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  1. Article ; Online: Human factor engineering of point-of-care near infrared spectroscopy device for intracranial hemorrhage detection in Traumatic Brain Injury: A multi-center comparative study using a hybrid methodology.

    Shah, Jaimin / Vithalapara, Kaushik / Malik, Shilpa / Lavania, Anupam / Solanki, Shailendra / Adhvaryu, Nilay S

    International journal of medical informatics

    2024  Volume 184, Page(s) 105367

    Abstract: Objective: This study assessed machine learning powered Near-infrared spectroscopy based (mNIRS) device's usability and human factor ergonomics in four distinct healthcare provider groups.: Background: Traumatic Brain Injury (TBI) is a global concern ...

    Abstract Objective: This study assessed machine learning powered Near-infrared spectroscopy based (mNIRS) device's usability and human factor ergonomics in four distinct healthcare provider groups.
    Background: Traumatic Brain Injury (TBI) is a global concern with significant well-being implications. Timely intracranial hemorrhage (ICH) detection is crucial. mNIRS offers efficient non-invasive TBI screening.
    Methods: Two device utilization stages involved operators (N = 21) and TBI-suspected subjects (n = 120). A hybrid approach used qualitative and quantitative methods, utilizing a 57-item survey and task completion time.
    Results: All groups positively perceived user-interface, physical, cognitive, and organizational ergonomics. The device's ease of use, calibration, size, cognitive support, and integration gained appreciation. Training reduced task completion time from 16.5 to 13.2 s.
    Conclusion: mNIRS-based CEREBO® proves usable for TBI point-of-care assessment. Positive feedback from diverse healthcare groups validates design and cost-effectiveness alignment. A hybrid approach, training, and practice scans enhance usage and experience.
    MeSH term(s) Humans ; Spectroscopy, Near-Infrared/methods ; Point-of-Care Systems ; Brain Injuries, Traumatic/diagnosis ; Intracranial Hemorrhages ; Ergonomics
    Language English
    Publishing date 2024-02-03
    Publishing country Ireland
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1466296-6
    ISSN 1872-8243 ; 1386-5056
    ISSN (online) 1872-8243
    ISSN 1386-5056
    DOI 10.1016/j.ijmedinf.2024.105367
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  2. Article ; Online: Evaluating CAPO®: A biocompatibility, transparency, and fitment assessment for use with CEREBO® in traumatic intracranial injury detection.

    Malik, Shilpa / Lavania, Anupam / Shukla, Dhaval / Shah, Jaimin / Raj, Sumit / Murugan, S S / Sathya, T N / Goswami, Arpana / Kumaravel, T S

    Journal of biophotonics

    2024  Volume 17, Issue 3, Page(s) e202300243

    Abstract: Healthcare-associated infections (HAIs) are a global concern affecting millions of patients, requiring robust infection prevention and control measures. In particular, patients with traumatic brain injury (TBI) are highly susceptible to nosocomial ... ...

    Abstract Healthcare-associated infections (HAIs) are a global concern affecting millions of patients, requiring robust infection prevention and control measures. In particular, patients with traumatic brain injury (TBI) are highly susceptible to nosocomial infections, emphasizing the importance of infection control. Non-invasive near infrared spectroscopy (NIRS) device, CEREBO® integrated with a disposable component CAPO® has emerged as a valuable tool for TBI patient triage and this study evaluated the safety and efficacy of this combination. Biocompatibility tests confirmed safety and transparency assessments demonstrated excellent light transmission. Clinical evaluation with 598 enrollments demonstrated high accuracy of CEREBO® in detecting traumatic intracranial hemorrhage. During these evaluations, the cap fitted well and moved smoothly with the probes demonstrating appropriate flexibility. These findings support the efficacy of the CAPO® and CEREBO® combination, potentially improving infection control and enhancing intracranial hemorrhage detection for TBI patient triage. Ultimately, this can lead to better healthcare outcomes and reduced global HAIs.
    MeSH term(s) Humans ; Intracranial Hemorrhage, Traumatic/complications ; Intracranial Hemorrhage, Traumatic/diagnosis ; Spectroscopy, Near-Infrared/methods ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/complications
    Language English
    Publishing date 2024-01-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202300243
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6723: Show issues Location:
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  3. Article: Acute Respiratory Distress Syndrome due to Vivax Malaria.

    Mukherjee, T / Lavania, A K

    Medical journal, Armed Forces India

    2011  Volume 64, Issue 4, Page(s) 365–366

    Language English
    Publishing date 2011-07-21
    Publishing country India
    Document type Case Reports
    ZDB-ID 196342-9
    ISSN 0377-1237
    ISSN 0377-1237
    DOI 10.1016/S0377-1237(08)80026-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6511: Show issues Location:
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  4. Article: OXYGEN TOXICITY.

    Chawla, A / Lavania, A K

    Medical journal, Armed Forces India

    2011  Volume 57, Issue 2, Page(s) 131–133

    Abstract: Oxygen, the gas vital to sustain life, can also destroy it. It may become toxic at an elevated partial pressure, which may be the result of a rise in inspired oxygen concentration, an increase in environmental pressure or a combination of both. The ... ...

    Abstract Oxygen, the gas vital to sustain life, can also destroy it. It may become toxic at an elevated partial pressure, which may be the result of a rise in inspired oxygen concentration, an increase in environmental pressure or a combination of both. The toxicity tends to express itself most recognizably in one of several forms including central nervous system manifestations, pulmonary signs and symptoms and ocular effects, especially in premature infants. Other forms of toxicity should be expected in severe exposure but are difficult to detect and hence are not often considered important limitations for the use of oxygen. The onset and degree of the toxicity vary with the concentration of the gas used and the duration of exposure. Marked variations in individual susceptibility are found. Prevention of its occurrence and early detection of toxicity are called for, the treatment being symptomatic.
    Language English
    Publishing date 2011-07-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 196342-9
    ISSN 0377-1237
    ISSN 0377-1237
    DOI 10.1016/S0377-1237(01)80133-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6511: Show issues Location:
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  5. Article ; Online: Allergic fungal sinusitis.

    Mallick, S / Sharma, V / Lavania, A / Borgohain, B

    Kathmandu University medical journal (KUMJ)

    2008  Volume 6, Issue 2, Page(s) 235–238

    Abstract: Allergic fungal sinusitis (AFS) is believed to be an allergic reaction of the sinus mucosa to environmental fungi that is finely dispersed into the air. We present a 23 year old man who presented to us with a unilateral nasal mass with foul smelling ... ...

    Abstract Allergic fungal sinusitis (AFS) is believed to be an allergic reaction of the sinus mucosa to environmental fungi that is finely dispersed into the air. We present a 23 year old man who presented to us with a unilateral nasal mass with foul smelling discharge and headache. Functional endoscopic sinus surgery (FESS) was performed. Microbiology and histopathological examination of the mass confirmed it to be a case of AFS.
    MeSH term(s) Aspergillosis/diagnosis ; Aspergillosis/diagnostic imaging ; Aspergillosis/surgery ; Aspergillus/isolation & purification ; Humans ; Hypersensitivity/microbiology ; Male ; Nasal Polyps/diagnostic imaging ; Nasal Polyps/microbiology ; Nasal Polyps/surgery ; Radiography ; Sinusitis/diagnostic imaging ; Sinusitis/microbiology ; Sinusitis/surgery ; Young Adult
    Language English
    Publishing date 2008-04
    Publishing country Nepal
    Document type Case Reports ; Journal Article
    ZDB-ID 2257651-4
    ISSN 1812-2078 ; 1812-2027
    ISSN (online) 1812-2078
    ISSN 1812-2027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: An overview of anticancer activity of Garcinia and Hypericum

    Brito, Lavínia de C / Ana Luiza Rangel Berenger / Maria Raquel Figueiredo

    Food and chemical toxicology. 2017,

    2017  

    Abstract: Cancer is one of the leading causes of death worldwide (approximately 8.2 million cases/year) and, over the next two decades, a 70% increase in new cancer cases is expected. Through analysis of the available drugs between the years of 1930 and 2014, it ... ...

    Abstract Cancer is one of the leading causes of death worldwide (approximately 8.2 million cases/year) and, over the next two decades, a 70% increase in new cancer cases is expected. Through analysis of the available drugs between the years of 1930 and 2014, it was found that 48% were either natural products or their derivatives. This proportion increased to 66% when semi-synthetic products were included. The family Clusiaceae Juss. (Malpighiales) includes approximately 1000 species distributed throughout all tropical and temperate regions. The phytochemical profile of this family includes many chemicals with interesting pharmacological activities, including anticancer activities. This study includes an overview of the in vitro and in vivo anticancer activity of secondary metabolites from Garcinia and Hypericum and the mechanisms involved in this activity. Hypericum no longer belong to Clusiaceae family, but was considered in the past by taxonomists, due to similarities with this family. Research in the area has shown that several compounds belonging to different chemical classes exhibit activity in several tumor cell lines in different experimental models. This review shows the significant antineoplasic activity of these compounds, in particular of these two genera and validates the importance of natural products in the search for anticancer drugs.
    Keywords antineoplastic activity ; antineoplastic agents ; death ; Garcinia ; Hypericum ; models ; neoplasm cells ; neoplasms ; phytopharmaceuticals ; secondary metabolites ; temperate zones ; toxicology
    Language English
    Size p. .
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2017.03.053
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4035: Show issues

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  7. Article: An In vitro SEM Study on the Effect of Bleaching Gel Enriched with NovaMin on Whitening of Teeth and Dentinal Tubule Occlusion.

    Kakodkar, Gaurangi / Lavania, Anuj / Ataide, Ida De Noronha De

    Journal of clinical and diagnostic research : JCDR

    2013  Volume 7, Issue 12, Page(s) 3032–3035

    Abstract: Introduction: Tooth whitening products enjoy substantial popularity. However, tooth hypersensitivity is invariably an undesirable consequence. Desensitizing toothpastes may be used for alleviating the symptoms. NovaMin, as an active ingredient in many ... ...

    Abstract Introduction: Tooth whitening products enjoy substantial popularity. However, tooth hypersensitivity is invariably an undesirable consequence. Desensitizing toothpastes may be used for alleviating the symptoms. NovaMin, as an active ingredient in many dentifrices, has been shown to deliver significant therapeutic desensitising benefits.
    Aim: To study the effect of NovaMin desensitising toothpaste mixed with 15% carbamide peroxide on tooth bleaching and tubule occlusion.
    Material and methods: This study was carried out in vitro, on extracted premolars which were bleached, using the above mentioned mixture and shade change was evaluated. They were then sectioned to be observed under a scanning Electron Microscope. The number of completely and partially blocked tubules as well as open tubules were counted for each specimen. Statistical analysis for shade change was done by using paired t-test. Mean and Standard deviation were calculated for the tubule counts and they were analyzed statistically.
    Conclusion: The results of this study indicated that the addition of NovaMin to 15% Carbamide peroxide occluded the dentinal tubules and that it did not affect the bleaching procedure. They also emphasized its clinical relevance in a dual advantage of desensitizing and bleaching with a single paste system.
    Language English
    Publishing date 2013-12-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 2775283-5
    ISSN 0973-709X ; 2249-782X
    ISSN (online) 0973-709X
    ISSN 2249-782X
    DOI 10.7860/JCDR/2013/5831.3841
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  8. Article: Air pollution and fuel vapour induced changes in lung functions: are fuel handlers safe?

    Chawla, Anuj / Lavania, A K

    Indian journal of physiology and pharmacology

    2008  Volume 52, Issue 3, Page(s) 255–261

    Abstract: Automobile exhaust derived air pollutants have become a major health hazard. Coupled with the inhalation of fuel vapour, as occurs in petrol station workers, this may lead to significant impairment of lung function. Spirometric lung functions were ... ...

    Abstract Automobile exhaust derived air pollutants have become a major health hazard. Coupled with the inhalation of fuel vapour, as occurs in petrol station workers, this may lead to significant impairment of lung function. Spirometric lung functions were studied in 58 petrol station workers to examine this possibility. The forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), forced expiratory flow 25%-75% (FEF25-75) and peak expiratory flow (PEF) were recorded and analysed separately for smokers and non-smokers. The workers were divided into 5 groups for analysis of data based on the number of years of work in the petrol pumps. Outdoor air analysis was also carried out. The FVC, FEV1 and PEF declined significantly with increasing years of work in petrol stations in both smokers and non-smokers. Smoking as an independent variable was found to affect the FEV1 significantly but not FVC or PEF. The FEF25-75 was found to be the most affected spirometric value with a significant reduction with increasing years of work. Smoking as such did not affect it. Oxides of nitrogen (NOx), suspended particulate matter (SPM) and particulate matter less than 10 microns (PM10) in outdoor air were higher than the national ambient air quality standards. Exposure to automobile exhaust and fuel vapour impairs lung function in a time-dependent manner. Cigarette smoking appears to accelerate the decline.
    MeSH term(s) Adolescent ; Adult ; Air Pollutants, Occupational/analysis ; Air Pollution/adverse effects ; Cross-Sectional Studies ; Fossil Fuels/adverse effects ; Humans ; Respiration/drug effects ; Smoking/adverse effects ; Spirometry ; Time Factors ; Vehicle Emissions
    Chemical Substances Air Pollutants, Occupational ; Fossil Fuels ; Vehicle Emissions
    Language English
    Publishing date 2008-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 604352-5
    ISSN 0019-5499
    ISSN 0019-5499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 336: Show issues Location:
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  9. Article ; Online: Ectopic canine tooth: a rare cause for maxillary antral mucocoele.

    Sharma, V / Lavania, A / Mallick, S A / Sharma, M

    Kathmandu University medical journal (KUMJ)

    2006  Volume 4, Issue 2, Page(s) 251–252

    Abstract: A 40-year-old female presented with a 10 year history of left sided facial pain and occasional purulent nasal discharge, refractory to antibiotics. Dental examination showed 3 missing teeth in left maxilla one of which had no history of extraction. X-ray ...

    Abstract A 40-year-old female presented with a 10 year history of left sided facial pain and occasional purulent nasal discharge, refractory to antibiotics. Dental examination showed 3 missing teeth in left maxilla one of which had no history of extraction. X-ray paranasal sinus showed a bony opacity in the maxillary sinus but nasal endoscopy was normal. C.T. scan revealed a radio-opaque shadow arising from medial wall of left maxillary sinus with a large maxillary mucocoele. Caldwell-Luc procedure was done and an ectopic canine tooth was seen arising from the medial antral wall. Extraction of the tooth with excision of mucocoele resulted in relieving of the symptoms.
    MeSH term(s) Adult ; Choristoma/complications ; Cuspid ; Female ; Humans ; Mucocele/diagnostic imaging ; Mucocele/etiology ; Mucocele/physiopathology ; Radiography ; Tooth Extraction/methods
    Language English
    Publishing date 2006-04
    Publishing country Nepal
    Document type Case Reports ; Journal Article
    ZDB-ID 2257651-4
    ISSN 1812-2078 ; 1812-2027
    ISSN (online) 1812-2078
    ISSN 1812-2027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Orbital cellulitis--a complication of sinusitis.

    Lavania, A / Sharma, V / Reddy, N S / Baksh, R

    Kathmandu University medical journal (KUMJ)

    2005  Volume 3, Issue 3, Page(s) 292–293

    Abstract: A 9 years old patient presented with swelling and severe pain in right eye with diplopia; with normal visual acuity. CT scan of paranasal sinus revealed right eye axial proptosis and dehiscence in lamina papyracia. After thorough investigation, patient ... ...

    Abstract A 9 years old patient presented with swelling and severe pain in right eye with diplopia; with normal visual acuity. CT scan of paranasal sinus revealed right eye axial proptosis and dehiscence in lamina papyracia. After thorough investigation, patient was posted for surgical drainage and decompression of the right orbit. Patient, improved after surgery and followed regularly for last 2 months.
    MeSH term(s) Child ; Humans ; Male ; Orbital Cellulitis/etiology ; Orbital Cellulitis/surgery ; Sinusitis/complications ; Sinusitis/surgery
    Language English
    Publishing date 2005-07
    Publishing country Nepal
    Document type Case Reports ; Journal Article
    ZDB-ID 2257651-4
    ISSN 1812-2078 ; 1812-2027
    ISSN (online) 1812-2078
    ISSN 1812-2027
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