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Article ; Online: Extracting lignin from sugarcane bagasse for methylene blue and hexavalent chromium adsorption in textile wastewater: a facile, green, and sustainable approach.

Nguyen-Thi, Nhu Y / Nguyen, Cuong Quoc / Le Dang, Quang / De Tran, Quang / Do-Thi, Tuyet Nhung / Vu Thanh, Luong Huynh

RSC advances

2024 Volume 14, Issue 7, Page(s) 4533–4542

Abstract: This study presents the process of extracting lignin from sugarcane bagasse collected in the Mekong Delta, Vietnam by the alkali method. NaOH has been used as an effective, environmentally friendly chemical to enhance the extraction process. The obtained ...

Abstract	This study presents the process of extracting lignin from sugarcane bagasse collected in the Mekong Delta, Vietnam by the alkali method. NaOH has been used as an effective, environmentally friendly chemical to enhance the extraction process. The obtained lignin was applied for methylene blue (MB) and hexavalent chromium (Cr(vi)) removal. Factors influencing lignin extraction and adsorption processes of MB and Cr(vi) were investigated, showcasing the sustainable reusability of lignin extracted from sugarcane bagasse. Lignin characterization was also carried out by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA) techniques. The results showed that the extracted lignin content reached 38.61% under optimal conditions (NaOH concentration of 10%, reaction temperature of 90 °C and reaction time of 90 min). The adsorption efficiency and capacity of lignin reached 90.90% and 9.09 mg g
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra08007b
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Article ; Online: Poly-ϵ-caprolactone scaffold as staple-line reinforcement of rectal anastomosis: an experimental piglet study.

Petersen, Laura Lovisa Køtlum / Dursun, Martin Dennis / Madsen, Gunvor / Le, Dang Quang Svend / Möller, Sören / Qvist, Niels / Ellebæk, Mark Bremholm

BMC gastroenterology

2024 Volume 24, Issue 1, Page(s) 112

Abstract: Purpose: Rectal anastomoses have a persisting high incidence of anastomotic leakage. This study aimed to assess whether the use of a poly-ϵ-caprolactone (PCL) scaffold as reinforcement of a circular stapled rectal anastomosis could increase tensile ... ...

Abstract	Purpose: Rectal anastomoses have a persisting high incidence of anastomotic leakage. This study aimed to assess whether the use of a poly-ϵ-caprolactone (PCL) scaffold as reinforcement of a circular stapled rectal anastomosis could increase tensile strength and improve healing compared to a control in a piglet model. Method: Twenty weaned female piglets received a stapled rectal anastomosis and were randomised to either reinforcement with PCL scaffold (intervention) or no reinforcement (control). On postoperative day five the anastomosis was subjected to a tensile strength test followed by a histological examination to evaluate the wound healing according to the Verhofstad scoring. Results: The tensile strength test showed no significant difference between the two groups, but histological evaluation revealed significant impaired wound healing in the intervention group. Conclusion: The incorporation of a PCL scaffold into a circular stapled rectal anastomosis did not increase anastomotic tensile strength in piglets and indicated an impaired histologically assessed wound healing.
MeSH term(s)	Animals ; Female ; Anastomosis, Surgical/adverse effects ; Anastomotic Leak/prevention & control ; Anastomotic Leak/etiology ; Caproates ; Lactones ; Rectum/surgery ; Surgical Stapling ; Swine
Chemical Substances	Caproates ; caprolactone (56RE988L1R) ; Lactones
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-024-03202-1
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Article: Antifungal properties of natural products from Pterocarya tonkinensis against phytopathogenic fungi

Thi Ngo, Men / Han, Jae Woo / Van Nguyen, Minh / Le Dang, Quang / Kim, Hun / Choi, Gyung Ja

Pest management science. 2021 Apr., v. 77, no. 4

2021

Abstract: BACKGROUND: In the search for new natural resources showing antifungal activity, we found that the methanol extract of Pterocarya tonkinensis (Fr.) Dode suppressed the disease development caused by fungi. The objectives of this article were (i) to ... ...

Abstract	BACKGROUND: In the search for new natural resources showing antifungal activity, we found that the methanol extract of Pterocarya tonkinensis (Fr.) Dode suppressed the disease development caused by fungi. The objectives of this article were (i) to isolate and identify the antifungal substances from the Pterocarya tonkinensis extract based on a bioassay‐guided fractionation and (ii) to investigate their potential as a biocontrol agent with their antifungal activities in vitro and in vivo. RESULTS: Eighteen compounds were identified from the methanol extract of Pterocarya tonkinensis, including two new natural products 1 and 2: 1, pterocaryalactone; 2, pterocaryafuranone; 3, (1S, 6R)‐9‐hydroxymegastigm‐7‐en‐3‐one; 4, (S)‐dimethyl malate; 5, α‐linolenic acid; 6–8, α‐tetralones; 9, (R)‐methyl‐2‐hydroxyl‐3‐phenyl‐propanoate; 10, (E)‐4‐hydroxycinnamic acid methyl ester; 11–14, diarylheptanoids, and 15–18, pentacyclic triterpenoids. Based on the results of the in vitro antifungal assay, Magnaporthe oryzae and Phytophthora infestans were the most sensitive to the isolated compounds among the tested phytopathogenic fungi. When ten active compounds were applied onto plants at a concentration of 100 or 500 μg mL⁻¹, compounds 1 and 8 effectively suppressed rice blast disease, and compounds 15 and 16 not only strongly reduced the development of blast on rice but also effectively controlled the development of late blight on tomatoes. CONCLUSION: This is the first report to evaluate the in vitro and in vivo antifungal activities of the isolated compounds from a methanol extract of Pterocarya tonkinensis against phytopathogenic fungi, and our results suggest that Pterocarya tonkinensis and its substances can be used as a source to develop natural fungicides. © 2020 Society of Chemical Industry
Keywords	Magnaporthe oryzae ; Phytophthora infestans ; Pterocarya tonkinensis ; antifungal properties ; biological control agents ; blast disease ; fractionation ; malates ; methanol ; rice ; triterpenoids
Language	English
Dates of publication	2021-04
Size	p. 1864-1872.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.6211
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Article ; Online: Rational design of novel diaryl ether-linked benzimidazole derivatives as potent and selective BACE1 inhibitors.

Quang De, Tran / Nguyen, Cuong Quoc / Le Dang, Quang / Nguyen Thi, Nhu Y / Trong Tuan, Nguyen / Hoon Suh, Dong / Chu, Jeonghyun / Bepary, Sukumar / Lee, Ge Hyeong / Kang, Nam Sook / Cho, Heeyeong / Park, Woo Kyu / Lim, Hee-Jong

Biochemical and biophysical research communications

2024 Volume 698, Page(s) 149538

Abstract: Due to the large size and high flexibility of the catalytic active site of BACE1 enzyme, the development of nonpeptide inhibitors with optimal pharmacological properties is still highly demanding. In this work, we have discovered 2-aminobenzimidazole- ... ...

Abstract	Due to the large size and high flexibility of the catalytic active site of BACE1 enzyme, the development of nonpeptide inhibitors with optimal pharmacological properties is still highly demanding. In this work, we have discovered 2-aminobenzimidazole-containg ether scaffolds having potent and selective inhibitory potentials against BACE1 enzyme. We have synthesized novel 29 compounds and optimization of aryl linker region resulted in highly potent BACE1 inhibitory activities with EC
MeSH term(s)	Humans ; Alzheimer Disease ; Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Aspartic Acid Endopeptidases/antagonists & inhibitors ; Benzimidazoles/pharmacology ; Ethers ; Molecular Docking Simulation ; Drug Design
Chemical Substances	Amyloid Precursor Protein Secretases (EC 3.4.-) ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; BACE1 protein, human (EC 3.4.23.46) ; Benzimidazoles ; Ethers
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149538
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Article ; Online: Stable biogenic silver nanoparticles from

Lan Pham, Thi / Dat Doan, Van / Le Dang, Quang / Anh Nguyen, Tuan / Huong Nguyen, Thi Lan / Thuy Tran, Thi Dieu / Lan Nguyen, Thi Phuong / Anh Vo, Thi Kieu / Huy Nguyen, Trung / Lam Tran, Dai

RSC advances

2023 Volume 13, Issue 30, Page(s) 20994–21007

Abstract: In the present study, the biosynthesis of stable silver nanoparticles (BioAgNPs) was accomplished successfully for the first time by using an aqueous extract derived from the buds ... ...

Abstract	In the present study, the biosynthesis of stable silver nanoparticles (BioAgNPs) was accomplished successfully for the first time by using an aqueous extract derived from the buds of
Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra02754f
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Article ; Online: Desmodinosides A-E: New Flavonoid C-glycosides from Desmodium heterocarpon var. stigosum with hepatoprotective and antifungal activity.

Le Dang, Quang / Vu, Hoang Dinh / Nguyen, Van Minh / Choi, Gyung Ja / Hoa, Le Thi Phuong / Dung, Duong Thi / Van Kiem, Phan / Nhiem, Nguyen Xuan / De Tran, Quang / Nguyen, Quoc Cuong / Nghiem, Duc Trong / Quang, Dang Ngoc

Fitoterapia

2023 Volume 169, Page(s) 105609

Abstract: Five new flavonoid C-glycosides named desmodinosides A-E (1-5) and one known compound, apigenin 6-C-β-d-xylopyranosyl-2''-O-β-D-glucopyranoside (6) have been isolated from the methanol extract of the aerial parts of Desmodium heterocarpon var. stigosum. ... ...

Abstract	Five new flavonoid C-glycosides named desmodinosides A-E (1-5) and one known compound, apigenin 6-C-β-d-xylopyranosyl-2''-O-β-D-glucopyranoside (6) have been isolated from the methanol extract of the aerial parts of Desmodium heterocarpon var. stigosum. These compounds were determined by 1D and 2D-NMR and HR-MS spectroscopies. The methanol extract of this plant, in particular, demonstrated hepatoprotection and antifungal inhibition. This extract has a remarkable hepatoprotection and activity-dose response with an EC
MeSH term(s)	Humans ; Flavonoids ; Antifungal Agents/pharmacology ; Methanol ; Molecular Structure ; Glycosides ; Plant Extracts/chemistry
Chemical Substances	C-glycoside ; Flavonoids ; Antifungal Agents ; Methanol (Y4S76JWI15) ; Glycosides ; Plant Extracts
Language	English
Publishing date	2023-07-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2023.105609
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Article ; Online: Characterization of thymol derivatives from

Nguyen-Ngoc, Hieu / Trang, Bui Thi Thu / Thu, Do Thi Hoai / Nguyen, Huu Tung / Hoang, Vu Dinh / Tran, Quang De / Nguyen, Tuan Ngoc / Quang, Dang Ngoc / Pham, Giang Nam / Le Dang, Quang

Natural product research

2023 , Page(s) 1–7

Abstract: From the aerial parts ... ...

Abstract	From the aerial parts of
Language	English
Publishing date	2023-01-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2023.2172726
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Article ; Online: Clerodane Diterpenoids Identified from

Nguyen, Minh Van / Han, Jae Woo / Le Dang, Quang / Ryu, Seung Mok / Lee, Dongho / Kim, Hun / Choi, Gyung Ja

Journal of agricultural and food chemistry

2021 Volume 69, Issue 36, Page(s) 10527–10535

Abstract: In the search for new natural resources showing plant disease control effects, we found that the methanol extract ... ...

Abstract	In the search for new natural resources showing plant disease control effects, we found that the methanol extract of
MeSH term(s)	Antifungal Agents/pharmacology ; Diterpenes, Clerodane/pharmacology ; Microbial Sensitivity Tests ; Plant Extracts/pharmacology ; Plant Leaves ; Polyalthia
Chemical Substances	Antifungal Agents ; Diterpenes, Clerodane ; Plant Extracts
Language	English
Publishing date	2021-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.1c02200
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Article ; Online: Biogenic synthesis of selenium nanoparticles by Shewanella sp. HN-41 using a modified bioelectrochemical system

Ho, Cuong Tu / Nguyễn, Thị Hạnh / Lam, Thuong-Thuong / Le, Dang-Quang / Nguyen, Canh Xuan / Lee, Ji-hoon / Hur, Hor-Gil

Electronic Journal of Biotechnology. 2021 Nov., v. 54 p.1-7

2021

Abstract: Synthesis of selenium nanoparticles from selenite by Shewanella sp. HN-41 demonstrated that particle size depended on the reaction time and biomass of cells. The slow reaction and low biomass tended to form small particles. In this study, Shewanella sp. ... ...

Abstract	Synthesis of selenium nanoparticles from selenite by Shewanella sp. HN-41 demonstrated that particle size depended on the reaction time and biomass of cells. The slow reaction and low biomass tended to form small particles. In this study, Shewanella sp. HN-41 was introduced into the anode of a nonexternal circuit bioelectrochemical system (nec_BES) to convert chemical energy from lactate to low electron current to the cathode, where selenite was reduced.Our experiment with two systems, one bioelectrochemical system with a cathode flushed with nitrogen and the other with a no-nitrogen-flushing cathode, showed that the former could not produce Se nanoparticles after 21 d, but the latter formed them with an average size of 37.7 nm. The SEM and TEM images demonstrated that the particle size of 10 nm occupied over 10% and most of the particles were in the range of 30–60 nm. The XRD result and SAED image demonstrated no clear peaks of crystal and proved that the Se nanoparticles are amorphous.The clean Se nanoparticles were synthesized and completely separated from bacterial cells in the bioelectrochemical system. This study opened a new approach for the biological synthesis of metal nanoparticles. Finally, the Se products in the range of 30–60 nm can be tested for antimicrobial activities in medical applications.How to cite: Ho CT, Nguyen T-H, Lam T-T, et al. Biogenic synthesis of selenium nanoparticles by Shewanella sp. HN-41 using a modified bioelectrochemical system. Electron J Biotechnol 2021;54. https://doi.org/10.1016/j.ejbt.2021.07.004
Keywords	Shewanella ; anodes ; bioelectrochemistry ; biomass ; cathodes ; crystals ; electric current ; lactic acid ; nanometals ; nanoparticles ; nitrogen ; particle size ; selenites ; selenium ; Anode ; Bioelectrochemical system ; Biogenic ; Cathode ; Nanosized selenium ; Nonexternal circuit ; Selenite ; Selenium nanoparticles ; Shewanella sp.
Language	English
Dates of publication	2021-11
Size	p. 1-7.
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	2020598-3
ISSN	0717-3458
ISSN	0717-3458
DOI	10.1016/j.ejbt.2021.07.004
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Article: Phytochemical constituents and extracts of the roots of Scutellaria baicalensis exhibit in vitro and in vivo control efficacy against various phytopathogenic microorganisms

Do, Hoai Thu Thi / Nguyen, Thanh Huong / Nghiem, Trong Duc / Nguyen, Huu Tung / Choi, Gyung Ja / Ho, Cuong Tu / Le Dang, Quang

SAAB South African journal of botany. 2021 Nov., v. 142

2021

Abstract: Scutellaria baicalensis is one of the most well-known medicinal herbs used in traditional Chinese herbal medicine. During our search of antimicrobial botanicals, the methanol extract from the roots of S. baicalensis displayed in vivo control efficacy ... ...

Abstract	Scutellaria baicalensis is one of the most well-known medicinal herbs used in traditional Chinese herbal medicine. During our search of antimicrobial botanicals, the methanol extract from the roots of S. baicalensis displayed in vivo control efficacy against various fungal plant diseases and in vitro inhibition against phytopathogenic bacteria. In an in vitro antifungal bioassay, ethyl acetate-soluble extract was highly active against the growth of Magnaporthe oryzae and Phytophthora sp. mycelia in the range of 500 to 5000 µg/mL. Through antifungal activity-guided bioassay, bioactive flavonoids and an oligosaccharide were identified from the EtOAc soluble extract of S. baicalensis roots by ESI-MS and 1D- and 2D-NMR data analyses. These constituents were assessed for their in vitro and in vivo antifungal activities. The major bioactive flavonoids SB1 (wogonin), SB4 (baicalein), and SB5 (baicalin) in the extracts of S. baicalensis’s roots were quantified by HPLC method. Among these three compounds, SB1 exhibited the best in vitro antifungal effect against M. oryzae and in vivo efficacy (63%) against rice blast at 500 µg/mL. SB4 was the most active against plant bacteria Acidovorax avenae subsp. cattlyae, Clavibacter michiganensis subsp. michiganensis, and Ralstonia solanacearum with an MIC value of 19 µg/mL. Moreover, the emulsion-type formulation containing the ethyl acetate-soluble extract of S. baicalensis significantly suppressed the development of rice blast caused and rice leaf blight on the rice plants in vivo. This is the first report that demonstrated bioactive constituents and extracts derived from S. baicalensis plants, which are promising to develop botanical fungicide and bactericide to control various plant diseases.
Keywords	Acidovorax avenae ; Clavibacter michiganensis subsp. michiganensis ; Magnaporthe oryzae ; Oriental traditional medicine ; Phytophthora ; Ralstonia solanacearum ; Scutellaria baicalensis ; antifungal properties ; baicalin ; bioassays ; blast disease ; ethyl acetate ; fungi ; fungicides ; leaf blight ; methanol ; mycelium ; oligosaccharides ; rice
Language	English
Dates of publication	2021-11
Size	p. 1-11.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2021.05.034
Database	NAL-Catalogue (AGRICOLA)

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