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  1. Article ; Online: Counter regulation of tumor angiogenesis by vascular endothelial growth factor and thrombospondin-1.

    Lawler, Jack

    Seminars in cancer biology

    2022  Volume 86, Issue Pt 2, Page(s) 126–135

    Abstract: Considerable progress has been made in our understanding of the process of angiogenesis in the context of normal and tumor tissue over the last fifty years. Angiogenesis, like most physiological processes, is carefully controlled by dynamic and opposing ... ...

    Abstract Considerable progress has been made in our understanding of the process of angiogenesis in the context of normal and tumor tissue over the last fifty years. Angiogenesis, like most physiological processes, is carefully controlled by dynamic and opposing effects of positive factors, such as vascular endothelial growth factor (VEGF), and negative factors, such as thrombospondin-1. In most cases, the progression of a small mass of cancerous cells to a life-threatening tumor depends upon the initiation of angiogenesis and involves the dysregulation of the angiogenic balance. Whereas our newfound appreciation for the role of angiogenesis in cancer has opened up new avenues for treatment, the success of these treatments, which have focused almost exclusively on antagonizing the VEGF pathway, has been limited to date. It is anticipated that this situation will improve as more therapeutics that target other pathways are developed, more strategies for combination therapies are advanced, more detailed stratification of patient populations occurs, and a better understanding of resistance to anti-angiogenic therapy is gained.
    MeSH term(s) Humans ; Neoplasms/blood supply ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Thrombospondin 1/metabolism
    Chemical Substances Vascular Endothelial Growth Factor A ; Thrombospondin 1
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2022.09.006
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    Zs.A 2922: Show issues Location:
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  2. Article ; Online: Attachment style to body dissatisfaction, restrained eating, and disordered eating in adolescent girls: Differential weight communication mediators.

    Valledor, Valerie / Lawler, Jamie / Jefferson, Stephen / Chow, Chong Man

    Appetite

    2024  Volume 198, Page(s) 107321

    Abstract: Body dissatisfaction and eating behaviors are disproportionately elevated amongst adolescent girls. Family relationships represent a context in which adolescent girls' body image issues emerge. Thus, we integrated attachment and confirmation theories to ... ...

    Abstract Body dissatisfaction and eating behaviors are disproportionately elevated amongst adolescent girls. Family relationships represent a context in which adolescent girls' body image issues emerge. Thus, we integrated attachment and confirmation theories to examine whether weight related supportive messages (i.e., acceptance and challenge) mediated the relationship between attachment style (i.e., anxiety and avoidance) and body image outcomes (i.e., body dissatisfaction (BD), restrained eating (RE), and disordered eating (DE)). Acceptance refers to weight related support that is characterized by warmth and accepting messages; challenge refers to weight related support that is characterized by instrumental assistance and problem-solving messages. A sample of 106 adolescent girls, ages 11 to 21, completed self-report measures on attachment (Relationship Structures Questionnaire), acceptance and challenge (weight related Parental Behavior Questionnaire), body dissatisfaction (Eating Disorders Inventory), and eating behaviors (Dutch Eating Behavior Questionnaire; Eating Disorder Diagnostic Scale). Attachment anxiety directly related to all body image outcomes, whereas attachment avoidance only directly related to RE. Attachment avoidance only related to BD and DE indirectly through perceived acceptance. Those with high anxiety endorsed lower perceived challenge, whereas avoidant individuals endorsed lower perceived acceptance and challenge. We concluded that attachment dimension characteristics to be either hyperactivated regarding relationships (i.e., anxiety), or deactivated and distant (i.e., avoidance), are associated with how individuals perceive support, and in turn, are related to body image and eating behavior outcomes. Further, we clarify the differential roles of acceptance and challenge. Although both supportive, acceptance encompasses a layer of warmth that is more meaningful in body image, particularly for avoidantly attached individuals. By integrating qualities of attachment and supportive weight communication, we reveal that potential pathways of attachment to body image and eating behaviors.
    MeSH term(s) Humans ; Female ; Adolescent ; Feeding and Eating Disorders/psychology ; Object Attachment ; Body Dissatisfaction/psychology ; Feeding Behavior/psychology ; Child ; Young Adult ; Surveys and Questionnaires ; Anxiety/psychology ; Body Weight ; Body Image/psychology ; Communication
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1461347-5
    ISSN 1095-8304 ; 0195-6663
    ISSN (online) 1095-8304
    ISSN 0195-6663
    DOI 10.1016/j.appet.2024.107321
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  3. Article ; Online: Thrombospondins in the tumor microenvironment.

    Petrik, James / Lauks, Sylvia / Garlisi, Bianca / Lawler, Jack

    Seminars in cell & developmental biology

    2023  Volume 155, Issue Pt B, Page(s) 3–11

    Abstract: Many cancers begin with the formation of a small nest of transformed cells that can remain dormant for years. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, a key early step in tumor progression. Over time, increases in ...

    Abstract Many cancers begin with the formation of a small nest of transformed cells that can remain dormant for years. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, a key early step in tumor progression. Over time, increases in drivers of angiogenesis predominate, and vascular cells, immune cells, and fibroblasts are recruited to the tumor mass forming a complex tissue, designated the tumor microenvironment. Numerous factors, including growth factors, chemokine/cytokine, and extracellular matrix, participate in the desmoplastic response that in many ways mimics wound healing. Vascular and lymphatic endothelial cells, and cancer-associated pericytes, fibroblasts, macrophages and immune cells are recruited to the tumor microenvironment, where multiple members of the TSP gene family promote their proliferation, migration and invasion. The TSPs also affect the immune signature of tumor tissue and the phenotype of tumor-associated macrophages. Consistent with these observations, expression of some TSPs has been established to correlate with poor outcomes in specific types of cancer.
    MeSH term(s) Humans ; Thrombospondins/genetics ; Thrombospondins/metabolism ; Endothelial Cells/metabolism ; Tumor Microenvironment ; Neoplasms/metabolism ; Extracellular Matrix/metabolism
    Chemical Substances Thrombospondins
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2023.05.010
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  4. Article: Incorporation of Graphene-Related Carbon Nanosheets in Membrane Fabrication for Water Treatment: A Review.

    Lawler, Jenny

    Membranes

    2016  Volume 6, Issue 4

    Abstract: The minimization of the trade-off between the flux and the selectivity of membranes is a key area that researchers are continually working to optimise, particularly in the area of fabrication of novel membranes. Flux versus selectivity issues apply in ... ...

    Abstract The minimization of the trade-off between the flux and the selectivity of membranes is a key area that researchers are continually working to optimise, particularly in the area of fabrication of novel membranes. Flux versus selectivity issues apply in many industrial applications of membranes, for example the unwanted diffusion of methanol in fuel cells, retention of valuable proteins in downstream processing of biopharmaceuticals, rejection of organic matter and micro-organisms in water treatment, or salt permeation in desalination. The incorporation of nanosheets within membrane structures can potentially lead to enhancements in such properties as the antifouling ability, hydrophilicy and permeability of membranes, with concomitant improvements in the flux/selectivity balance. Graphene nanosheets and derivatives such as graphene oxide and reduced graphene oxide have been investigated for this purpose, for example inclusion of nanosheets within the active layer of Reverse Osmosis or Nanofiltration membranes or the blending of nanosheets as fillers within Ultrafiltration membranes. This review summarizes the incorporation of graphene derivatives into polymeric membranes for water treatment with a focus on a number of industrial applications, including desalination and pharmaceutical removal, where enhancement of productivity and reduction in fouling characteristics have been afforded by appropriate incorporation of graphene derived nanosheets during membrane fabrication.
    Language English
    Publishing date 2016-12-19
    Publishing country Switzerland
    Document type Review ; Journal Article
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes6040057
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  5. Article ; Online: When is a thrombogenic matrix not thrombogenic?

    Lawler, Jack

    Blood

    2016  Volume 128, Issue 12, Page(s) 1543–1544

    MeSH term(s) Humans ; Thrombosis
    Language English
    Publishing date 2016-09-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2016-08-732149
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  6. Book: Behind the screens

    Lawler, Jocalyn

    nursing, somology, and the problem of the body

    1991  

    Author's details Jocalyn Lawler
    Keywords Body Image ; Kinesics ; Nurses / psychology ; Nursing
    Size XI, 247 S.
    Publisher Churchill Livingstone
    Publishing place Melbourne u.a.
    Publishing country Australia
    Document type Book
    HBZ-ID HT004002737
    ISBN 0-443-04444-9 ; 978-0-443-04444-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1992 A 607 order for loan Magazin

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  7. Article: Endothelial Cell Behavior Is Determined by Receptor Clustering Induced by Thrombospondin-1.

    Morandi, Verônica / Petrik, Jim / Lawler, Jack

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 664696

    Abstract: The thrombospondins (TSPs) are a family of multimeric extracellular matrix proteins that dynamically regulate cellular behavior and response to stimuli. In so doing, the TSPs directly and indirectly affect biological processes such as embryonic ... ...

    Abstract The thrombospondins (TSPs) are a family of multimeric extracellular matrix proteins that dynamically regulate cellular behavior and response to stimuli. In so doing, the TSPs directly and indirectly affect biological processes such as embryonic development, wound healing, immune response, angiogenesis, and cancer progression. Many of the direct effects of Thrombospondin 1 (TSP-1) result from the engagement of a wide range of cell surface receptors including syndecans, low density lipoprotein receptor-related protein 1 (LRP1), CD36, integrins, and CD47. Different or even opposing outcomes of TSP-1 actions in certain pathologic contexts may occur, depending on the structural/functional domain involved. To expedite response to external stimuli, these receptors, along with vascular endothelial growth factor receptor 2 (VEGFR2) and Src family kinases, are present in specific membrane microdomains, such as lipid rafts or tetraspanin-enriched microdomains. The molecular organization of these membrane microdomains and their constituents is modulated by TSP-1. In this review, we will describe how the presence of TSP-1 at the plasma membrane affects endothelial cell signal transduction and angiogenesis.
    Language English
    Publishing date 2021-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.664696
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  8. Article ; Online: Antiangiogenic Variant of TSP-1 Targets Tumor Cells in Glioblastomas.

    Choi, Sung Hugh / Tamura, Kaoru / Khajuria, Rajiv Kumar / Bhere, Deepak / Nesterenko, Irina / Lawler, Jack / Shah, Khalid

    Molecular therapy : the journal of the American Society of Gene Therapy

    2024  

    Language English
    Publishing date 2024-05-05
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2024.04.031
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    Zs.A 5640: Show issues Location:
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  9. Article ; Online: Antiangiogenic Variant of TSP-1 Targets Tumor Cells in Glioblastomas.

    Choi, Sung Hugh / Tamura, Kaoru / Khajuria, Rajiv Kumar / Bhere, Deepak / Nesterenko, Irina / Lawler, Jack / Shah, Khalid

    Molecular therapy : the journal of the American Society of Gene Therapy

    2024  Volume 32, Issue 5, Page(s) 1595

    MeSH term(s) Humans ; Glioblastoma/metabolism ; Glioblastoma/genetics ; Glioblastoma/pathology ; Thrombospondin 1/metabolism ; Thrombospondin 1/genetics ; Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/genetics ; Animals
    Chemical Substances Thrombospondin 1 ; Angiogenesis Inhibitors
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article ; Expression of Concern
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2024.04.022
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  10. Article ; Online: Meta-analysis of the impact of postoperative infective complications on oncological outcomes in colorectal cancer surgery.

    Lawler, J / Choynowski, M / Bailey, K / Bucholc, M / Johnston, A / Sugrue, M

    BJS open

    2020  Volume 4, Issue 5, Page(s) 737–747

    Abstract: Background: Cancer outcomes are complex, involving prevention, early detection and optimal multidisciplinary care. Postoperative infection and surgical site-infection (SSI) are not only uncomfortable for patients and costly, but may also be associated ... ...

    Abstract Background: Cancer outcomes are complex, involving prevention, early detection and optimal multidisciplinary care. Postoperative infection and surgical site-infection (SSI) are not only uncomfortable for patients and costly, but may also be associated with poor oncological outcomes. A meta-analysis was undertaken to assess the oncological effects of SSI in patients with colorectal cancer.
    Methods: An ethically approved PROSPERO-registered meta-analysis was conducted following PRISMA guidelines. PubMed and Scopus databases were searched for studies published between 2007 and 2017 reporting the effects of postoperative infective complications on oncological survival in colorectal cancer. Results were separated into those for SSI and those concerning anastomotic leakage. Articles with a Methodological Index for Non-Randomized Studies score of at least 18 were included. Hazard ratios (HRs) with 95 per cent confidence intervals were computed for risk factors using an observed to expected and variance fixed-effect model.
    Results: Of 5027 articles were reviewed, 43 met the inclusion criteria, with a total of 154 981 patients. Infective complications had significant negative effects on overall survival (HR 1·37, 95 per cent c.i. 1·28 to 1·46) and cancer-specific survival (HR 2·58, 2·15 to 3·10). Anastomotic leakage occurred in 7·4 per cent and had a significant negative impact on disease-free survival (HR 1·14, 1·09 to 1·20), overall survival (HR 1·34, 1·28 to 1·39), cancer-specific survival (HR 1·43, 1·31 to 1·55), local recurrence (HR 1·18, 1·06 to 1·32) and overall recurrence (HR 1·46, 1·27 to 1·68).
    Conclusion: This meta-analysis identified a significant negative impact of postoperative infective complications on overall and cancer-specific survival in patients undergoing colorectal surgery.
    MeSH term(s) Anastomotic Leak/etiology ; Anastomotic Leak/mortality ; Colorectal Neoplasms/microbiology ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/surgery ; Colorectal Surgery/adverse effects ; Disease-Free Survival ; Humans ; Postoperative Complications ; Surgical Wound Infection/etiology
    Language English
    Publishing date 2020-06-11
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1002/bjs5.50302
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