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  1. Book: The heterogeneity of cancer metabolism

    Le, Anne

    (Advances in experimental medicine and biology ; 1311)

    2021  

    Author's details Anne Le editor
    Series title Advances in experimental medicine and biology ; 1311
    Collection
    Keywords cancer cell metabolism ; glucose metabolism ; glutamine metabolism ; amino acid metabolism ; lipid metabolism ; epigenetics and oncometabolites
    Subject code 610
    Language English
    Size xxiii, 271 Seiten, Illustrationen, Diagramme, 23.5 cm x 15.5 cm
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020940527
    ISBN 978-3-030-65767-3 ; 9783030657680 ; 3-030-65767-1 ; 303065768X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1311- not available for loan Zeitschriften-Lesesaal

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  2. Book ; Online: The Heterogeneity of Cancer Metabolism

    Le, Anne

    (Advances in Experimental Medicine and Biology ; 1311)

    2021  

    Author's details edited by Anne Le
    Series title Advances in Experimental Medicine and Biology ; 1311
    Keywords Cancer research
    Subject code 614.5999
    Language English
    Size 1 Online-Ressource (XXIII, 271 p. 55 illus., 54 illus. in color)
    Edition 2nd ed. 2021
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT020939011
    ISBN 978-3-030-65768-0 ; 9783030657673 ; 9783030657697 ; 3-030-65768-X ; 3030657671 ; 3030657698
    DOI 10.1007/978-3-030-65768-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: The Heterogeneity of Cancer Metabolism

    Le, Anne

    2021  

    Keywords Oncology ; Cancer Research ; Cancer Metabolism ; Cancer Therapy ; Cancer Biology ; open access ; personalized cancer treatment ; glucose metabolism ; glutamine metabolism ; metabolism biomarkers ; metabolic pathways ; drug treatments ; glioblastoma ; pancreatic cancer ; breast cancer ; renal cell carcinoma ; non-hodgkin's lymphoma ; cancer-associated fibroblasts ; tumor microenvironment ; covid-19 ; diabetes ; cardiovascular diseases ; gene profiles ; chemotherapeutic agenet ; clinical trials
    Size 1 electronic resource (271 pages)
    Publisher Springer Nature
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021050714
    ISBN 9783030657680 ; 303065768X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: The heterogeneity of cancer metabolism

    Le, Anne

    (Advances in experimental medicine and biology ; 1063)

    2018  

    Author's details Anne Le editor
    Series title Advances in experimental medicine and biology ; 1063
    Collection
    Keywords cancer cell metabolism ; glucose metabolism ; glutamine metabolism ; amino acid metabolism ; lipid metabolism ; epigenetics and oncometabolites
    Subject code 610
    Language English
    Size xv, 182 Seiten, Illustrationen, Diagramme, 23.5 cm x 15.5 cm
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019717414
    ISBN 978-3-319-77735-1 ; 3-319-77735-1 ; 9783319777368 ; 331977736X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1063- not available for loan Zeitschriften-Lesesaal

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  5. Book ; Online ; E-Book: Emerging research in play therapy, child counseling, and consultation

    Steen, Rheta LeAnne

    (Advances in psychology, mental health, and behavioral studies (APMHBS) book series)

    2017  

    Abstract: This book provides relevant theoretical and conceptual frameworks and the latest empirical research findings in the area. It will be written for professionals who want to improve their understanding of the strategic role play therapists and child ... ...

    Author's details Rheta LeAnne Steen, Loyola University New Orleans, USA
    Series title Advances in psychology, mental health, and behavioral studies (APMHBS) book series
    Abstract "This book provides relevant theoretical and conceptual frameworks and the latest empirical research findings in the area. It will be written for professionals who want to improve their understanding of the strategic role play therapists and child counselors have in working with a variety of children and families, caregivers, and systems"--
    Keywords Play Therapy ; Child ; Counseling
    Subject code 618.92/891653
    Language English
    Size 1 Online-Ressource (xxvii, 436 Seiten), Illustrationen, 29 cm
    Publisher IGI Global
    Publishing place Hershey PA
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019359761
    ISBN 9781522522256 ; 9781522522249 ; 1522522255 ; 1522522247
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article: Diabetes and Cancer: The Epidemiological and Metabolic Associations.

    Zhang, Cissy / Le, Anne

    Advances in experimental medicine and biology

    2021  Volume 1311, Page(s) 217–227

    Abstract: Diabetes mellitus, commonly known as diabetes, and cancer are two of the most common diseases plaguing the world today. According to the Centers for Disease Control and Prevention (CDC), there are currently more than 20 million people with diabetes in ... ...

    Abstract Diabetes mellitus, commonly known as diabetes, and cancer are two of the most common diseases plaguing the world today. According to the Centers for Disease Control and Prevention (CDC), there are currently more than 20 million people with diabetes in the United States [1]. According to the International Agency for Research on Cancer (IARC), there were around 18 million people diagnosed with cancer, with approximately ten million deaths globally in 2018 [2]. Given the prevalence and deadliness of diabetes and cancer, these two diseases have long been the focus of many researchers with the goal of improving treatment outcomes. While diabetes and cancer may seem to be two very different diseases at first glance, they share several similarities, especially regarding their metabolic characteristics. This chapter discusses the similarities and relationships between the metabolism of diabetes, especially type 2 diabetes (T2D), and cancer, including their abnormal glucose and amino acid metabolism, the contribution of hyperglycemia to oncogenic mutation, and the contribution of hyperinsulinemia to cancer progression. Investigating the metabolic interplay between diabetes and cancer in an effort to exploit this connection for cancer treatment has the potential to significantly improve clinical efficacy.
    MeSH term(s) Diabetes Mellitus, Type 2/epidemiology ; Humans ; Hyperglycemia ; Hyperinsulinism ; Neoplasms/epidemiology ; United States
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-65768-0_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Intricate Metabolism of Pancreatic Cancers.

    Camelo, Felipe / Le, Anne

    Advances in experimental medicine and biology

    2021  Volume 1311, Page(s) 77–88

    Abstract: Currently, approximately 95% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC), which are the most aggressive form and the fourth leading cause of cancer death with extremely poor prognosis [1]. Poor prognosis is primarily attributed to ... ...

    Abstract Currently, approximately 95% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC), which are the most aggressive form and the fourth leading cause of cancer death with extremely poor prognosis [1]. Poor prognosis is primarily attributed to the late diagnosis of the disease when patients are no longer candidates for surgical resection [2]. Cancer cells are dependent on the oncogenes that allow them to proliferate limitlessly. Thus, targeting the expression of known oncogenes in pancreatic cancer has been shown to lead to more effective treatment [3]. This chapter discusses the complexity of metabolic features in pancreatic cancers. In order to comprehend the heterogeneous nature of cancer metabolism fully, we need to take into account the close relationship between cancer metabolism and genetics. Gene expression varies tremendously, not only among different types of cancers but also within the same type of cancer among different patients. Cancer metabolism heterogeneity is often prompted and perpetuated not only by mutations in oncogenes and tumor-suppressor genes but also by the innate diversity of the tumor microenvironment. Much effort has been focused on elucidating the genetic alterations that correlate with disease progression and treatment response [4, 5]. However, the precise mechanisms by which tumor metabolism contributes to cancer growth, survival, mobility, and aggressiveness represent a functional readout of tumor progression (Fig. 1).
    MeSH term(s) Carcinoma, Pancreatic Ductal/genetics ; Humans ; Mutation ; Oncogenes/genetics ; Pancreatic Neoplasms/genetics ; Tumor Microenvironment
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-65768-0_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Targeting Metabolic Cross Talk Between Cancer Cells and Cancer-Associated Fibroblasts.

    Jung, Jin G / Le, Anne

    Advances in experimental medicine and biology

    2021  Volume 1311, Page(s) 205–214

    Abstract: Although cancer has classically been regarded as a genetic disease of uncontrolled cell growth, the importance of the tumor microenvironment (TME) [1, 2] is continuously emphasized by the accumulating evidence that cancer growth is not simply dependent ... ...

    Abstract Although cancer has classically been regarded as a genetic disease of uncontrolled cell growth, the importance of the tumor microenvironment (TME) [1, 2] is continuously emphasized by the accumulating evidence that cancer growth is not simply dependent on the cancer cells themselves [3, 4] but also dependent on angiogenesis [5-8], inflammation [9, 10], and the supporting roles of cancer-associated fibroblasts (CAFs) [11-13]. After the discovery that CAFs are able to remodel the tumor matrix within the TME and provide the nutrients and chemicals to promote cancer cell growth [14], many studies have aimed to uncover the cross talk between cancer cells and CAFs. Moreover, a new paradigm in cancer metabolism shows how cancer cells act like "metabolic parasites" to take up the high-energy metabolites, such as lactate, ketone bodies, free fatty acids, and glutamine from supporting cells, including CAFs and cancer-associated adipocytes (CAAs) [15, 16]. This chapter provides an overview of the metabolic coupling between CAFs and cancer cells to further define the therapeutic options to disrupt the CAF-cancer cell interactions.
    MeSH term(s) Cancer-Associated Fibroblasts ; Cell Communication ; Cell Proliferation ; Fibroblasts ; Humans ; Neoplasms ; Tumor Microenvironment
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-65768-0_15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Heterogeneity of Liver Cancer Metabolism.

    Salazar, Javier / Le, Anne

    Advances in experimental medicine and biology

    2021  Volume 1311, Page(s) 127–136

    Abstract: Primary liver cancer is the fourth leading cause of cancer death around the world. Histologically, it can be divided into two major groups, hepatocellular carcinoma (75% of all liver cancer) and intrahepatic cholangiocarcinoma (15% of all liver cancer) [ ... ...

    Abstract Primary liver cancer is the fourth leading cause of cancer death around the world. Histologically, it can be divided into two major groups, hepatocellular carcinoma (75% of all liver cancer) and intrahepatic cholangiocarcinoma (15% of all liver cancer) [1, 2]. Primary liver cancer usually happens in liver disease or cirrhosis patients [1], and the risk factors for developing HCC depend on the etiology [3] and the country of provenance [1]. There is an urgent need for an accurate diagnostic test given the high proportion of false positives and false negatives for alpha-fetoprotein (AFP), a common HCC biomarker [4]. Due to often being diagnosed in advanced stages, HCCrelated deaths per year have doubled since 1999 [3]. With the use of metabolomics technologies [5], the aberrant metabolism characteristics of cancer tissues can be discovered and exploited for the new biomarkers and new therapies to treat HCC [6, 7].
    MeSH term(s) Biomarkers ; Biomarkers, Tumor/genetics ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/epidemiology ; Humans ; Liver Cirrhosis ; Liver Neoplasms/diagnosis ; Liver Neoplasms/epidemiology ; Metabolomics ; alpha-Fetoproteins
    Chemical Substances Biomarkers ; Biomarkers, Tumor ; alpha-Fetoproteins
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-65768-0_9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Metabolic Relationship Between Cancer-Associated Fibroblasts and Cancer Cells.

    Sazeides, Christos / Le, Anne

    Advances in experimental medicine and biology

    2021  Volume 1311, Page(s) 189–204

    Abstract: Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play an important role in cancer initiation, progression, and metastasis. Recent findings have demonstrated that the TME not only provides physical support for ... ...

    Abstract Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play an important role in cancer initiation, progression, and metastasis. Recent findings have demonstrated that the TME not only provides physical support for cancer cells but also directs cell-to-cell interactions (in this case, the interaction between cancer cells and CAFs). As cancer progresses, the CAFs also coevolve, transitioning from an inactivated state to an activated state. The elucidation and understanding of the interaction between cancer cells and CAFs will pave the way for new cancer therapies [1-3].
    MeSH term(s) Cancer-Associated Fibroblasts ; Cell Communication ; Fibroblasts ; Humans ; Neoplasms ; Tumor Microenvironment
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-65768-0_14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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