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  1. Article ; Online: [Conservative treatment of iatrogenic milk fistula].

    Laustsen-Kiel, Cecilie Mullerup / Ibrahim, Rami Mossad / Lang, Christian Lyngsaa

    Ugeskrift for laeger

    2022  Volume 184, Issue 32

    Abstract: A milk fistula is a rare condition, and only 27 cases have been reported in the latest systematic review from 2020. A fistula can be iatrogenic or spontaneous. The content of tissue factors in breast milk promotes granulation in wounds, which can lead to ...

    Abstract A milk fistula is a rare condition, and only 27 cases have been reported in the latest systematic review from 2020. A fistula can be iatrogenic or spontaneous. The content of tissue factors in breast milk promotes granulation in wounds, which can lead to hypergranulation and lack of epithelialization. In this case report, a 29-year-old breastfeeding woman developed a milk fistula after surgical removal of a naevus on suspicion of being a melanoma. Hypergranulation of the wound was successfully treated with corticosteroid, which inhibits growth factor in breastmilk, and breastfeeding was continued during treatment.
    MeSH term(s) Adult ; Breast Feeding ; Conservative Treatment ; Female ; Fistula/drug therapy ; Fistula/etiology ; Humans ; Iatrogenic Disease ; Milk, Human
    Language Danish
    Publishing date 2022-08-12
    Publishing country Denmark
    Document type Case Reports ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Indocyanine green angiography in oncoplastic breast surgery, a prospective study.

    Lauritzen, Elisabeth / Bredgaard, Rikke / Laustsen-Kiel, Cecilie Mullerup / Hansen, Laura / Tvedskov, Tove / Damsgaard, Tine Engberg

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2023  Volume 85, Page(s) 276–286

    Abstract: Introduction: The use of Indocyanine green angiography (ICG-A) in oncoplastic breast-conserving surgery (OBCS) has not yet been investigated. This prospective trial applied ICG-A in volume displacement and replacement OBCS to localize perforators and ... ...

    Abstract Introduction: The use of Indocyanine green angiography (ICG-A) in oncoplastic breast-conserving surgery (OBCS) has not yet been investigated. This prospective trial applied ICG-A in volume displacement and replacement OBCS to localize perforators and determine tissue supplied by the perforator. Furthermore, to investigate and correlate the intraoperative ICG-A to postoperative surgical site infection, skin necrosis, epidermolysis, and timely onset of adjuvant therapy.
    Methods: ICG-A was performed at three pre-set timepoints during surgery; after lumpectomy, upon dissection of possible perforators, and after wound closure. All patients were followed with clinical evaluations before surgery, 4 weeks, 4-6 months, and 12 months postoperatively.
    Results: Eleven patients were included: seven volume displacement and four volume replacement OBCS. ICG-A located the tissue supplied by the perforator and demonstrated sufficient perfusion in all cases. The ICG-A corresponded to the surgeons' clinical assessment. One patient developed a postoperative infection and seroma and was treated conservatively. No patients had postoperative necrosis, loss of reconstruction, or lymphedema of the arm. Edema of the breast occurred in four patients (36.4%). Scar assessments were significantly worse at 4-weeks and 4-6 months. The quality of life improved significantly during follow-up. Adjuvant treatment was administered timely in all cases.
    Conclusion: ICG-A was feasible for OBCS in assessing intraoperative perfusion. Perfusion was sufficient in all patients and corresponded to the surgeon's clinical evaluation. No patients developed postoperative necrosis. Though edema of the breast occurred in 36.4%, a larger sample size is needed to investigate a possible correlation with ICG-A. Further studies, which includes patients requiring extensive tissue replacement challenging the borders of perfusion, are needed.
    MeSH term(s) Humans ; Female ; Prospective Studies ; Indocyanine Green ; Quality of Life ; Angiography ; Necrosis ; Breast Neoplasms/surgery ; Fluorescein Angiography
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2023-07-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2023.07.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Study protocol for a 10-year prospective observational study, examining lymphoedema and patient-reported outcome after breast reconstruction.

    Laustsen-Kiel, Cecilie Mullerup / Lauritzen, Elisabeth / Langhans, Linnea / Engberg Damsgaard, Tine

    BMJ open

    2021  Volume 11, Issue 12, Page(s) e052676

    Abstract: Introduction: Over the last decades, treatment of breast cancer has become increasingly more effective. Consequently, an increasing number of women are living with late effects of breast cancer treatment, including disfiguring scars, deformity or ... ...

    Abstract Introduction: Over the last decades, treatment of breast cancer has become increasingly more effective. Consequently, an increasing number of women are living with late effects of breast cancer treatment, including disfiguring scars, deformity or asymmetry of the breast, secondary lymphoedema and other physical and psychosocial late effects. Data from this study will provide knowledge on how to guide breast reconstruction in the future towards outcomes with fewer complications, higher long-term quality of life (QoL) and satisfaction with the aesthetic outcome. The development of secondary lymphoedema, for which the effect of breast reconstruction has yet to be established, will be thoroughly examined.
    Methods and analysis: Women receiving breast reconstruction (autologous and implant based) at the Department of Plastic Surgery and Burns Treatment, Rigshospitalet, will be invited to participate. The patients will be followed for 10 years postoperatively. Demographic, health-related, oncological characteristics and treatment data will be registered. Validated assessment tools, such as the BREAST-Q and Beck Depression Inventory, will be used to measure an extensive range of clinical outcomes, including QoL, life and aesthetic satisfaction and depression. Arm range of motion will be measured with a goniometer and lymphoedema by bioimpedance spectroscopy, compared with circular arm measurements.
    Ethics and dissemination: This study will be conducted according to the 5th version of the Helsinki Declaration. The regional ethical committee for Capital Region Denmark did not find the study notifiable, according to the law of the committee § 1, part 4. All data will be anonymised before its publication. This study will be conducted according to the Danish data protection regulation and is catalogued and approved by the Capital Region Head of Knowledge Centre. According to the Danish health law § 46, part 2, this study does not need the Danish Patient Safety Authority's approval. The findings of this study will be submitted to international peer-reviewed journals.
    MeSH term(s) Breast Neoplasms/surgery ; Female ; Humans ; Lymphedema/etiology ; Lymphedema/surgery ; Mammaplasty/adverse effects ; Observational Studies as Topic ; Patient Reported Outcome Measures ; Prospective Studies ; Quality of Life
    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-052676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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