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  1. Article ; Online: Mechanisms and biomarkers of subcutaneous immunotherapy and sublingual immunotherapy in allergen immunotherapy.

    Tan, Tiak Ju / Layhadi, Janice A / Shamji, Mohamed H

    Allergy and asthma proceedings

    2022  Volume 43, Issue 4, Page(s) 254–259

    Abstract: There are currently no biomarkers that can accurately predict clinical outcomes and segregate responders from nonresponders in allergen immunotherapy (AIT). Therefore, identifying a reliable predictive biomarker is essential to enable clinicians to ... ...

    Abstract There are currently no biomarkers that can accurately predict clinical outcomes and segregate responders from nonresponders in allergen immunotherapy (AIT). Therefore, identifying a reliable predictive biomarker is essential to enable clinicians to tailor personalized therapy. New developments in AIT biomarkers are currently being explored, and it would be important to identify key areas of development and their feasibility for use in the clinic. Biomarkers can be categorized broadly into seven domains: (i) Immunoglobulin E (IgE), (ii) IgG and IgA responses, (iii) IgE -facilitated allergen binding/blocking factor, (iv) basophil activation, (v) cytokines and chemokines, (vi) cellular markers, and (vii) in vivo biomarkers. Despite their potential, most biomarkers remain infeasible to be translated to the clinical setting due to requirements of complex instruments such as flow cytometry. The identification of suitable biomarkers remains key in predicting outcomes of AIT and requires more research. Additional exploration into integrative biomarkers may be required.
    MeSH term(s) Allergens/therapeutic use ; Biomarkers ; Desensitization, Immunologic ; Humans ; Immunoglobulin E ; Sublingual Immunotherapy
    Chemical Substances Allergens ; Biomarkers ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1312445-6
    ISSN 1539-6304 ; 1088-5412
    ISSN (online) 1539-6304
    ISSN 1088-5412
    DOI 10.2500/aap.2022.43.220030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1804: Show issues Location:
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  2. Article ; Online: Uncovering the immunological properties of isolated lymphoid follicles.

    Layhadi, Janice A / Shamji, Mohamed H

    Allergy

    2020  Volume 76, Issue 4, Page(s) 1292–1293

    MeSH term(s) Humans ; Immunoglobulin A ; Intestinal Mucosa ; Lymphoid Tissue ; Peyer's Patches
    Chemical Substances Immunoglobulin A
    Language English
    Publishing date 2020-10-19
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14598
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  3. Article ; Online: ATP-Evoked Intracellular Ca

    Layhadi, Janice A / Fountain, Samuel J

    International journal of molecular sciences

    2019  Volume 20, Issue 20

    Abstract: Tissues differentially secrete multiple colony stimulating factors under conditions of homeostasis and inflammation, orientating recruited circulating monocytes to differentiate to macrophage with differing functional phenotypes. Here, we investigated ... ...

    Abstract Tissues differentially secrete multiple colony stimulating factors under conditions of homeostasis and inflammation, orientating recruited circulating monocytes to differentiate to macrophage with differing functional phenotypes. Here, we investigated ATP-evoked intracellular Ca
    MeSH term(s) Adenosine Triphosphate/metabolism ; Calcium/metabolism ; Calcium Signaling ; Cell Differentiation ; Humans ; Macrophage Colony-Stimulating Factor/metabolism ; Macrophages/cytology ; Macrophages/immunology ; Macrophages/metabolism ; Receptors, Purinergic P2/metabolism ; Receptors, Purinergic P2X4/metabolism
    Chemical Substances P2RY11 protein, human ; Receptors, Purinergic P2 ; Receptors, Purinergic P2X4 ; Macrophage Colony-Stimulating Factor (81627-83-0) ; Adenosine Triphosphate (8L70Q75FXE) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-10-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20205113
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  4. Article ; Online: Mechanisms of Allergen Immunotherapy in Allergic Rhinitis.

    Drazdauskaitė, Gabija / Layhadi, Janice A / Shamji, Mohamed H

    Current allergy and asthma reports

    2020  Volume 21, Issue 1, Page(s) 2

    Abstract: Purpose of review: Allergic rhinitis (AR) is a chronic inflammatory immunoglobulin (Ig) E-mediated disease of the nasal mucosa that can be triggered by the inhalation of seasonal or perennial allergens. Typical symptoms include sneezing, rhinorrhea, ... ...

    Abstract Purpose of review: Allergic rhinitis (AR) is a chronic inflammatory immunoglobulin (Ig) E-mediated disease of the nasal mucosa that can be triggered by the inhalation of seasonal or perennial allergens. Typical symptoms include sneezing, rhinorrhea, nasal itching, nasal congestion and symptoms of allergic conjunctivitis. AR affects a quarter of the population in the United States of America and Europe.
    Recent findings: AR has been shown to reduce work productivity in 36-59% of the patients with 20% reporting deteriorated job attendance. Moreover, 42% of children with AR report reduced at-school productivity and lower grades. Most importantly, AR impacts the patient's quality of life, due to sleep deprivation. However, a proportion of patients fails to respond to conventional medication and opts for the allergen immunotherapy (AIT), which currently is the only disease-modifying therapeutic option. AIT can be administered by either subcutaneous (SCIT) or sublingual (SLIT) route. Both routes of administration are safe, effective, and can lead to tolerance lasting years after treatment cessation. Both innate and adaptive immune responses that contribute to allergic inflammation are suppressed by AIT. Innate responses are ameliorated by reducing local mast cell, basophil, eosinophil, and circulating group 2 innate lymphoid cell frequencies which is accompanied by decreased basophil sensitivity. Induction of allergen-specific blocking antibodies, immunosuppressive cytokines, and regulatory T and B cell phenotypes are key pro-tolerogenic adaptive immune responses.
    Conclusion: A comprehensive understanding of these mechanisms is necessary for optimal selection of AIT-responsive patients and monitoring treatment efficacy. Moreover, it could inspire novel and more efficient AIT approaches.
    MeSH term(s) Desensitization, Immunologic/methods ; Female ; Humans ; Male ; Quality of Life/psychology ; Rhinitis, Allergic/immunology ; United States
    Language English
    Publishing date 2020-12-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-020-00977-7
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    Zs.A 5548: Show issues Location:
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  5. Article ; Online: Diverse immune mechanisms of allergen immunotherapy for allergic rhinitis with and without asthma.

    Shamji, Mohamed H / Sharif, Hanisah / Layhadi, Janice A / Zhu, Rongfei / Kishore, Uday / Renz, Harald

    The Journal of allergy and clinical immunology

    2022  Volume 149, Issue 3, Page(s) 791–801

    Abstract: Allergen immunotherapy (AIT) is an effective treatment for allergic rhinitis, inducing long-term clinical tolerance to the sensitizing allergen. Clinical tolerance induction can be achieved when AIT is administered for at least 3 years. AIT is associated ...

    Abstract Allergen immunotherapy (AIT) is an effective treatment for allergic rhinitis, inducing long-term clinical tolerance to the sensitizing allergen. Clinical tolerance induction can be achieved when AIT is administered for at least 3 years. AIT is associated with the modulation of innate and adaptive immune systems. This comprises inhibition of IgE-dependent activation of mast cells and basophils in the local target organ, suppression of T
    MeSH term(s) Allergens ; Asthma ; Desensitization, Immunologic ; Humans ; Immunity, Innate ; Lymphocytes ; Rhinitis, Allergic
    Chemical Substances Allergens
    Language English
    Publishing date 2022-01-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.01.016
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  6. Article: Immunological mechanisms of tolerance: Central, peripheral and the role of T and B cells.

    Meng, Xun / Layhadi, Janice A / Keane, Sean T / Cartwright, Natanya J K / Durham, Stephen R / Shamji, Mohamed H

    Asia Pacific allergy

    2023  Volume 13, Issue 4, Page(s) 175–186

    Abstract: T and B cells are key components of the adaptive immune system. Through their immune properties and their interactions with other immune cells and cytokines around them, they build a complex network to achieve immune tolerance and maintain homeostasis of ...

    Abstract T and B cells are key components of the adaptive immune system. Through their immune properties and their interactions with other immune cells and cytokines around them, they build a complex network to achieve immune tolerance and maintain homeostasis of the body. This is achieved through mechanisms of central and peripheral tolerance, both of which are associated with advantages and disadvantages. For this reason, the immune system is tightly regulated and their dysregulation can result in the subsequent initiation of various diseases. In this review, we will summarize the roles played by T cells and B cells within immune tolerance with specific examples in the context of different diseases that include allergic disease. In addition, we will also provide an overview on their suitability as biomarkers of allergen-specific immunotherapy.
    Language English
    Publishing date 2023-12-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2614800-6
    ISSN 2233-8268 ; 2233-8276
    ISSN (online) 2233-8268
    ISSN 2233-8276
    DOI 10.5415/apallergy.0000000000000128
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  7. Article ; Online: P2X4 Receptor-Dependent Ca

    Layhadi, Janice A / Fountain, Samuel J

    International journal of molecular sciences

    2017  Volume 18, Issue 11

    Abstract: Monocytes and macrophages express a repertoire of cell surface P2 receptors for adenosine 5'-triphosphate (ATP) a damage-associated molecular pattern molecule (DAMP), which are capable of raising cytoplasmic calcium when activated. This is achieved ... ...

    Abstract Monocytes and macrophages express a repertoire of cell surface P2 receptors for adenosine 5'-triphosphate (ATP) a damage-associated molecular pattern molecule (DAMP), which are capable of raising cytoplasmic calcium when activated. This is achieved either through direct permeation (ionotropic P2X receptors) or by mobilizing intracellular calcium stores (metabotropic P2Y receptors). Here, a side-by-side comparison to investigate the contribution of P2X4 receptor activation in ATP-evoked calcium responses in model human monocytes and macrophages was performed. The expression of P2X1, P2X4, P2X5 and P2X7 was confirmed by qRT-PCR and immunocytochemistry in both model monocyte and macrophage. ATP evoked a concentration-dependent increase in intracellular calcium in both THP-1 monocyte and macrophages. The sarco/endoplasmic reticulum Ca
    MeSH term(s) Action Potentials ; Adenosine Triphosphate/metabolism ; Biological Transport ; Calcium/metabolism ; Cell Line ; Gene Knockdown Techniques ; Gene Silencing ; Humans ; Immunohistochemistry ; Macrophages/drug effects ; Macrophages/metabolism ; Monocytes/drug effects ; Monocytes/metabolism ; Purinergic P2X Receptor Antagonists/pharmacology ; Receptors, Purinergic P2X4/genetics ; Receptors, Purinergic P2X4/metabolism
    Chemical Substances Purinergic P2X Receptor Antagonists ; Receptors, Purinergic P2X4 ; Adenosine Triphosphate (8L70Q75FXE) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2017-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms18112261
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  8. Article ; Online: Influence of ER leak on resting cytoplasmic Ca

    Layhadi, Janice A / Fountain, Samuel J

    Biochemical and biophysical research communications

    2017  Volume 487, Issue 3, Page(s) 633–639

    Abstract: Mechanisms controlling endoplasmic reticulum (ER) ... ...

    Abstract Mechanisms controlling endoplasmic reticulum (ER) Ca
    MeSH term(s) Calcium/metabolism ; Calcium Signaling/physiology ; Cells, Cultured ; Cytoplasm/metabolism ; Endoplasmic Reticulum/metabolism ; Humans ; Macrophages/metabolism ; Receptors, Purinergic/metabolism
    Chemical Substances Receptors, Purinergic ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2017-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2017.04.106
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    Zs.A 116: Show issues Location:
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  9. Article ; Online: Mechanisms and Predictive Biomarkers of Allergen Immunotherapy in the Clinic.

    Layhadi, Janice A / Lalioti, Anastasia / Palmer, Elizabeth / van Zelm, Menno C / Wambre, Erik / Shamji, Mohamed H

    The journal of allergy and clinical immunology. In practice

    2023  Volume 12, Issue 1, Page(s) 59–66

    Abstract: Allergen immunotherapy (AIT) remains to be the only disease-modifying treatment for IgE-mediated allergic diseases such as allergic rhinitis. It can provide long-term clinical benefits when given for 3 years or longer. Mechanisms of immune tolerance ... ...

    Abstract Allergen immunotherapy (AIT) remains to be the only disease-modifying treatment for IgE-mediated allergic diseases such as allergic rhinitis. It can provide long-term clinical benefits when given for 3 years or longer. Mechanisms of immune tolerance induction by AIT are underscored by the modulation of several compartments within the immune system. These include repair of disruption in epithelial barrier integrity, modulation of the innate immune compartment that includes regulatory dendritic cells and innate lymphoid cells, and adaptive immune compartments such as induction of regulatory T and B cells. Altogether, these are also associated with the dampening of allergen-specific T
    MeSH term(s) Humans ; Immunity, Innate ; Immune Tolerance ; Lymphocytes ; Desensitization, Immunologic ; Rhinitis, Allergic ; Allergens/therapeutic use ; Biomarkers/metabolism
    Chemical Substances Allergens ; Biomarkers
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.11.027
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    Zs.A 7086: Show issues Location:
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  10. Article ; Online: Nasal allergen-neutralizing antibodies correlate closely with tolerated intranasal allergen challenge dose following grass pollen subcutaneous immunotherapy in patients with local allergic rhinitis.

    Eguiluz-Gracia, Ibon / Parkin, Rebecca V / Layhadi, Janice A / Palmer, Elizabeth / Meng, Xun / Zhu, Rongfei / Sahiner, Umit / Durham, Stephen R / Torres, Maria Jose / Mayorga, Cristobalina / Rondon, Carmen / Shamji, Mohamed H

    Allergy

    2024  

    Abstract: Background: Local allergic rhinitis (LAR) is defined by chronic nasal symptoms, absence of atopy, positive nasal allergen challenge (NAC) and a good response to subcutaneous allergen immunotherapy (SCIT). We sought to investigate SCIT capacity to induce ...

    Abstract Background: Local allergic rhinitis (LAR) is defined by chronic nasal symptoms, absence of atopy, positive nasal allergen challenge (NAC) and a good response to subcutaneous allergen immunotherapy (SCIT). We sought to investigate SCIT capacity to induce local and systemic blocking antibodies in LAR patients.
    Methods: A RDBPC study of grass SCIT was performed, with participants receiving either SCIT (Group A; n = 10) or placebo (Group B; n = 14) in the first 6 months. Both groups subsequently received SCIT for 12 months at Year 2. Nasal and serum antibodies (IgG
    Results: The allergen concentration tolerated increased significantly at 6 months (Group A; p = .047) and 24 months (Group B; p = .049) compared with baseline and persisted until the end of the study. Induction of serum sIgA
    Conclusions: Grass pollen SCIT induced functional systemic blocking antibodies that correlate with the concentration of allergen tolerated following NAC, highlighting their potential as a biomarker of SCIT in LAR.
    Language English
    Publishing date 2024-03-14
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.16083
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