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  1. Article ; Online: Treatment of Sinusoidal Obstruction Syndrome With Defibrotide in Pediatric Cancer Patients Following Nontransplant-associated Chemotherapy: A Case Report and Review of the Literature.

    Lawrence, Marc R / Bassal, Mylène / Ramphal, Raveena / Johnston, Donna L

    Journal of pediatric hematology/oncology

    2021  Volume 44, Issue 3, Page(s) e788–e791

    Abstract: Sinusoidal obstruction syndrome (SOS), formerly veno-occlusive disease (VOD), in pediatric cancer patients often presents as a complication of hematopoietic stem cell transplantation, and less commonly secondary to nontransplant-associated chemotherapy. ... ...

    Abstract Sinusoidal obstruction syndrome (SOS), formerly veno-occlusive disease (VOD), in pediatric cancer patients often presents as a complication of hematopoietic stem cell transplantation, and less commonly secondary to nontransplant-associated chemotherapy. Therapy with defibrotide is well-described as standard care for transplant-associated SOS/VOD, but the treatment of nontransplant-associated SOS/VOD is less clear. We report a 3-year-old with relapsed Wilms tumor and recurrent SOS/VOD, with successful use of defibrotide during chemotherapy. A review of pediatric cancer patients with nontransplant-associated SOS/VOD treated with defibrotide revealed 83 patients, and 66 were in remission. This review supports early treatment with defibrotide in patients with nontransplant-associated SOS/VOD.
    MeSH term(s) Child ; Child, Preschool ; Female ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hepatic Veno-Occlusive Disease/chemically induced ; Hepatic Veno-Occlusive Disease/drug therapy ; Humans ; Kidney Neoplasms/drug therapy ; Male ; Neoplasm Recurrence, Local/drug therapy ; Polydeoxyribonucleotides/therapeutic use
    Chemical Substances Polydeoxyribonucleotides ; defibrotide (438HCF2X0M)
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCD.

    Hiebert, Nole M / Lawrence, Marc R / Ganjavi, Hooman / Watling, Mark / Owen, Adrian M / Seergobin, Ken N / MacDonald, Penny A

    Frontiers in psychiatry

    2020  Volume 11, Page(s) 13

    Abstract: Obsessive compulsive disorder (OCD) is a prevalent psychiatric disorder characterized by obsessions and compulsions. Studies investigating symptomatology and cognitive deficits in OCD frequently implicate the striatum. The aim of this study was to ... ...

    Abstract Obsessive compulsive disorder (OCD) is a prevalent psychiatric disorder characterized by obsessions and compulsions. Studies investigating symptomatology and cognitive deficits in OCD frequently implicate the striatum. The aim of this study was to explore striatum-mediated cognitive deficits in patients with OCD as they complete a stimulus-response learning task previously shown to differentially rely on the dorsal (DS) and ventral striatum (VS). We hypothesized that patients with OCD will show both impaired decision-making and learning, coupled with reduced task-relevant activity in DS and VS, respectively, compared to healthy controls. We found that patients with OCD (n = 14) exhibited decision-making deficits and learned associations slower compared to healthy age-matched controls (n = 16). Along with these behavioral deficits, OCD patients had reduced task-relevant activity in DS and VS, compared to controls. This study reveals that responses in DS and VS are altered in OCD, and sheds light on the cognitive deficits and symptoms experienced by patients with OCD.
    Language English
    Publishing date 2020-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2020.00013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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