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  1. Article ; Online: Utility of DNA Methylation as a Biomarker in Aging and Alzheimer's Disease.

    Milicic, Lidija / Porter, Tenielle / Vacher, Michael / Laws, Simon M

    Journal of Alzheimer's disease reports

    2023  Volume 7, Issue 1, Page(s) 475–503

    Abstract: Epigenetic mechanisms such as DNA methylation have been implicated in a number of diseases including cancer, heart disease, autoimmune disorders, and neurodegenerative diseases. While it is recognized that DNA methylation is tissue-specific, a limitation ...

    Abstract Epigenetic mechanisms such as DNA methylation have been implicated in a number of diseases including cancer, heart disease, autoimmune disorders, and neurodegenerative diseases. While it is recognized that DNA methylation is tissue-specific, a limitation for many studies is the ability to sample the tissue of interest, which is why there is a need for a proxy tissue such as blood, that is reflective of the methylation state of the target tissue. In the last decade, DNA methylation has been utilized in the design of epigenetic clocks, which aim to predict an individual's biological age based on an algorithmically defined set of CpGs. A number of studies have found associations between disease and/or disease risk with increased biological age, adding weight to the theory of increased biological age being linked with disease processes. Hence, this review takes a closer look at the utility of DNA methylation as a biomarker in aging and disease, with a particular focus on Alzheimer's disease.
    Language English
    Publishing date 2023-05-31
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2542-4823
    ISSN (online) 2542-4823
    DOI 10.3233/ADR-220109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sleep, Sirtuin 1 and Alzheimer's disease: A review.

    Mehramiz, Mehrane / Porter, Tenielle / Laws, Simon M / Rainey-Smith, Stephanie R

    Aging brain

    2022  Volume 2, Page(s) 100050

    Abstract: Sleep plays a major role in brain health, and cognition. Disrupted sleep is a well-described symptom of Alzheimer's disease (AD). However, accumulating evidence suggests suboptimal sleep also increases AD risk. The deacetylase Sirtuin 1 (Sirt 1), encoded ...

    Abstract Sleep plays a major role in brain health, and cognition. Disrupted sleep is a well-described symptom of Alzheimer's disease (AD). However, accumulating evidence suggests suboptimal sleep also increases AD risk. The deacetylase Sirtuin 1 (Sirt 1), encoded by the
    Language English
    Publishing date 2022-09-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2589-9589
    ISSN (online) 2589-9589
    DOI 10.1016/j.nbas.2022.100050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dose-response effects of exercise on mental health in community-dwelling older adults: Exploration of genetic moderators.

    Gujral, Swathi / Burns, Marcia / Erickson, Kirk I / Rofey, Dana / Peiffer, Jeremiah J / Laws, Simon M / Brown, Belinda

    International journal of clinical and health psychology : IJCHP

    2024  Volume 24, Issue 1, Page(s) 100443

    Abstract: Background/objective: (1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor (: Method: This study is ...

    Abstract Background/objective: (1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor (
    Method: This study is a secondary analysis of a three-arm randomized controlled trial, comparing the effects of 6 months of high-intensity aerobic training vs. moderate-intensity aerobic training vs. a no-contact control group on mental health symptoms assessed using the Depression, Anxiety, and Stress Scale (DASS). The
    Results: The exercise intervention did not influence mental health symptoms. The
    Conclusions: APOE
    Language English
    Publishing date 2024-01-19
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2208162-8
    ISSN 2174-0852 ; 1697-2600
    ISSN (online) 2174-0852
    ISSN 1697-2600
    DOI 10.1016/j.ijchp.2024.100443
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  4. Article ; Online: Insights into the pathogenesis of normal-pressure hydrocephalus.

    Spina, Salvatore / Laws, Simon M

    Neurology

    2019  Volume 92, Issue 20, Page(s) 933–934

    MeSH term(s) Codon, Nonsense ; Humans ; Hydrocephalus ; Hydrocephalus, Normal Pressure
    Chemical Substances Codon, Nonsense
    Language English
    Publishing date 2019-04-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000007495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Potential Role for Sirtuin-1 in Alzheimer's Disease: Reviewing the Biological and Environmental Evidence.

    Mehramiz, Mehrane / Porter, Tenielle / O'Brien, Eleanor K / Rainey-Smith, Stephanie R / Laws, Simon M

    Journal of Alzheimer's disease reports

    2023  Volume 7, Issue 1, Page(s) 823–843

    Abstract: Sirtuin-1 (Sirt1), encoded by ... ...

    Abstract Sirtuin-1 (Sirt1), encoded by the
    Language English
    Publishing date 2023-08-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2542-4823
    ISSN (online) 2542-4823
    DOI 10.3233/ADR-220088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Relationship of Cognition and Alzheimer's Disease with Gastrointestinal Tract Disorders: A Large-Scale Genetic Overlap and Mendelian Randomisation Analysis.

    Adewuyi, Emmanuel O / O'Brien, Eleanor K / Porter, Tenielle / Laws, Simon M

    International journal of molecular sciences

    2022  Volume 23, Issue 24

    Abstract: Emerging observational evidence suggests links between cognitive impairment and a range of gastrointestinal tract (GIT) disorders; however, the mechanisms underlying their relationships remain unclear. Leveraging large-scale genome-wide association ... ...

    Abstract Emerging observational evidence suggests links between cognitive impairment and a range of gastrointestinal tract (GIT) disorders; however, the mechanisms underlying their relationships remain unclear. Leveraging large-scale genome-wide association studies’ summary statistics, we comprehensively assessed genetic overlap and potential causality of cognitive traits and Alzheimer’s disease (AD) with several GIT disorders. We demonstrate a strong and highly significant inverse global genetic correlation between cognitive traits and GIT disorders—peptic ulcer disease (PUD), gastritis-duodenitis, diverticulosis, irritable bowel syndrome, and gastroesophageal reflux disease (GERD), but not inflammatory bowel disease (IBD). Further analysis detects 35 significant (p < 4.37 × 10−5) bivariate local genetic correlations between cognitive traits, AD, and GIT disorders (including IBD). Mendelian randomisation analysis suggests a risk-decreasing causality of educational attainment, intelligence, and other cognitive traits on PUD and GERD, but not IBD, and a putative association of GERD with cognitive function decline. Gene-based analysis reveals a significant gene-level genetic overlap of cognitive traits with AD and GIT disorders (IBD inclusive, pbinomial-test = 1.18 × 10−3−2.20 × 10−16). Our study supports the protective roles of genetically-influenced educational attainments and other cognitive traits on the risk of GIT disorders and highlights a putative association of GERD with cognitive function decline. Findings from local genetic correlation analysis provide novel insights, indicating that the relationship of IBD with cognitive traits (and AD) will depend largely on their local effects across the genome.
    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Genome-Wide Association Study ; Cognition ; Gastroesophageal Reflux ; Inflammatory Bowel Diseases ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2022-12-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232416199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders.

    Adewuyi, Emmanuel O / O'Brien, Eleanor K / Nyholt, Dale R / Porter, Tenielle / Laws, Simon M

    Communications biology

    2022  Volume 5, Issue 1, Page(s) 691

    Abstract: Consistent with the concept of the gut-brain phenomenon, observational studies suggest a relationship between Alzheimer's disease (AD) and gastrointestinal tract (GIT) disorders; however, their underlying mechanisms remain unclear. Here, we analyse ... ...

    Abstract Consistent with the concept of the gut-brain phenomenon, observational studies suggest a relationship between Alzheimer's disease (AD) and gastrointestinal tract (GIT) disorders; however, their underlying mechanisms remain unclear. Here, we analyse several genome-wide association studies (GWAS) summary statistics (N = 34,652-456,327), to assess the relationship of AD with GIT disorders. Findings reveal a positive significant genetic overlap and correlation between AD and gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), gastritis-duodenitis, irritable bowel syndrome and diverticulosis, but not inflammatory bowel disease. Cross-trait meta-analysis identifies several loci (P
    MeSH term(s) Alzheimer Disease/genetics ; Gastroesophageal Reflux/complications ; Genome-Wide Association Study ; Humans ; Membrane Proteins/genetics ; Nerve Tissue Proteins/genetics ; Polymorphism, Single Nucleotide
    Chemical Substances Membrane Proteins ; Nerve Tissue Proteins ; SEMA3F protein, human
    Language English
    Publishing date 2022-07-18
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-022-03607-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Discovery of a Missense Mutation (Q222K) of the

    Roberts, Blaine R / Laffoon, Scott B / Roberts, Anne M / Porter, Tenielle / Fowler, Chris / Masters, Colin L / Dratz, Edward A / Laws, Simon M

    Journal of Alzheimer's disease reports

    2023  Volume 7, Issue 1, Page(s) 165–172

    Abstract: After age, polymorphisms of the Apolipoprotein E ( ...

    Abstract After age, polymorphisms of the Apolipoprotein E (
    Language English
    Publishing date 2023-02-24
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2542-4823
    ISSN (online) 2542-4823
    DOI 10.3233/ADR-220075
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  9. Article ; Online: The relationships between multidimensional sleep health and work productivity in individuals with neurological conditions.

    Turner, Mitchell / Laws, Manja / Griffiths, Madeline / Turner, Kate / Dempsey, Leah / Laws, Simon M / Cruickshank, Travis

    Journal of sleep research

    2023  , Page(s) e14107

    Abstract: Numerous studies have reported the negative impacts of poor sleep on work productivity in the general population. However, despite the known sleep issues that individuals living with neurological conditions experience, no study has explored its impact on ...

    Abstract Numerous studies have reported the negative impacts of poor sleep on work productivity in the general population. However, despite the known sleep issues that individuals living with neurological conditions experience, no study has explored its impact on their work productivity. Sleep health is a concept that includes multiple domains of sleep, measured with a combination of objective and subjective measures. Therefore, this study aimed to ascertain the associations between sleep health and its domains and work productivity in individuals with neurological conditions. Sleep health domains were determined through actigraphy data collected over 1 week and sleep questionnaires. Work productivity was assessed via the Work Productivity and Activity Impairment Questionnaire. A comparison of sleep health scores between demographic variables was performed using Mann-Whitney U and Kruskal-Wallis tests. Associations between the sleep health domains and work productivity were performed using linear regression models. There were no significant differences in sleep health scores between sex, smoking status, education level, employment status or any work productivity domain. Individuals with non-optimal sleep timing had greater absenteeism (22.99%) than the optimal group. Individuals with non-optimal sleep quality had an increase in presenteeism (30.85%), work productivity loss (26.44%) and activity impairment (25.81%) compared to those in the optimal group. The findings from this study highlight that self-reported sleep quality has the largest impact on work productivity. Improving individuals' sleep quality through triage for potential sleep disorders or improving their sleep hygiene (sleep behaviour and environment) may positively impact work productivity.
    Language English
    Publishing date 2023-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1122722-9
    ISSN 1365-2869 ; 0962-1105
    ISSN (online) 1365-2869
    ISSN 0962-1105
    DOI 10.1111/jsr.14107
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    Zs.A 3464: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 343: Show issues

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  10. Article ; Online: Hair and salivary cortisol and their relationship with lifestyle, mood and cognitive outcomes in premanifest Huntington's disease.

    Cruickshank, Travis / Porter, Tenielle / Laws, Simon M / Ziman, Mel / Bartlett, Danielle M

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 5464

    Abstract: Salivary cortisol dysrhythmias have been reported in some, but not all studies assessing hypothalamic-pituitary-adrenal (HPA) axis function in Huntington's disease (HD). These differences are presumed to be due to environmental influences on temporal ... ...

    Abstract Salivary cortisol dysrhythmias have been reported in some, but not all studies assessing hypothalamic-pituitary-adrenal (HPA) axis function in Huntington's disease (HD). These differences are presumed to be due to environmental influences on temporal salivary cortisol measurement. Further exploration of HPA-axis function using a more stable and longer-term measure, such as hair cortisol, is needed to confirm earlier findings. This study aimed to evaluate hair and salivary cortisol concentrations and their associations with clinical and lifestyle outcomes in individuals with premanifest HD (n = 26) compared to healthy controls (n = 14). Participants provided saliva and hair samples and data were collected on clinical disease outcomes, mood, cognition, physical activity, cognitive reserve, sleep quality and social network size to investigate relationships between clinical and lifestyle outcomes and cortisol concentrations. Hair and salivary cortisol concentrations did not significantly differ between the premanifest HD and control groups. No significant associations were observed between hair or salivary cortisol concentrations and cognitive, mood or lifestyle outcomes. However, hair cortisol concentrations were significantly associated with disease outcomes in individuals with premanifest HD. Significant associations between hair cortisol concentrations and measures of disease burden and onset may suggest a potential disease marker and should be explored longitudinally in a larger sample of individuals with HD.
    MeSH term(s) Adult ; Affect ; Cognition ; Cross-Sectional Studies ; Female ; Hair/chemistry ; Hair/metabolism ; Humans ; Huntington Disease/diagnosis ; Huntington Disease/metabolism ; Huntington Disease/physiopathology ; Hydrocortisone/analysis ; Hydrocortisone/metabolism ; Life Style ; Male ; Middle Aged ; Saliva/chemistry ; Saliva/metabolism ; Sleep Quality
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2021-03-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-84726-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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