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Book ; Thesis: Klinische Anwendungsmöglichkeiten der digitalen Subtraktionsangiographie bei perkutaner transluminaler Angioplastie der Extremitäten- und Nierengefäße

Lauterbach, Thomas

1984

Size	129 S. : Ill.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Frankfurt (Main), Univ., Diss., 1985
HBZ-ID	HT003237341
Database	Catalogue ZB MED Medicine, Health

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Book: Digital audio broadcasting

Hoeg, Wolfgang / Lauterbach, Thomas

principles and applications of DAB, DAB+ and DMB

2009

Author's details	eds. Wolfgang Hoeg and Thomas Lauterbach
Keywords	Digital audio broadcasting
Language	English
Size	XXXII, 420 S., Ill., graph. Darst., Kt.
Edition	3. ed.
Publisher	Wiley
Publishing place	Chichester
Document type	Book
Note	Literaturverz. S. [395] - 411
ISBN	9780470510377 ; 0470510374
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book: Schlußbericht über die Arbeiten zu Digital Audio Broadcasting (EU 147)

Lauterbach, Thomas

Entwicklung eines Labormusters für einen DAB-Empfänger und Felderprobung des Gesamtsystems, [Abschlußdatum des Vorhabens: Dezember 1994]

1995

Institution	Robert Bosch GmbH
Author's details	Robert Bosch GmbH. Projektleiter: Thomas Lauterbach
Language	German
Size	Getr. Zählung, Ill., graph. Darst
Publishing place	Hildesheim
Document type	Book
Note	Die Vorlage enth. insgesamt 3 Werke ; Förderkennzeichen BMFT 01BK201B9
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book: 1000 Konstruktionsbeispiele für die Praxis

Krahn, Heinrich / Eh, Dieter / Lauterbach, Thomas

2010

Title variant	Tausend Konstruktionsbeispiele für die Praxis
Author's details	Heinrich Krahn; Dieter Eh; Thomas Lauterbach
Keywords	Maschinenbau ; Konstruktion
Language	German
Size	XL, 495 S, Ill., graph. Darst., 26,5 cm
Edition	3., erw. Aufl
Publisher	Hanser
Publishing place	München u.a.
Document type	Book
Note	Literaturverz. S. 461 - 463
Accompanying material	1 DVD-ROM (12 cm)
ISBN	3446420347 ; 9783446420342
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Reduction of gastrointestinal symptoms in Parkinson's disease after a switch from oral therapy to rotigotine transdermal patch: a non-interventional prospective multicenter trial.

Woitalla, Dirk / Kassubek, Jan / Timmermann, Lars / Lauterbach, Thomas / Berkels, Reinhard / Grieger, Frank / Müller, Thomas

Parkinsonism & related disorders

2015 Volume 21, Issue 3, Page(s) 199–204

Abstract: Introduction: Gastrointestinal (GI) symptoms are common among patients with Parkinson's disease (PD), due to both the disease itself and anti-PD drugs. We hypothesized that transdermal drug administration may result in fewer GI problems. This ... ...

Abstract	Introduction: Gastrointestinal (GI) symptoms are common among patients with Parkinson's disease (PD), due to both the disease itself and anti-PD drugs. We hypothesized that transdermal drug administration may result in fewer GI problems. This prospective observational study (ClinicalTrials.gov: NCT01159691) investigated effect of switching to rotigotine transdermal patch from oral anti-PD medications in patients with PD and existing GI symptoms. Methods: Patients were enrolled if their physician was planning to switch them to rotigotine because of GI symptoms experienced while receiving oral anti-PD medications. Effectiveness assessments included a visual analog scale (VAS) measuring intensity of GI symptoms from 0 (no disorder) to 100 mm (extremely severe disorder), a questionnaire on the frequency and intensity of six individual GI complaints (heartburn, bloating, nausea, vomiting, abdominal pain, diarrhea), each rated 0-12 for a sum score of 0-72, and patient satisfaction regarding GI symptoms over approximately 6 weeks after switching. Results: Of 75 patients who received rotigotine, 58 had follow-up data available for final analysis. Intensity of GI complaints improved numerically on both the VAS (47.5 ± 24.4 mm [n = 65] at baseline, 19.7 ± 23.3 mm [n = 58] after around 6 weeks) and the sum score of GI complaints (11.2 ± 9.0 at baseline, 2.1 ± 4.4 [n = 58] after around 6 weeks). Fifty of 58 patients were "satisfied" or "very satisfied" regarding GI symptoms over around 6 weeks following switch to the patch. Conclusion: This study suggests that a switch from oral anti-PD medications to rotigotine transdermal patch may improve existing GI symptoms among patients with PD. Additional controlled studies are needed to confirm this finding.
MeSH term(s)	Administration, Oral ; Aged ; Aged, 80 and over ; Antiparkinson Agents/administration & dosage ; Female ; Follow-Up Studies ; Gastrointestinal Diseases/drug therapy ; Gastrointestinal Diseases/etiology ; Humans ; Male ; Middle Aged ; Pain Measurement ; Parkinson Disease/complications ; Parkinson Disease/drug therapy ; Patient Satisfaction ; Tetrahydronaphthalenes/administration & dosage ; Thiophenes/administration & dosage ; Transdermal Patch
Chemical Substances	Antiparkinson Agents ; Tetrahydronaphthalenes ; Thiophenes ; rotigotine (87T4T8BO2E)
Language	English
Publishing date	2015-03
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2014.11.024
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4553: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Patients' perception of Parkinson's disease-associated pain following initiation of rotigotine: a multicenter non-interventional study.

Timmermann, Lars / Oehlwein, Christian / Ransmayr, Gerhard / Fröhlich, Holger / Will, Edgar / Schroeder, Hanna / Lauterbach, Thomas / Bauer, Lars / Kassubek, Jan

Postgraduate medicine

2017 Volume 129, Issue 1, Page(s) 46–54

Abstract: Objectives: To evaluate Parkinson's disease (PD)-associated pain as perceived by the patients (subjective characterization), and how this may change following initiation of rotigotine transdermal patch.: Methods: SP1058 was a non-interventional study ...

Abstract	Objectives: To evaluate Parkinson's disease (PD)-associated pain as perceived by the patients (subjective characterization), and how this may change following initiation of rotigotine transdermal patch. Methods: SP1058 was a non-interventional study conducted in routine clinical practice in Germany and Austria in patients experiencing PD-associated pain (per the physician's assessment). Data were collected at baseline (ie, before rotigotine initiation) and at a routine visit after ≥25 days (-3 days allowed) of treatment on a maintenance dose of rotigotine (end of study [EoS]). Pain perception was assessed using the 12-item Pain Description List of the validated German Pain Questionnaire (each item ranked 0 = 'not true' to 3 = 'very true'). Primary effectiveness variable: change from baseline to EoS in the sum score of the 4 'affective dimension' items of the Pain Description List. Secondary effectiveness variables: change from baseline to EoS in Unified Parkinson's Disease Rating Scale (UPDRS) II, III, and II+III scores, and Parkinson's Disease Questionnaire (PDQ-8) total score (PD-related quality-of-life). Other variables included scores of the eight 'sensory dimension' items of the Pain Description List. Results: Of 93 enrolled patients (mean [SD] age: 71.1 [9.0] years; male: 48 [52%]), 77 (83%) completed the study, and 70 comprised the full analysis set. The mean (SD) change from baseline in the sum score of the four 'affective dimension' items was -1.3 (2.8) indicating a numerical improvement (baseline: 3.9 [3.4]). In the 'sensory dimension', pain was mostly perceived as 'pulling' at baseline (49/70 [70%]); 'largely true'/'very true'). Numerical improvements were observed in all UPDRS scores (mean [SD] change in UPDRS II+III: -5.3 [10.5]; baseline: 36.0 [15.9]), and in PDQ-8 total score (-2.0 [4.8]; baseline: 10.7 [5.9]). Adverse drug reactions were consistent with dopaminergic stimulation and transdermal administration. Conclusion: The perception of the 'affective dimension' of PD-associated pain numerically improved in patients treated with rotigotine. ClinicalTrials.gov identifier: NCT01606670; https://clinicaltrials.gov/ct2/show/NCT01606670?term=NCT01606670&rank=1.
MeSH term(s)	Activities of Daily Living ; Administration, Cutaneous ; Aged ; Aged, 80 and over ; Austria ; Dopamine Agonists/therapeutic use ; Female ; Follow-Up Studies ; Germany ; Humans ; Male ; Middle Aged ; Pain/drug therapy ; Pain/etiology ; Parkinson Disease/complications ; Surveys and Questionnaires ; Tetrahydronaphthalenes/therapeutic use ; Thiophenes/therapeutic use
Chemical Substances	Dopamine Agonists ; Tetrahydronaphthalenes ; Thiophenes ; rotigotine (87T4T8BO2E)
Language	English
Publishing date	2017-01
Publishing country	England
Document type	Clinical Trial ; Comparative Study ; Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	410138-8
ISSN	1941-9260 ; 0032-5481
ISSN (online)	1941-9260
ISSN	0032-5481
DOI	10.1080/00325481.2017.1258953
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Conference proceedings ; Online: Empirical study on implicit polarization diversity and space diversity for short range indoor-to-outdoor radio links below 1 GHz

Rauh, Sebastian / Lauterbach, Thomas / Lieske, Hendrik / Kilian, Gerd / Robert, Jörg / Heuberger, Albert

2017

Abstract: 9 S. ... To assess the properties of short-range indoor-tooutdoor radio channels for applications like telemetry and smart metering we performed several field trials. They were operated in urban and commercial areas for several weeks each. Multiantenna ... ...

Abstract	9 S. To assess the properties of short-range indoor-tooutdoor radio channels for applications like telemetry and smart metering we performed several field trials. They were operated in urban and commercial areas for several weeks each. Multiantenna receivers were used to record signal levels from two different antennas in parallel. Due to multipath propagation, in some of the channels low signal levels were observed. We therefore investigated if diversity techniques can be applied to improve reception, focussing on implicit polarization diversity and space diversity. From measurements over long time periods we derived the distributions of correlation coefficients and signal levels obtained from more than 80 radio links each using 3, 7 and 27 channels in the 169 MHz, 434 MHz and 868 MHz bands, respectively. For implicit polarization diversity and space diversity with horizontal spacing of antennas of one to six wavelengths we find the signals from the two antennas to be sufficiently decorrelated (correlation coefficents < 0.7) for most of the radio links and channels. In contrast, for space diversity with two antennas placed on the same mast at different heights, in many cases the signals were not sufficiently decorrelated. With respect to cross-polarization imbalance, we find values between -3 dB and 9 dB in the different trials and in the different frequency bands. The results show that generally both diversity schemes have the potential to significantly improve the performance of short range indoor-to-outdoor radio transmission systems. If space diversity with two vertically polarized antennas is not feasible due to lack of a second antenna mast, implicit polarization diversity will perform well, in particular if the imbalance of signal levels can be compensated e.g. by using a cross-polarized antenna with appropriately higher gain.
Keywords	Nachrichtentechnik
Subject code	621
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Changes in drug load during lacosamide combination therapy: A noninterventional, observational study in German and Austrian clinical practice.

Reinhardt, Fritjof / Weber, Yvonne G / Mayer, Thomas / Luef, Gerhard / Joeres, Lars / Tennigkeit, Frank / Dedeken, Peter / De Backer, Marc / Hellot, Scarlett / Lauterbach, Thomas / Webers, Tanja / Arnold, Stephan

Epilepsia open

2019 Volume 4, Issue 3, Page(s) 409–419

Abstract: Introduction: Effects of antiepileptic drug (AED) load changes in patients with focal seizures have not been well evaluated.: Methods: SP1065 (NCT01673282) was a noninterventional, prospective, observational study conducted in a clinical practice ... ...

Abstract	Introduction: Effects of antiepileptic drug (AED) load changes in patients with focal seizures have not been well evaluated. Methods: SP1065 (NCT01673282) was a noninterventional, prospective, observational study conducted in a clinical practice setting. Patients (aged ≥18 years) with focal seizures were enrolled within 7 days of being prescribed adjunctive lacosamide. Observation period was ~6 months. Drug load was assessed using percentage change in ratio of actual prescribed dose and World Health Organization defined daily dose (DDD) for concomitant AEDs and all AEDs (including lacosamide). Subgroups were defined for patients with at least one concomitant sodium channel-blocking AED (SCB [+]) and those without (SCB [-]). Results: A total of 311 patients were assessed for safety, 302 for measurement of drug load, and 240 for effectiveness. Ratio of AED dose to DDD decreased for concomitant AEDs (-9.6%) and increased for all AEDs (including lacosamide; 15.5%). Median reduction in focal seizure frequency per 28 days was 100% (range: -100, 2275.8). 70.4% and 61.7% of patients had a ≥50% or ≥75% reduction in seizure frequency, respectively; 50.8% became seizure-free. In the SCB (+) subgroup (n = 149), ratio of AED dose to DDD decreased for concomitant AEDs (-15.0%) and increased for all AEDs (10.7%). In the SCB (-) subgroup (n = 153), ratio of AED dose to DDD decreased for concomitant AEDs (-4.4%) and increased for all AEDs (20.2%). Fifty-seven patients (18.3%) reported ADRs, most commonly dose >400 mg/d (7.1%). Seventeen patients (5.5%) had ADRs leading to discontinuation. Significance: Addition of lacosamide resulted in reduction of concomitant AED drug load regardless of whether concomitant AEDs were SCB (+) or SCB (-). These results indicate that addition of lacosamide in patients with focal seizures could allow clinicians to withdraw or reduce the dose of less well-tolerated or less effective AEDs.
Language	English
Publishing date	2019-06-22
Publishing country	United States
Document type	Journal Article
ISSN	2470-9239
ISSN	2470-9239
DOI	10.1002/epi4.12346
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: 1000 Konstruktionsbeispiele für die Praxis

Krahn, Heinrich / Eh, Dieter / Lauterbach, Thomas

2007

Title variant	tausend eintausend
Author's details	Heinrich Krahn; Dieter Eh; Thomas Lauterbach
Keywords	Maschinenbau ; Konstruktion
Language	German ; English
Size	XL, 463 S., zahlr. graph. Darst.
Edition	2., [erw.] Aufl.
Publisher	Hanser
Publishing place	München u.a.
Document type	Book
Note	Literaturverz. S. 429 - 431
Accompanying material	1 DVD-ROM (12 cm)
ISBN	3446411917 ; 9783446411913
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Caregivers' and physicians' attitudes to rotigotine transdermal patch versus oral Parkinson's disease medication: an observational study.

Sieb, Jörn Peter / Themann, Peter / Warnecke, Tobias / Lauterbach, Thomas / Berkels, Reinhard / Grieger, Frank / Lorenzl, Stefan

Current medical research and opinion

2015 Volume 31, Issue 5, Page(s) 967–974

Abstract: Objective: To provide real-world data on caregiver and physician perceptions of the advantages and disadvantages of rotigotine transdermal patch (Neupro * ) versus oral Parkinson's Disease (PD) medication.: Methods: Cross-sectional, non- ... ...

Abstract	Objective: To provide real-world data on caregiver and physician perceptions of the advantages and disadvantages of rotigotine transdermal patch (Neupro * ) versus oral Parkinson's Disease (PD) medication. Methods: Cross-sectional, non-interventional study in routine clinical practice in Germany (NCT01330290). Patients had PD with documented need for care, and had received rotigotine transdermal patch as add-on to oral PD treatment for ≥1 month. Caregivers/nurses and physicians assessed rotigotine transdermal patch versus oral PD medications using questionnaires. Specific questions regarding the possible benefits of transdermal application were asked and comprised questions on: swallowing dysfunction, nausea/vomiting, monitoring therapy, once daily application, application independently from meals, application to sleeping patients, caregiving efforts (caregivers only) and clinical aspects (physicians only). Each question was assessed on a 5 point scale ranging from -2 (major disadvantage) to 2 (major advantage) compared with oral treatment. Primary outcomes were mean total scores of all questions for caregivers/nurses and physicians who provided responses for ≥4 questions. As there are no validated tools to assess physician/caregiver preference in the PD setting, there is no reference against which the current findings can be compared; this study serves to pilot the questionnaires. Results: Questionnaire responses from 128 caregivers/nurses and 41 physicians were documented for 147 patients. One hundred (68%) patients had a caregiving family member; 40 (27%) were cared for by a nurse. Mean PD duration was 8.2 (SD 6.3) years; 136 (93%) patients were taking levodopa. Mean total score of caregivers'/nurses' questionnaires was 1.32 (SD 0.67) and of physicians' questionnaires was 1.46 (0.32) indicating a perceived advantage of rotigotine transdermal patch over oral PD therapy. Mean scores for individual questions were in the range 1.03-1.54 for caregivers/nurses and 1.15-1.87 for physicians. When given a choice about rationale to prescribe, physicians cited pharmaceutical form (patch) in 139 (95%) cases and active agent (rotigotine) in 89 (61%) cases. Conclusion: Caregivers/nurses and physicians perceived advantages with rotigotine transdermal patch compared to an oral PD medication as add-on therapy in patients with PD; advantages were observed in aspects of medical treatment as well as in everyday situations of caregiving of PD patients.
MeSH term(s)	Administration, Cutaneous ; Administration, Oral ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Caregivers/statistics & numerical data ; Cross-Sectional Studies ; Dopamine Agonists/administration & dosage ; Dopamine Agonists/therapeutic use ; Female ; Germany ; Humans ; Levodopa/therapeutic use ; Male ; Middle Aged ; Parkinson Disease/drug therapy ; Physicians/statistics & numerical data ; Pilot Projects ; Surveys and Questionnaires ; Tetrahydronaphthalenes/administration & dosage ; Tetrahydronaphthalenes/therapeutic use ; Thiophenes/administration & dosage ; Thiophenes/therapeutic use ; Transdermal Patch ; Young Adult
Chemical Substances	Dopamine Agonists ; Tetrahydronaphthalenes ; Thiophenes ; Levodopa (46627O600J) ; rotigotine (87T4T8BO2E)
Language	English
Publishing date	2015-05
Publishing country	England
Document type	Clinical Trial ; Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	80296-7
ISSN	1473-4877 ; 0300-7995
ISSN (online)	1473-4877
ISSN	0300-7995
DOI	10.1185/03007995.2015.1030376
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