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  1. Article ; Online: Infection biology: Molecular recognition of fungal spores stimulates host hygiene.

    Lazzaro, Brian P

    Current biology : CB

    2023  Volume 33, Issue 2, Page(s) R70–R72

    Abstract: Hygienic behaviors that remove pathogens can be crucial in preventing disease. But how are such behaviors stimulated? A new study shows that Drosophila recognize proteins on the surface of Metarhizium spores as a cue to initiate grooming and spore ... ...

    Abstract Hygienic behaviors that remove pathogens can be crucial in preventing disease. But how are such behaviors stimulated? A new study shows that Drosophila recognize proteins on the surface of Metarhizium spores as a cue to initiate grooming and spore removal.
    MeSH term(s) Animals ; Spores, Fungal ; Metarhizium ; Drosophila ; Hygiene ; Biology
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2022.12.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Corrigendum: Interactions between innate immunity and insulin signaling affect resistance to infection in insects.

    Darby, Andrea M / Lazzaro, Brian P

    Frontiers in immunology

    2024  Volume 15, Page(s) 1400514

    Abstract: This corrects the article DOI: 10.3389/fimmu.2023.1276357.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2023.1276357.].
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1400514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: No evidence for trans-generational immune priming in Drosophila melanogaster.

    Radhika, R / Lazzaro, Brian P

    PloS one

    2023  Volume 18, Issue 7, Page(s) e0288342

    Abstract: Most organisms are under constant and repeated exposure to pathogens, leading to perpetual natural selection for more effective ways to fight-off infections. This could include the evolution of memory-based immunity to increase protection from repeatedly- ...

    Abstract Most organisms are under constant and repeated exposure to pathogens, leading to perpetual natural selection for more effective ways to fight-off infections. This could include the evolution of memory-based immunity to increase protection from repeatedly-encountered pathogens both within and across generations. There is mixed evidence for intra- and trans-generational priming in non-vertebrates, which lack the antibody-mediated acquired immunity characteristic of vertebrates. In this work, we tested for trans-generational immune priming in adult offspring of the fruit fly, Drosophila melanogaster, after maternal challenge with 10 different bacterial pathogens. We focused on natural opportunistic pathogens of Drosophila spanning a range of virulence from 10% to 100% host mortality. We infected mothers via septic injury and tested for enhanced resistance to infection in their adult offspring, measured as the ability to suppress bacterial proliferation and survive infection. We categorized the mothers into four classes for each bacterium tested: those that survived infection, those that succumbed to infection, sterile-injury controls, and uninjured controls. We found no evidence for trans-generational priming by any class of mother in response to any of the bacteria.
    MeSH term(s) Female ; Animals ; Humans ; Drosophila melanogaster ; Mothers ; Selection, Genetic
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0288342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: No evidence for trans-generational immune priming in

    Radhika, R / Lazzaro, Brian P

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Most organisms are under constant and repeated exposure to pathogens, leading to perpetual natural selection for more effective ways to fight-off infections. This could include the evolution of memory-based immunity to increase protection from repeatedly- ...

    Abstract Most organisms are under constant and repeated exposure to pathogens, leading to perpetual natural selection for more effective ways to fight-off infections. This could include the evolution of memory-based immunity to increase protection from repeatedly-encountered pathogens both within and across generations. There is mixed evidence for intra- and trans-generational priming in non-vertebrates, which lack the antibody-mediated acquired immunity characteristic of vertebrates. In this work, we tested for trans-generational immune priming in adult offspring of the fruit fly,
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.25.538340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Interactions between innate immunity and insulin signaling affect resistance to infection in insects.

    Darby, Andrea M / Lazzaro, Brian P

    Frontiers in immunology

    2023  Volume 14, Page(s) 1276357

    Abstract: An active immune response is energetically demanding and requires reallocation of nutrients to support resistance to and tolerance of infection. Insulin signaling is a critical global regulator of metabolism and whole-body homeostasis in response to ... ...

    Abstract An active immune response is energetically demanding and requires reallocation of nutrients to support resistance to and tolerance of infection. Insulin signaling is a critical global regulator of metabolism and whole-body homeostasis in response to nutrient availability and energetic needs, including those required for mobilization of energy in support of the immune system. In this review, we share findings that demonstrate interactions between innate immune activity and insulin signaling primarily in the insect model
    MeSH term(s) Animals ; Insulin/metabolism ; Drosophila melanogaster ; Immunity, Innate ; Insecta ; Anopheles/metabolism
    Chemical Substances Insulin
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1276357
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  6. Article ; Online: Balancing sensitivity, risk, and immunopathology in immune regulation.

    Lazzaro, Brian P / Tate, Ann T

    Current opinion in insect science

    2022  Volume 50, Page(s) 100874

    Abstract: Activation of an immune response is energetically costly and excessive immune system activity can result in immunopathology, yet a slow or insufficient immune response carries the risk of pathogen establishment with consequent pathology arising from the ... ...

    Abstract Activation of an immune response is energetically costly and excessive immune system activity can result in immunopathology, yet a slow or insufficient immune response carries the risk of pathogen establishment with consequent pathology arising from the infection. Mathematical theory and empirical data demonstrate that hosts balance the costs of immunity against the risk of infection by closely regulating immunological dynamics. An optimal immune system is rapidly and robustly deployed against a true infectious threat and rapidly deactivated once the threat has been controlled. Genetic variation in the sensitivity of an immune system, as well as in the activation and shutdown kinetics of host immune responses, can contribute to the evolution of pathogen virulence and host tolerance of infection. Improved understanding of the adaptive forces that operate on immune regulatory dynamics will clarify fundamental principles governing the evolution and maintenance of innate immune systems.
    MeSH term(s) Animals ; Immunity/physiology ; Risk ; Virulence
    Language English
    Publishing date 2022-01-17
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2772833-X
    ISSN 2214-5753 ; 2214-5745
    ISSN (online) 2214-5753
    ISSN 2214-5745
    DOI 10.1016/j.cois.2022.100874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A robust method to isolate Drosophila fat body nuclei for transcriptomic analysis

    Gupta, Vanika / Lazzaro, Brian P.

    Fly. 2022 Dec. 31, v. 16, no. 1 p.62-67

    2022  

    Abstract: Gene expression profiles are typically described at the level of the tissue or, often in Drosophila, at the level of the whole organism. Collapsing the gene expression of entire tissues into single measures averages over potentially important ... ...

    Abstract Gene expression profiles are typically described at the level of the tissue or, often in Drosophila, at the level of the whole organism. Collapsing the gene expression of entire tissues into single measures averages over potentially important heterogeneity among the cells that make up that tissue. The advent of single-cell RNA-sequencing technology (sc-RNAseq) allows transcriptomic evaluation of the individual cells that make up a tissue. However, sc-RNAseq requires a high-quality suspension of viable cells or nuclei, and cell dissociation methods that yield healthy cells and nuclei are still lacking for many important tissues. The insect fat body is a polyfunctional tissue responsible for diverse physiological processes and therefore is an important target for sc-RNAseq. The Drosophila adult fat body consists of fragile cells that are difficult to dissociate while maintaining cell viability. As an alternative, we developed a method to isolate single fat body nuclei for RNA-seq. Our isolation method is largely free of mitochondrial contamination and yields higher capture of transcripts per nucleus compared to other nuclei preparation methods. Our method works well for single-cell nuclei sequencing and can potentially be implemented for bulk RNA-seq.
    Keywords Drosophila ; adults ; cell viability ; dissociation ; fat body ; gene expression ; insects ; isolation techniques ; mitochondria ; sequence analysis ; transcriptomics ; single-cell sequencing ; scSeq ; RNAseq ; transcriptome ; profiling ; metabolism ; immune response
    Language English
    Dates of publication 2022-1231
    Size p. 62-67.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ISSN 1933-6942
    DOI 10.1080/19336934.2021.1978776
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Detecting Adaptation with Genome-Scale Molecule Evolutionary Analysis: An Educational Primer for Use with "RNA Interference Pathways Display High Rates of Adaptive Protein Evolution in Multiple Invertebrates".

    Lazzaro, Brian P

    Genetics

    2018  Volume 210, Issue 3, Page(s) 773–780

    Abstract: Hosts and pathogens impose coevolutionary pressure on each other as pathogens strive to establish themselves and hosts seek to suppress infection. RNA interference (RNAi) is a mechanism by which cells repress viruses and transposable elements, thereby ... ...

    Abstract Hosts and pathogens impose coevolutionary pressure on each other as pathogens strive to establish themselves and hosts seek to suppress infection. RNA interference (RNAi) is a mechanism by which cells repress viruses and transposable elements, thereby serving as a form of immune defense. Previous studies have shown that antiviral RNAi genes evolve extraordinarily quickly in the fruit fly
    MeSH term(s) Adaptation, Physiological/genetics ; Animals ; Databases, Genetic ; Evolution, Molecular ; Genomics/methods ; Invertebrates/genetics ; Invertebrates/physiology ; RNA Interference
    Language English
    Publishing date 2018-11-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1534/genetics.118.301453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 767: Show issues Location:
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  9. Article ; Online: A robust method to isolate

    Gupta, Vanika / Lazzaro, Brian P

    Fly

    2021  Volume 16, Issue 1, Page(s) 62–67

    Abstract: Gene expression profiles are typically described at the level of the tissue or, often ... ...

    Abstract Gene expression profiles are typically described at the level of the tissue or, often in
    MeSH term(s) Animals ; Cell Nucleus ; Drosophila/genetics ; Fat Body ; Gene Expression Profiling ; Sequence Analysis, RNA ; Transcriptome
    Language English
    Publishing date 2021-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1933-6942
    ISSN (online) 1933-6942
    DOI 10.1080/19336934.2021.1978776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics.

    Hollingsworth, Brandon D / Grubaugh, Nathan D / Lazzaro, Brian P / Murdock, Courtney C

    PLoS pathogens

    2023  Volume 19, Issue 8, Page(s) e1011588

    Abstract: Several aspects of mosquito ecology that are important for vectored disease transmission and control have been difficult to measure at epidemiologically important scales in the field. In particular, the ability to describe mosquito population structure ... ...

    Abstract Several aspects of mosquito ecology that are important for vectored disease transmission and control have been difficult to measure at epidemiologically important scales in the field. In particular, the ability to describe mosquito population structure and movement rates has been hindered by difficulty in quantifying fine-scale genetic variation among populations. The mosquito virome represents a possible avenue for quantifying population structure and movement rates across multiple spatial scales. Mosquito viromes contain a diversity of viruses, including several insect-specific viruses (ISVs) and "core" viruses that have high prevalence across populations. To date, virome studies have focused on viral discovery and have only recently begun examining viral ecology. While nonpathogenic ISVs may be of little public health relevance themselves, they provide a possible route for quantifying mosquito population structure and dynamics. For example, vertically transmitted viruses could behave as a rapidly evolving extension of the host's genome. It should be possible to apply established analytical methods to appropriate viral phylogenies and incidence data to generate novel approaches for estimating mosquito population structure and dispersal over epidemiologically relevant timescales. By studying the virome through the lens of spatial and genomic epidemiology, it may be possible to investigate otherwise cryptic aspects of mosquito ecology. A better understanding of mosquito population structure and dynamics are key for understanding mosquito-borne disease ecology and methods based on ISVs could provide a powerful tool for informing mosquito control programs.
    MeSH term(s) Animals ; Insect Viruses ; Ecology ; Genetic Vectors ; Genomics ; Insecta
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011588
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