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  1. Article: Letter to the editor on "new algorithmic approach for easier and faster extended disability status scale calculation".

    Cohen, Mikael / Lebrun Frenay, Christine

    Multiple sclerosis journal - experimental, translational and clinical

    2023  Volume 9, Issue 3, Page(s) 20552173231192941

    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2841884-0
    ISSN 2055-2173 ; 2055-2173
    ISSN (online) 2055-2173
    ISSN 2055-2173
    DOI 10.1177/20552173231192941
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  2. Article ; Online: Radiologically isolated syndrome in the spectrum of multiple sclerosis.

    Okuda, Darin T / Lebrun-Frénay, Christine

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2024  Volume 30, Issue 6, Page(s) 630–636

    Abstract: The radiologically isolated syndrome (RIS) currently represents the earliest detectable preclinical phase of multiple sclerosis (MS). Remarkable advancements have been recently made, including the identification of risk factors for disease evolution, ... ...

    Abstract The radiologically isolated syndrome (RIS) currently represents the earliest detectable preclinical phase of multiple sclerosis (MS). Remarkable advancements have been recently made, including the identification of risk factors for disease evolution, revisions to the existing 2009 RIS criteria, and our understanding of the impact of early disease-modifying therapy use in the prevention/delay of symptomatic MS from two randomized clinical trials. Here, we discuss RIS in the context of the spectrum of MS, implications in the clinical management of individuals, and provide insights into future opportunities and challenges given the anticipated inclusion of asymptomatic MS in the formal definition of MS.
    MeSH term(s) Humans ; Multiple Sclerosis/diagnostic imaging ; Magnetic Resonance Imaging ; Disease Progression
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585241245306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4428: Show issues Location:
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  3. Article ; Online: Time to move past typical syndromes in the diagnosis of multiple sclerosis.

    Lebrun-Frenay, Christine / Okuda, Darin T

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2024  , Page(s) 13524585241253519

    Language English
    Publishing date 2024-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585241253519
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  4. Article ; Online: Presymptomatic MS or radiologically isolated syndrome should be actively monitored and treated: Yes.

    Lebrun-Frenay, Christine / Okuda, Darin T

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2023  Volume 29, Issue 7, Page(s) 793–795

    MeSH term(s) Humans ; Demyelinating Diseases/diagnostic imaging ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/drug therapy ; Autoimmune Diseases of the Nervous System ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585231172943
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  5. Article ; Online: MRI findings in blinded trials should be available to treating physicians - Yes.

    Vukusic, Sandra / Lebrun-Frenay, Christine

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2021  Volume 27, Issue 6, Page(s) 812–813

    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Physicians ; Research Design ; Research Personnel
    Language English
    Publishing date 2021-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458520984744
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  6. Article ; Online: Towards a more precise rating of neurological disability in multiple sclerosis: A new automatic and linear quantification of limbs function.

    Cohen, Mikael / Mondot, Lydiane / Landes-Chateau, Cassandre / Lebrun-Frenay, Christine

    Multiple sclerosis and related disorders

    2023  Volume 77, Page(s) 104904

    Abstract: Introduction: The Expanded Disability Status Scale (EDSS) is the gold standard for evaluating clinical disability in multiple sclerosis (MS) in daily practice. However, more precise clinical assessment tools are needed. We assessed a new, automated ... ...

    Abstract Introduction: The Expanded Disability Status Scale (EDSS) is the gold standard for evaluating clinical disability in multiple sclerosis (MS) in daily practice. However, more precise clinical assessment tools are needed. We assessed a new, automated rating of the neurological examination obtained with a mobile application (Quantified Neurological Examination - QNE).
    Method: Consecutive MS patients were assessed for EDSS score and QNE application that calculates, from the description of the examination, a global score and subscores (qFSS) corresponding to the EDSS functional system scores (FSS). Brain MRI was analysed to obtain automatic measures of brain atrophy.
    Results: We performed 200 examinations and included 78 patients in the MRI analysis. The global QNE score was strongly correlated with the EDSS. qFSS was statistically different according to the corresponding FSS for each function, except for the visual FSS. EDSS was predominantly correlated to the pyramidal function of the lower limbs. QNE score and qFSS had at least equivalent correlation to MRI measures than EDSS, particularly regarding the gray matter and cortical volumes.
    Discussion: We propose an automated method to rate neurological disability in MS. While QNE strongly correlates with EDSS, it may allow a more precise way to monitor the evolution of disability.
    MeSH term(s) Humans ; Multiple Sclerosis/complications ; Multiple Sclerosis/diagnostic imaging ; Lower Extremity ; Gray Matter ; Mobile Applications ; Neuroimaging
    Language English
    Publishing date 2023-07-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2023.104904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reply: Do we need new MRI criteria for the diagnosis of radiologically isolated syndrome?

    Lebrun-Frenay, Christine / Kantarci, Orhun H / Siva, Aksel / Pelletier, Daniel / Okuda, Darin T

    Brain : a journal of neurology

    2023  Volume 146, Issue 11, Page(s) e104–e106

    MeSH term(s) Humans ; Demyelinating Diseases/diagnostic imaging ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awad186
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    Ui II Zs.26: Show issues Location:
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  8. Article ; Online: Vaccinations in multiple sclerosis patients receiving disease-modifying drugs.

    Otero-Romero, Susana / Ascherio, Alberto / Lebrun-Frénay, Christine

    Current opinion in neurology

    2021  Volume 34, Issue 3, Page(s) 322–328

    Abstract: Purpose of review: This review focuses on new evidence supporting the global immunization strategy for multiple sclerosis (MS) patients receiving disease-modifying drugs (DMDs), including the recently available vaccines against severe acute respiratory ... ...

    Abstract Purpose of review: This review focuses on new evidence supporting the global immunization strategy for multiple sclerosis (MS) patients receiving disease-modifying drugs (DMDs), including the recently available vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
    Recent findings: New data strengthen the evidence against a causal link between MS and vaccination. Recent consensus statements agree on the need to start vaccination early. Timings for vaccine administration should be adjusted to ensure safety and optimize vaccine responses, given the potential interference of DMDs. Patients treated with Ocrelizumab (and potentially other B-cell depleting therapies) are at risk of diminished immunogenicity to vaccines. This has relevant implications for the upcoming vaccination against SARS-CoV-2.
    Summary: An early assessment and immunization of MS patients allows optimizing vaccine responses and avoiding potential interference with treatment plans. Vaccinations are safe and effective but some specific considerations should be followed when vaccinating before, during, and after receiving immunotherapy. A time-window for vaccination taking into account the kinetics of B cell repopulation could potentially improve vaccine responses. Further understanding of SARS-CoV-2 vaccine response dynamics in MS patients under specific therapies will be key for defining the best vaccination strategy.
    MeSH term(s) Antirheumatic Agents/adverse effects ; Antirheumatic Agents/therapeutic use ; COVID-19 Vaccines/therapeutic use ; Humans ; Immunization Programs/organization & administration ; Immunotherapy/adverse effects ; Immunotherapy/methods ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology ; Vaccination ; Viral Vaccines/adverse effects ; Viral Vaccines/immunology
    Chemical Substances Antirheumatic Agents ; COVID-19 Vaccines ; Viral Vaccines
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000000929
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  9. Article ; Online: The multiple sclerosis prodrome is just unspecific symptoms in radiologically isolated syndrome patients - No.

    Tremlett, Helen / Okuda, Darin T / Lebrun-Frenay, Christine

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2021  Volume 27, Issue 12, Page(s) 1824–1826

    MeSH term(s) Demyelinating Diseases/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Multiple Sclerosis/diagnostic imaging
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585211035951
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  10. Article ; Online: Kappa Free Light Chain Index Predicts Disease Course in Clinically and Radiologically Isolated Syndromes.

    Levraut, Michael / Gavoille, Antoine / Landes-Chateau, Cassandre / Cohen, Mikael / Bresch, Saskia / Seitz-Polski, Barbara / Mondot, Lydiane / Lebrun-Frenay, Christine

    Neurology(R) neuroimmunology & neuroinflammation

    2023  Volume 10, Issue 6

    Abstract: Background and objectives: To evaluate whether the kappa free light chain index (K-index) can predict the occurrence of new T2-weighted MRI lesions (T2L) and clinical events in clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) ...

    Abstract Background and objectives: To evaluate whether the kappa free light chain index (K-index) can predict the occurrence of new T2-weighted MRI lesions (T2L) and clinical events in clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS).
    Methods: All consecutive patients presenting for the diagnostic workup, including CSF analysis, of clinical and/or MRI suspicion of multiple sclerosis (MS) since May 1, 2018, were evaluated. All patients diagnosed with CIS and RIS with at least 1-year follow-up were included. Clinical events and new T2L were collected during follow-up. The K-index performances in predicting new T2L and a clinical event were evaluated using time-dependent ROC analyses. The time to clinical event or new T2L was estimated using survival analysis according to the binarized K-index using an independent cutoff of 8.9, and the ability of each variable to predict outcomes was compared using the Harrell c-index.
    Results: One hundred and eighty two patients (146 CIS and 36 RIS, median age 39 [30; 48] y-o, 70% females) were included with a median follow-up of 21 [13, 33] months. One hundred five (58%) patients (85 CIS and 20 RIS) experienced new T2L, and 28 (15%; 21 CIS and 7 RIS) experienced a clinical event. The K-index could predict new T2L over time in CIS (area under the curve [AUC] ranging from 0.86 to 0.96) and in RIS (AUC ranging from 0.84 to 0.54) but also a clinical event in CIS (AUC ranging from 0.75 to 0.87). Compared with oligoclonal bands (OCBs), the K-index had a better sensitivity and a slight lower specificity in predicting new T2L and clinical events in both populations. In the predictive model, the K-index was the variable that best predict new T2L in both CIS and RIS but also clinical events in CIS (c-index ranging from 0.70 to 0.77), better than the other variables, including OCB.
    Discussion: This study provides evidence that the K-index predicts new T2L in CIS and RIS but also clinical attack in patients with CIS. We suggest adding the K-index in the further MS diagnosis criteria revisions as a dissemination-in-time biomarker.
    MeSH term(s) Female ; Humans ; Adult ; Male ; Syndrome ; Immunoglobulin kappa-Chains ; Demyelinating Diseases/diagnostic imaging ; Autoimmune Diseases of the Nervous System ; Multiple Sclerosis/diagnostic imaging ; Disease Progression
    Chemical Substances Immunoglobulin kappa-Chains
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2767740-0
    ISSN 2332-7812 ; 2332-7812
    ISSN (online) 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000200156
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