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  1. Article ; Online: Epigenetic remodeling by vitamin C potentiates plasma cell differentiation.

    Chen, Heng-Yi / Almonte-Loya, Ana / Lay, Fang-Yun / Hsu, Michael / Johnson, Eric / González-Avalos, Edahí / Yin, Jieyun / Bruno, Richard S / Ma, Qin / Ghoneim, Hazem E / Wozniak, Daniel J / Harrison, Fiona E / Lio, Chan-Wang Jerry

    eLife

    2022  Volume 11

    Abstract: Ascorbate (vitamin C) is an essential micronutrient in humans. The severe chronic deficiency of ascorbate, termed scurvy, has long been associated with increased susceptibility to infections. How ascorbate affects the immune system at the cellular and ... ...

    Abstract Ascorbate (vitamin C) is an essential micronutrient in humans. The severe chronic deficiency of ascorbate, termed scurvy, has long been associated with increased susceptibility to infections. How ascorbate affects the immune system at the cellular and molecular levels remained unclear. From a micronutrient analysis, we identified ascorbate as a potent enhancer for antibody response by facilitating the IL-21/STAT3-dependent plasma cell differentiation in mouse and human B cells. The effect of ascorbate is unique as other antioxidants failed to promote plasma cell differentiation. Ascorbate is especially critical during early B cell activation by poising the cells to plasma cell lineage without affecting the proximal IL-21/STAT3 signaling and the overall transcriptome. As a cofactor for epigenetic enzymes, ascorbate facilitates TET2/3-mediated DNA modification and demethylation of multiple elements at the
    MeSH term(s) Animals ; Ascorbic Acid/pharmacology ; Cell Differentiation ; Epigenesis, Genetic ; Epigenomics ; Humans ; Mice ; Vitamins
    Chemical Substances Vitamins ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2022-09-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.73754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Anti-cytomegalovirus IgG antibody titer is positively associated with advanced T cell differentiation and coronary artery disease in end-stage renal disease.

    Yang, Feng-Jung / Shu, Kai-Hsiang / Chen, Hung-Yuan / Chen, I-Yu / Lay, Fang-Yun / Chuang, Yi-Fang / Wu, Chien-Sheng / Tsai, Wan-Chuan / Peng, Yu-Sen / Hsu, Shih-Ping / Chiang, Chih-Kang / Wang, George / Chiu, Yen-Ling

    Immunity & ageing : I & A

    2018  Volume 15, Page(s) 15

    Abstract: Background: Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. ... ...

    Abstract Background: Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown.
    Results: Among 412 of the immunity in ESRD study (iESRD study) participants, 408 were HCMV seropositive and were analyzed. Compared to 57 healthy individuals, ESRD patients had higher levels of anti-HCMV IgG. In a multivariate-adjusted logistic regression model, the log level of anti-HCMV IgG was independently associated with prevalent coronary artery disease (OR = 1.93, 95% CI = 1.2~ 3.2,
    Conclusion: This is the first study showing that the magnitude of anti-HCMV humoral immune response positively correlates with T cell immunosenescence and coronary artery disease in ESRD patients. The impact of persistent HCMV infection should be further investigated in this special patient population.
    Language English
    Publishing date 2018-07-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2168941-6
    ISSN 1742-4933
    ISSN 1742-4933
    DOI 10.1186/s12979-018-0120-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A comprehensive characterization of aggravated aging-related changes in T lymphocytes and monocytes in end-stage renal disease: the iESRD study.

    Chiu, Yen-Ling / Shu, Kai-Hsiang / Yang, Feng-Jung / Chou, Tzu-Ying / Chen, Ping-Min / Lay, Fang-Yun / Pan, Szu-Yu / Lin, Cheng-Jui / Litjens, Nicolle H R / Betjes, Michiel G H / Bermudez, Selma / Kao, Kung-Chi / Chia, Jean-San / Wang, George / Peng, Yu-Sen / Chuang, Yi-Fang

    Immunity & ageing : I & A

    2018  Volume 15, Page(s) 27

    Abstract: Background: Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of the immune system. Nevertheless, the etiology and impact of these changes in ESRD patients remain unknown.: Results: Compared to healthy individuals, ESRD ...

    Abstract Background: Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of the immune system. Nevertheless, the etiology and impact of these changes in ESRD patients remain unknown.
    Results: Compared to healthy individuals, ESRD patients exhibit accelerated immunosenescence in both T cell and monocyte compartments, characterized by a dramatic reduction in naïve CD4+ and CD8+ T cell numbers but increase in CD8+ T
    Conclusions: Aging-associated adaptive and innate immune changes are aggravated in ESRD and are associated with cardiovascular diseases. For the first time, our study demonstrates the potential link between immunosenescence in ESRD and duration of exposure to the uremic milieu.
    Language English
    Publishing date 2018-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2168941-6
    ISSN 1742-4933
    ISSN 1742-4933
    DOI 10.1186/s12979-018-0131-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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