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  1. Book ; Online ; E-Book: Early vascular aging (EVA)

    Cunha, Pedro Guimarães / Nilsson, Peter M. / Hecht Olsen, Michael / Boutouyrie, Pierre / Laurent, Stéphane

    new directions in cardiovascular protection and cardiovascular translational medicine

    2024  

    Author's details edited by Pedro Guimarães Cunha, Peter M. Nilsson, Michael Hecht Olsen, Pierre Boutouyrie, Stéphane Laurent
    Language English
    Size 1 Online-Ressource (xxiv, 747 Seiten), Illustrationen
    Edition Second edition
    Publisher Elsevier AP Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030690752
    ISBN 978-0-443-15513-0 ; 9780443155123 ; 0-443-15513-5 ; 0443155127
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Arterial stiffness and renal function decline: are all stiffness measurements equally predictive?

    Laurent, Stéphane

    Journal of hypertension

    2022  Volume 40, Issue 7, Page(s) 1265–1267

    MeSH term(s) Glomerular Filtration Rate ; Humans ; Kidney/physiology ; Pulse Wave Analysis ; Vascular Stiffness
    Language English
    Publishing date 2022-07-23
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Longitudinal Versus Cross-Sectional Changes in Aortic Stiffness With Aging.

    Laurent, Stéphane

    Hypertension (Dallas, Tex. : 1979)

    2021  Volume 77, Issue 4, Page(s) 1166–1168

    MeSH term(s) Cross-Sectional Studies ; Pulse Wave Analysis ; Vascular Stiffness
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.120.16740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1488: Show issues Location:
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  4. Book ; Conference proceedings: Gros troncs artériels, microcirculation et myocarde dans l'hypertension artérielle

    Laurent, Stéphane

    aspects thérapeutiques ; articles tirés du symposium satellite du XIXe congrès de la Société Italienne d'Hypertension, Bologne, 2002 = Large arteries, microcirculation and myocardium in hypertension : therapeutic issues ; based on the satellite symposium of the XIXth Italian Society of Hypertension congress, Bologna, 2002

    (Drugs ; 63, Special issue 1)

    2003  

    Title variant Large arteries, microcirculation and myocardium in hypertension
    Institution Società Italiana dell'Ipertensione Arteriosa
    Author's details red. en chef invité S. Laurent
    Series title Drugs ; 63, Special issue 1
    Collection
    Language English ; French
    Size 47 S. : Ill., graph. Darst.
    Publisher Adis Internat
    Publishing place Auckland u.a.
    Publishing country New Zealand
    Document type Book ; Conference proceedings
    Note Beitr. in franz., Vorw. in engl. und franz. Sprache ; Zsfassung in engl. und franz. Sprache
    HBZ-ID HT013636661
    Database Catalogue ZB MED Medicine, Health

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    Zs A 762 -63,Spec.iss.1- not available for loan Zeitschriften-Lesesaal

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  5. Book: Early vascular aging (EVA)

    Nilsson, Peter M. / Olsen, Michael H. / Laurent, Stéphane

    new directions in cardiovascular protection

    2015  

    Author's details ed. by Peter M. Nilsson ; Michael H. Olsen ; Stéphane Laurent
    Keywords Cardiovascular system/Diseases
    Subject code 616.1
    Language English
    Size XII, 363 S. : Ill., graph. Darst.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    Note Includes Internet access
    HBZ-ID HT018737637
    ISBN 978-0-12-801387-8 ; 0-12-801387-7
    Database Catalogue ZB MED Medicine, Health

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    2015 A 3087 available for loan (reading room) Lesesaal EG

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  6. Article ; Online: Antihypertensive drugs.

    Laurent, Stéphane

    Pharmacological research

    2017  Volume 124, Page(s) 116–125

    Abstract: Successful treatment of hypertension is possible with limited side effects given the availability of multiple antihypertensive drug classes. This review describes the various pharmacological classes of antihypertensive drugs, under two major aspects: ... ...

    Abstract Successful treatment of hypertension is possible with limited side effects given the availability of multiple antihypertensive drug classes. This review describes the various pharmacological classes of antihypertensive drugs, under two major aspects: their mechanisms of action and side effects. The mechanism of action is analysed through a pharmacological approach, i.e. the molecular receptor targets, the various sites along the arterial system, and the extra-arterial sites of action, in order to better understand in which type of hypertension a given pharmacological class of antihypertensive drug is most indicated. In addition, side effects are described and explained through their pharmacological mechanisms, in order to better understand their mechanism of occurrence and in which patients drugs are contra-indicated. This review does not address the effectiveness of monotherapies in large randomized clinical trials and combination therapies, since these are the matters of other articles of the present issue. Five major pharmacological classes of antihypertensive drugs are detailed here: beta-blockers, diuretics, angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists, and calcium channel blockers. Four additional pharmacological classes are described in a shorter manner: renin inhibitors, alpha-adrenergic receptor blockers, centrally acting agents, and direct acting vasodilators.
    Language English
    Publishing date 2017-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2017.07.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Arterial Stiffness: From Basic Primers to Integrative Physiology.

    Regnault, Véronique / Lacolley, Patrick / Laurent, Stéphane

    Annual review of physiology

    2023  Volume 86, Page(s) 99–121

    Abstract: The elastic properties of conductance arteries are one of the most important hemodynamic functions in the body, and data continue to emerge regarding the importance of their dysfunction in vascular aging and a range of cardiovascular diseases. Here, we ... ...

    Abstract The elastic properties of conductance arteries are one of the most important hemodynamic functions in the body, and data continue to emerge regarding the importance of their dysfunction in vascular aging and a range of cardiovascular diseases. Here, we provide new insight into the integrative physiology of arterial stiffening and its clinical consequence. We also comprehensively review progress made on pathways/molecules that appear today as important basic determinants of arterial stiffness, particularly those mediating the vascular smooth muscle cell (VSMC) contractility, plasticity and stiffness. We focus on membrane and nuclear mechanotransduction, clearance function of the vascular wall, phenotypic switching of VSMCs, immunoinflammatory stimuli and epigenetic mechanisms. Finally, we discuss the most important advances of the latest clinical studies that revisit the classical therapeutic concepts of arterial stiffness and lead to a patient-by-patient strategy according to cardiovascular risk exposure and underlying disease.
    MeSH term(s) Humans ; Vascular Stiffness ; Mechanotransduction, Cellular ; Arteries/metabolism ; Cardiovascular Diseases/metabolism ; Aging/metabolism
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207933-1
    ISSN 1545-1585 ; 0066-4278
    ISSN (online) 1545-1585
    ISSN 0066-4278
    DOI 10.1146/annurev-physiol-042022-031925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Vascular Ageing - State of Play, Gaps and Key Issues.

    Laurent, Stéphane / Boutouyrie, Pierre

    Heart, lung & circulation

    2021  Volume 30, Issue 11, Page(s) 1591–1594

    MeSH term(s) Aging ; Humans ; Vascular Stiffness
    Language English
    Publishing date 2021-08-12
    Publishing country Australia
    Document type Editorial
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2021.06.528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4988: Show issues Location:
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  9. Article ; Online: How to measure arterial stiffness independently of blood pressure: the QKD method.

    Gosse, Philippe / Boulestreau, Romain / Doublet, Julien / Laurent, Stephane / Cremer, Antoine

    Journal of hypertension

    2023  Volume 41, Issue 7, Page(s) 1168–1174

    Abstract: Objective: Arterial stiffness, an important predictor of cardiovascular event, has two components: one linked to the nonlinear elastic behaviour of the arterial wall and dependent of the blood pressure (BP) at the time of measurement, and the other ... ...

    Abstract Objective: Arterial stiffness, an important predictor of cardiovascular event, has two components: one linked to the nonlinear elastic behaviour of the arterial wall and dependent of the blood pressure (BP) at the time of measurement, and the other linked to the structural modifications of the arterial wall as the consequences of the long-term effects of all cardiovascular risk factors, including BP. This second component is certainly the most important one and can be assessed with 24-h ambulatory monitoring of cardio-arm pulse transmission time (QKD method).
    Methods: The working hypothesis of this study is that QKD100-60, the value of the QKD for a 100 mmHg SBP and 60 bpm heart rate is independent of 24-h SBP in both normotensive volunteers and treated hypertensive patients, in whom the long-term influence of BP is limited, whereas QKD100-60 is not independent of 24-h SBP in untreated hypertensive patients in whom high BP was able to damage the arterial wall on the long term. So we studied the relationships of QKD100-60 with 24-h BP and heart rate together with age, sex, height in multivariate regression analysis in three groups of patients; normal, untreated and treated hypertensive patients. QKD was measured with Novacor devices.
    Results: In the normal population (n = 323, aged 29 ± 10 years) and in the treated hypertensive population (n = 425, aged 58 ± 13 years) the QKD100-60 was indeed not significantly related to 24-h SBP. In the untreated hypertensive population (n = 614, aged 51 ± 13 years) the QKD100-60 was weakly but significantly related to 24-h SBP (r = 0.249, P < 0.0001).
    Conclusion: Ambulatory monitoring of QKD provides indices of arterial stiffness independent of BP level at the time of measurement and most interestingly of 24-h BP with the potential to refine risk in patients with low traditional risk scores.
    MeSH term(s) Humans ; Blood Pressure/physiology ; Vascular Stiffness ; Blood Pressure Monitoring, Ambulatory ; Hypertension ; Arteries
    Language English
    Publishing date 2023-04-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Achieving Goal Blood Pressure.

    Laurent, Stéphane

    High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

    2015  Volume 22 Suppl 1, Page(s) S5–9

    Abstract: Both monotherapy and combination therapy options are appropriate for antihypertensive therapy according to the 2013 European Society of Hypertension (ESH)/European Society of Cardiology (ESC) guidelines. Most patients require more than one agent to ... ...

    Abstract Both monotherapy and combination therapy options are appropriate for antihypertensive therapy according to the 2013 European Society of Hypertension (ESH)/European Society of Cardiology (ESC) guidelines. Most patients require more than one agent to achieve blood pressure (BP) control, and adding a second agent is more effective than doubling the dose of existing therapy. The addition of a third agent may be required to achieve adequate BP reductions in some patients. Single-pill fixed-dose combinations (FDCs) allow multiple-drug regimens to be delivered without any negative impact on patient compliance or persistence with therapy. FDCs also have documented beneficial clinical effects and use of FDCs containing two or three agents is recommended by the 2013 ESH/ESC guidelines.
    MeSH term(s) Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Drug Combinations ; Drug Resistance ; Guideline Adherence ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/physiopathology ; Medication Adherence ; Practice Guidelines as Topic ; Treatment Outcome
    Chemical Substances Antihypertensive Agents ; Drug Combinations
    Language English
    Publishing date 2015-07
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1236337-6
    ISSN 1179-1985 ; 1120-9879
    ISSN (online) 1179-1985
    ISSN 1120-9879
    DOI 10.1007/s40292-015-0099-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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