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  1. Article ; Online: Response to 'Clinical outcomes and inflammatory response to single-incision laparoscopic (SIL) colorectal surgery: a single-blinded randomized controlled pilot study'.

    Macmillan, A / Massey, L / Lawday, S / Bethune, R M

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2019  Volume 21, Issue 5, Page(s) 603

    MeSH term(s) Colectomy ; Colorectal Surgery ; Laparoscopy ; Pilot Projects
    Language English
    Publishing date 2019-03-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.14605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Response to 'Preoperative geriatric assessment and tailored interventions in frail older patients with colorectal cancer: a randomized controlled trial'.

    Lawday, S / Ricciardi, E / Bethune, R / McDermott, F

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2018  Volume 20, Issue 4, Page(s) 350

    MeSH term(s) Aged ; Colonic Neoplasms ; Colorectal Neoplasms ; Frail Elderly ; Geriatric Assessment ; Humans
    Language English
    Publishing date 2018-02-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.14046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rectal stump management in inflammatory bowel disease: a cohort study, systematic review and proportional analysis of perioperative complications.

    Lawday, S / Leaning, M / Flannery, O / Summers, S / Antoniou, G A / Goodhand, J / Bethune, R / Antoniou, S A

    Techniques in coloproctology

    2020  Volume 24, Issue 7, Page(s) 671–684

    Abstract: Background: The aim of this study was to analyse local single-institution data and perform a systematic review of the literature to calculate precise risk estimates of rectal stump-related morbidity and mortality following subtotal colectomy in patients ...

    Abstract Background: The aim of this study was to analyse local single-institution data and perform a systematic review of the literature to calculate precise risk estimates of rectal stump-related morbidity and mortality following subtotal colectomy in patients with inflammatory bowel disease (IBD), including Crohn's colitis, ulcerative colitis and indeterminate colitis.
    Methods: Institutional information systems were interrogated to obtain local patient data. A systematic review of MEDLINE and EMBASE was performed to identify relevant articles. Fixed-effects or random-effects meta-analysis of proportions was performed to calculate pooled incidence estimates, including local data.
    Results: Sixty-one patients were included locally and all had their rectal stump closed intra-abdominally. Four patients (8.3%) had a rectal stump perforation and 30-day mortality was 0. Fourteen papers were included in our review alongside local data, with a total of 1330 patients included. Pooled mortality was 1.7% (95% confidence interval, CI 1.0-2.8), pooled incidence of pelvic abscess/sepsis, stump leak and wound infection was 5.7% (95% CI 4.4-7.3), 4.9% (95% CI 3.7-6.6) and 11.3% (95% CI 7.8-16), respectively. Subcutaneous placement of the stump was associated with the highest incidence of stump leak (12.6%, 95% CI 8.3-18.6), and closure of the stump with both staples and suture was associated with the highest incidence of pelvic abscess (11.1%, 95% CI 5.8-20.3). Mortality and the incidence of wound infection were similar across stump closure techniques. There was evidence suggesting considerable heterogeneity and publication bias among studies.
    Conclusions: This study provides estimates of morbidity associated with the rectal stump after subtotal colectomy for IBD. A closed intra-abdominal stump seems to be associated with the highest rate of pelvic abscess/sepsis. Further work in form of an international collaborative project would allow individual patient data analysis and identification of risk factors for complications.
    MeSH term(s) Cohort Studies ; Colectomy ; Colitis/surgery ; Colitis, Ulcerative/surgery ; Humans ; Inflammatory Bowel Diseases/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Rectum/surgery
    Language English
    Publishing date 2020-03-31
    Publishing country Italy
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-020-02188-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply to: "Factors affecting the mortality of patients with COVID-19 undergoing surgery and the safety of medical staff: A systematic review and meta-analysis".

    Lawday, Samuel / Mills, Emily C / Jones, Conor S / Nepogodiev, Dmitri / Glasbey, James C

    EClinicalMedicine

    2021  Volume 31, Page(s) 100705

    Language English
    Publishing date 2021-01-15
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Follow-up of the STOMAMESH Cohort.

    Lawday, Samuel / Leaning, Matthew / Flannery, Oliver / Bethune, Rob

    Annals of surgery

    2018  Volume 268, Issue 2, Page(s) e30

    MeSH term(s) Cohort Studies ; Colostomy ; Follow-Up Studies ; Hernia ; Humans ; Surgical Mesh
    Language English
    Publishing date 2018-06-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000002786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Quality of life in restorative versus non-restorative resections for rectal cancer: systematic review.

    Lawday, Samuel / Flamey, Nicholas / Fowler, George E / Leaning, Matthew / Dyar, Nadine / Daniels, Ian R / Smart, Neil J / Hyde, Christopher

    BJS open

    2022  Volume 5, Issue 6

    Abstract: Background: Low rectal cancers could be treated using restorative (anterior resection, AR) or non-restorative procedures with an end/permanent stoma (Hartmann's, HE; or abdominoperineal excision, APE). Although the surgical choice is determined by ... ...

    Abstract Background: Low rectal cancers could be treated using restorative (anterior resection, AR) or non-restorative procedures with an end/permanent stoma (Hartmann's, HE; or abdominoperineal excision, APE). Although the surgical choice is determined by tumour and patient factors, quality of life (QoL) will also influence the patient's future beyond cancer. This systematic review of the literature compared postoperative QoL between the restorative and non-restorative techniques using validated measurement tools.
    Methods: The review was registered on PROSPERO (CRD42020131492). Embase and MEDLINE, along with grey literature and trials websites, were searched comprehensively for papers published since 2012. Inclusion criteria were original research in an adult population with rectal cancer that reported QoL using a validated tool, including the European Organization for Research and Treatment of Cancer QLQ-CR30, QLQ-CR29, and QLQ-CR38. Studies were included if they compared AR with APE (or HE), independent of study design. Risk of bias was assessed using the Risk Of Bias In Non-Randomized Studies of Interventions (ROBINS-I) tool. Outcomes of interest were: QoL, pain, gastrointestinal (GI) symptoms (stool frequency, flatulence, diarrhoea and constipation), and body image.
    Results: Nineteen studies met the inclusion criteria with a total of 6453 patients; all papers were observational and just four included preoperative evaluations. There was no identifiable difference in global QoL and pain between the two surgical techniques. Reported results regarding GI symptoms and body image documented similar findings. The ROBINS-I tool highlighted a significant risk of bias across the studies.
    Conclusion: Currently, it is not possible to draw a firm conclusion on postoperative QoL, pain, GI symptoms, and body image following restorative or non-restorative surgery. The included studies were generally of poor quality, lacked preoperative evaluations, and showed considerable bias in the data.
    MeSH term(s) Abdomen ; Adult ; Colostomy ; Humans ; Quality of Life ; Rectal Neoplasms/surgery ; Rectum/surgery
    Language English
    Publishing date 2022-02-08
    Publishing country England
    Document type Journal Article ; Systematic Review
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrab101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: 'I've got a little list'-the scourge of a surgical junior. A quality improvement project to change the surgical patient list in a district general hospital.

    Khan, Hiba / Flesher, Elizabeth / Marshman, James / Harding, Alexander / Bethune, Rob / Lawday, Samuel

    BMJ open quality

    2020  Volume 9, Issue 2

    Abstract: Background: Junior doctors at the Royal Devon and Exeter Hospital spend hours every day creating and updating patient lists for all surgical specialties on Microsoft Excel spreadsheets. This not only consumes time that should be spent on clinical tasks, ...

    Abstract Background: Junior doctors at the Royal Devon and Exeter Hospital spend hours every day creating and updating patient lists for all surgical specialties on Microsoft Excel spreadsheets. This not only consumes time that should be spent on clinical tasks, it allows for human errors, system errors and patient safety concerns. Our aim was to reduce time spent on the list and reduce the chance for error.
    Methods: We measured the time junior doctors spent creating and updating the surgical lists for one specialty, and on-call shifts. Our first Plan-Do-Study-Act (PDSA) cycle was to introduce clinical secretaries; this reduced the time spent by ward teams on the list but had no effect on the on-call team. We then worked with the hospital application developer to adapt software currently used to suit all surgical teams. Once completed, this software was rolled out alongside the existing spreadsheet method with a view to a switch after a transition period.
    Results: The introduction of clinical secretaries reduced the time spent on the colorectal surgery list from 99.22 min a day to 43.38 min. The on-call team however did not benefit from this intervention. Following the introduction of the new software, the day on-call team time spent on the list changed from 121 min a day to 4.66 min. The night on-call team time changed from 91 min to 7.38 min.
    Conclusion: Reducing the time juniors spend compiling surgical lists has clear benefits to patients with extra time for junior doctors to clerk patients. The use of an automated system removes the chance of error in transcription of blood results. Due to the success of this project, colorectal, upper gastrointestinal, urology, vascular and on-call teams have adopted the new list permanently.
    MeSH term(s) Documentation/methods ; Documentation/standards ; Documentation/statistics & numerical data ; Education, Medical, Graduate/methods ; England ; Hospitals, General/organization & administration ; Hospitals, General/statistics & numerical data ; Humans ; Quality Improvement ; Surgeons/education ; Surgeons/psychology ; Surgeons/statistics & numerical data ; Workload/psychology ; Workload/standards ; Workload/statistics & numerical data
    Language English
    Publishing date 2020-06-13
    Publishing country England
    Document type Journal Article
    ISSN 2399-6641
    ISSN (online) 2399-6641
    DOI 10.1136/bmjoq-2019-000829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Prognostic models for surgical-site infection in gastrointestinal surgery: systematic review.

    McLean, Kenneth A / Goel, Tanvi / Lawday, Samuel / Riad, Aya / Simoes, Joana / Knight, Stephen R / Ghosh, Dhruva / Glasbey, James C / Bhangu, Aneel / Harrison, Ewen M

    The British journal of surgery

    2023  Volume 110, Issue 11, Page(s) 1441–1450

    Abstract: Background: Identification of patients at high risk of surgical-site infection may allow clinicians to target interventions and monitoring to minimize associated morbidity. The aim of this systematic review was to identify and evaluate prognostic tools ... ...

    Abstract Background: Identification of patients at high risk of surgical-site infection may allow clinicians to target interventions and monitoring to minimize associated morbidity. The aim of this systematic review was to identify and evaluate prognostic tools for the prediction of surgical-site infection in gastrointestinal surgery.
    Methods: This systematic review sought to identify original studies describing the development and validation of prognostic models for 30-day SSI after gastrointestinal surgery (PROSPERO: CRD42022311019). MEDLINE, Embase, Global Health, and IEEE Xplore were searched from 1 January 2000 to 24 February 2022. Studies were excluded if prognostic models included postoperative parameters or were procedure specific. A narrative synthesis was performed, with sample-size sufficiency, discriminative ability (area under the receiver operating characteristic curve), and prognostic accuracy compared.
    Results: Of 2249 records reviewed, 23 eligible prognostic models were identified. A total of 13 (57 per cent) reported no internal validation and only 4 (17 per cent) had undergone external validation. Most identified operative contamination (57 per cent, 13 of 23) and duration (52 per cent, 12 of 23) as important predictors; however, there remained substantial heterogeneity in other predictors identified (range 2-28). All models demonstrated a high risk of bias due to the analytic approach, with overall low applicability to an undifferentiated gastrointestinal surgical population. Model discrimination was reported in most studies (83 per cent, 19 of 23); however, calibration (22 per cent, 5 of 23) and prognostic accuracy (17 per cent, 4 of 23) were infrequently assessed. Of externally validated models (of which there were four), none displayed 'good' discrimination (area under the receiver operating characteristic curve greater than or equal to 0.7).
    Conclusion: The risk of surgical-site infection after gastrointestinal surgery is insufficiently described by existing risk-prediction tools, which are not suitable for routine use. Novel risk-stratification tools are required to target perioperative interventions and mitigate modifiable risk factors.
    Language English
    Publishing date 2023-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Development and internal validation of clinical prediction models for outcomes of complicated intra-abdominal infection.

    Ahmed, S / Bonnett, L / Melhuish, A / Adil, M T / Aggarwal, I / Ali, W / Bennett, J / Boldock, E / Burns, F A / Czarniak, E / Dennis, R / Flower, B / Fok, R / Goodman, A L / Halai, S / Hanna, T / Hashem, M / Hodgson, S H / Hughes, G /
    Hurndall, K-H / Hyland, R / Iqbal, M R / Jarchow-MacDonald, A / Kailavasan, M / Klimovskij, M / Laliotis, A / Lambourne, J / Lawday, S / Lee, F / Lindsey, B / Lund, J N / Mabayoje, D A / Malik, K I / Muir, A / Narula, H S / Ofor, U / Parsons, H / Pavelle, T / Prescott, K / Rajgopal, A / Roy, I / Sagar, J / Scarborough, C / Shaikh, S / Smart, C J / Snape, S / Tabaqchali, M A / Tennakoon, A / Tilley, R / Vink, E / White, L / Burke, D / Kirby, A

    The British journal of surgery

    2021  Volume 108, Issue 4, Page(s) 441–447

    Abstract: Background: Complicated intra-abdominal infections (cIAIs) are associated with significant morbidity and mortality. The aim of this study was to describe the clinical characteristics of patients with cIAI in a multicentre study and to develop clinical ... ...

    Abstract Background: Complicated intra-abdominal infections (cIAIs) are associated with significant morbidity and mortality. The aim of this study was to describe the clinical characteristics of patients with cIAI in a multicentre study and to develop clinical prediction models (CPMs) to help identify patients at risk of mortality or relapse.
    Methods: A multicentre observational study was conducted from August 2016 to February 2017 in the UK. Adult patients diagnosed with cIAI were included. Multivariable logistic regression was performed to develop CPMs for mortality and cIAI relapse. The c-statistic was used to test model discrimination. Model calibration was tested using calibration slopes and calibration in the large (CITL). The CPMs were then presented as point scoring systems and validated further.
    Results: Overall, 417 patients from 31 surgical centres were included in the analysis. At 90 days after diagnosis, 17.3 per cent had a cIAI relapse and the mortality rate was 11.3 per cent. Predictors in the mortality model were age, cIAI aetiology, presence of a perforated viscus and source control procedure. Predictors of cIAI relapse included the presence of collections, outcome of initial management, and duration of antibiotic treatment. The c-statistic adjusted for model optimism was 0.79 (95 per cent c.i. 0.75 to 0.87) and 0.74 (0.73 to 0.85) for mortality and cIAI relapse CPMs. Adjusted calibration slopes were 0.88 (95 per cent c.i. 0.76 to 0.90) for the mortality model and 0.91 (0.88 to 0.94) for the relapse model; CITL was -0.19 (95 per cent c.i. -0.39 to -0.12) and - 0.01 (- 0.17 to -0.03) respectively.
    Conclusion: Relapse of infection and death after complicated intra-abdominal infections are common. Clinical prediction models were developed to identify patients at increased risk of relapse or death after treatment, these now require external validation.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Clinical Decision Rules ; Female ; Humans ; Intraabdominal Infections/diagnosis ; Intraabdominal Infections/drug therapy ; Intraabdominal Infections/etiology ; Intraabdominal Infections/mortality ; Male ; Middle Aged ; Models, Statistical ; Recurrence ; Risk Factors
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-02-11
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znaa117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Global guidance for surgical care during the COVID-19 pandemic

    Bhangu, A. / Lawani, I. / Ng-Kamstra, J. S. / Wang, Y. / Chan, A. / Futaba, K. / Ng, S. / Ebele, E. / Lederhuber, H. / Tabiri, S. / Ghosh, D. / Gallo, G. / Pata, F. / Di Saverio, S. / Spinelli, A. / la Medina, A. R. -D. / Ademuyiwa, A. O. / Akinbode, G. / Ingabire, J. C. A. /
    Ntirenganya, F. / Kamara, T. B. / Goh, M. / Moore, R. / Kim, H. J. / Lee, S. -H. / Minaya-Bravo, A. / Abbott, T. / Chakrabortee, S. / Denning, M. / Fitzgerald, J. E. / Glasbey, J. / Griffiths, E. / Halkias, C. / Harrison, E. M. / Jones, C. S. / Kinross, J. / Lawday, S. / Li, E. / Markar, S. / Morton, D. G. / Nepogodiev, D. / Pinkney, T. D. / Simoes, J. / Warren, O. / Wong, D. J. N. / Bankhead-Kendall, B. / Breen, K. A. / Davidson, G. H. / Kaafarani, H. / Keller, D. S. / Mazingi, D. / Kamarajah, S. K. / Blackwell, S. / Dames, N.

    2020  

    Abstract: Background: Surgeons urgently need guidance on how to deliver surgical services safely and effectively during the COVID-19 pandemic. The aim was to identify the key domains that should be considered when developing pandemic preparedness plans for ... ...

    Abstract Background: Surgeons urgently need guidance on how to deliver surgical services safely and effectively during the COVID-19 pandemic. The aim was to identify the key domains that should be considered when developing pandemic preparedness plans for surgical services. Methods: A scoping search was conducted to identify published articles relating to management of surgical patients during pandemics. Key informant interviews were conducted with surgeons and anaesthetists with direct experience of working during infectious disease outbreaks, in order to identify key challenges and solutions to delivering effective surgical services during the COVID-19 pandemic. Results: Thirteen articles were identified from the scoping search, and surgeons and anaesthetists representing 11 territories were interviewed. To mount an effective response to COVID-19, a pandemic response plan for surgical services should be developed in advance. Key domains that should be included are: provision of staff training (such as patient transfers, donning and doffing personal protection equipment, recognizing and managing COVID-19 infection); support for the overall hospital response to COVID-19 (reduction in non-urgent activities such as clinics, endoscopy, non-urgent elective surgery); establishment of a team-based approach for running emergency services; and recognition and management of COVID-19 infection in patients treated as an emergency and those who have had surgery. A backlog of procedures after the end of the COVID-19 pandemic is inevitable, and hospitals should plan how to address this effectively to ensure that patients having elective treatment have the best possible outcomes. Conclusion: Hospitals should prepare detailed context-specific pandemic preparedness plans addressing the identified domains. Specific guidance should be updated continuously to reflect emerging evidence during the COVID-19 pandemic.
    Keywords covid19
    Subject code 360
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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