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  1. AU="Le, Uyen Nguyen Phuong"
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  1. Article ; Online: Combining virtual screening with cis-/trans-cleavage enzymatic assays effectively reveals broad-spectrum inhibitors that target the main proteases of SARS-CoV-2 and MERS-CoV.

    Chang, Yu-Jen / Le, Uyen Nguyen Phuong / Liu, Jia-Jun / Li, Sin-Rong / Chao, Shao-Ting / Lai, Hsueh-Chou / Lin, Yu-Feng / Hsu, Kai-Cheng / Lu, Chih-Hao / Lin, Cheng-Wen

    Antiviral research

    2023  Volume 216, Page(s) 105653

    Abstract: The main protease ( ... ...

    Abstract The main protease (M
    MeSH term(s) Humans ; SARS-CoV-2 ; Middle East Respiratory Syndrome Coronavirus ; COVID-19 ; Protease Inhibitors/pharmacology ; Protease Inhibitors/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Cysteine Endopeptidases/chemistry ; Molecular Docking Simulation
    Chemical Substances Protease Inhibitors ; Antiviral Agents ; Cysteine Endopeptidases (EC 3.4.22.-)
    Language English
    Publishing date 2023-06-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2023.105653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Functional assessments of SARS-CoV-2 single-round infectious particles with variant-specific spike proteins on infectivity, drug sensitivity, and antibody neutralization.

    Su, Wen-Chi / Chen, Zan-Yu / Chang, Young-Sheng / Jeng, King-Song / Le, Uyen Nguyen Phuong / Chou, Yu-Chi / Kuo, Li-Lan / Melano, Ivonne / Jesse / Wang, Wei-Jan / Song, Ying-Chyi / Li, Sin-Rong / Hung, Mien-Chie / Lai, Michael M C / Lin, Cheng-Wen

    Antiviral research

    2023  Volume 220, Page(s) 105744

    Abstract: Working with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is restricted to biosafety level III (BSL-3) laboratory. The study used a trans-complementation system consisting of virus-like particles (VLPs) and DNA-launched replicons to ... ...

    Abstract Working with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is restricted to biosafety level III (BSL-3) laboratory. The study used a trans-complementation system consisting of virus-like particles (VLPs) and DNA-launched replicons to generate SARS-CoV-2 single-round infectious particles (SRIPs) with variant-specific spike (S) proteins. S gene of Wuhan-Hu-1 strain (S
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus ; Antibodies, Neutralizing ; Antibodies, Viral
    Chemical Substances spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2023-11-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2023.105744
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Comparison between the analytical sensitivity and clinical performance of two cobas SARS-CoV-2 tests based on high-throughput and point-of-care systems.

    Lin, Tsai-Hsiu / Bui, Ngoc-Niem / Chang, Yu-Chang / Hsu, Li-Yun / Su, Yang-Di / Chang, Chieh-Min / Hong, Wei-An / Le, Uyen Nguyen Phuong / Huang, Su-Hua / Lin, Cheng-Wen

    BioMedicine

    2022  Volume 12, Issue 2, Page(s) 40–46

    Abstract: Objectives: This study examined analytical sensitivity, specificity, and the clinical performance in detecting SARS-CoV-2 of the Cobas SARS-CoV-2 Test based on the high-throughput Cobas 6800 system and the Cobas SARS-CoV-2 & Flu A/B Test based on the ... ...

    Abstract Objectives: This study examined analytical sensitivity, specificity, and the clinical performance in detecting SARS-CoV-2 of the Cobas SARS-CoV-2 Test based on the high-throughput Cobas 6800 system and the Cobas SARS-CoV-2 & Flu A/B Test based on the point-of-care cobas Liat system.
    Methods: The commercial reagents containing SARS-CoV-2 RNA subgenomes were diluted for assessing the sensitivity of the RT-qPCR assay. 385 nasopharyngeal swab specimens taken from contacts of COVID-19 cases were tested for the SARS-CoV-2 detection with both Cobas SARS-CoV-2 Tests.
    Results: In analytical sensitivity assays, the Cobas SARS-CoV-2 & Flu A/B Test on the Liat system had a lower limit of detection (12.5-25 copies/mL) than the cobas SARS-CoV-2 Test on the cobas 6800 system (25-50 copies/mL). In clinical performance assays, the cobas SARS-CoV-2 Test demonstrated 89.36% (42 out of 47) PPA (positive percent agreement) and 98.82% (334 out of 338) NPA (negative percent agreement) compared to the results of the Cobas SARS-CoV-2 & Flu A/B test. Among five discordant specimens, four had the positive result of the cobas SARS-CoV-2 test, but the negative result of the cobas SARS-CoV-2 & Flu A/B Test. Moreover, these discordant specimens had the Ct values of greater than 33 for the cobas SARS-CoV-2 Test, implying a very small number of virions in the samples. Remarkably, four specimens with a presumptive positive result of the cobas SARS-CoV-2 test had been confirmed by the Cobas SARS-CoV-2 & Flu A/B Test. Next, the scatter plots of the Ct values showed a highly positive correlation between cobas SARS-CoV-2 & Flu A/B Test and the cobas SARS-CoV-2 Test (R-squared value = 0.954-0.962).
    Conclusions: Both SARS-CoV2 tests of the cobas 6800 and Liat systems produce reliable high throughput and point-of-care assays respectively for the early virus detection and the personal care decision-making during COVID-19 pandemic.
    Language English
    Publishing date 2022-06-01
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 2648006-2
    ISSN 2211-8039 ; 2211-8020
    ISSN (online) 2211-8039
    ISSN 2211-8020
    DOI 10.37796/2211-8039.1334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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