
    MeSH term(s) COVID-19 ; Caregivers ; Critical Care ; Humans
    Language French
    Publishing date 2022-01-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 632590-7
    ISSN 0241-6972
    ISSN 0241-6972
    DOI 10.1016/j.spsy.2022.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2800: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Billet-Doux to Baron Liebig: Letter Addressed to Baron Liebig, Professor at the University of Giessen.

    Laurent, Aug / Gerhardt, Ch

    Western journal of medicine and surgery

    2024  Volume 6, Issue 4, Page(s) 356

    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mitochondrial function in sickle cell disease.

    Messonnier, Laurent A

    Blood

    2022  Volume 139, Issue 11, Page(s) 1616–1617

    MeSH term(s) Anemia, Sickle Cell/genetics ; Anemia, Sickle Cell/physiopathology ; Humans ; Mitochondria
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021015216
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    Zs.MO 364: Show issues

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  5. Article: Letter Addressed to Baron Liebig, Professor at the University of Giessen.

    Laurent, Aug / Gerhardt, Ch

    Medical examiner (Philadelphia, Pa.)

    2023  Volume 2, Issue 21, Page(s) 582

    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lupus systémique de l’enfant.

    Laurent, Audrey / Belot, Alexandre

    La Revue du praticien

    2023  Volume 73, Issue 7, Page(s) 775–781

    Abstract: CHILDHOOD-ONSET SYSTEMIC LUPUS. Childhood-onset systemic lupus (SL) is a rare multifactorial autoimmune disease belonging to connectivitis. Clinical presentation is very heterogeneous with multi-systemic involvement: skin, joint, renal, hematological, ... ...

    Title translation Childhood-onset systemic lupus.
    Abstract CHILDHOOD-ONSET SYSTEMIC LUPUS. Childhood-onset systemic lupus (SL) is a rare multifactorial autoimmune disease belonging to connectivitis. Clinical presentation is very heterogeneous with multi-systemic involvement: skin, joint, renal, hematological, neuropsychiatric, pulmonary, cardiac among others. Renal involvement is particularly frequent and severe in children and must be checked ou on a regular basis by screening for proteinuria. Lab exams show the production of antibodies directed against the native double-stranded DNA, excessive production of type I interferon, consumption of complement is observed during periods of flare-up. There are rare forms of monogenic SL which must be evocated in case of early-onset, familial cases or when occurring in boys.
    MeSH term(s) Child ; Male ; Humans ; Autoimmune Diseases ; Kidney ; Proteinuria/diagnosis ; Proteinuria/etiology
    Language French
    Publishing date 2023-10-05
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Rose's second life after ICU: a tale of post-traumatic growth.

    Gérard, Pauline / Laurent, Alexandra

    Intensive care medicine

    2023  Volume 49, Issue 11, Page(s) 1436–1437

    MeSH term(s) Humans ; Posttraumatic Growth, Psychological ; Intensive Care Units
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07241-2
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  8. Article ; Online: Genome-wide comparative methylation analysis reveals the fate of germ stem cells after surrogate production in teleost.

    Nayak, Rigolin / Franěk, Roman / Laurent, Audrey / Pšenička, Martin

    BMC biology

    2024  Volume 22, Issue 1, Page(s) 39

    Abstract: Background: Surrogate production by germline stem cell transplantation is a powerful method to produce donor-derived gametes via a host, a practice known as surrogacy. The gametes produced by surrogates are often analysed on the basis of their ... ...

    Abstract Background: Surrogate production by germline stem cell transplantation is a powerful method to produce donor-derived gametes via a host, a practice known as surrogacy. The gametes produced by surrogates are often analysed on the basis of their morphology and species-specific genotyping, which enables conclusion to be drawn about the donor's characteristics. However, in-depth information, such as data on epigenetic changes, is rarely acquired. Germ cells develop in close contact with supporting somatic cells during gametogenesis in vertebrates, and we hypothesize that the recipient's gonadal environment may cause epigenetic changes in produced gametes and progeny. Here, we extensively characterize the DNA methylome of donor-derived sperm and their intergenerational effects in both inter- and intraspecific surrogates.
    Results: We found more than 3000 differentially methylated regions in both the sperm and progeny derived from inter- and intraspecific surrogates. Hypermethylation in the promoter regions of the protocadherin gamma gene in the intraspecific surrogates was found to be associated with germline transmission. On the contrary, gene expression level and the embryonic development of the offspring remained unaffected. We also discovered MAPK/p53 pathway disruption in interspecific surrogates due to promoter hypermethylation and identified that the inefficient removal of meiotic-arrested endogenous germ cells in hybrid gonads led to the production of infertile spermatozoa.
    Conclusions: Donor-derived sperm and progeny from inter- and intraspecific surrogates were more globally hypermethylated than those of the donors. The observed changes in DNA methylation marks in the surrogates had no significant phenotypic effects in the offspring.
    MeSH term(s) Pregnancy ; Animals ; Female ; Male ; Semen ; Germ Cells/metabolism ; Spermatozoa ; DNA Methylation ; Stem Cells
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2133020-7
    ISSN 1741-7007 ; 1741-7007
    ISSN (online) 1741-7007
    ISSN 1741-7007
    DOI 10.1186/s12915-024-01842-z
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  9. Article ; Online: Individualized physiology-based digital twin model for sports performance prediction: a reinterpretation of the Margaria-Morton model.

    Boillet, Alice / Messonnier, Laurent A / Cohen, Caroline

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5470

    Abstract: Performance in many racing sports depends on the ability of the athletes to produce and maintain the highest possible work i.e., the highest power for the duration of the race. To model this energy production in an individualized way, an adaptation and a ...

    Abstract Performance in many racing sports depends on the ability of the athletes to produce and maintain the highest possible work i.e., the highest power for the duration of the race. To model this energy production in an individualized way, an adaptation and a reinterpretation (including a physiological meaning of parameters) of the three-component Margaria-Morton model were performed. The model is applied to the muscles involved in a given task. The introduction of physiological meanings was possible thanks to the measurement of physiological characteristics for a given athlete. A method for creating a digital twin was therefore proposed and applied for national-level cyclists. The twins thus created were validated by comparison with field performance, experimental observations, and literature data. Simulations of record times and 3-minute all-out tests were consistent with experimental data. Considering the literature, the model provided good estimates of the time course of muscle metabolite concentrations (e.g., lactate and phosphocreatine). It also simulated the behavior of oxygen kinetics at exercise onset and during recovery. This methodology has a wide range of applications, including prediction and optimization of the performance of individually modeled athletes.
    MeSH term(s) Humans ; Athletic Performance ; Athletes ; Exercise ; Kinetics ; Lactic Acid
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56042-0
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  10. Article ; Online: Pediatric obstructive sleep apnea.

    Bhatt, Ayushi / St-Laurent, Aaron / Graham, M Elise

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2024  Volume 196, Issue 7, Page(s) E241

    MeSH term(s) Child ; Humans ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/therapy ; Polysomnography
    Language English
    Publishing date 2024-02-25
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.230897
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    Ua VI Zs.136: Show issues Location:
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