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  1. Article ; Online: Emergence of tick-borne encephalitis (TBE) in the Netherlands.

    Dekker, Margriet / Laverman, Gozewijn Dirk / de Vries, Ankje / Reimerink, Johan / Geeraedts, Felix

    Ticks and tick-borne diseases

    2018  Volume 10, Issue 1, Page(s) 176–179

    Abstract: Recently, tick-borne encephalitis virus (TBEV) was detected in the Netherlands for the first time, in ticks collected in 2015 in the National Park Sallandse heuvelrug in response to the detection of anti-TBEV antibodies in roe deer. Hereafter, two human ... ...

    Abstract Recently, tick-borne encephalitis virus (TBEV) was detected in the Netherlands for the first time, in ticks collected in 2015 in the National Park Sallandse heuvelrug in response to the detection of anti-TBEV antibodies in roe deer. Hereafter, two human cases of autochthonous TBE have been reported, occurring in 2016. One case was geographically linked to the area of the previously reported ticks, which harbored a genetically divergent TBEV-Eu strain variant (TBEV-NL). So far these are the few reported events that point to endemic transmission of TBEV in the Netherlands and the true prevalence of TBEV and TBE disease in the Netherlands and its impact on the human population remains to be determined. We describe the third human case, identified in 2017, which geographically clusters with the aforementioned case and TBEV-positive ticks. We also describe the identification of another TBEV-NL-positive tick in the Netherlands, collected 2 years after the initial find in that same region (in 2017). These observations support the concept of continued circulation of TBEV-NL and the presence of a possible TBEV hot spot in the Sallandse Heuvelrug region.
    MeSH term(s) Animals ; Cluster Analysis ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/virology ; Deer/virology ; Encephalitis Viruses, Tick-Borne/genetics ; Encephalitis Viruses, Tick-Borne/isolation & purification ; Encephalitis, Tick-Borne/epidemiology ; Encephalitis, Tick-Borne/virology ; Female ; Genetic Variation ; Humans ; Male ; Middle Aged ; Netherlands/epidemiology ; Zoonoses
    Language English
    Publishing date 2018-10-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2018.10.008
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  2. Article ; Online: Correlations between plasma strontium concentration, components of calcium and phosphate metabolism and renal function in type 2 diabetes mellitus.

    van den Berkhof, Yvette Sophie / Gant, Christina Maria / Maatman, Ronald / De Graaf, Albert / Navis, Gerjan J / Bakker, Stephan J L / Laverman, Gozewijn Dirk

    European journal of clinical investigation

    2018  Volume 48, Issue 9, Page(s) e12987

    Abstract: Background: Renal function decline in diabetic kidney disease is accompanied by calcium and phosphate metabolism alterations. Whereas strontium (Sr: Materials and methods: Plasma Sr: Results: Overall, median plasma Sr: Conclusions: We found an ... ...

    Abstract Background: Renal function decline in diabetic kidney disease is accompanied by calcium and phosphate metabolism alterations. Whereas strontium (Sr
    Materials and methods: Plasma Sr
    Results: Overall, median plasma Sr
    Conclusions: We found an independent inverse association between eGFR and plasma Sr
    MeSH term(s) Aged ; Calcium/metabolism ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/metabolism ; Female ; Fibroblast Growth Factors/blood ; Glomerular Filtration Rate ; Humans ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Phosphates/metabolism ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/metabolism ; Severity of Illness Index ; Strontium/blood
    Chemical Substances Phosphates ; Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 23 (7Q7P4S7RRE) ; Calcium (SY7Q814VUP) ; Strontium (YZS2RPE8LE)
    Language English
    Publishing date 2018-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.12987
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    Zs.A 677: Show issues Location:
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  3. Article: Effects of Dapagliflozin on Volume Status When Added to Renin-Angiotensin System Inhibitors.

    Eickhoff, Mie K / Dekkers, Claire C J / Kramers, Bart J / Laverman, Gozewijn Dirk / Frimodt-Møller, Marie / Jørgensen, Niklas Rye / Faber, Jens / Danser, A H Jan / Gansevoort, Ron T / Rossing, Peter / Persson, Frederik / Heerspink, Hiddo J L

    Journal of clinical medicine

    2019  Volume 8, Issue 6

    Abstract: Sodium glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of heart and kidney failure in patients with type 2 diabetes, possibly due to diuretic effects. Previous non-placebo-controlled studies with SGLT2 inhibitors observed changes in volume ... ...

    Abstract Sodium glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of heart and kidney failure in patients with type 2 diabetes, possibly due to diuretic effects. Previous non-placebo-controlled studies with SGLT2 inhibitors observed changes in volume markers in healthy individuals and in patients with type 2 diabetes with preserved kidney function. It is unclear whether patients with type 2 diabetes and signs of kidney damage show similar changes. Therefore, a post hoc analysis was performed on two randomized controlled trials (
    Language English
    Publishing date 2019-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm8060779
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  4. Article ; Online: Lower Renal Function Is Associated With Derangement of 11-

    Gant, Christina Maria / Minovic, Isidor / Binnenmars, Heleen / de Vries, Laura / Kema, Ido / van Beek, André / Navis, Gerjan / Bakker, Stephan / Laverman, Gozewijn Dirk

    Journal of the Endocrine Society

    2018  Volume 2, Issue 7, Page(s) 609–620

    Abstract: Context: Derangement of 11-: Objectives: To compare 11: Design: Cross-sectional analysis in the Diabetes and Lifestyle Cohort Twente (DIALECT-1).: Setting: Referral center for T2D.: Patients: Patient with T2D [n = 373, age 64 ± 9 years, 58% ... ...

    Abstract Context: Derangement of 11-
    Objectives: To compare 11
    Design: Cross-sectional analysis in the Diabetes and Lifestyle Cohort Twente (DIALECT-1).
    Setting: Referral center for T2D.
    Patients: Patient with T2D [n = 373, age 64 ± 9 years, 58% men, 26% of patients estimated glomerular filtration rate (eGFR) <60 mL/min·1.73 m
    Mean outcome measure: We measured cortisol, cortisone, and metabolites [tetrahydrocortisol (THF), allo-THF (aTHF), and tetrahydrocortisone (THE)] in 24-hour urine samples. Whole body 11
    Results: Patients with T2D had a higher (THF + aTHF)/THE ratio [1.02 (0.84 to 1.27) vs 0.94 (0.79 to 1.0),
    Conclusions: In this real-life secondary care setting of patients with T2D, 11
    Language English
    Publishing date 2018-05-22
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/js.2018-00088
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  5. Article ; Online: Pooled Analysis of Multiple Crossover Trials To Optimize Individual Therapy Response to Renin-Angiotensin-Aldosterone System Intervention.

    Petrykiv, Sergei I / Laverman, Gozewijn Dirk / Persson, Frederik / Vogt, Liffert / Rossing, Peter / de Borst, Martin H / Gansevoort, Ronald T / de Zeeuw, Dick / Heerspink, Hiddo J L

    Clinical journal of the American Society of Nephrology : CJASN

    2017  Volume 12, Issue 11, Page(s) 1804–1813

    Abstract: Background and objectives: In the treatment of CKD, individual patients show a wide variation in their response to many drugs, including renin-angiotensin-aldosterone system inhibitors (RAASi). To investigate whether therapy resistance to RAASi can be ... ...

    Abstract Background and objectives: In the treatment of CKD, individual patients show a wide variation in their response to many drugs, including renin-angiotensin-aldosterone system inhibitors (RAASi). To investigate whether therapy resistance to RAASi can be overcome by uptitrating the dose of drug, changing the mode of intervention (with drugs from similar or different classes), or lowering dietary sodium intake, we meta-analyzed individual responses to different modes of interventions.
    Design, setting, participants, & measurements: Randomized crossover trials were analyzed to assess correlation of individual responses to RAASi and nonsteroidal anti-inflammatory drugs (NSAIDs;
    Results: The albuminuria response to one dose of RAASi or NSAIDs positively correlated with the response to a higher dose of the same drug (
    Conclusions: Individuals who show a poor response to one dose or type of RAASi also show a poor response to higher doses, other types of RAASi or NSAIDs, or a reduction in dietary salt intake. Whether other drugs or drug combinations targeting pathways beyond the renin-angiotensin-aldosterone system and prostaglandins would improve the individual poor response requires further study.
    MeSH term(s) Albuminuria/etiology ; Angiotensin Receptor Antagonists/administration & dosage ; Angiotensin-Converting Enzyme Inhibitors/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Blood Pressure/drug effects ; Cross-Over Studies ; Humans ; Potassium/blood ; Precision Medicine ; Randomized Controlled Trials as Topic ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Renin/antagonists & inhibitors ; Renin-Angiotensin System/drug effects ; Sodium, Dietary/administration & dosage
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Anti-Inflammatory Agents, Non-Steroidal ; Sodium, Dietary ; Renin (EC 3.4.23.15) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2017-10-11
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.00390117
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6584: Show issues Location:
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  6. Article ; Online: Epstein-Barr virus-positive post-transplant lymphoproliferative disorder of the central nervous system, after renal transplantation with a discrepancy in viral load between peripheral blood and cerebrospinal fluid.

    Boersma, Marijke Nynke / van der Zanden, Adri / Laverman, Gozewijn Dirk / Sanders, Jan Stephan / de Vries, Peter Alexander Marcel

    Transplant international : official journal of the European Society for Organ Transplantation

    2012  Volume 25, Issue 11, Page(s) e113–6

    Abstract: A 43-year-old female developed an Epstein-Barr virus (EBV)-positive post-transplant lymphoproliferative disorder (PTLD) in the central nervous system (CNS), 14 years after renal transplantation. One year prior to presentation, the patients' treatment ... ...

    Abstract A 43-year-old female developed an Epstein-Barr virus (EBV)-positive post-transplant lymphoproliferative disorder (PTLD) in the central nervous system (CNS), 14 years after renal transplantation. One year prior to presentation, the patients' treatment regimen was altered from cyclosporine, azathioprine, and prednisone to mycophenolate mofetil and prednisone. Magnetic resonance imaging of the brain revealed lesions suspect for malignant lymphoma. The EBV real-time polymerase chain reaction (PCR) on peripheral blood was negative, but highly positive on cerebrospinal fluid. EBV-positive PTLD was confirmed using histological analysis of cerebral biopsies. Despite tapering of immune suppressive medication and treatment with rituximab and chemotherapy, the patient deceased 50 days after presentation. This case illustrates that vigilance is required when presented with a negative EBV PCR result on peripheral blood when PTLD of the CNS is suspected. This late presentation suggests a relation to the switch in immunosuppressive regimen 1 year earlier.
    MeSH term(s) Adult ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Cerebrospinal Fluid/virology ; Epstein-Barr Virus Infections/blood ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/drug therapy ; Epstein-Barr Virus Infections/virology ; Fatal Outcome ; Female ; Herpesvirus 4, Human/genetics ; Humans ; Kidney Transplantation/adverse effects ; Lymphoma/cerebrospinal fluid ; Lymphoma/virology ; Lymphoproliferative Disorders/blood ; Lymphoproliferative Disorders/cerebrospinal fluid ; Lymphoproliferative Disorders/diagnosis ; Lymphoproliferative Disorders/virology ; Real-Time Polymerase Chain Reaction ; Rituximab ; Viral Load
    Chemical Substances Antibodies, Monoclonal, Murine-Derived ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2012-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/j.1432-2277.2012.01552.x
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    Zs.A 2358: Show issues Location:
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  7. Article: Renoprotection with and without blood pressure reduction.

    Laverman, Gozewijn Dirk / Andersen, Steen / Rossing, Peter / Navis, Gerjan / de Zeeuw, Dick / Parving, Hans-Henrik

    Kidney international. Supplement

    2005  , Issue 94, Page(s) S54–9

    Abstract: Background: AT1-receptor blockade dose dependently lowers blood pressure (BP) and albuminuria. Reduction of BP and albuminuria are independent treatment targets for renoprotection, but whether this requires similar dose titration is unknown.: Methods!# ...

    Abstract Background: AT1-receptor blockade dose dependently lowers blood pressure (BP) and albuminuria. Reduction of BP and albuminuria are independent treatment targets for renoprotection, but whether this requires similar dose titration is unknown.
    Methods: We tested this in two studies designed to find the optimal antialbuminuric dose of losartan in type 1 diabetic (DM, N= 50) and nondiabetic renal patients (ND, N= 12). After baseline, treatment followed with losartan 50, 100, and 150 mg/day, each dose for eight (DM) or six weeks (ND). At the end of each period, albuminuria (24-hour samples) and mean arterial pressure (MAP) were measured. Patients were divided into "good" and "poor" BP responders (BP+, BP-) according to BP response above or below group median.
    Results: Baseline MAP in the BP- groups was 102 (97, 104) mm Hg in DM (median, 95% CI) and 91 (80, 108) mm Hg in ND. The top of the dose response for BP (obtained at losartan 100 mg) in the BP- groups was -2 (-4, 3) mm Hg in DM and -1 (-6, 2) mm Hg in ND, versus -15 (-18, -12) mm Hg and -16 (-26, -18) mm Hg in BP+ groups (both P < 0.05). Albuminuria was reduced dose dependently both in BP- and BP+: with 100 mg, the reduction in albuminuria in DM BP- was -32% (-49, 13) versus -45% (-60, -38) in DM BP+ and -45% (-70,-7) versus -25% (-58, -6) in ND BP- and BP+ (all P > 0.05). Moreover, in patients in whom BP fell below the recommended treatment target of 130/80 mm Hg (13 in DM and 10 in ND), albuminuria was progressively reduced, with further increasing the dose of losartan in most patients.
    Conclusion: Absence of BP response to losartan does not preclude a reduction in albuminuria, and optimal reduction of albuminuria may require titration beyond the predefined BP target.
    MeSH term(s) Adult ; Albuminuria/drug therapy ; Antihypertensive Agents/administration & dosage ; Blood Pressure/drug effects ; Female ; Humans ; Hypertension, Renal/drug therapy ; Losartan/administration & dosage ; Male ; Middle Aged
    Chemical Substances Antihypertensive Agents ; Losartan (JMS50MPO89)
    Language English
    Publishing date 2005-04
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 193442-9
    ISSN 2157-1716 ; 0098-6577 ; 2157-1724
    ISSN (online) 2157-1716
    ISSN 0098-6577 ; 2157-1724
    DOI 10.1111/j.1523-1755.2005.09414.x
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    Zs.A 797 -Suppl.-: Show issues Location:
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