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  1. Article ; Online: Overview of the current situation of embryo donation in Belgian fertility centers.

    Puga-Leal, Rita / Pennings, Guido / Tournaye, Herman

    European journal of obstetrics, gynecology, and reproductive biology

    2024  Volume 296, Page(s) 227–232

    Abstract: Objectives: The aim of this study is to survey the current situation in Belgium regarding embryo donation (ED) practices and to explore the potential reasons for not offering this treatment option.: Study design: A questionnaire was sent to all ... ...

    Abstract Objectives: The aim of this study is to survey the current situation in Belgium regarding embryo donation (ED) practices and to explore the potential reasons for not offering this treatment option.
    Study design: A questionnaire was sent to all fertility centers in Belgium that are allowed to perform IVF regarding whether or not they perform ED for third parties, their overall experience with ED and the possible reasons for not doing it. The questionnaire was divided into three different sections, depending on whether the center currently performs ED for third parties, has never performed it or once performed it but no longer does. All respondents were anonymized.
    Results: The questionnaire was returned by 16 out of 18 centers. Only three out of 16 centers currently perform ED. All these centers require additional actions before ED can be performed. Sometimes ED is not performed although it was indicated in the contract; the most important reasons are the need for additional investigations, the administrative obstacles and the non-eligibility of the embryos. Between 2017 and 2021, few ED were performed in these centers (n = 2, 38 and 6). Eight out of 16 centers previously offered ED but ceased. In two centers, patients who want to donate their supernumerary embryos are referred for treatment to a center where ED is performed, but none of these centers transfer embryos to a center performing ED. The main reasons for discontinuing ED were the additional investigations required and the unprofitable investment in time and personnel. Five out of 16 centers never offered ED. At one center, patients who still indicate ED for their supernumerary embryos are referred to a center performing ED. The reduction of the administrative burden and avoiding additional testing are the most indicated measures that could facilitate the introduction of an ED program.
    Conclusions: Embryo donation, although legally allowed, is currently hardly performed in Belgium. The reasons for this are mainly associated to additional mandatory post-hoc testing and the extra administrative burden which is not financially covered. Poor transparency and communication between Belgian centers may be an additional factor explaining the country's low embryo donation rate.
    MeSH term(s) Humans ; Embryo Disposition ; Belgium ; Embryo Research ; Fertilization in Vitro ; Surveys and Questionnaires
    Language English
    Publishing date 2024-03-03
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2024.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Role of Emergent Processing Technologies in Beer Production

    Carvalho, Gonçalo / Leite, Ana Catarina / Leal, Rita / Pereira, Ricardo

    Beverages. 2023 Jan. 16, v. 9, no. 1

    2023  

    Abstract: The brewing industry is regarded as a fiercely competitive and insatiable sector of activity, driven by the significant technological improvements observed in recent years and the most recent consumer trends pointing to a sharp demand for sensory ... ...

    Abstract The brewing industry is regarded as a fiercely competitive and insatiable sector of activity, driven by the significant technological improvements observed in recent years and the most recent consumer trends pointing to a sharp demand for sensory enhanced beers. Some emergent and sustainable technologies regarding food processing such as pulsed electric fields (PEF), ultrasound (US), thermosonication (TS), high-pressure processing (HPP), and ohmic heating (OH) have shown the potential to contribute to the development of currently employed brewing methodologies by both enhancing the quality of beer and contributing to processing efficiency with a promise of being more environmentally friendly. Some of these technologies have not yet found their way into the industrial brewing process but already show potential to be embedded in continuous thermal and non-thermal unit operations such as pasteurization, boiling and sterilization, resulting in beer with improved organoleptic properties. This review article aims to explore the potential of different advanced processing technologies for industrial application in several key stages of brewing, with particular emphasis on continuous beer production.
    Keywords beers ; industrial applications ; ohmic heating ; pasteurization ; sonication ; ultrasonics
    Language English
    Dates of publication 2023-0116
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2785444-9
    ISSN 2306-5710
    ISSN 2306-5710
    DOI 10.3390/beverages9010007
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Charcot-Marie-Tooth disease: from historical landmarks in Brazil to current care perspectives.

    Cavalcanti, Eduardo Boiteux Uchôa / Leal, Rita de Cássia Carvalho / Marques Junior, Wilson / Nascimento, Osvaldo José Moreira do

    Arquivos de neuro-psiquiatria

    2023  Volume 81, Issue 10, Page(s) 913–921

    Abstract: Hereditary motor and sensory neuropathy, also known as Charcot-Marie-Tooth disease (CMT), traditionally refers to a group of genetic disorders in which neuropathy is the main or sole feature. Its prevalence varies according to different populations ... ...

    Title translation Doença de Charcot-Marie-Tooth: dos marcos históricos no Brasil até as perspectivas atuais de cuidado.
    Abstract Hereditary motor and sensory neuropathy, also known as Charcot-Marie-Tooth disease (CMT), traditionally refers to a group of genetic disorders in which neuropathy is the main or sole feature. Its prevalence varies according to different populations studied, with an estimate between 1:2,500 to 1:10,000. Since the identification of
    MeSH term(s) Humans ; Charcot-Marie-Tooth Disease/genetics ; Charcot-Marie-Tooth Disease/therapy ; Brazil ; Hereditary Sensory and Motor Neuropathy
    Language English
    Publishing date 2023-08-23
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1055/s-0043-1770348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Electrical Fields in the Processing of Protein-Based Foods.

    Pereira, Ricardo N / Rodrigues, Rui / Avelar, Zita / Leite, Ana Catarina / Leal, Rita / Pereira, Ricardo S / Vicente, António

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: Electric field-based technologies offer interesting perspectives which include controlled heat dissipation (via the ohmic heating effect) and the influence of electrical variables (e.g., electroporation). These factors collectively provide an opportunity ...

    Abstract Electric field-based technologies offer interesting perspectives which include controlled heat dissipation (via the ohmic heating effect) and the influence of electrical variables (e.g., electroporation). These factors collectively provide an opportunity to modify the functional and technological properties of numerous food proteins, including ones from emergent plant- and microbial-based sources. Currently, numerous scientific studies are underway, contributing to the emerging body of knowledge about the effects on protein properties. In this review, "Electric Field Processing" acknowledges the broader range of technologies that fall under the umbrella of using the direct passage of electrical current in food material, giving particular focus to the ones that are industrially implemented. The structural and biological effects of electric field processing (thermal and non-thermal) on protein fractions from various sources will be addressed. For a more comprehensive contextualization of the significance of these effects, both conventional and alternative protein sources, along with their respective ingredients, will be introduced initially.
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13040577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Strategies to Overcome HLA Sensitization and Improve Access to Retransplantation after Kidney Graft Loss.

    Leal, Rita / Pardinhas, Clara / Martinho, António / Sá, Helena Oliveira / Figueiredo, Arnaldo / Alves, Rui

    Journal of clinical medicine

    2022  Volume 11, Issue 19

    Abstract: An increasing number of patients waitlisted for kidney transplantation have a previously failed graft. Retransplantation provides a significant improvement in morbidity, mortality, and quality of life when compared to dialysis. However, HLA sensitization ...

    Abstract An increasing number of patients waitlisted for kidney transplantation have a previously failed graft. Retransplantation provides a significant improvement in morbidity, mortality, and quality of life when compared to dialysis. However, HLA sensitization is a major barrier to kidney retransplantation and the majority of the highly sensitized patients are waiting for a subsequent kidney transplant. A multidisciplinary team that includes immunogeneticists, transplant nephrologists and surgeons, and adequate allocation policies is fundamental to increase access to a kidney retransplant. A review of Pubmed, ScienceDirect, and the Cochrane Library was performed on the challenges of kidney retransplantation after graft loss, focusing on the HLA barrier and new strategies to overcome sensitization. Conclusion: Technical advances in immunogenetics, new desensitization protocols, and complex allocation programs have emerged in recent years to provide a new hope to kidney recipients with a previously failed graft.
    Language English
    Publishing date 2022-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11195753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Challenges in the Management of the Patient with a Failing Kidney Graft: A Narrative Review.

    Leal, Rita / Pardinhas, Clara / Martinho, António / Sá, Helena Oliveira / Figueiredo, Arnaldo / Alves, Rui

    Journal of clinical medicine

    2022  Volume 11, Issue 20

    Abstract: Patients with a failed kidney allograft have steadily increase in recent years and returning to dialysis after graft loss is one of the most difficult transitions for chronic kidney disease patients and their assistant physicians. The management of these ...

    Abstract Patients with a failed kidney allograft have steadily increase in recent years and returning to dialysis after graft loss is one of the most difficult transitions for chronic kidney disease patients and their assistant physicians. The management of these patients is complex and encompasses the treatment of chronic kidney disease complications, dialysis restart and access planning, immunosuppression withdrawal, graft nephrectomy, and evaluation for a potential retransplant. In recent years, several groups have focused on the management of the patient with a failing renal graft and expert recommendations are arising. A review of Pubmed, ScienceDirect and the Cochrane Library was performed focusing on the specific care of these patients, from the management of low clearance complications to concerns with a subsequent kidney transplant. Conclusion: There is a growing interest in the failing renal graft and new approaches to improve these patients' outcomes are being defined including specific multidisciplinary programs, individualized immunosuppression withdrawal schemes, and strategies to prevent HLA sensitization and increase retransplant rates.
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11206108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dual Kidney Transplantation: Single-Center Experience.

    Duarte, Rui / Castro, Pedro / Leal, Rita / Marques, Maria Guedes / Rodrigues, Luís / Santos, Lídia / Romãozinho, Catarina / Alves, Rui / Figueiredo, Arnaldo

    Transplantation proceedings

    2023  Volume 55, Issue 6, Page(s) 1390–1395

    Abstract: Background: Dual and en bloc kidney transplantation are strategies used to mitigate the disparity between a reduced organ pool and an ever-increasing need for organ procurement. En bloc refers to the implantation of 2 kidneys from a pediatric donor, ... ...

    Abstract Background: Dual and en bloc kidney transplantation are strategies used to mitigate the disparity between a reduced organ pool and an ever-increasing need for organ procurement. En bloc refers to the implantation of 2 kidneys from a pediatric donor, compensating for small renal mass, whereas dual expanded criteria donor (DECD) transplantation refers to older donors with grafts otherwise rejected for single transplant, including expanded. This study describes one center's experience with dual and en bloc transplantation.
    Methods: A retrospective cohort study of dual kidney transplants (en bloc and DECD) from 1990 through 2021. The analysis included demographic, clinical, and survival analysis.
    Results: Of 46 patients who underwent dual kidney transplantation, 17 (37 %) received en-bloc transplantation. The overall mean recipient age was 49.4 ± 13.9 years old, younger in the en-bloc subgroup (39.2 vs 59.8 years old, P < .01). The mean time on dialysis was 37 ± 25 months. Delayed graft function was present in 17.4 % and primary nonfunction in 6.4 %, all from the DECD group. The estimated glomerular filtration rates at 1 and 5 years were 76.7 ± 28.7 and 80.4 ± 24.8 mL/min/1.73 m
    Conclusions: Both DECD and en bloc strategies provide safe and effective options to further expand the use of otherwise rejected kidneys. Neither of the 2 techniques was superior to the other.
    MeSH term(s) Humans ; Child ; Adult ; Middle Aged ; Kidney Transplantation/methods ; Retrospective Studies ; Renal Dialysis ; Kidney ; Tissue Donors ; Graft Survival ; Treatment Outcome ; Age Factors
    Chemical Substances diethylamine-N-carbodithioate
    Language English
    Publishing date 2023-07-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2023.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Factors Influencing Short-Term Patient Survival in Elderly Kidney Transplant Recipients.

    Silva, Rita M / Leal, Rita / Marques, Maria G / Rodrigues, Luís / Santos, Lídia / Romãozinho, Catarina / Alves, Rui / Figueiredo, Arnaldo

    Transplantation proceedings

    2023  Volume 55, Issue 6, Page(s) 1400–1403

    Abstract: Background: For the average patient with end-stage renal disease, kidney transplantation improves quality of life and prolongs survival compared with patients on the transplant waiting list who remain on dialysis. Patients ≥65 years of age represent an ... ...

    Abstract Background: For the average patient with end-stage renal disease, kidney transplantation improves quality of life and prolongs survival compared with patients on the transplant waiting list who remain on dialysis. Patients ≥65 years of age represent an increasing proportion of adults with end-stage renal disease, and kidney transplantation outcomes remain controversial in this population. The aim of this study was to evaluate factors that may increase 1-year mortality after renal transplantation in older recipients.
    Methods: A retrospective study that included 147 patients (75.5% men) ≥65 years old (mean age 67.5 ± 2 years) who were transplanted between January 2011 and December 2020. The mean follow-up was 52.6 ± 27.2 months.
    Results: Rehospitalization (<1 year) occurred in 39.5% of patients. Infectious complications were present in 18.4% of patients. The overall mortality rate was 23.1%, and 1-year mortality was 6.8%. As 1-year mortality predictors, we found a positive correlation with factors related to kidney transplant, such as cold ischemia time (P = .003), increasing donor age (P = .001); and factors related to the receptor such as pretransplantation dialysis modality as peritoneal dialysis (P = .04), cardiovascular disease (P = .004), delayed graft function (P = .002), early cardiovascular complications after kidney transplant (P < .001), and early rehospitalizations (P < .001). No correlation was found between 1-year mortality and age, sex, race, body mass index, and type of kidney transplant.
    Conclusion: A more rigorous pretransplant evaluation, focusing on cardiovascular disease and strict exclusion criteria, is recommended for patients ≥65 years old.
    MeSH term(s) Adult ; Male ; Humans ; Aged ; Female ; Kidney Transplantation/adverse effects ; Renal Dialysis ; Retrospective Studies ; Cardiovascular Diseases/etiology ; Quality of Life ; Kidney Failure, Chronic/etiology ; Graft Survival
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2023.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Treatment of Recurrent Antineutrophil Cytoplasmic Antibody-Associated Vasculitis After Kidney Transplant With Rituximab: A Successful Case Report.

    Silva, Rita M / Leal, Rita / Marques, Maria G / Rodrigues, Luis / Santos, Lidia / Romaozinho, Catarina / Alves, Rui / Figueiredo, Arnaldo

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2023  Volume 21, Issue 2, Page(s) 171–174

    Abstract: Antineutrophil cytoplasm antibody-associated systemic vasculitis is a rare disease that frequently leads to end-stage renal disease. Kidney transplant should be delayed until patients are in complete clinical remission for at least 6 months, but the ... ...

    Abstract Antineutrophil cytoplasm antibody-associated systemic vasculitis is a rare disease that frequently leads to end-stage renal disease. Kidney transplant should be delayed until patients are in complete clinical remission for at least 6 months, but the persistence of antineutrophil cytoplasmic antibody titers should not delay transplant. Recurrence of disease after kidney transplant is rare, with only a few cases described in the literature with heterogenous clinical manifestations, therapeutic approaches, and prognosis. We describe the case of a young male patient with recurrent antineutrophil cytoplasmic antibody vasculitis, 5 years after kidney transplant, successfully treated with methylprednisolone pulses plus rituximab. Rituximab presents a new valid option for the treatment of antineutrophil cytoplasmic antibody vasculitis relapse in kidney grafts.
    MeSH term(s) Humans ; Male ; Rituximab/therapeutic use ; Antibodies, Antineutrophil Cytoplasmic/therapeutic use ; Kidney Transplantation/adverse effects ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Prognosis ; Recurrence
    Chemical Substances Rituximab (4F4X42SYQ6) ; Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2023-04-07
    Publishing country Turkey
    Document type Case Reports ; Journal Article
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.2023.0012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Renal Transplantation in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single-Center 10-Year Experience.

    Silva, Rita M / Leal, Rita / Marques, Maria G / Rodrigues, Luís / Santos, Lídia / Romãozinho, Catarina / Alves, Rui / Figueiredo, Arnaldo

    Transplantation proceedings

    2023  Volume 55, Issue 6, Page(s) 1396–1399

    Abstract: Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a common cause of rapidly progressive glomerulonephritis resulting in end-stage renal disease. The optimal timing of kidney transplantation for end-stage renal disease ...

    Abstract Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a common cause of rapidly progressive glomerulonephritis resulting in end-stage renal disease. The optimal timing of kidney transplantation for end-stage renal disease due to AAV and the risk of relapse after kidney are poorly defined. Our study aimed to evaluate the clinical outcomes of AAV after kidney transplantation, namely the risk of relapse, rejection, and oncologic disease.
    Methods: This retrospective study included all patients with AAV submitted to a kidney transplant between January 2011 and December 2020.
    Results: Twenty-seven patients (20 males/7 females; mean age 47 years) received a kidney transplant for end-stage renal disease secondary to microscopic polyangiitis (n = 25) or granulomatosis with polyangiitis (n = 2). All patients were in clinical remission at the time of the kidney transplant, but 11 patients were ANCA-positive. A vasculitis relapse after kidney transplantation occurred in only 1 patient (3.7%). Rejection episodes, proven by allograft biopsy, were present in 3 patients (11.1%), with graft losses in 2 (66.7%). The median time until the graft was lost after the initial rejection diagnosis was 27 ± 8 months. Oncologic complications were present in 9 patients (33.3%). Five patients died (18.5%), and the main cause of death was cardiovascular disease (n = 3, 60.0%), followed by oncologic disease (n = 2, 40.0%).
    Conclusions: Kidney transplantation is a safe and effective option for treating end-stage renal disease secondary to AAV. Current immunosuppression regimens make relapses and rejection infrequent but place oncologic complications at a higher incidence.
    MeSH term(s) Male ; Female ; Humans ; Middle Aged ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Antibodies, Antineutrophil Cytoplasmic ; Retrospective Studies ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/surgery ; Kidney Failure, Chronic/surgery ; Kidney Failure, Chronic/complications ; Recurrence
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2023.04.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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