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  1. Article: Synergy of Plant Essential Oils in Antibiotic Therapy to Combat

    Romo-Castillo, Mariana / Flores-Bautista, Victor Andrés / Guzmán-Gutiérrez, Silvia Laura / Reyes-Chilpa, Ricardo / León-Santiago, Mayra / Luna-Pineda, Victor Manuel

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 6

    Abstract: Increased antibiotic resistance presents a health problem worldwide. The World Health Organization published a list of pathogens considered a priority for designing new treatments. ...

    Abstract Increased antibiotic resistance presents a health problem worldwide. The World Health Organization published a list of pathogens considered a priority for designing new treatments.
    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16060839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Microsatellites, morphological, and alkaloids characterization of Zephyranthes fosteri and Z. alba (Amaryllidaceae): Allopatric populations

    Centeno-Betanzos, Lucia Y. / López-Caamal, Alfredo / Cortés Rendon, Natalie / León Santiago, Mayra / Osorio, Edison / Bastida Armengol, Jaume / Cano-Santana, Zenón / Reyes-Chilpa, Ricardo / Tovar-Sánchez, Efraín

    Biochemical systematics and ecology. 2022 Apr., v. 101

    2022  

    Abstract: Zephyranthes (Amaryllidaceae) is a taxonomically complex genus due to the frequent overlap of interspecific morphological variation. In Mexico, Z. alba and Z. fosteri are herbaceous plants that, when distributed in sympatry, generate individuals with ... ...

    Abstract Zephyranthes (Amaryllidaceae) is a taxonomically complex genus due to the frequent overlap of interspecific morphological variation. In Mexico, Z. alba and Z. fosteri are herbaceous plants that, when distributed in sympatry, generate individuals with complex patterns of morphological variation, leading to taxonomic confusion. Therefore, it is necessary to first characterize these species in allopatric populations. In this contribution, molecular, morphological, and alkaloid profiles were used to characterize both species in allopatric sites. Our results show that Z. alba and Z. fosteri allopatric populations are two well-defined genetic and morphological groups. Flower-related characters were the ones that best allowed us to distinguish between species. In a similar fashion, the alkaloid profile showed remarkable differences among species: four alkaloids were specific to Z. alba and five to Z. fosteri. Lycorine (43.3-88.8%) and galanthamine (87.7-91.4%) were the most abundant alkaloids for each species, respectively. In conclusion, Z. fosteri and Z. alba exhibit noticeable differences when distributed in allopatry. In addition, Z. fosteri has greater genetic and phenotypic plasticity compared to Z. alba, which could be related to the former's ability to colonize new habitats. Finally, the molecular, genetic and chemical markers developed here will provide a framework to further studies aiming to explore if hybridization among Z. alba and Z. fosteri occurs in sympatric populations.
    Keywords Zephyranthes ; allopatry ; chemotaxonomy ; lycorine ; microsatellite repeats ; phenotypic plasticity ; sympatry ; Mexico
    Language English
    Dates of publication 2022-04
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0305-1978
    DOI 10.1016/j.bse.2022.104398
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Erratum: Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea.

    Guzmán-Gutiérrez, Silvia Laura / Silva-Miranda, Mayra / Krengel, Felix / Huerta-Salazar, Elizabeth / León-Santiago, Mayra / Díaz-Cantón, Jessica Karina / Espitia Pinzón, Clara / Reyes-Chilpa, Ricardo

    Planta medica

    2020  Volume 88, Issue 1, Page(s) e1

    Language English
    Publishing date 2020-05-18
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/a-1177-3691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea.

    Guzmán-Gutiérrez, Silvia Laura / Silva-Miranda, Mayra / Krengel, Felix / Huerta-Salazar, Elizabeth / León-Santiago, Mayra / Díaz-Cantón, Jessica Karina / Espitia Pinzón, Clara / Reyes-Chilpa, Ricardo

    Planta medica

    2020  Volume 88, Issue 1, Page(s) 53–61

    Abstract: Tuberculosis is the main cause of death from a single infectious agent. Globally, according to the World Health Organization, in 2018, there were an estimated 1.2 million tuberculosis deaths. Moreover, there is a continuous appearance of drug-resistant ... ...

    Abstract Tuberculosis is the main cause of death from a single infectious agent. Globally, according to the World Health Organization, in 2018, there were an estimated 1.2 million tuberculosis deaths. Moreover, there is a continuous appearance of drug-resistant strains. Thus, development of new antituberculosis medicines should receive high priority. Plant-derived natural products are promising candidates for this purpose. We therefore screened alkaloid extracts obtained from the root and stem barks of the Mexican Apocynaceae species
    MeSH term(s) Alkaloids/pharmacology ; Animals ; Apocynaceae ; Chlorocebus aethiops ; Indole Alkaloids ; Plant Extracts/pharmacology ; Tabernaemontana ; Vero Cells
    Chemical Substances Alkaloids ; Indole Alkaloids ; Plant Extracts
    Language English
    Publishing date 2020-05-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/a-1157-1732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea

    Guzmán-Gutiérrez, Silvia Laura / Silva-Miranda, Mayra / Krengel, Felix / Huerta-Salazar, Elizabeth / León-Santiago, Mayra / Díaz-Cantón, Jessica Karina / Espitia Pinzón, Clara / Reyes-Chilpa, Ricardo

    Planta Medica

    2020  Volume 88, Issue 01, Page(s) 53–61

    Abstract: Tuberculosis is the main cause of death from a single infectious agent. Globally, according to the World Health Organization, in 2018, there were an estimated 1.2 million tuberculosis deaths. Moreover, there is a continuous appearance of drug-resistant ... ...

    Abstract Tuberculosis is the main cause of death from a single infectious agent. Globally, according to the World Health Organization, in 2018, there were an estimated 1.2 million tuberculosis deaths. Moreover, there is a continuous appearance of drug-resistant strains. Thus, development of new antituberculosis medicines should receive high priority. Plant-derived natural products are promising candidates for this purpose. We therefore screened alkaloid extracts obtained from the root and stem barks of the Mexican Apocynaceae species Tabernaemontana alba and Tabernaemontana arborea, as well as the pure alkaloids ibogaine, voacangine, and voacamine, tested for activity against Mycobacterium tuberculosis H37Rv and cytotoxicity to mammalian Vero cells using the resazurin microtiter and the MTT assays, respectively. The extracts were analyzed by GC-MS and HPLC-UV. T. arborea root bark alkaloid extract showed the highest activity against

    M. tuberculosis (MIC 100  = 7.8 µg/mL) of the four extracts tested. HPLC suggested that voacangine and voacamine were the major components. The latter was isolated by column chromatography, and its chemical structure was elucidated by 1 H and 13 C NMR, and MS. Unambiguous assignation was performed by HSQC, HMBC, and NOESY experiments. Voacamine is a dimeric bis-indole-type alkaloid and is 15 times more potent than the monomeric ibogan-type alkaloids ibogaine and voacangine (MIC 100  = 15.6, 250.0, and 250.0 µg/mL, respectively). However, all of these compounds showed cytotoxicity to Vero cells, with a poor selectivity index of 1.00, 0.16, and 1.42, respectively. This is the first report of voacamine activity against M. tuberculosis
    Keywords Apocynaceae ; antimycobacterial activity ; voacamine ; ibogan alkaloids ; GC-MS ; NMR
    Language English
    Publishing date 2020-05-11
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/a-1157-1732
    Database Thieme publisher's database

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  6. Article: Erratum: Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea

    Guzmán-Gutiérrez, Silvia Laura / Silva-Miranda, Mayra / Krengel, Felix / Huerta-Salazar, Elizabeth / León-Santiago, Mayra / Díaz-Cantón, Jessica Karina / Espitia Pinzón, Clara / Reyes-Chilpa, Ricardo

    Planta Medica

    2020  Volume 88, Issue 01, Page(s) e1–e1

    Language English
    Publishing date 2020-05-18
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/a-1177-3691
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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