LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 64

Search options

  1. Article ; Online: Serum ceramides could predict durable diabetes remission following gastric bypass surgery.

    Hajduch, Eric / Le Stunff, Hervé

    Med (New York, N.Y.)

    2022  Volume 3, Issue 7, Page(s) 440–441

    Abstract: Morbid obesity is a major risk factor for the development of type 2 diabetes (T2D). One strategy to both lose weight and counteract T2D is bariatric surgery (RYGB). In a study published in this issue of Med, Poss et al. revealed that circulating ... ...

    Abstract Morbid obesity is a major risk factor for the development of type 2 diabetes (T2D). One strategy to both lose weight and counteract T2D is bariatric surgery (RYGB). In a study published in this issue of Med, Poss et al. revealed that circulating ceramides could predict the durability of T2D remission independently of weight loss following RYGB.
    MeSH term(s) Ceramides ; Diabetes Mellitus, Type 2/surgery ; Gastric Bypass ; Humans ; Obesity, Morbid/complications ; Weight Loss
    Chemical Substances Ceramides
    Language English
    Publishing date 2022-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2022.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Role of hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders.

    Magnan, Christophe / Le Stunff, Hervé

    Molecular metabolism

    2021  Volume 53, Page(s) 101298

    Abstract: Background: Sphingolipid-mediated signalling pathways are described as important players in the normal functioning of neurons and nonneuronal cells in the central nervous system (CNS).: Scope of review: This review aims to show role of de novo ... ...

    Abstract Background: Sphingolipid-mediated signalling pathways are described as important players in the normal functioning of neurons and nonneuronal cells in the central nervous system (CNS).
    Scope of review: This review aims to show role of de novo ceramide synthesis in the CNS in controling key physiological processes, including food intake, energy expenditure, and thermogenesis. The corollary is a condition that leads to a dysfunction in ceramide metabolism in these central regions that can have major consequences on the physiological regulation of energy balance.
    Major conclusions: Excessive hypothalamic de novo ceramide synthesis has been shown to result in the establishment of central insulin resistance, endoplasmic reticulum stress, and inflammation. Additionally, excessive hypothalamic de novo ceramide synthesis has also been associated with changes in the activity of the autonomic nervous system. Such dysregulation of hypothalamic de novo ceramide synthesis forms the key starting point for the initiation of pathophysiological conditions such as obesity - which may or may not be associated with type 2 diabetes.
    MeSH term(s) Animals ; Ceramides/biosynthesis ; Ceramides/chemistry ; Humans ; Hypothalamus/chemistry ; Hypothalamus/metabolism ; Metabolic Diseases/metabolism ; Obesity/metabolism
    Chemical Substances Ceramides
    Language English
    Publishing date 2021-07-15
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2708735-9
    ISSN 2212-8778 ; 2212-8778
    ISSN (online) 2212-8778
    ISSN 2212-8778
    DOI 10.1016/j.molmet.2021.101298
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Editorial: The Role of Sphingolipid Metabolism in the Development of Type 2 Diabetes and Obesity.

    Blachnio-Zabielska, Agnieszka / Hajduch, Eric / Le Stunff, Hervé

    Frontiers in endocrinology

    2022  Volume 12, Page(s) 835751

    Language English
    Publishing date 2022-01-07
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Introductory Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2021.835751
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: La synthèse des céramides C18:0 par les muscles squelettiques, à l’origine de l’insulino-résistance induite par l’obésité ?

    Pineau, Ana-Magdalena / Vessely, Romain / Le Stunff, Hervé

    Medecine sciences : M/S

    2021  Volume 37, Issue 1, Page(s) 100–102

    Title translation Is obesity-induced insulin resistance mediated by ceramide C18:0 synthesis de novo in skeletal muscles.
    MeSH term(s) Animals ; Blood Glucose/metabolism ; Ceramides/biosynthesis ; Energy Metabolism ; Glucose Tolerance Test ; Insulin Resistance ; Male ; Muscle, Skeletal/metabolism ; Obesity/metabolism ; Sphingosine N-Acyltransferase/biosynthesis
    Chemical Substances Blood Glucose ; Ceramides ; Sphingosine N-Acyltransferase (EC 2.3.1.24)
    Language French
    Publishing date 2021-01-25
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2020264
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Role of Sphingosine Kinase 1 in Glucolipotoxicity-Induced Early Activation of Autophagy in INS-1 Pancreatic β Cells.

    Coant, Nicolas / Rendja, Karima / Bellini, Lara / Flamment, Mélissa / Lherminier, Jeannine / Portha, Bernard / Codogno, Patrice / Le Stunff, Hervé

    Cells

    2024  Volume 13, Issue 7

    Abstract: Insulin-producing pancreatic β cells play a crucial role in the regulation of glucose homeostasis, and their failure is a key event for diabetes development. Prolonged exposure to palmitate in the presence of elevated glucose levels, termed gluco- ... ...

    Abstract Insulin-producing pancreatic β cells play a crucial role in the regulation of glucose homeostasis, and their failure is a key event for diabetes development. Prolonged exposure to palmitate in the presence of elevated glucose levels, termed gluco-lipotoxicity, is known to induce β cell apoptosis. Autophagy has been proposed to be regulated by gluco-lipotoxicity in order to favor β cell survival. However, the role of palmitate metabolism in gluco-lipotoxcity-induced autophagy is presently unknown. We therefore treated INS-1 cells for 6 and 24 h with palmitate in the presence of low and high glucose concentrations and then monitored autophagy. Gluco-lipotoxicity induces accumulation of LC3-II levels in INS-1 at 6 h which returns to basal levels at 24 h. Using the RFP-GFP-LC3 probe, gluco-lipotoxicity increased both autophagosomes and autolysosmes structures, reflecting early stimulation of an autophagy flux. Triacsin C, a potent inhibitor of the long fatty acid acetyl-coA synthase, completely prevents LC3-II formation and recruitment to autophagosomes, suggesting that autophagic response requires palmitate metabolism. In contrast, etomoxir and bromo-palmitate, inhibitors of fatty acid mitochondrial β-oxidation, are unable to prevent gluco-lipotoxicity-induced LC3-II accumulation and recruitment to autophagosomes. Moreover, bromo-palmitate and etomoxir potentiate palmitate autophagic response. Even if gluco-lipotoxicity raised ceramide levels in INS-1 cells, ceramide synthase 4 overexpression does not potentiate LC3-II accumulation. Gluco-lipotoxicity also still stimulates an autophagic flux in the presence of an ER stress repressor. Finally, selective inhibition of sphingosine kinase 1 (SphK1) activity precludes gluco-lipotoxicity to induce LC3-II accumulation. Moreover, SphK1 overexpression potentiates autophagic flux induced by gluco-lipotxicity. Altogether, our results indicate that early activation of autophagy by gluco-lipotoxicity is mediated by SphK1, which plays a protective role in β cells.
    MeSH term(s) Autophagy ; Epoxy Compounds ; Glucose/metabolism ; Insulin-Secreting Cells/metabolism ; Palmitates/metabolism ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Cell Line ; Animals ; Rats
    Chemical Substances Epoxy Compounds ; etomoxir (MSB3DD2XP6) ; Glucose (IY9XDZ35W2) ; Palmitates ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; sphingosine kinase (EC 2.7.1.-)
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13070636
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Circulating Sphingolipids and Glucose Homeostasis: An Update.

    Ali-Berrada, Sarah / Guitton, Jeanne / Tan-Chen, Sophie / Gyulkhandanyan, Anna / Hajduch, Eric / Le Stunff, Hervé

    International journal of molecular sciences

    2023  Volume 24, Issue 16

    Abstract: Sphingolipids are a family of lipid molecules produced through different pathways in mammals. Sphingolipids are structural components of membranes, but in response to obesity, they are implicated in the regulation of various cellular processes, including ...

    Abstract Sphingolipids are a family of lipid molecules produced through different pathways in mammals. Sphingolipids are structural components of membranes, but in response to obesity, they are implicated in the regulation of various cellular processes, including inflammation, apoptosis, cell proliferation, autophagy, and insulin resistance which favors dysregulation of glucose metabolism. Of all sphingolipids, two species, ceramides and sphingosine-1-phosphate (S1P), are also found abundantly secreted into the bloodstream and associated with lipoproteins or extracellular vesicles. Plasma concentrations of these sphingolipids can be altered upon metabolic disorders and could serve as predictive biomarkers of these diseases. Recent important advances suggest that circulating sphingolipids not only serve as biomarkers but could also serve as mediators in the dysregulation of glucose homeostasis. In this review, advances of molecular mechanisms involved in the regulation of ceramides and S1P association to lipoproteins or extracellular vesicles and how they could alter glucose metabolism are discussed.
    MeSH term(s) Animals ; Sphingolipids ; Ceramides ; Homeostasis ; Glucose ; Mammals
    Chemical Substances Sphingolipids ; Ceramides ; sphingosine 1-phosphate (26993-30-6) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-08-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241612720
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Fish oil minimises feed intake and improves insulin sensitivity in Zucker fa/fa rats.

    Corporeau, Charlotte / Le Foll, Christelle / Cruciani-Guglielmacci, Céline / Le Stunff, Hervé / Mithieux, Gilles / Magnan, Christophe / Delarue, Jacques

    The British journal of nutrition

    2023  Volume 131, Issue 5, Page(s) 749–761

    Abstract: ... Long- ... ...

    Abstract Long-chain
    MeSH term(s) Humans ; Male ; Rats ; Animals ; Insulin Resistance/physiology ; Fish Oils/pharmacology ; Rats, Zucker ; Blood Glucose/metabolism ; Insulin/metabolism ; Obesity/metabolism ; Glucose/pharmacology ; Eating ; Weight Gain ; Fatty Acids, Unsaturated/pharmacology ; Corn Oil/pharmacology ; Fatty Acids, Omega-3/pharmacology
    Chemical Substances Fish Oils ; Blood Glucose ; Insulin ; Glucose (IY9XDZ35W2) ; Fatty Acids, Unsaturated ; Corn Oil (8001-30-7) ; Fatty Acids, Omega-3
    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1017/S0007114523002404
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Régulation du métabolisme lipidique par les hormones thyroïdiennes - Rôle de l’hypothalamus.

    Hottin, Catherine / Simoneau, Bastien / Le Stunff, Hervé

    Medecine sciences : M/S

    2019  Volume 35, Issue 3, Page(s) 271–274

    Title translation Regulation of lipid metabolism by thyroid hormones: role of hypothalamus.
    MeSH term(s) Adenylate Kinase/metabolism ; Adipose Tissue, Brown/physiology ; Animals ; Humans ; Hypothalamus/drug effects ; Hypothalamus/metabolism ; Hypothalamus/physiology ; Lipid Metabolism/drug effects ; Thyroid Hormones/pharmacology
    Chemical Substances Thyroid Hormones ; Adenylate Kinase (EC 2.7.4.3)
    Language French
    Publishing date 2019-04-01
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2019045
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: La sphingosine kinase 1 : rôle dans la stéatose hépatique.

    Pruvost, Roxane / Le Stunff, Hervé

    Medecine sciences : M/S

    2016  Volume 32, Issue 8-9, Page(s) 716–718

    Title translation Sphingosine kinase-1: role in non alcoholic fatty liver disease.
    MeSH term(s) Animals ; Hepatocytes/metabolism ; Humans ; Liver/metabolism ; Lysophospholipids/metabolism ; Mice ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/genetics ; PPAR gamma/physiology ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Phosphotransferases (Alcohol Group Acceptor)/physiology ; Signal Transduction/genetics ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism
    Chemical Substances Lysophospholipids ; PPAR gamma ; sphingosine 1-phosphate (26993-30-6) ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; sphingosine kinase (EC 2.7.1.-) ; Sphingosine (NGZ37HRE42)
    Language French
    Publishing date 2016
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/20163208018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Identification of the Interactions Interference Between the PH and START Domain of CERT by Limonoid and HPA Inhibitors.

    Ghoula, Mariem / Le Marec, Axelle / Magnan, Christophe / Le Stunff, Hervé / Taboureau, Olivier

    Frontiers in molecular biosciences

    2020  Volume 7, Page(s) 603983

    Abstract: The multi domain ceramide transfer protein (CERT) which contains the domains START and PH, is a protein that allows the transport of ceramide from the endoplasmic reticulum to the Golgi and so it plays a major role in sphingolipid metabolism. Recently, ... ...

    Abstract The multi domain ceramide transfer protein (CERT) which contains the domains START and PH, is a protein that allows the transport of ceramide from the endoplasmic reticulum to the Golgi and so it plays a major role in sphingolipid metabolism. Recently, the crystal structure of the PH-START complex has been released, suggesting an inhibitory action of START to the binding of the PH domain to the Golgi apparatus and thus limiting the CERT activity. Our study presents a combination of docking and molecular dynamic simulations of N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)alkanamides (HPA) analogs and limonoids compounds known to inhibit CERT. Through our computational study, we compared the binding affinity of 14 ligands at both domains (START and PH) and also at the START-PH interface, including several mutations known to play a role in the CERT's activity. At the difference of HPA compounds, limonoids have a stronger binding affinity for the START-PH interface. Furthermore, 2 inhibitors (HPA-12 and isogedunin) were investigated through molecular dynamic (MD) simulations. 50 ns of molecular dynamic simulations have displayed the stability of isogedunin as well as keys residues in the binding of this molecule at the interface of the PH-START complex. Therefore, this study suggests a novel inhibitory mechanism of CERT for limonoid compounds involving the stabilization of the START-PH interface. This could help to develop new and potentially more selective inhibitors of this transporter, which is a potent target in cancer therapy.
    Language English
    Publishing date 2020-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2020.603983
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top