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  1. Book: The complete guide to core stability

    Lawrence, Matt

    2011  

    Author's details Matt Lawrence
    Size XI, 258 Seiten: Illustrationen
    Edition 3. ed.
    Publisher A. & C. Black; London
    Document type Book
    HBZ-ID HT016995939
    ISBN 978-1-408-13324-8 ; 1-408-13324-5
    Database Central Library of Sport Science of the German Sport University Cologne

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  2. Article ; Online: Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia.

    Gurbatri, Candice R / Radford, Georgette A / Vrbanac, Laura / Im, Jongwon / Thomas, Elaine M / Coker, Courtney / Taylor, Samuel R / Jang, YoungUk / Sivan, Ayelet / Rhee, Kyu / Saleh, Anas A / Chien, Tiffany / Zandkarimi, Fereshteh / Lia, Ioana / Lannagan, Tamsin R M / Wang, Tongtong / Wright, Josephine A / Kobayashi, Hiroki / Ng, Jia Q /
    Lawrence, Matt / Sammour, Tarik / Thomas, Michelle / Lewis, Mark / Papanicolas, Lito / Perry, Joanne / Fitzsimmons, Tracy / Kaazan, Patricia / Lim, Amanda / Stavropoulos, Alexandra M / Gouskos, Dion A / Marker, Julie / Ostroff, Cheri / Rogers, Geraint / Arpaia, Nicholas / Worthley, Daniel L / Woods, Susan L / Danino, Tal

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 646

    Abstract: Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli Nissle 1917 (EcN) ...

    Abstract Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli Nissle 1917 (EcN) to a genetically-engineered murine model of CRC predisposition and orthotopic models of CRC. We next undertake an interventional, double-blind, dual-centre, prospective clinical trial, in which CRC patients take either placebo or EcN for two weeks prior to resection of neoplastic and adjacent normal colorectal tissue (ACTRN12619000210178). We detect enrichment of EcN in tumor samples over normal tissue from probiotic-treated patients (primary outcome of the trial). Next, we develop early CRC intervention strategies. To detect lesions, we engineer EcN to produce a small molecule, salicylate. Oral delivery of this strain results in increased levels of salicylate in the urine of adenoma-bearing mice, in comparison to healthy controls. To assess therapeutic potential, we engineer EcN to locally release a cytokine, GM-CSF, and blocking nanobodies against PD-L1 and CTLA-4 at the neoplastic site, and demonstrate that oral delivery of this strain reduces adenoma burden by ~50%. Together, these results support the use of EcN as an orally-deliverable platform to detect disease and treat CRC through the production of screening and therapeutic molecules.
    MeSH term(s) Animals ; Humans ; Mice ; Adenoma/diagnosis ; Adenoma/therapy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/therapy ; Escherichia coli/genetics ; Prospective Studies ; Salicylates ; Double-Blind Method
    Chemical Substances Salicylates
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Multicenter Study
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44776-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: The complete guide to core stability

    Lawrence, Matt

    (<> complete guide series)

    2003  

    Author's details Matt Lawrence
    Series title <<The>> complete guide series
    Size IX, 182 Seiten: zahlreiche Illustrationen
    Publisher Black; London
    Document type Book
    HBZ-ID HT014224817
    ISBN 0-7136-5376-0 ; 978-0-7136-5376-2
    Database Central Library of Sport Science of the German Sport University Cologne

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  4. Article: Colorectal cancer detection and treatment with engineered probiotics.

    Gurbatri, Candice R / Radford, Georgette / Vrbanac, Laura / Coker, Courtney / Im, Jong-Won / Taylor, Samuel R / Jang, YoungUk / Sivan, Ayelet / Rhee, Kyu / Saleh, Anas A / Chien, Tiffany / Zandkarimi, Fereshteh / Lia, Ioana / Lannagan, Tamsin Rm / Wang, Tongtong / Wright, Josephine A / Thomas, Elaine / Kobayashi, Hiroki / Ng, Jia Q /
    Lawrence, Matt / Sammour, Tarik / Thomas, Michelle / Lewis, Mark / Papanicolas, Lito / Perry, Joanne / Fitzsimmons, Tracy / Kaazan, Patricia / Lim, Amanda / Marker, Julie / Ostroff, Cheri / Rogers, Geraint / Arpaia, Nicholas / Worthley, Daniel L / Woods, Susan L / Danino, Tal

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral delivery of ... ...

    Abstract Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral delivery of probiotic
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.03.535370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The protein partners of GTP cyclohydrolase I in rat organs.

    Du, Jianhai / Teng, Ru-Jeng / Lawrence, Matt / Guan, Tongju / Xu, Hao / Ge, Ying / Shi, Yang

    PloS one

    2012  Volume 7, Issue 3, Page(s) e33991

    Abstract: Objective: GTP cyclohydrolase I (GCH1) is the rate-limiting enzyme for tetrahydrobiopterin biosynthesis and has been shown to be a promising therapeutic target in ischemic heart disease, hypertension, atherosclerosis and diabetes. The endogenous GCH1- ... ...

    Abstract Objective: GTP cyclohydrolase I (GCH1) is the rate-limiting enzyme for tetrahydrobiopterin biosynthesis and has been shown to be a promising therapeutic target in ischemic heart disease, hypertension, atherosclerosis and diabetes. The endogenous GCH1-interacting partners have not been identified. Here, we determined endogenous GCH1-interacting proteins in rat.
    Methods and results: A pulldown and proteomics approach were used to identify GCH1 interacting proteins in rat liver, brain, heart and kidney. We demonstrated that GCH1 interacts with at least 17 proteins including GTP cyclohydrolase I feedback regulatory protein (GFRP) in rat liver by affinity purification followed by proteomics and validated six protein partners in liver, brain, heart and kidney by immunoblotting. GCH1 interacts with GFRP and very long-chain specific acyl-CoA dehydrogenase in the liver, tubulin beta-2A chain in the liver and brain, DnaJ homolog subfamily A member 1 and fatty aldehyde dehydrogenase in the liver, heart and kidney and eukaryotic translation initiation factor 3 subunit I (EIF3I) in all organs tested. Furthermore, GCH1 associates with mitochondrial proteins and GCH1 itself locates in mitochondria.
    Conclusion: GCH1 interacts with proteins in an organ dependant manner and EIF3I might be a general regulator of GCH1. Our finding indicates GCH1 might have broader functions beyond tetrahydrobiopterin biosynthesis.
    MeSH term(s) Acyl-CoA Dehydrogenase, Long-Chain/metabolism ; Animals ; Cell Line ; Eukaryotic Initiation Factor-3/metabolism ; GTP Cyclohydrolase/genetics ; GTP Cyclohydrolase/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins ; Liver/metabolism ; Male ; Mitochondria/metabolism ; Multiprotein Complexes/isolation & purification ; Protein Binding ; Protein Interaction Mapping ; Protein Transport ; Proteins/metabolism ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Retinal Dehydrogenase/metabolism
    Chemical Substances Eukaryotic Initiation Factor-3 ; Gchfr protein, rat ; Intracellular Signaling Peptides and Proteins ; Multiprotein Complexes ; Proteins ; Retinal Dehydrogenase (EC 1.2.1.36) ; Acyl-CoA Dehydrogenase, Long-Chain (EC 1.3.8.8) ; GTP Cyclohydrolase (EC 3.5.4.16)
    Language English
    Publishing date 2012-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0033991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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