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  1. Article ; Online: Use of denosumab in castration sensitive prostate cancer.

    Laurent, Michaël R

    BMJ (Clinical research ed.)

    2023  Volume 383, Page(s) 2827

    MeSH term(s) Male ; Humans ; Denosumab/therapeutic use ; Prostatic Neoplasms/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Castration ; Bone Neoplasms ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Bone Density Conservation Agents/adverse effects ; Diphosphonates
    Chemical Substances Denosumab (4EQZ6YO2HI) ; Antibodies, Monoclonal, Humanized ; Bone Density Conservation Agents ; Diphosphonates
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p2827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Editorial: Rickets and osteomalacia, from genes to nutrition.

    Doulgeraki, Artemis / Laurent, Michaël R

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1141888

    MeSH term(s) Humans ; Osteomalacia/genetics ; Rickets/genetics ; Hypophosphatemia/genetics ; Nutritional Status
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1141888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Frailty and mortality in patients with COVID-19.

    Laurent, Michaël R

    The Lancet. Public health

    2020  Volume 5, Issue 11, Page(s) e579

    MeSH term(s) Betacoronavirus ; COVID-19 ; Cohort Studies ; Coronavirus Infections ; Frailty ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-28
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(20)30227-9
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  4. Article ; Online: Give Your Geriatric Patients FAST HUGS BID.

    Laurent, Michaël R

    Journal of the American Geriatrics Society

    2020  Volume 68, Issue 6, Page(s) E33–E35

    MeSH term(s) Aged ; Delivery of Health Care/standards ; Emergency Service, Hospital ; Geriatrics ; Health Personnel ; Humans ; Patient Care Team ; Patient Transfer
    Language English
    Publishing date 2020-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.16446
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    Ud II Zs.168: Show issues Location:
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  5. Article: Monitors to improve indoor air carbon dioxide concentrations in the hospital: A randomized crossover trial

    Laurent, Michaël R. / Frans, Johan

    Science of the total environment. 2022 Feb. 01, v. 806

    2022  

    Abstract: Ventilation has emerged as an important strategy to reduce indoor aerosol transmission of coronavirus disease 2019. Indoor air carbon dioxide (CO₂) concentrations are a surrogate measure of respiratory pathogen transmission risk.To determine whether CO₂ ... ...

    Abstract Ventilation has emerged as an important strategy to reduce indoor aerosol transmission of coronavirus disease 2019. Indoor air carbon dioxide (CO₂) concentrations are a surrogate measure of respiratory pathogen transmission risk.To determine whether CO₂ monitors are necessary and effective to improve ventilation in hospitals.A randomized, placebo (sham)-controlled, crossover, open label trial. Between February and May 2021, we placed CO₂ monitors in twelve double-bed patient rooms across two geriatric wards. Staff were instructed to open windows, increase the air exchange rate and reduce room crowding to maintain indoor air CO₂ concentrations ≤800 parts per million (ppm).CO₂ levels increased during morning care and especially in rooms housing couples (rooming-in). The median (interquartile range, IQR) time/day with CO₂ concentration > 800 ppm (primary outcome) was 110 min (IQR 47–207) at baseline, 82 min (IQR 12–226.5) during sham periods, 78 min (IQR 20–154) during intervention periods and 140 min (IQR 19.5–612.5) post-intervention. The intervention period only differed significantly from the post-intervention period (P = 0.02), mainly due to an imbalance in rooming-in. Significant but small differences were observed in secondary outcomes of time/day with CO₂ concentrations > 1000 ppm and daily peak CO₂ concentrations during the intervention vs. baseline and vs. the post-intervention period, but not vs. sham. Staff reported cold discomfort for patients as the main barrier towards increasing ventilation.Indoor air CO₂ concentrations in hospital rooms commonly peaked above recommended levels, especially during morning care and rooming-in. There are many possible barriers towards implementing CO₂ monitors to improve ventilation in a real-world hospital setting. A paradigm shift in hospital infection control towards adequate ventilation is warranted.ClinicalTrials.gov Identifier: NCT04770597
    Keywords COVID-19 infection ; aerosols ; air ; carbon dioxide ; cold ; cross-over studies ; disease transmission ; environment ; hospitals ; patients ; placebos
    Language English
    Dates of publication 2022-0201
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.151349
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 74/341: Show issues

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  6. Article ; Online: Development and validation of an eight-item calcium screener to assess daily calcium intake of patients with osteoporosis in clinical practice.

    Verbeke, Joke / Laurent, Michaël R / Matthys, Christophe

    European journal of clinical nutrition

    2023  Volume 78, Issue 4, Page(s) 301–306

    Abstract: Objective: To validate a short food frequency questionnaire (screener) estimating daily average calcium intake from dietary sources to guide calcium supplementation of patients with osteoporosis in clinical practice.: Methods: An eight-item calcium ... ...

    Abstract Objective: To validate a short food frequency questionnaire (screener) estimating daily average calcium intake from dietary sources to guide calcium supplementation of patients with osteoporosis in clinical practice.
    Methods: An eight-item calcium screener was developed based on existing literature, food consumption data and expert opinion. Convergent validity was determined by comparison with 3-day food records using mean difference, Spearman's correlation coefficients (SCC) and Bland-Altman analysis. Test-retest reliability was assessed by SCC and intraclass correlation coefficients (ICC). We calculated sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) to identify patients requiring calcium supplementation (<1200 mg dietary calcium intake/day).
    Results: Fifty-two patients filled out the eight-item calcium screener and the 3-day Food record (mean age of 66.8 ± 12.9 (SD)) and 38 patients filled out the screener twice for reliability analysis (mean age of 65.8 ± 12.8 (SD)). Dietary calcium intake between the calcium screener and food records showed a strong correlation (N = 52 patients, SCC = 0.53, p ≤ 0.001) and mean difference of 21 mg (p = 0.70). Bland-Altman analysis showed agreement within 95% confidence intervals for 49/52 comparisons (94%). Test-retest reliability of the calcium screener was excellent (SCC = 0.96, p ≤ 0.001; ICC = 0.99, p ≤ 0.001).
    Conclusion: The calcium screener shows good convergent validity, reliability and feasibility to estimate daily calcium intake of patients with osteoporosis in routine clinical practice.
    MeSH term(s) Humans ; Middle Aged ; Aged ; Calcium, Dietary ; Calcium ; Reproducibility of Results ; Surveys and Questionnaires ; Osteoporosis/diagnosis ; Diet Records
    Chemical Substances Calcium, Dietary ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-12-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 639358-5
    ISSN 1476-5640 ; 0954-3007
    ISSN (online) 1476-5640
    ISSN 0954-3007
    DOI 10.1038/s41430-023-01390-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1045: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Bone: best papers of the year 2017.

    Laurent, Michaël R

    Archives of osteoporosis

    2018  Volume 13, Issue 1, Page(s) 29

    Abstract: An overview of selected papers related to bone published in 2017 is provided.: Purpose: This paper accompanies a lecture at the 2018 Belgian Bone Club annual Clinical Update Symposium held in Brussels on January 20th, discussing the best papers (in ... ...

    Abstract An overview of selected papers related to bone published in 2017 is provided.
    Purpose: This paper accompanies a lecture at the 2018 Belgian Bone Club annual Clinical Update Symposium held in Brussels on January 20th, discussing the best papers (in the opinion of the author) published in the previous year.
    Methods: A PubMed search using the keyword "bone" and articles published in 2017.
    Results: Hot topics include screening for osteoporosis, novel anabolic drugs such as romosozumab and abaloparatide for osteoporosis and rare metabolic bone diseases, as well as long-term efficacy of denosumab and possible risk of multiple vertebral fractures following its discontinuation. Other selected articles cover effectiveness of bisphosphonates and changes in mineralization after long-term use, new guidelines for glucocorticoid- and aromatase inhibitor-induced osteoporosis, increasing use of high-dose vitamin D supplements despite lack of evidence for their widespread high-dose use, and cardiovascular safety concerns surrounding the use of calcium supplements. Other topics discussed are effects of diabetes on bone health, reciprocal crosstalk between bone cells and adipose tissue, and resistance exercise training to prevent bone loss and sarcopenia.
    Conclusions: These papers offer a hopeful outlook for a better treatment and management of patients with osteoporosis and other metabolic bone diseases anno 2018.
    MeSH term(s) Bone Density Conservation Agents/pharmacology ; Bone Diseases, Metabolic/diagnosis ; Bone Diseases, Metabolic/drug therapy ; Bone Diseases, Metabolic/etiology ; Bone and Bones/drug effects ; Bone and Bones/metabolism ; Bone and Bones/pathology ; Disease Management ; Humans ; Osteoporosis/diagnosis ; Osteoporosis/drug therapy ; Osteoporosis/etiology ; Practice Guidelines as Topic ; Risk Factors
    Chemical Substances Bone Density Conservation Agents
    Language English
    Publishing date 2018-03-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2253231-6
    ISSN 1862-3514 ; 1862-3522
    ISSN (online) 1862-3514
    ISSN 1862-3522
    DOI 10.1007/s11657-018-0437-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Monitors to improve indoor air carbon dioxide concentrations in the hospital: A randomized crossover trial.

    Laurent, Michaël R / Frans, Johan

    The Science of the total environment

    2021  Volume 806, Issue Pt 3, Page(s) 151349

    Abstract: Background: Ventilation has emerged as an important strategy to reduce indoor aerosol transmission of coronavirus disease 2019. Indoor air carbon dioxide (CO: Objectives: To determine whether CO: Methods: A randomized, placebo (sham)-controlled, ... ...

    Abstract Background: Ventilation has emerged as an important strategy to reduce indoor aerosol transmission of coronavirus disease 2019. Indoor air carbon dioxide (CO
    Objectives: To determine whether CO
    Methods: A randomized, placebo (sham)-controlled, crossover, open label trial. Between February and May 2021, we placed CO
    Results: CO
    Discussion: Indoor air CO
    Trial registration: ClinicalTrials.gov Identifier: NCT04770597.
    MeSH term(s) Aged ; Air Pollution, Indoor/analysis ; COVID-19 ; Carbon Dioxide/analysis ; Cross-Over Studies ; Hospitals ; Humans ; SARS-CoV-2 ; Ventilation
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2021-10-30
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.151349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 949: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Frailty and mortality in patients with COVID-19

    Laurent, Michaël R.

    The Lancet Public Health

    2020  Volume 5, Issue 11, Page(s) e579

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2468-2667
    DOI 10.1016/s2468-2667(20)30227-9
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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