Artikel ; Online: Baseline circulating tumour DNA and total metabolic tumour volume as early outcome predictors in aggressive large B-cell lymphoma. A real-world 112-patient cohort.
British journal of haematology
2023 Band 202, Heft 1, Seite(n) 54–64
Abstract: Approximately 20%-50% of patients with large B-cell lymphoma (LBCL) experience poor outcomes. We aimed to evaluate the combined prognostic value of circulating tumour DNA (ctDNA) and total metabolic tumour volume (TMTV) in LBCL. This observational single- ...
| Abstract | Approximately 20%-50% of patients with large B-cell lymphoma (LBCL) experience poor outcomes. We aimed to evaluate the combined prognostic value of circulating tumour DNA (ctDNA) and total metabolic tumour volume (TMTV) in LBCL. This observational single-centre study included 112 newly diagnosed LBCL patients, receiving R-CHOP/R-CHOP-like chemotherapies. CtDNA load was calculated following next-generation sequencing of cell-free DNA (cfDNA) using a targeted 40-gene lymphopanel. TMTV was measured using a fully automated artificial intelligence-based method for lymphoma lesion segmentation. CtDNA was detected in cfDNA samples from 95 patients with a median concentration of 3.15 log haploid genome equivalents per mL. TMTV measurements were available for 102 patients. The median TMTV was 501 mL. High ctDNA load (>3.57 log hGE/mL) or high TMTV (>200 mL) were associated with shorter 1-year PFS (44% vs. 83%, p < 0.001 and 64% vs. 97%, p = 0.002, respectively). When combined, three prognostic groups were identified. The shortest PFS was observed when both TMTV and ctDNA load were high (p < 0.001). Even with a short follow up, combining ctDNA load with TMTV improved the risk stratification of patients with aggressive LBCL. In the near future, very high-risk patients could benefit from CAR T-cell therapy or bispecific antibodies as first-line treatments. |
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| Mesh-Begriff(e) | Humans ; Circulating Tumor DNA/genetics ; Tumor Burden ; Artificial Intelligence ; Prognosis ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/therapy ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Fluorodeoxyglucose F18/therapeutic use ; Positron Emission Tomography Computed Tomography ; Retrospective Studies | |||||
| Chemische Substanzen | Circulating Tumor DNA ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2023-04-10 | |||||
| Erscheinungsland | England | |||||
| Dokumenttyp | Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 80077-6 | |||||
| ISSN | 1365-2141 ; 0007-1048 | |||||
| ISSN (online) | 1365-2141 | |||||
| ISSN | 0007-1048 | |||||
| DOI | 10.1111/bjh.18809 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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