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Article ; Online: A look at staphylococci from the one health perspective.

Cuny, Christiane / Layer-Nicolaou, Franziska / Werner, Guido / Witte, Wolfgang

International journal of medical microbiology : IJMM

2024 Volume 314, Page(s) 151604

Abstract: Staphylococcus aureus and other staphylococcal species are resident and transient multihost colonizers as well as conditional pathogens. Especially S. aureus represents an excellent model bacterium for the "One Health" concept because of its dynamics at ... ...

Abstract	Staphylococcus aureus and other staphylococcal species are resident and transient multihost colonizers as well as conditional pathogens. Especially S. aureus represents an excellent model bacterium for the "One Health" concept because of its dynamics at the human-animal interface and versatility with respect to host adaptation. The development of antimicrobial resistance plays another integral part. This overview will focus on studies at the human-animal interface with respect to livestock farming and to companion animals, as well as on staphylococci in wildlife. In this context transmissions of staphylococci and of antimicrobial resistance genes between animals and humans are of particular significance.
MeSH term(s)	Animals ; Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents ; Methicillin-Resistant Staphylococcus aureus/genetics ; One Health ; Staphylococcal Infections/veterinary ; Staphylococcal Infections/microbiology ; Staphylococcus/genetics ; Staphylococcus aureus/genetics
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2024-01-18
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2006518-8
ISSN	1618-0607 ; 1438-4221
ISSN (online)	1618-0607
ISSN	1438-4221
DOI	10.1016/j.ijmm.2024.151604
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Article: Mandatory Notification of Panton-Valentine Leukocidin-Positive Methicillin-Resistant

Helbig, Utta / Riemschneider, Constance / Werner, Guido / Kriebel, Nancy / Layer-Nicolaou, Franziska

Microorganisms

2023 Volume 11, Issue 6

Abstract: In Germany, Saxony is the only federal state where the detection of a Panton-Valentine Leukocidin (PVL)-positive Methicillin- ... ...

Abstract	In Germany, Saxony is the only federal state where the detection of a Panton-Valentine Leukocidin (PVL)-positive Methicillin-resistant
Language	English
Publishing date	2023-05-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11061437
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Article ; Online: Eigenschaften, Häufigkeit und Verbreitung von MRSA in Deutschland – Zur Situation 2021/2022

Layer-Nicolaou, Franziska / Strommenger, Birgit / Cuny, Christiane / Werner, Guido

2023

Abstract: Seit einigen Jahren nimmt der Anteil Methicillin-resistenter Staphylococcus aureus (MRSA) an der S. aureus-Population ab, was sich auch in den Daten verschiedener nationaler und internationaler Surveillancesysteme widerspiegelt. Die nationale Antibiotika- ...

Abstract	Seit einigen Jahren nimmt der Anteil Methicillin-resistenter Staphylococcus aureus (MRSA) an der S. aureus-Population ab, was sich auch in den Daten verschiedener nationaler und internationaler Surveillancesysteme widerspiegelt. Die nationale Antibiotika-Resistenz-Surveillance ARS des Robert Koch-Instituts basiert auf Resistenzdaten aus der Routinediagnostik der stationären und ambulanten Versorgung. Für das Jahr 2021 liegen Daten aus ca. 700 Krankenhäusern und 24.000 Arztpraxen vor. In der stationären Versorgung sank der Anteil von MRSA an S. aureus-Isolaten von 12,5 % im Jahr 2017 auf 7,3 % bzw. 7,1 % in den Jahren 2021 und 2022, in der ambulanten Versorgung im gleichen Zeitraum von 7,7 % auf 4,8 % bzw. 4,7 %. Im vorliegenden Bericht werden Daten zur Häufigkeit, den Eigenschaften und dem Auftreten epidemischer MRSA in Krankhäusern in Deutschland zusammengefasst. Ebenfalls beschrieben werden Trends in der Resistenzentwicklung, das Auftreten und die Verbreitung von Community- und Livestock-assoziierten MRSA sowie Untersuchungen im Rahmen von Ausbruchsgeschehen. Peer Reviewed
Keywords	MRSA ; S. aureus ; Methicillinresistenz ; Antibiotikaresistenz ; Surveillance ; 610 Medizin und Gesundheit ; ddc:610
Language	German
Publishing date	2023-11-02
Publisher	Robert Koch-Institut
Publishing country	de
Document type	Article ; Online
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Article: Colonization of Dogs and Their Owners with

Cuny, Christiane / Layer-Nicolaou, Franziska / Weber, Robert / Köck, Robin / Witte, Wolfgang

Microorganisms

2022 Volume 10, Issue 4

Abstract: There are uncertainties with respect to the transmission of methicillin-susceptible and methicillin- ... ...

Abstract	There are uncertainties with respect to the transmission of methicillin-susceptible and methicillin-resistant
Language	English
Publishing date	2022-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10040677
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Article ; Online: First Report of a Methicillin-Resistant, High-Level Mupirocin-Resistant

Shittu, Adebayo Osagie / Layer-Nicolaou, Franziska / Strommenger, Birgit / Nguyen, Minh-Thu / Bletz, Stefan / Mellmann, Alexander / Schaumburg, Frieder

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 860163

Abstract: We describe the identification of a methicillin-resistant, high-level mupirocin- ... ...

Abstract	We describe the identification of a methicillin-resistant, high-level mupirocin-resistant
MeSH term(s)	Methicillin Resistance ; Methicillin-Resistant Staphylococcus aureus/genetics ; Mupirocin/pharmacology ; Phylogeny ; Staphylococcus
Chemical Substances	Mupirocin (D0GX863OA5)
Language	English
Publishing date	2022-03-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.860163
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Article ; Online: Investigating a possible link between antiseptic treatment and the increased occurrence of daptomycin-resistant Staphylococcus aureus.

Wendel, Andreas F / Otchwemah, Robin / Layer-Nicolaou, Franziska / Mattner, Frauke / Tellez-Castillo, Carlos J / Skov, Robert / Oberländer, Henrik / Werner, Guido / Strommenger, Birgit

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2023 Volume 29, Issue 10, Page(s) 1334.e1–1334.e6

Abstract: Objectives: Because of a steady increase in the detection of daptomycin-resistant (DAP-R) Staphylococcus aureus at three medical centres in Cologne, Germany, molecular surveillance was established from June 2016 to June 2018 to investigate the causes of ...

Abstract	Objectives: Because of a steady increase in the detection of daptomycin-resistant (DAP-R) Staphylococcus aureus at three medical centres in Cologne, Germany, molecular surveillance was established from June 2016 to June 2018 to investigate the causes of the emergence and spread of respective isolates. Seventy-five S. aureus isolates, both DAP-R and DAP-susceptible, were collected from 42 patients for further analysis. Methods: Broth microdilution was used to determine the MICs for DAP and polyhexamethylene biguanide/polyhexanide (PHMB). To investigate the effect of PHMB on the development of DAP resistance, we performed selection experiments with PHMB. All isolates studied were subjected to whole-genome sequencing. Epidemiological, clinical, microbiological and molecular data were analysed comparatively. Results: Acquisition of DAP resistance was mainly observed in patients with acute and chronic wounds (40/42, 96.2%) treated with antiseptic (32/42, 76.2%) rather than systemic antibiotic therapy using DAP or vancomycin (7/42, 16.7%). DAP-R S. aureus had a diverse genetic background; however, within individual patients, isolates were closely related. At least three potential transmission events were detected. Most DAP-R isolates had concomitant elevated MICs for PHMB (50/54, 92.6%), and in vitro selection experiments confirmed that PHMB treatment is capable of generating DAP resistance. DAP resistance could be linked to 12 different polymorphisms in the mprF gene in the majority of clinical isolates (52/54, 96.3%) as well as in all in vitro selected strains. Discussion: DAP resistance in S. aureus can occur independently of prior antibiotic therapy and can be selected by PHMB. Therefore, wound treatment with PHMB may trigger individual resistance development associated with gain-of-function mutations in the mprF gene.
MeSH term(s)	Humans ; Daptomycin/pharmacology ; Daptomycin/therapeutic use ; Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus ; Anti-Infective Agents, Local/pharmacology ; Anti-Infective Agents, Local/therapeutic use ; Polymorphism, Single Nucleotide ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/microbiology ; Microbial Sensitivity Tests ; Bacterial Proteins/genetics
Chemical Substances	Daptomycin (NWQ5N31VKK) ; Anti-Infective Agents, Local ; Anti-Bacterial Agents ; Bacterial Proteins
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2023.06.007
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: Glycopeptide resistance in Enterococcus spp. and coagulase-negative staphylococci from hospitalised patients in Germany: occurrence, characteristics and dalbavancin susceptibility.

Kresken, Michael / Klare, Ingo / Wichelhaus, Thomas A / Wohlfarth, Esther / Layer-Nicolaou, Franziska / Neumann, Bernd / Werner, Guido

Journal of global antimicrobial resistance

2021 Volume 28, Page(s) 102–107

Abstract: Objectives: The aim of this study was to evaluate the occurrence of glycopeptide resistance in enterococci and coagulase-negative staphylococci (CoNS) and to determine the susceptibilities of the identified glycopeptide-resistant isolates to dalbavancin. ...

Abstract	Objectives: The aim of this study was to evaluate the occurrence of glycopeptide resistance in enterococci and coagulase-negative staphylococci (CoNS) and to determine the susceptibilities of the identified glycopeptide-resistant isolates to dalbavancin. Methods: Twenty-two medical laboratories participated in the study conducted in 2016/17 by the Paul-Ehrlich-Society for Chemotherapy. Each laboratory was asked to collect 30 Enterococcus spp. (limited to Enterococcus faecalis and Enterococcus faecium) and 30 CoNS isolates consecutively from hospitalised patients with a proven or suspected infection. Results: A total of 1285 isolates were collected, comprising 364 E. faecalis, 291 E. faecium and 630 CoNS. No E. faecalis isolates (0%) but 76 E. faecium isolates (26.1%) were vancomycin-resistant, of which 21 showed the VanA type and 55 the VanB type. The proportion of vancomycin-resistant strains among E. faecium isolates from patients in intensive care units (21.6%) was significantly lower than that from patients on regular wards (30.5%). Among the CoNS, 67 isolates (10.6%) were teicoplanin-resistant but none were vancomycin-resistant, with resistance only detected in Staphylococcus epidermidis (12.2%), Staphylococcus haemolyticus (17.9%) and Staphylococcus hominis (13.2%). Dalbavancin at ≤0.25 mg/L inhibited all VanB-type enterococci and 95.5% of teicoplanin-resistant CoNS. Conclusion: The level of glycopeptide resistance in E. faecalis remains very low in Germany but achieved 26% in E. faecium and was >10% in CoNS. Dalbavancin appears to be a feasible option for treating infections caused by VanB-type vancomycin-resistant E. faecium and teicoplanin-resistant CoNS.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Coagulase ; Enterococcus ; Glycopeptides/pharmacology ; Humans ; Microbial Sensitivity Tests ; Staphylococcus ; Teicoplanin/analogs & derivatives ; Teicoplanin/pharmacology ; Vancomycin/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Coagulase ; Glycopeptides ; Teicoplanin (61036-62-2) ; Vancomycin (6Q205EH1VU) ; dalbavancin (808UI9MS5K)
Language	English
Publishing date	2021-12-25
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2710046-7
ISSN	2213-7173 ; 2213-7173
ISSN (online)	2213-7173
ISSN	2213-7173
DOI	10.1016/j.jgar.2021.12.016
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Article ; Online: CHROMAgar™ LIN-R as an efficient screening tool to assess the prevalence of linezolid-resistant enterococci in German hospital patients-a multicentre study approach, 2021-2022.

Bender, Jennifer K / Baufeld, Elsa / Becker, Karsten / Claus, Heike / Dudakova, Anna / Dörre, Achim / Fila, Nikoletta / Fleige, Carola / Hamprecht, Axel / Hoffmann, Armin / Hogardt, Michael / Kaasch, Achim J / Kola, Axel / Kriebel, Nancy / Layer-Nicolaou, Franziska / Marschal, Matthias / Molitor, Ernst / Mutters, Nico T / Liese, Jan /

Nelkenbrecher, Claudia / Neumann, Bernd / Rohde, Holger / Steinmann, Jörg / Sörensen, Michael / Thelen, Philipp / Weig, Michael / Zautner, Andreas E / Werner, Guido

The Journal of antimicrobial chemotherapy

2023 Volume 78, Issue 9, Page(s) 2185–2191

Abstract: Background: In recent years, an increasing number of linezolid-resistant enterococci (LRE) was recognized at the German National Reference Centre (NRC) for Enterococci. National guidelines on infection prevention recommend screening for LRE in ... ...

Abstract	Background: In recent years, an increasing number of linezolid-resistant enterococci (LRE) was recognized at the German National Reference Centre (NRC) for Enterococci. National guidelines on infection prevention recommend screening for LRE in epidemiologically linked hospital settings without referring to a reliable and rapid diagnostic method. Since 2020, CHROMAgar™ provide a chromogenic linezolid screening agar, LIN-R, suitable to simultaneously screen for linezolid-resistant staphylococci and enterococci. Objectives: To assess the applicability of CHROMAgar™ LIN-R in clinical settings for detecting LRE directly from patient material and to infer prevalence rates of LRE amongst German hospital patients. Methods: During the 3-month trial period, clinical samples were plated on CHROMAgar™ LIN-R. Antimicrobial susceptibility testing was performed using VITEK2 or disc diffusion. At the NRC, linezolid resistance was determined by broth microdilution, multiplex-PCR for cfr/optrA/poxtA and by a restriction-based assay for 23S rDNA mutations. Results: The 12 participating study sites used 13 963 CHROMAgar™ LIN-R plates during the study period. Of 442 presumptive LRE, 192 were confirmed by phenotypic methods. Of these, 161 were received by the NRC and 121 (75%) were verified as LRE. Most of LR-E. faecium 53/81 (65%) exhibited a 23S rRNA gene mutation as the sole resistance-mediating mechanism, whereas optrA constituted the dominant resistance trait in LR-E. faecalis [39/40 (98%)]. Prevalence of LRE across sites was estimated as 1% (ranging 0.18%-3.7% between sites). Conclusions: CHROMAgar™ LIN-R represents a simple and efficient LRE screening tool in hospital settings. A high proportion of false-positive results demands validation of linezolid resistance by a reference method.
MeSH term(s)	Humans ; Linezolid/pharmacology ; Anti-Bacterial Agents/pharmacology ; Prevalence ; Drug Resistance, Bacterial/genetics ; Enterococcus/genetics ; Hospitals ; Gram-Positive Bacterial Infections/epidemiology ; Enterococcus faecium/genetics ; Microbial Sensitivity Tests ; Enterococcus faecalis
Chemical Substances	Linezolid (ISQ9I6J12J) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-07-15
Publishing country	England
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad218
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Zs.MO 124: Show issues

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Article ; Online: Glycopeptide resistance in Enterococcus spp. and coagulase-negative staphylococci from hospitalised patients in Germany

Kresken, Michael / Klare, Ingo / Wichelhaus, Thomas A. / Wohlfarth, Esther / Layer-Nicolaou, Franziska / Neumann, Bernd / Werner, Guido / Study Group ‘Antimicrobial Resistance’ of the Paul-Ehrlich-Society for Chemotherapy

occurrence, characteristics and dalbavancin susceptibility

2021

Abstract	Objectives: The aim of this study was to evaluate the occurrence of glycopeptide resistance in enterococci and coagulase-negative staphylococci (CoNS) and to determine the susceptibilities of the identified glycopeptide-resistant isolates to dalbavancin. Methods: Twenty-two medical laboratories participated in the study conducted in 2016/17 by the Paul-Ehrlich-Society for Chemotherapy. Each laboratory was asked to collect 30 Enterococcus spp. (limited to Enterococcus faecalis and Enterococcus faecium) and 30 CoNS isolates consecutively from hospitalised patients with a proven or suspected infection. Results: A total of 1285 isolates were collected, comprising 364 E. faecalis, 291 E. faecium and 630 CoNS. No E. faecalis isolates (0%) but 76 E. faecium isolates (26.1%) were vancomycin-resistant, of which 21 showed the VanA type and 55 the VanB type. The proportion of vancomycin-resistant strains among E. faecium isolates from patients in intensive care units (21.6%) was significantly lower than that from patients on regular wards (30.5%). Among the CoNS, 67 isolates (10.6%) were teicoplanin-resistant but none were vancomycin-resistant, with resistance only detected in Staphylococcus epidermidis (12.2%), Staphylococcus haemolyticus (17.9%) and Staphylococcus hominis (13.2%). Dalbavancin at ≤0.25 mg/L inhibited all VanB-type enterococci and 95.5% of teicoplanin-resistant CoNS. Conclusion: The level of glycopeptide resistance in E. faecalis remains very low in Germany but achieved 26% in E. faecium and was >10% in CoNS. Dalbavancin appears to be a feasible option for treating infections caused by VanB-type vancomycin-resistant E. faecium and teicoplanin-resistant CoNS. Peer Reviewed
Keywords	Vancomycin ; Teicoplanin ; Lipoglycopeptide ; Dalbavancin ; vanA ; vanB ; 610 Medizin und Gesundheit ; ddc:610
Language	English
Publishing date	2021-12-25
Publisher	Robert Koch-Institut
Publishing country	de
Document type	Article ; Online
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