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  1. Article ; Online: A typical babesiosis in an immunocompetent patient.

    Voisin, Olivier / Monpierre, Lorra / Le Lorc'h, Erwan / Pilmis, Benoit / Le Monnier, Alban / Mourad, Jean-Jacques / Senghor, Yaye / Mizrahi, Assaf

    Annales de biologie clinique

    2021  Volume 79, Issue 5, Page(s) 456–459

    Abstract: Babesiosis is a tick-borne infectious disease, caused by an intraerythrocytic parasite of the genus Babesia. It has clinical, biological and microbiological similarities with Plasmodium related infections. In rare cases, babesiosis may be complicated by ... ...

    Abstract Babesiosis is a tick-borne infectious disease, caused by an intraerythrocytic parasite of the genus Babesia. It has clinical, biological and microbiological similarities with Plasmodium related infections. In rare cases, babesiosis may be complicated by hemophagocytic lymphohistiocytosis, which occurs preferentially in the immunodeficient patient. We report here the case of a non-immunocompromised patient living in Manhattan, New York hospitalized for a complicated babesiosis of a hemophagocytic lymphohistiocytosis. After 7 days of hospitalization and treatment by azithromycin 500 mg/day and atovaquone 750 mg twice a day, the patient was discharged with an improvement in clinical symptoms and biological parameters.
    MeSH term(s) Atovaquone/therapeutic use ; Azithromycin/therapeutic use ; Babesia ; Babesiosis/complications ; Babesiosis/diagnosis ; Babesiosis/drug therapy ; Humans
    Chemical Substances Azithromycin (83905-01-5) ; Atovaquone (Y883P1Z2LT)
    Language English
    Publishing date 2021-10-13
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 418098-7
    ISSN 1950-6112 ; 0003-3898
    ISSN (online) 1950-6112
    ISSN 0003-3898
    DOI 10.1684/abc.2021.1675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: No significant difference between ceftriaxone and cefotaxime in the emergence of antibiotic resistance in the gut microbiota of hospitalized patients: A pilot study.

    Pilmis, Benoît / Jiang, Olivier / Mizrahi, Assaf / Nguyen Van, Jean-Claude / Lourtet-Hascoët, Julie / Voisin, Olivier / Le Lorc'h, Erwan / Hubert, Sidonie / Ménage, Elodie / Azria, Philippe / Borie, Marie-Françoise / Mahé, Annabelle / Mourad, Jean-Jacques / Trabattoni, Eloïse / Ganansia, Olivier / Zahar, Jean-Ralph / Le Monnier, Alban

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2021  Volume 104, Page(s) 617–623

    Abstract: Background: Ceftriaxone and cefotaxime share a similar antibacterial spectrum and similar indications but have different pharmacokinetic characteristics. Ceftriaxone is administered once daily and 40% of its clearance is by biliary elimination, whereas ... ...

    Abstract Background: Ceftriaxone and cefotaxime share a similar antibacterial spectrum and similar indications but have different pharmacokinetic characteristics. Ceftriaxone is administered once daily and 40% of its clearance is by biliary elimination, whereas cefotaxime requires three administrations per day and shows less than 10% biliary elimination. The high biliary elimination of ceftriaxone suggests a greater impact of this antibiotic on the gut microbiota than cefotaxime. The objective of this study was to compare the impact of ceftriaxone and cefotaxime on the gut microbiota.
    Methods: A prospective clinical trial was performed that included 55 patients treated with intravenous ceftriaxone (1 g/24 h) or cefotaxime (1 g/8 h) for at least 3 days. Three fresh stool samples were collected from each patient (days 0, 3, and 7 or at the end of intravenous treatment) to assess the emergence of third-generation cephalosporin (3GC)-resistant Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae, Pseudomonas aeruginosa, toxigenic Clostridioides difficile, and vancomycin-resistant enterococci.
    Results: The emergence of 3GC-resistant gram-negative enteric bacilli (Enterobacteriaceae) (5.9% vs 4.7%, p > 0.99), Enterococcus spp, and non-commensal microorganisms did not differ significantly between the groups. Both antibiotics reduced the counts of total gram-negative enteric bacilli and decreased the cultivable diversity of the microbiota, but the differences between the groups were not significant.
    Conclusion: No significant difference was observed between ceftriaxone and cefotaxime in terms of the emergence of resistance.
    MeSH term(s) Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Cefotaxime/therapeutic use ; Ceftriaxone/therapeutic use ; Drug Resistance, Bacterial ; Feces/microbiology ; Female ; Gastrointestinal Microbiome/drug effects ; Gram-Negative Bacteria/drug effects ; Hospitalization ; Humans ; Male ; Microbial Sensitivity Tests ; Pilot Projects ; Prospective Studies
    Chemical Substances Anti-Bacterial Agents ; Ceftriaxone (75J73V1629) ; Cefotaxime (N2GI8B1GK7)
    Language English
    Publishing date 2021-01-13
    Publishing country Canada
    Document type Clinical Trial ; Comparative Study ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.01.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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