LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: Reversion of glucocorticoid-induced senescence and collagen synthesis decrease by LY294002 is mediated through p38 in skin.

    Le, Quoc-Vu / Wen, Su-Ying / Chen, Chih-Jung / Huang, Chih-Yang / Kuo, Wei-Wen

    International journal of biological sciences

    2022  Volume 18, Issue 16, Page(s) 6102–6113

    Abstract: Glucocorticoids (GCs) are the most common treatment for inflammatory skin disorders; however, they show several adverse side effects, including atrophy and collagen decrease following chronic treatment. In particular, transcription factors and p38 ... ...

    Abstract Glucocorticoids (GCs) are the most common treatment for inflammatory skin disorders; however, they show several adverse side effects, including atrophy and collagen decrease following chronic treatment. In particular, transcription factors and p38 signaling for collagen synthesis have been shown to be suppressed by the active glucocorticoid receptor (GR). LY294002 (LY), a phosphoinositide 3-kinase (PI3K) inhibitor, has been reported to protect keratinocytes in epidermis against GC-induced hypoplasia; however, its protective effect in dermis remains unclear. Furthermore, clobetasol propionate (CP) is the most used commercial synthetic GC, yet studies on how CP causes side effects in dermal fibroblasts are limited. In this study, dermal atrophy was modeled using CP in human dermal fibroblasts (HDFs) and C57BL/6 mice. CP treatment significantly upregulated FK506 binding protein 5 (FKBP51), an atrophy marker (2.4 ± 0.25 and 3.3 ± 0.3 fold in
    MeSH term(s) Mice ; Humans ; Animals ; Glucocorticoids ; Phosphatidylinositol 3-Kinases ; Mice, Inbred C57BL ; Receptors, Glucocorticoid ; Phosphoinositide-3 Kinase Inhibitors ; Atrophy
    Chemical Substances 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (31M2U1DVID) ; Glucocorticoids ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Receptors, Glucocorticoid ; Phosphoinositide-3 Kinase Inhibitors
    Language English
    Publishing date 2022-10-18
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.73915
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Seven traditional Chinese herbal extracts fermented by Lactobacillus rhamnosus provide anti-pigmentation effects by regulating the CREB/MITF/tyrosinase pathway.

    Ho, Chih-Chu / Ng, Shang-Chuan / Chuang, Ho-Lin / Chen, Jia-Yi / Wen, Su-Ying / Kuo, Chia-Hua / Mahalakshmi, B / Le, Quoc-Vu / Huang, Chih-Yang / Kuo, Wei-Wen

    Environmental toxicology

    2020  Volume 36, Issue 4, Page(s) 654–664

    Abstract: Skin pigmentation is resulted from several processes, such as melanin synthesis transportation and abnormal melanin accumulation in keratinocytes. Various studies have suggested that seven traditional Chinese herbal extracts from Atractylodes ... ...

    Abstract Skin pigmentation is resulted from several processes, such as melanin synthesis transportation and abnormal melanin accumulation in keratinocytes. Various studies have suggested that seven traditional Chinese herbal extracts from Atractylodes macrocephala, Paeonia lactiflora, Bletilla striata, Poria cocos, Dictamnus dasycarpus, Ampelopsis japonica and Tribulus terrestris (which we collectively named ChiBai), show several protective effects toward skin-related diseases. Lactobacillus rhamnosus, a lactic acid bacterium, has been reported to treat skin inflammation and atopic dermatitis. In this study, the broth produced by the cofermentation of ChiBai with Lactobacillus rhamnosus was studied for its effects on skin pigmentation through in vitro and in vitro experiments. In the in vitro experiments, we found that the fermented broth of ChiBai (FB-ChiBai) suppressed alpha-melanocyte stimulating hormone (α-MSH)-induced melanogenesis in B16F0 murine melanoma cells without any cytotoxicity at a concentration of 0.5%. FB-ChiBai significantly attenuated melanin production, tyrosinase activities and melanogenesis-related signaling pathways. Treatment with FB-ChiBai also reduced the nuclear translocation and promoter binding activities of MITF. In the in vivo experiments, FB-ChiBai was topically applied to the dorsal skin of C57BL/6J nude mice and concurrently irradiated with UVB, three times a week for 8 weeks. The results indicated that FB-ChiBai alleviated UVB-induced hyperpigmentation by reducing epidermal hyperplasia and inhibiting the CREB/MITF/tyrosinase pathway. In conclusion, our data indicated that the anti-melanogenic effects of FB-ChiBai are mediated by the inhibition of CREB/MITF/tyrosinase signaling pathway. The findings suggest that FB-ChiBai can protect against UV-B irradiation and that it might be used as an agent in cosmetic products to protect against UVB-induced hyperpigmentation.
    MeSH term(s) Animals ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/pharmacology ; Fermentation ; Humans ; Lactobacillus rhamnosus/metabolism ; Melanins/biosynthesis ; Mice ; Mice, Inbred C57BL ; Mice, Nude ; Microphthalmia-Associated Transcription Factor/metabolism ; Monophenol Monooxygenase/metabolism ; Signal Transduction ; Skin/drug effects ; Skin/metabolism ; Skin/pathology ; Skin/radiation effects ; Skin Pigmentation/drug effects ; Skin Pigmentation/radiation effects ; Ultraviolet Rays ; alpha-MSH/antagonists & inhibitors
    Chemical Substances Drugs, Chinese Herbal ; Melanins ; Microphthalmia-Associated Transcription Factor ; alpha-MSH (581-05-5) ; Monophenol Monooxygenase (EC 1.14.18.1)
    Language English
    Publishing date 2020-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23069
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top