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Article ; Online: Anatomical biology guides a search for nutrients for the aging brain.

Lauriola, Vincenzo / Brickman, Adam M / Sloan, Richard P / Small, Scott A

2022 Volume 89, Page(s) 101154

Abstract: Considerable evidence has established the importance of specific nutrients that have been found vital for the developing brain. We hypothesize that in a similar manner there should be nutrients vital to the aging brain and that based on aging's distinct ... ...

Abstract	Considerable evidence has established the importance of specific nutrients that have been found vital for the developing brain. We hypothesize that in a similar manner there should be nutrients vital to the aging brain and that based on aging's distinct pathophysiology they should be different than those essential to development. Specific brain networks that govern cognition are particularly vulnerable to the aging process, resulting in what is referred to as 'cognitive aging'. Common late-life disorders, however, such as Alzheimer's disease also target these same brain networks. Studies have disambiguated cognitive aging from late-life disease by isolating regions and biological pathways within each network differentially linked to one or the other. This anatomical biology anchors a framework to identify nutrients and/or dietary bioactives relevant to cognitive aging whose utility is illustrated via a decades-long research program into how dietary bioactive flavanols benefit the brain. As we are living longer in cognitively more demanding lives, the framework's ultimate goal is to generate specific dietary recommendations that will fortify our mind for its golden years.
MeSH term(s)	Humans ; Brain/metabolism ; Aging ; Alzheimer Disease/metabolism ; Nutrients ; Biology ; Cognition
Language	English
Publishing date	2022-11-10
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	197640-0
ISSN	1872-9452 ; 0098-2997
ISSN (online)	1872-9452
ISSN	0098-2997
DOI	10.1016/j.mam.2022.101154
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Article ; Online: Nature, economics, property and commons. Subversive notes inspired by Elinor Ostrom

Lauriola Vincenzo M.

E3S Web of Conferences, Vol 2, p

2014 Volume 04003

Abstract: Nature-economy relations also are the result of economics’ concepts, ideas and paradigms. Heterodox economic views and paradigms are urgently needed to foster shifts towards the planet’s future sustainability paths. Elinor Ostrom, 2009 Nobel economics ... ...

Abstract	Nature-economy relations also are the result of economics’ concepts, ideas and paradigms. Heterodox economic views and paradigms are urgently needed to foster shifts towards the planet’s future sustainability paths. Elinor Ostrom, 2009 Nobel economics laureate, stands as one of the authors whose long neglected views are most inspiring in subverting mainstream paradigms on property regimes and natural resource management. Challenging the tragedy of the commons orthodoxy, she shows humans are able to escape the prisoner’s dilemma, as well as the public vs private property, and state vs market modern dichotomy in natural resources’ management models, by recognizing common property as a third option, and re-inventing the commons as indeed diverse and resilient institutions to foster more sustainable economy-nature relations. Brazil’s indigenous territories are cited as a living example of commons’ sustainability, although increasingly threatened by economic growth.
Keywords	Environmental sciences ; GE1-350
Subject code	306
Language	English
Publishing date	2014-03-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ecologia global contra diversidade cultural? Conservação da natureza e povos indígenas no Brasil

Lauriola Vincenzo

Ambiente & Sociedade, Vol 5, Iss 2, Pp 165-

O Monte Roraima entre Parque Nacional e terra indígena Raposa-Serra do Sol

2003 Volume 189

Abstract: As políticas de conservação da natureza em diversos paises estão cada vez mais ligadas à tomada de decisões ecológicas globais. Exemplos destas ligações variam entre a definição de prioridades e objetivos das políticas, à ação de ONG's ambientalistas ... ...

Abstract	As políticas de conservação da natureza em diversos paises estão cada vez mais ligadas à tomada de decisões ecológicas globais. Exemplos destas ligações variam entre a definição de prioridades e objetivos das políticas, à ação de ONG's ambientalistas internacionais, à existência de fundos e programas globais para o meio ambiente e o desenvolvimento sustentável, até as novas oportunidades econômicas representadas pelos mercados emergentes para serviços ecológicos globais e ''commodities ambientais''. Estas políticas freqüentemente conflitam com os direitos e as necessidades de diferentes populações locais, pois a implementação de áreas protegidas que excluem o homem recebe prioridade com respeito a outros modelos de conservação e uso sustentável da biodiversidade. O Brasil não faz exceção a esta regra. Hoje as políticas de conservação da natureza estão entrando em conflito direto com as políticas de preservação do direito à diferença cultural dos povos indígenas. Isto acontece a diversos níveis e em vários contextos locais diferenciados, desde a região Atlântica até a Amazônia e o Escudo das Guianas. A existência de fundos globais e suas prioridades podem contribuir para explicar estes conflitos, pois a ligação ecológica global contribui para redefinir as relações políticas nacionais e locais. O caso do Parque Nacional do Monte Roraima na Terra Indígena Raposa-Serra do Sol ilustra como modelos de conservação baseados na exclusão do homem, concebidos e implementados de cima para baixo, acirram conflitos preexistentes, políticos e sobre o direito à terra. Abordado através de um angulo diferente, este caso também aponta um possível caminho para soluções viáveis. Conversando, andando de canoa a remo e a pé com os índios Ingarikó na Serra do Sol, è possível perceber sua própria perspectiva cultural ecológica como elemento fundamental para a preservação dos recursos naturais. Adotar a perspectiva cultural indígena para entender e esclarecer suas regras efetivas de uso e manejo dos recursos naturais pode representar o ponto de partida para desenvolver e implementar planos de manejo ecologicamente eficazes e socialmente benéficos. Redirecionar a disponibilidade ecológica global a pagar na direção dos povos indígenas representaria uma contribuição nesta direção.
Keywords	políticas de conservação ; povos indígenas ; ONGs ; Roraima ; Brasil ; Human ecology. Anthropogeography ; GF1-900
Language	English
Publishing date	2003-01-01T00:00:00Z
Publisher	Associação Nacional de Pós-Graduação e Pesquisa em Ambiente e Sociedade (ANPPAS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Impact of Aerobic Training on Cardiovascular Reactivity to and Recovery From Psychological and Orthostatic Challenge.

Sloan, Richard P / Shapiro, Peter A / Lauriola, Vincenzo / McIntyre, Kathleen / Pavlicova, Martina / Choi, Chien-Wen Jean / Choo, Tse-Hwei / Scodes, Jennifer M

Psychosomatic medicine

2020 Volume 83, Issue 2, Page(s) 125–137

Abstract: Objective: Elevated cardiovascular reactivity to, and reduced recovery from, challenging events may increase the risk of cardiovascular disease, and exercise training may reduce this reactivity. However, in a randomized controlled trial of aerobic ... ...

Abstract	Objective: Elevated cardiovascular reactivity to, and reduced recovery from, challenging events may increase the risk of cardiovascular disease, and exercise training may reduce this reactivity. However, in a randomized controlled trial of aerobic versus strength training in sedentary, healthy young adults, we found no training group differences in reactivity or recovery. Because strength training also may have a reactivity-reducing effect, we conducted a secondary analysis of data from another trial, this time with a wait-list control condition. Methods: One hundred nineteen healthy, young, sedentary adults were randomized to a 12-week aerobic training program or wait-list control. Before (T1) and after (T2) training and after 4 weeks of sedentary deconditioning (T3), we measured heart rate (HR), heart rate variability, and blood pressure at rest and in response to and recovery from psychological and orthostatic challenge. Data were analyzed using a group (aerobic versus wait-list) by session (T1, T2, and deconditioning) and by period (baseline, psychological challenge, recovery, standing) three-way analysis of variance with prespecified contrasts. Results: Aerobic capacity significantly increased at T2 and decreased at T3 only in the aerobic training group. The groups did not differ on HR, heart rate variability, or blood pressure reactivity to or recovery from challenge. Without baseline adjustment, there were no significant treatment differences in response to challenges. With baseline adjustment, there were significant treatment by session effects for HR (Cohen d = 0.54, p = .002), systolic blood pressure (d = 0.44, p = .014), diastolic blood pressure (d = 0.74, p = .002), and root mean squared successive difference (d = 0.48, p = .006) reactivity from T1 to T2 only for orthostatic challenge: at T2, reactivity in the aerobic group was nonsignificantly reduced, compared with T1. In the wait-list group, reactivity significantly increased after T1. Conclusions: This study raises further doubt about attenuation of cardiovascular reactivity or enhancement of recovery as a cardioprotective mechanism of aerobic exercise training.Clinical Trial Registration:ClinicalTrials.gov Unique identifier: NCT01335737.
MeSH term(s)	Blood Pressure ; Exercise ; Exercise Test ; Female ; Heart Rate ; Humans ; Male ; Resistance Training ; Young Adult
Language	English
Publishing date	2020-12-09
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	3469-1
ISSN	1534-7796 ; 0033-3174
ISSN (online)	1534-7796
ISSN	0033-3174
DOI	10.1097/PSY.0000000000000896
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Article ; Online: Maternal childhood adversity and inflammation during pregnancy: Interactions with diet quality and depressive symptoms.

McCormack, Clare / Lauriola, Vincenzo / Feng, Tianshu / Lee, Seonjoo / Spann, Marisa / Mitchell, Anika / Champagne, Frances / Monk, Catherine

Brain, behavior, and immunity

2020 Volume 91, Page(s) 172–180

Abstract: Inflammatory processes are a candidate mechanism by which early adversity may be biologically embedded and subsequently lead to poorer health outcomes; in pregnancy, this has been posited as a pathway for intergenerational transmission of adversity. ... ...

Abstract	Inflammatory processes are a candidate mechanism by which early adversity may be biologically embedded and subsequently lead to poorer health outcomes; in pregnancy, this has been posited as a pathway for intergenerational transmission of adversity. Studies in non-pregnant adults suggest that factors such as mood, diet, BMI, and social support may moderate associations between childhood trauma history and inflammation in adulthood, though few studies have examined these associations among pregnant women. In a sample of healthy pregnant women (N = 187), we analyzed associations between maternal childhood adversity, including maltreatment and non-optimal caregiving experiences, with circulating Interleukin-6 (IL-6) levels during trimesters 2 (T2) and 3 (T3) of pregnancy. We also assessed whether these associations were moderated by psychosocial and lifestyle factors including depressive symptoms, social support, physical activity, and diet quality. History of childhood maltreatment was not associated with IL-6 in either T2 or T3 of pregnancy, either independently or in interaction with depressive symptom severity. However, in there was a significant positive association between childhood maltreatment and IL-6 in Trimester 2 in the context of poorer diet quality (p = 0.01), even after adjusting for BMI. Additionally, the quality of caregiving women received in childhood was associated with levels of IL-6 in Trimester 3, but only via interaction with concurrent depressive symptoms (p = 0.02). These findings provide evidence that for those with a history of childhood adversity, levels of inflammatory cytokines in pregnancy may be more sensitive to depressive symptoms and diet quality.
MeSH term(s)	Adult ; Depression ; Diet ; Family ; Female ; Humans ; Inflammation ; Pregnancy ; Pregnant Women
Language	English
Publishing date	2020-10-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2020.09.023
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Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial.

Sloan, Richard P / Wall, Melanie / Yeung, Lok-Kin / Feng, Tianshu / Feng, Xinyang / Provenzano, Frank / Schroeter, Hagen / Lauriola, Vincenzo / Brickman, Adam M / Small, Scott A

Scientific reports

2021 Volume 11, Issue 1, Page(s) 3837

Abstract: With the world's population aging, age-related memory decline is an impending cognitive epidemic. Assessing the impact of diet on cognitive aging, we conducted a controlled, randomized, parallel-arm dietary intervention with 211 healthy adults (50-75 ... ...

Abstract	With the world's population aging, age-related memory decline is an impending cognitive epidemic. Assessing the impact of diet on cognitive aging, we conducted a controlled, randomized, parallel-arm dietary intervention with 211 healthy adults (50-75 years) investigating effects of either a placebo or 260, 510 and 770 mg/day of cocoa flavanols for 12-weeks followed by 8-weeks washout. The primary outcome was a newly-developed object-recognition task localized to the hippocampus' dentate gyrus. Secondary outcomes included a hippocampal-dependent list-learning task and a prefrontal cortex-dependent list-sorting task. The alternative Healthy Eating Index and a biomarker of flavanol intake (gVLM) were measured. In an MRI substudy, hippocampal cerebral blood volume was mapped. Object-recognition and list-sorting performance did not correlate with baseline diet quality and did not improve after flavanol intake. However, the hippocampal-dependent list-learning performance was directly associated with baseline diet quality and improved after flavanol intake, particularly in participants in the bottom tertile of baseline diet quality. In the imaging substudy, a region-of-interest analysis was negative but a voxel-based-analysis suggested that dietary flavanols target the dentate gyrus. While replication is needed, these findings suggest that diet in general, and dietary flavanols in particular, may be associated with memory function of the aging hippocampus and normal cognitive decline.
MeSH term(s)	Aged ; Aging/psychology ; Brain/diagnostic imaging ; Brain/physiopathology ; Cognition ; Cognitive Aging ; Diet ; Dietary Supplements ; Female ; Flavonols/administration & dosage ; Healthy Volunteers ; Humans ; Learning ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nutritional Status ; Physical Functional Performance ; Public Health Surveillance ; Randomized Controlled Trials as Topic
Chemical Substances	Flavonols
Language	English
Publishing date	2021-02-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-83370-2
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Article: Psychobiological regulation of plasma and saliva GDF15 dynamics in health and mitochondrial diseases.

Huang, Qiuhan / Trumpff, Caroline / Monzel, Anna S / Rausser, Shannon / Haahr, Rachel / Devine, Jack / Liu, Cynthia C / Kelly, Catherine / Thompson, Elizabeth / Kurade, Mangesh / Michelson, Jeremy / Shaulson, Evan D / Li, Shufang / Engelstad, Kris / Tanji, Kurenai / Lauriola, Vincenzo / Wang, Tian / Wang, Shuang / Zuraikat, Faris M /

St-Onge, Marie-Pierre / Kaufman, Brett A / Sloan, Richard / Juster, Robert-Paul / Marsland, Anna L / Gouspillou, Gilles / Hirano, Michio / Picard, Martin

bioRxiv : the preprint server for biology

2024

Abstract: GDF15 (growth differentiation factor 15) is a marker of cellular energetic stress linked to physical-mental illness, aging, and mortality. However, questions remain about its dynamic properties and measurability in human biofluids other than blood. Here, ...

Abstract	GDF15 (growth differentiation factor 15) is a marker of cellular energetic stress linked to physical-mental illness, aging, and mortality. However, questions remain about its dynamic properties and measurability in human biofluids other than blood. Here, we examine the natural dynamics and psychobiological regulation of plasma and saliva GDF15 in four human studies representing 4,749 samples from 188 individuals. We show that GDF15 protein is detectable in saliva (8% of plasma concentration), likely produced by salivary glands secretory duct cells. Using a brief laboratory socio-evaluative stressor paradigm, we find that psychosocial stress increases plasma (+3.5-5.9%) and saliva GDF15 (+43%) with distinct kinetics, within minutes. Moreover, saliva GDF15 exhibits a robust awakening response, declining by ∼40-89% within 30-45 minutes from its peak level at the time of waking up. Clinically, individuals with genetic mitochondrial OxPhos diseases show elevated baseline plasma and saliva GDF15, and post-stress GDF15 levels in both biofluids correlate with multi-system disease severity, exercise intolerance, and the subjective experience of fatigue. Taken together, our data establish that saliva GDF15 is dynamic, sensitive to psychological states, a clinically relevant endocrine marker of mitochondrial diseases. These findings also point to a shared psychobiological pathway integrating metabolic and mental stress.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.19.590241
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Article ; Online: Mitochondrial respiratory capacity modulates LPS-induced inflammatory signatures in human blood.

Karan, Kalpita Rashmi / Trumpff, Caroline / McGill, Marlon A / Thomas, Jacob E / Sturm, Gabriel / Lauriola, Vincenzo / Sloan, Richard P / Rohleder, Nicolas / Kaufman, Brett A / Marsland, Anna L / Picard, Martin

Brain, behavior, & immunity - health

2020 Volume 5

Abstract: Mitochondria modulate inflammatory processes in various model organisms, but it is unclear how much mitochondria regulate immune responses in human blood leukocytes. Here, we examine the effect of i) experimental perturbations of mitochondrial ... ...

Abstract	Mitochondria modulate inflammatory processes in various model organisms, but it is unclear how much mitochondria regulate immune responses in human blood leukocytes. Here, we examine the effect of i) experimental perturbations of mitochondrial respiratory chain function, and ii) baseline inter-individual variation in leukocyte mitochondrial energy production capacity on stimulated cytokine release and glucocorticoid (GC) sensitivity. In a first cohort, whole blood from 20 healthy women and men was stimulated with increasing concentrations of the immune agonist lipopolysaccharide (LPS). Four inhibitors of mitochondrial respiratory chain Complexes I, III, IV, and V were used (LPS + Mito-Inhibitors) to acutely perturb mitochondrial function, GC sensitivity was quantified using the GC-mimetic dexamethasone (DEX) (LPS + DEX), and the resultant cytokine signatures mapped with a 20-cytokine array. Inhibiting mitochondrial respiration caused large inter-individual differences in LPS-stimulated IL-6 reactivity (Cohen's
Language	English
Publishing date	2020-05-06
Publishing country	United States
Document type	Journal Article
ISSN	2666-3546
ISSN (online)	2666-3546
DOI	10.1016/j.bbih.2020.100080
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Article: Le développement soutenable de l'école de Londres

Lauriola, Vincenzo

Economies et sociétés : cahiers de l'ISMEA Vol. 31, No. 4 , p. 71-89

une approche "orwellienne"?

1997 Volume 31, Issue 4, Page(s) 71–89

Author's details	Vincenzo Lauriola
Keywords	Nachhaltige Entwicklung ; Ressourcenökonomik ; Umweltökonomik ; Theorie
Language	French
Publisher	ISMEA
Publishing place	Paris
Document type	Article
Note	Zsfassung in engl. Sprache
ZDB-ID	1805-3
Database	ECONomics Information System

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Article: Liquid chromatography–tandem mass spectrometry method as the golden standard for therapeutic drug monitoring in renal transplant

Aucella, Filippo / Lauriola, Vincenzo / Vecchione, Gennaro / Tiscia, Giovanni Luca / Grandone, Elvira

Journal of pharmaceutical and biomedical analysis. 2013 Dec., v. 86

2013

Abstract: Kidney transplanted patients need immunosuppressant therapies. Therapeutic drug monitoring approaches produce the optimal clinical outcome is still under debate. This review details strength and limits of methods available: immunoassay and chromatography- ...

Abstract	Kidney transplanted patients need immunosuppressant therapies. Therapeutic drug monitoring approaches produce the optimal clinical outcome is still under debate. This review details strength and limits of methods available: immunoassay and chromatography-based. Liquid chromatography with mass spectrometry detection is a major breakthrough in therapeutic drug monitoring of immunosuppressive agents and is considered as the method of choice in therapeutic drug monitoring (TDM) of immunosuppressants. Despite the initial high cost for the instrumentation, HPLC–MS is more cost effective than microparticle enzyme immunoassay. The main important features of LC–MS/MS methodology for immunosuppressive drugs are the shortened analysis time, an increased throughput, higher selectivity, specificity, and sensitivity, and low cost of analysis.
Keywords	cost analysis ; cost effectiveness ; drug therapy ; enzyme immunoassays ; high performance liquid chromatography ; immunosuppressive agents ; instrumentation ; kidney transplant ; kidneys ; monitoring ; patients ; tandem mass spectrometry
Language	English
Dates of publication	2013-12
Size	p. 123-126.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	604917-5
ISSN	0731-7085
ISSN	0731-7085
DOI	10.1016/j.jpba.2013.08.001
Database	NAL-Catalogue (AGRICOLA)

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