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  1. Article ; Online: History of anaesthesia: Nurse anaesthesia practice in the G7 countries (Canada, France, Germany, Italy, Japan, the United Kingdom and the United States of America).

    Tenedios, Christina / O'Leary, Sian / Capocci, Mauro / Desai, Sukumar P

    European journal of anaesthesiology

    2018  Volume 35, Issue 3, Page(s) 158–164

    Abstract: Many factors determine whether nurses, physicians or both administer anaesthesia in any country. We examined the status of nurse-administered anaesthesia in the Group of Seven (G7) countries (Canada, France, Germany, Italy, Japan, the United Kingdom ... ...

    Abstract : Many factors determine whether nurses, physicians or both administer anaesthesia in any country. We examined the status of nurse-administered anaesthesia in the Group of Seven (G7) countries (Canada, France, Germany, Italy, Japan, the United Kingdom and the United States of America) and explored how historical factors, mixing global and local contexts (such as professional relations, medical and nursing education, social status of nurses, demographics and World Wars in the 20th century), help explain observed differences. Nearly equal numbers of physicians and nurses are currently engaged in the delivery of anaesthesia care in the United States but, remarkably, although the introduction or re-introduction of nurse anaesthesia in the 20th century was attempted in all the other G7 countries (except Japan), it has been successful only in France because of the cooperation with the United States during World War II.
    MeSH term(s) Anesthesia/economics ; Anesthesia/methods ; Anesthesia/trends ; Canada/epidemiology ; Delivery of Health Care/economics ; Delivery of Health Care/methods ; Delivery of Health Care/trends ; Education, Nursing/economics ; Education, Nursing/methods ; Education, Nursing/trends ; France/epidemiology ; Germany/epidemiology ; Health Care Costs/trends ; Humans ; Italy/epidemiology ; Japan/epidemiology ; Nurse Anesthetists/economics ; Nurse Anesthetists/education ; Nurse Anesthetists/trends ; United Kingdom/epidemiology ; United States/epidemiology ; World War I ; World War II
    Language English
    Publishing date 2018-03-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 605770-6
    ISSN 1365-2346 ; 0265-0215
    ISSN (online) 1365-2346
    ISSN 0265-0215
    DOI 10.1097/EJA.0000000000000774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Perioperative Code Status Discussions: How Are We Doing?

    O'Leary, Sian / Pimentel, Marc Philip / Ford, Shauna / Vacanti, Joshua C / Bleday, Ronald / Salmasian, Hojjat / Mendu, Mallika L

    A&A practice

    2021  Volume 15, Issue 6, Page(s) e01473

    Abstract: Approximately 15% of patients with a code status of do-not-resuscitate (DNR) or do-not-intubate (DNI) present for surgery. Despite professional guidelines requiring discussions with patients regarding perioperative resuscitation, it is unclear whether ... ...

    Abstract Approximately 15% of patients with a code status of do-not-resuscitate (DNR) or do-not-intubate (DNI) present for surgery. Despite professional guidelines requiring discussions with patients regarding perioperative resuscitation, it is unclear whether these recommendations are consistently followed. Our review of 158 patient encounters with established DNR/DNI code status found that code status discussions (CSDs) were documented only 70% of the time, and code status orders were inconsistently entered to reflect those discussions. We present solutions to improve CSD documentation, including refining perioperative workflows, simplifying code status choices, optimizing electronic health record order entry, and a supplementary consent form to facilitate code status review.
    MeSH term(s) Documentation ; Humans ; Resuscitation Orders
    Language English
    Publishing date 2021-05-26
    Publishing country United States
    Document type Journal Article
    ISSN 2575-3126
    ISSN (online) 2575-3126
    DOI 10.1213/XAA.0000000000001473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Typing myalgic encephalomyelitis by infection at onset: A DecodeME study.

    Bretherick, Andrew D / McGrath, Simon J / Devereux-Cooke, Andy / Leary, Sian / Northwood, Emma / Redshaw, Anna / Stacey, Pippa / Tripp, Claire / Wilson, Jim / Chowdhury, Sonya / Lewis, Isabel / Almelid, Øyvind / Baby, Sumy V / Baker, Tom / Becher, Hannes / Boutin, Thibaud / Clyde, Malgorzata / Garcia, Diana / Ireland, John /
    Kerr, Shona M / McDowall, Ewan / Perry, David / Samms, Gemma L / Vitart, Veronique / Wolfe, Jareth C / Ponting, Chris P

    NIHR open research

    2023  Volume 3, Page(s) 20

    Abstract: Background: People with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) experience core symptoms of post-exertional malaise, unrefreshing sleep, and cognitive impairment. Despite numbering 0.2-0.4% of the population, no laboratory test is ... ...

    Abstract Background: People with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) experience core symptoms of post-exertional malaise, unrefreshing sleep, and cognitive impairment. Despite numbering 0.2-0.4% of the population, no laboratory test is available for their diagnosis, no effective therapy exists for their treatment, and no scientific breakthrough regarding pathogenesis has been made. It remains unknown, despite decades of small-scale studies, whether individuals experience different types of ME/CFS separated by onset-type, sex or age.
    Methods: DecodeME is a large population-based study of ME/CFS that recruited 17,074 participants in the first 3 months following full launch. Detailed questionnaire responses from UK-based participants who all reported being diagnosed with ME/CFS by a health professional provided an unparalleled opportunity to investigate, using logistic regression, whether ME/CFS severity or onset type is significantly associated with sex, age, illness duration, comorbid conditions or symptoms.
    Results: The well-established sex-bias among ME/CFS patients is evident in the initial DecodeME cohort: 83.5% of participants were females. What was not known previously was that females tend to have more comorbidities than males. Moreover, being female, being older and being over 10 years from ME/CFS onset are significantly associated with greater severity. Five different ME/CFS onset types were examined in the self-reported data: those with ME/CFS onset (i) after glandular fever (infectious mononucleosis); (ii) after COVID-19 infection; (iii) after other infections; (iv) without an infection at onset; and, (v) where the occurrence of an infection at or preceding onset is not known. Among other findings, ME/CFS onset with unknown infection status was significantly associated with active fibromyalgia.
    Conclusions: DecodeME participants differ in symptoms, comorbid conditions and/or illness severity when stratified by their sex-at-birth and/or infection around the time of ME/CFS onset.
    Language English
    Publishing date 2023-08-21
    Publishing country England
    Document type Journal Article
    ISSN 2633-4402
    ISSN (online) 2633-4402
    DOI 10.3310/nihropenres.13421.4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: DecodeME: community recruitment for a large genetics study of myalgic encephalomyelitis / chronic fatigue syndrome.

    Devereux-Cooke, Andy / Leary, Sian / McGrath, Simon J / Northwood, Emma / Redshaw, Anna / Shepherd, Charles / Stacey, Pippa / Tripp, Claire / Wilson, Jim / Mar, Margaret / Boobyer, Danielle / Bromiley, Sam / Chowdhury, Sonya / Dransfield, Claire / Almas, Mohammed / Almelid, Øyvind / Buchanan, David / Garcia, Diana / Ireland, John /
    Kerr, Shona M / Lewis, Isabel / McDowall, Ewan / Migdal, Malgorzata / Murray, Phil / Perry, David / Ponting, Chris P / Vitart, Veronique / Wolfe, Jareth C

    BMC neurology

    2022  Volume 22, Issue 1, Page(s) 269

    Abstract: Background: Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a common, long-term condition characterised by post-exertional malaise, often with fatigue that is not significantly relieved by rest. ME/CFS has no confirmed diagnostic test ... ...

    Abstract Background: Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a common, long-term condition characterised by post-exertional malaise, often with fatigue that is not significantly relieved by rest. ME/CFS has no confirmed diagnostic test or effective treatment and we lack knowledge of its causes. Identification of genes and cellular processes whose disruption adds to ME/CFS risk is a necessary first step towards development of effective therapy.
    Methods: Here we describe DecodeME, an ongoing study co-produced by people with lived experience of ME/CFS and scientists. Together we designed the study and obtained funding and are now recruiting up to 25,000 people in the UK with a clinical diagnosis of ME/CFS. Those eligible for the study are at least 16 years old, pass international study criteria, and lack any alternative diagnoses that can result in chronic fatigue. These will include 5,000 people whose ME/CFS diagnosis was a consequence of SARS-CoV-2 infection. Questionnaires are completed online or on paper. Participants' saliva DNA samples are acquired by post, which improves participation by more severely-affected individuals. Digital marketing and social media approaches resulted in 29,000 people with ME/CFS in the UK pre-registering their interest in participating. We will perform a genome-wide association study, comparing participants' genotypes with those from UK Biobank as controls. This should generate hypotheses regarding the genes, mechanisms and cell types contributing to ME/CFS disease aetiology.
    Discussion: The DecodeME study has been reviewed and given a favourable opinion by the North West - Liverpool Central Research Ethics Committee (21/NW/0169). Relevant documents will be available online ( www.decodeme.org.uk ). Genetic data will be disseminated as associated variants and genomic intervals, and as summary statistics. Results will be reported on the DecodeME website and via open access publications.
    MeSH term(s) Adolescent ; COVID-19 ; Fatigue Syndrome, Chronic/genetics ; Genome-Wide Association Study ; Humans ; Longitudinal Studies ; SARS-CoV-2
    Language English
    Publishing date 2022-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-022-02763-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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