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Article ; Online: Life quality among psoriasis patients based on Dermatology Life Quality Index evaluation and its association with psoriasis severity in China

Yiran Chen / Lei Wei / Yu Song / Rui Zhang / Le Kuai / Bin Li / Ruiping Wang

Annals of Medicine, Vol 55, Iss

a cross-sectional study

2023 Volume 1

Abstract: AbstractBackground Psoriasis critically influences the psychosocial well-being of patients and reduces their quality of life and work efficiency beyond skin symptoms. However, evidence on the association between life quality based on the Dermatology Life ...

Abstract	AbstractBackground Psoriasis critically influences the psychosocial well-being of patients and reduces their quality of life and work efficiency beyond skin symptoms. However, evidence on the association between life quality based on the Dermatology Life Quality Index (DLQI) and psoriasis severity is limited, particularly in China. This study aimed to explore the association between life quality based on the DLQI evaluation and disease severity among psoriasis patients in China.Methods Four thousand two hundred and thirty psoriasis patients were recruited from the Chinese National Clinical Research Center for Skin and Immune Diseases from 2020 to 2021. Information was collected by applying a structured questionnaire and onsite physical examination. Data analysis was performed by using SAS software (version 9.4; SAS Inc., Cary, NC), and statistical significance was set at p < .05.Results Four thousand two hundred and thirty psoriasis patients were predominantly male (64.6%), with a median age of 38.6 years (interquartile range (IQR): 30.0–50.9). The Psoriasis Area and Severity Index (PASI) score for patients with psoriasis was 7.2 (IQR: 3.0–13.5), and 50% of patients with PASI scored over 7. A total of 84.1% of psoriasis patients reported that psoriasis affected their quality of life from mild to severe. The DLQI scores among psoriasis patients were positively correlated with PASI scores (r = 0.43, p < .01), both in patients of different sex and different age. Logistic regression analysis with the adjustment of potential confounders indicated that patients with higher PASI score also had higher DLQI score, the odds ratio (OR) were 1.69 (95% confidence interval (CI): 1.38–2.08) for patients with PASI score 3–7, 2.61 (95% CI: 2.10–3.25) for patients with PASI score 8–11 and 3.36 (95% CI: 2.78–4.07) for patients with PASI score ≥12, compared with patients with PASI score <3, respectively.Conclusions Life quality based on DLQI evaluation positively correlated with disease severity among patients with ...
Keywords	Psoriasis severity ; Dermatology Life Quality Index ; Psoriasis Area and Severity Index ; quality of life ; association ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Current status and prospect of acupuncture-moxibustion in treatment of cancer pain

Le KUAI

Journal of Integrative Medicine (JIM), Vol 6, Iss 2, Pp 197-

a review

2008 Volume 202

Keywords	neoplasms ; pain ; acupuncture-moxibustion ; review literature ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2008-02-01T00:00:00Z
Publisher	Journal of Chinese Integrative Medicine Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prevalence of Tobacco Smoking and Its Association With Disease Severity Among Patients With Psoriasis in China

Lei Wei / Siting Chen / Zhan Zhang / Le Kuai / Rui Zhang / Ning Yu / Yuling Shi / Bin Li / Ruiping Wang

Frontiers in Medicine, Vol

A Cross-Sectional Study

2022 Volume 9

Abstract: IntroductionTobacco smoking is associated with the onset and severity of psoriasis, and understanding the prevalence of tobacco smoking among patients with psoriasis is critical due to its high physical and mental influence and heavy disease burden. ... ...

Abstract	IntroductionTobacco smoking is associated with the onset and severity of psoriasis, and understanding the prevalence of tobacco smoking among patients with psoriasis is critical due to its high physical and mental influence and heavy disease burden. However, evidence on the association between tobacco smoking and psoriasis severity is still limited in China.ObjectivesThe objective of this study was to examine the prevalence of tobacco smoking and explore the association between tobacco smoking and diseases severity among patients with psoriasis.MethodsA total of 4,529 patients with psoriasis in 200 selected hospitals were recruited in China between January 2020 and September 2021. Detailed information covering demographic feature, tobacco smoking, and psoriasis history were collected through an electronic questionnaire, and clinical data were extracted from the health information system (HIS). SAS 9.4 was used for data analysis, and a p-value of <0.05 was considered statistically significant.ResultsThe prevalence of tobacco smoking was 30.8%, with 24.6% for current smoking. The average Psoriasis Area and Severity Index (PASI) score for patients with psoriasis was 9.4, with male patients having a higher PASI score than female patients. The odds ratio (OR) of former tobacco smoking prevalence was 1.5 [95% confidence interval (CI): (1.0–2.3)] for PASI score (3.0–7.0), 2.2 for PASI score (7.1–13.0), and 4.2 for PASI score >13, when compared with patients with PASI score < 3.0. Similarly, the OR of current tobacco smoking prevalence was 1.8 [95% CI: (1.5–2.2)] for PASI score (3.0–7.0), 1.9 for PASI score (7.1–13.0), and 3.1 for PASI score >13, when compared with patients with PASI score <3.0. The Spearman correlation analysis indicated that both tobacco smoking intensity and smoking duration were positively correlated with psoriasis severity (p < 0.05).ConclusionThe prevalence of tobacco smoking was high, especially among male patients with psoriasis and those with senior high education. Tobacco ...
Keywords	tobacco smoking ; psoriasis severity ; current smoker ; former smoker ; smoking intensity ; smoking duration ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: RNA sequencing analysis reveals the potential therapeutic mechanisms of Huzhang Tongfeng granule in MSU-induced acute gouty arthritis mouse model

Siting Chen / Lei Wei / Dan Yang / Le Kuai / Ying Luo / Ruiping Wang / Yanwei Xiang / Bin Li / Wanchun Wang / Mi Zhou / Jiankun Song

Pharmacological Research - Modern Chinese Medicine, Vol 6, Iss , Pp 100217- (2023)

2023

Abstract: Background: Gout is one of the most prevailing inflammatory arthritis, in which joint pain and dysfunction may drastically reduce patients' quality of life, work efficiency, and increase the burden of medical treatment. The Huzhang Tongfeng granule ( ... ...

Abstract	Background: Gout is one of the most prevailing inflammatory arthritis, in which joint pain and dysfunction may drastically reduce patients' quality of life, work efficiency, and increase the burden of medical treatment. The Huzhang Tongfeng granule (HZTFG) has been utilized clinically for more than 30 years with satisfactory effects and no significant adverse reactions. However, the mechanisms that underlie HZTFG's effect remain indeterminate. Methods: Firstly, the Liquid Chromatography-Mass Spectrometry (LC-MS) analyses were applied to clarify the multi-components of HZTFG to establish the quality control parameters. After the monosodium urate (MSU) crystals induced Acute gouty arthritis (AGA) model was established, behavioral testing, joint swelling, hematoxylin, and eosin (H&E) staining were applied to assess the effect of HZTFG on improving joint pain, swelling, synovial inflammation of the MSU crystals-injected mice. Moreover, to further understand the underlying mechanism of the action of HZTFG on AGA, RNA Sequencing (RNA-seq) analysis was performed to detect differentially expressed genes (DEGs) after HZTFG treatment. Thereafter, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were enriched via gene set enrichment analysis (GSEA) to assess the functions and pathways of DEGs. Furthermore, Reverse Transcription Polymerase Chain Reaction (RT-qPCR) analysis and enzyme-linked immunosorbent assay (ELISA) were applied for validation in vivo. Results: After treatment with HZTFG, RNA-seq results revealed 44 DEGs, of which 20 genes were remarkably down-regulated and 24 genes were up-regulated. Besides, the expression of these assayed genes were noticeably decreased, including Cxcl1, Cxcl2, Cebpb, Lcn2, Ptgs2, Mmp13, Fos, Socs3, Sele, and Junb. Moreover, animal experiments also demonstrated that TNF signaling pathway and IL-17 signaling pathway are key pathways in HZTFG treated MSU-induced AGA mouse model. Conclusion: HZTFG attenuated MSU crystals-induced inflammatory response through TNF ...
Keywords	Acute gouty arthritis ; Huzhang Tongfeng granule ; RNA sequencing analysis ; Transcriptome ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
Subject code	572
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1

Xiangyu Lu / Le Kuai / Fang Huang / Jingsi Jiang / Jiankun Song / Yiqiong Liu / Si Chen / Lijie Mao / Wei Peng / Ying Luo / Yongyong Li / Haiqing Dong / Bin Li / Jianlin Shi

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 15

Abstract: Abstract Psoriasis is a common inflammatory disease of especially high recurrence rate (90%) which is suffered by approximately 3% of the world population. The overexpression of reactive oxygen species (ROS) plays a critical role in psoriasis progress. ... ...

Abstract	Abstract Psoriasis is a common inflammatory disease of especially high recurrence rate (90%) which is suffered by approximately 3% of the world population. The overexpression of reactive oxygen species (ROS) plays a critical role in psoriasis progress. Here we show that biomimetic iron single-atom catalysts (FeN4O2-SACs) with broad-spectrum ROS scavenging capability can be used for psoriasis treatment and relapse prevention via related gene restoration. FeN4O2-SACs demonstrate attractive multiple enzyme-mimicking activities based on atomically dispersed Fe active structures, which are analogous to those of natural antioxidant enzymes, iron superoxide dismutase, human erythrocyte catalase, and ascorbate peroxidase. Further, in vitro and in vivo experiments show that FeN4O2-SACs can effectively ameliorate psoriasis-like symptoms and prevent the relapse with augmented efficacy compared with the clinical drug calcipotriol. Mechanistically, estrogen receptor 1 (ESR1) is identified as the core protein upregulated in psoriasis treatment through RNA sequencing and bioinformatic analysis. Together, this study provides a proof of concept of psoriasis catalytic therapy (PCT) and multienzyme-inspired bionics (MIB).
Keywords	Science ; Q
Subject code	572
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Post-Translational Modifications in Atopic Dermatitis

Xin Ma / Yi Ru / Ying Luo / Le Kuai / Qi-Long Chen / Yun Bai / Ye-Qiang Liu / Jia Chen / Yue Luo / Jian-Kun Song / Mi Zhou / Bin Li

Frontiers in Cell and Developmental Biology, Vol

Current Research and Clinical Relevance

2022 Volume 10

Abstract: Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption. Post-translational modifications (PTMs) are covalent and enzymatic modifications of ... ...

Abstract	Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption. Post-translational modifications (PTMs) are covalent and enzymatic modifications of proteins after their translation, which have been reported to play roles in inflammatory and allergic diseases. However, less attention has been paid to the effect of PTMs on AD. This review summarized the knowledge of six major classes (including phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, o-glycosylation, and glycation) of PTMs in AD pathogenesis and discussed the opportunities for disease management.
Keywords	atopic dermatitis ; post-translational modifications ; skin disorders ; therapeutic potential ; epigenetics ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An Efficacy Predictive Method for Diabetic Ulcers Based on Higher-Order Markov Chain-Set Pair Analysis

Le Kuai / Xiao-ya Fei / Jia-qi Xing / Jing-ting Zhang / Ke-qin Zhao / Kan Ze / Xin Li / Bin Li

Evidence-Based Complementary and Alternative Medicine, Vol

2020 Volume 2020

Abstract: Background. Clinical comprehensive decision-making of diabetic ulcers includes curative effect evaluation and curative effect prediction. Nevertheless, there are few studies on the prediction of diabetic ulcers. Methods. Set pair analysis (SPA) was used ... ...

Abstract	Background. Clinical comprehensive decision-making of diabetic ulcers includes curative effect evaluation and curative effect prediction. Nevertheless, there are few studies on the prediction of diabetic ulcers. Methods. Set pair analysis (SPA) was used to assess the curative effect evaluation, and therapeutic effect was evaluated by connection degree (CD). The higher-order Markov chain-SPA curative effect prediction model was established to predict the future curative effect development. The predicted results with higher-order Markov chain-SPA and traditional first-order Markov-SPA model were compared with the actual results of the patients to verify the effectiveness of prediction. Results. The connection degree of index levels I and II of 15 patients with diabetic ulcers after traditional Chinese medicine (TCM) treatment increased with time, while that of index levels IV and V decreased, indicating that the curative effect tends to improve. The higher-order Markov chain-SPA model was used to predict the curative effect. The results showed that the relative errors were fewer than the traditional first-order Markov-SPA model. Conclusions. The present study suggests that a method of SPA combined with higher-order Markov-SPA is relatively effective and can be applied to the clinical prediction of diabetic ulcers, which has higher accuracy than traditional first-order curative effect prediction model.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fuzzy cluster analysis of therapeutic effects of electro-acupuncture at different parameters

Le KUAI / Hua-yuan YANG

Journal of Integrative Medicine (JIM), Vol 7, Iss 5, Pp 478-

2009 Volume 481

Abstract: Objective: To probe into the application of fuzzy cluster in analysis of therapeutic effects of electro-acupuncture at different parameters on adjuvant-induced arthritis (AA) in rats.Methods: One hundred Wistar rats were randomly divided into ten groups: ...

Abstract	Objective: To probe into the application of fuzzy cluster in analysis of therapeutic effects of electro-acupuncture at different parameters on adjuvant-induced arthritis (AA) in rats.Methods: One hundred Wistar rats were randomly divided into ten groups: normal control group, untreated group and eight electro-acupuncture groups at different parameters. There were ten rats in each group. AA rats were treated by electro-acupuncture at different frequencies (2 Hz or 100 Hz), waveforms (successive wave or intermittent wave) and current intensities (0.1 mA or 0.2 mA). Firstly, the anti-inflammatory and analgesic effects of electro-acupuncture at different parameters were compared with orthogonal experiment, and then with the application of fuzzy mathematics, the data of joint swelling, pain threshold and the contents of β-endorphin (β-EP) and interleukin-1β (IL-1β) after the treatment in all groups were standardized by the method of data range normalization. Programming and solution were done by MATLAB. The methods of fuzzy similar matrix and the transitive closure were used in similarity evaluation of therapeutic effects of electro-acupuncture at different parameters.Results: Based on index determination and variance analysis, both the normal control group and untreated group were clustered to one category as λ equaled to 0.72. Electro-acupuncture at 100 Hz, successive wave, 0.2 mA, electro-acupuncture at 100 Hz, intermittent wave, 0.1 mA and electro-acupuncture at 100 Hz, intermittent wave, 0.2 mA were clustered to one category and had similar good anti-inflammatory and analgesic effects. The therapeutic effects of the remaining electro-acupuncture types were similar.Conclusion: Fuzzy cluster analysis provides a better method for evaluating the overall therapeutic effects of electro-acupuncture with multiple factors.
Keywords	fuzzy mathematics ; cluster analysis ; electroacupuncture ; treatment outcome ; rats ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	630
Language	English
Publishing date	2009-05-01T00:00:00Z
Publisher	Journal of Chinese Integrative Medicine Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells

Shubhranshu S. Gupta / Robert Sharp / Colby Hofferek / Le Kuai / Gerald W. Dorn, II / Jin Wang / Min Chen

Cell Reports, Vol 29, Iss 7, Pp 1862-1877.e

2019 Volume 7

Abstract: Summary: Autophagy plays a critical role in the maintenance of immunological memory. However, the molecular mechanisms involved in autophagy-regulated effector memory formation in CD8+ T cells remain unclear. Here we show that deficiency in NIX-dependent ...

Abstract	Summary: Autophagy plays a critical role in the maintenance of immunological memory. However, the molecular mechanisms involved in autophagy-regulated effector memory formation in CD8+ T cells remain unclear. Here we show that deficiency in NIX-dependent mitophagy leads to metabolic defects in effector memory T cells. Deletion of NIX caused HIF1α accumulation and altered cellular metabolism from long-chain fatty acid to short/branched-chain fatty acid oxidation, thereby compromising ATP synthesis during effector memory formation. Preventing HIF1α accumulation restored long-chain fatty acid metabolism and effector memory formation in antigen-specific CD8+ T cells. Our study suggests that NIX-mediated mitophagy is critical for effector memory formation in T cells. : Gupta et al. demonstrate that mitophagy mediated by NIX, a mitochondrial outer membrane protein, plays a critical role in CD8+ T cell effector memory formation by regulating mitochondrial superoxide-dependent HIF1α protein accumulation and fatty acid metabolism. These findings elucidate the molecular mechanisms regulating T cell effector memory formation against viruses. Keywords: NIX, mitophagy, autophagy, CD8+ T cells, effector memory cells, HIF1α, fatty acid metabolism, long-chain fatty acid oxidation, short/branched-chain fatty acid oxidation, mitochondrial superoxide
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quyu Shengji Formula Facilitates Diabetic Wound Healing via Inhibiting the Expression of Prostaglandin Transporter

Yi Lu / Xiaojie Ding / Fei Qi / Yi Ru / Le Kuai / Siting Chen / Yingyao Yang / Xin Li / Fulun Li / Bin Li / Mi Zhou / Kan Ze

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: Background. Quyu Shengji Formula (QSF), a Chinese medicine formula widely used in the clinic, has proven therapeutic effects on diabetic ulcers. Nevertheless, the potential mechanism of how QSF cures diabetic ulcer remains elusive. Objective. To assess ... ...

Abstract	Background. Quyu Shengji Formula (QSF), a Chinese medicine formula widely used in the clinic, has proven therapeutic effects on diabetic ulcers. Nevertheless, the potential mechanism of how QSF cures diabetic ulcer remains elusive. Objective. To assess the mechanism of QSF against wound healing defects in diabetes. Methods. Db/db mice were adopted to determine the therapeutic potential of QSF. Further histology analysis was performed by hematoxylin and eosin (H&E) staining. Moreover, the expression patterns of prostaglandin transporter (PGT), prostaglandin E2 (PGE2), and angiogenesis factor vascular endothelial growth factor (VEGF) were evaluated by immunostaining (IHC) analysis, ELISA assay, real-time quantitative polymerase chain reaction (RT-qPCR), and western blot analysis in vivo. Human dermal microvascular endothelial cells (HDMECs) and the shRNA interference technique were used to explore the effects of QSF on cell migration, PGT, PGE2, and angiogenesis factor VEGF in vitro. Results. Applied QSF on the wound of db/db mice significantly accelerated wound closure. Reductions of PGT and elevations of PGE2 and increased angiogenesis factor VEGF levels were shown after QSF treatment in vivo and in vitro. Furthermore, QSF promoted HDMEC migration. Inhibition of the expression of PGT by shRNA reversed phenotypes of QSF treatment in vitro. Conclusion. Taken together, our findings reveal that QSF ameliorates diabetes-associated wound healing defects by abolishing the expression of PGT.
Keywords	Other systems of medicine ; RZ201-999
Subject code	616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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