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Article ; Online: Sarcopenia does not affect liver regeneration and postoperative course after a major hepatectomy. A prospective study on 125 patients using CT volumetry and HIDA scintigraphy.

Fulbert, Maxence / El Amrani, Mehdi / Baillet, Clio / Lecolle, Katia / Ernst, Olivier / Louvet, Alexandre / Pruvot, François-René / Huglo, Damien / Truant, Stéphanie

Clinics and research in hepatology and gastroenterology

2024 Volume 48, Issue 5, Page(s) 102332

Abstract: Background & objectives: Sarcopenia is a morbi-mortality risk factor in digestive surgery, though its impact after major hepatectomy (MH) remains unknown. This prospective pilot study investigated whether volume and function of a regenerating liver is ... ...

Abstract	Background & objectives: Sarcopenia is a morbi-mortality risk factor in digestive surgery, though its impact after major hepatectomy (MH) remains unknown. This prospective pilot study investigated whether volume and function of a regenerating liver is influenced by body composition. Methods: From 2011 to 2016, 125 consecutive patients had computed tomography and 99mTc-labelled-mebrofenin SPECT-scintigraphy before and after MH at day 7 and 1 month for measurements of liver volumes and functions. L3 vertebra muscle mass identified sarcopenia. Primary endpoint was the impact of sarcopenia on regeneration capacities (i.e. volume/function changes and post-hepatectomy liver failure (PHLF) rate). Secondary endpoint was 3-month morbi-mortality. Results: Sarcopenic patients (SP; N = 69) were significantly older than non-sarcopenic (NSP), with lower BMI and more malignancies, but with comparable liver function/volume at baseline. Postoperatively, SP showed higher rates of ISGLS_PHLF (24.6 % vs 10.9 %; p = 0.05) but with comparable rates of severe morbidity (23.2 % vs 16.4 %; p = 0.35), overall (8.7 % vs 3.6 %; p = 0.3) and PHLF-related mortality (8,7 % vs 1.8 %; p = 0.075). After matching on the extent of resection or using propensity score, regeneration and PHLF rates were similar. Conclusion: This prospective study using first sequential SPECT-scintigraphy showed that sarcopenia by itself does not affect liver regeneration capacities and short-term postoperative course after MH.
Language	English
Publishing date	2024-04-02
Publishing country	France
Document type	Journal Article
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2024.102332
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Article ; Online: Duct-to-duct biliary reconstruction with or without an intraductal removable stent in liver transplantation: The BILIDRAIN-T multicentric randomised trial.

Goumard, Claire / Boleslawski, Emmanuel / Brustia, Rafaelle / Dondero, Federica / Herrero, Astrid / Lesurtel, Mickael / Barbier, Louise / Lecolle, Katia / Soubrane, Olivier / Bouyabrine, Hassan / Mabrut, Jean Yves / Salamé, Ephrem / Cachanado, Marine / Simon, Tabassome / Scatton, Olivier

JHEP reports : innovation in hepatology

2022 Volume 4, Issue 10, Page(s) 100530

Abstract: Background & aims: Biliary complications (BC) following liver transplantation (LT) are responsible for significant morbidity. No technical procedure during reconstruction has been associated with a risk reduction of BC. The placement of an intraductal ... ...

Abstract	Background & aims: Biliary complications (BC) following liver transplantation (LT) are responsible for significant morbidity. No technical procedure during reconstruction has been associated with a risk reduction of BC. The placement of an intraductal removable stent (IRS) during reconstruction followed by its endoscopic removal showed feasibility and safety in a preliminary study. This multicentric randomised controlled trial aimed at evaluating the impact of an IRS on BC following LT. Methods: This multicentric randomised controlled trial was conducted in 7 centres from April 2015 to February 2019. Randomisation was done during LT when a duct-to-duct anastomosis was confirmed with at least 1 of the stump diameters ≤7 mm. In the IRS group, a custom-made segment of a T-tube was placed into the bile duct to act as a stake during healing and was removed endoscopically 4 to 6 months post LT. The primary endpoint was the incidence of BC (fistulae and strictures) within 6 months post LT. The secondary criteria were complications related to the IRS placement or extraction, including endoscopic retrograde cholangio-pancreatography (ERCP)-related complications. Results: In total, 235 patients were randomised: 117 in the IRS group and 118 in the control group. BC occurred in 31 patients (26.5%) in the IRS group Conclusions: IRS does not prevent BC after LT and may require specific endoscopic expertise for removal. Trial registration number clinicaltrialsgov: NCT02356939 (https://clinicaltrials.gov/ct2/show/NCT02356939?term=NCT02356939&draw=2&rank=1). Lay summary: Liver transplantation is a life-saving treatment for many patients with end-stage liver disease. However, it can be associated with complications involving the bile duct reconstruction. Herein, the placement of a specific stent called an intraductal removable stent was trialled as a way of reducing bile duct complications in patients undergoing liver transplantation. Unfortunately, it did not help preventing such complications.
Language	English
Publishing date	2022-07-06
Publishing country	Netherlands
Document type	Journal Article
ISSN	2589-5559
ISSN (online)	2589-5559
DOI	10.1016/j.jhepr.2022.100530
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Article: Laparoscopic Partial ALPPS: Much Better Than ALPPS!

Truant, Stéphanie / El Amrani, Mehdi / Baillet, Clio / Ploquin, Anne / Lecolle, Katia / Ernst, Olivier / Hebbar, Mohamed / Huglo, Damien / Pruvot, François-René

Annals of hepatology

2019 Volume 18, Issue 1, Page(s) 269–273

Abstract: Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) has emerged as an alternative for patients with bilobar colorectal liver metastasis deemed unresectable due to inadequate future remnant liver (FRL). Nevertheless, high ... ...

Abstract	Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) has emerged as an alternative for patients with bilobar colorectal liver metastasis deemed unresectable due to inadequate future remnant liver (FRL). Nevertheless, high morbidity and mortality rates have been reported. In this setting, including hepatobiliary scintigraphy in the clinical and surgical management of patients offered ALPPS has been advocated to both assess eligibility for ALPPS stagel and suitable time for ALPPS stage2. Recently, it was stated that partial ALPPS with a liver split restricted to 50% of the transection line (or up to the middle hepatic vein in case of right extended hepatectomy) and a shortened stagel allows improving the postoperative course without precluding the inter-stages FRL hypertrophy. We describe a case series of p-ALPPS with stagel performed laparoscopically, including sequential assessments of the FRL volumes and functions via pre-stagel and pre-stage2 computed tomography volumetry and HIDA SPECT-scintigraphy. In five patients, laparoscopic p-ALPPS was associated with rapid and significant gain of remnant functional volume - much better than previously observed for ALPPS - facilitating early stage2 without inflammatory adherences. In conclusion, laparoscopic p-ALPPS is feasible and seems less aggressive than the original ALPPS technique with total transection. It may be an interesting alternative to the classical portal vein embolization (PVE) and two-stage hepatectomy strategy.
MeSH term(s)	Aged ; Colorectal Neoplasms/pathology ; Female ; Hepatectomy/methods ; Humans ; Laparoscopy/methods ; Laparotomy/methods ; Ligation ; Liver Neoplasms/diagnosis ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Metastasis ; Portal Vein/diagnostic imaging ; Portal Vein/surgery ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-05-20
Publishing country	Mexico
Document type	Case Reports ; Journal Article
ZDB-ID	2188733-0
ISSN	1665-2681
ISSN	1665-2681
DOI	10.5604/01.3001.0012.7937
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Article ; Online: Impact of sarcopenia on outcomes of patients undergoing pancreatectomy: A retrospective analysis of 107 patients.

El Amrani, Mehdi / Vermersch, Mathilde / Fulbert, Maxence / Prodeau, Mathieu / Lecolle, Katia / Hebbar, Mohamed / Ernst, Olivier / Pruvot, François-René / Truant, Stéphanie

Medicine

2018 Volume 97, Issue 39, Page(s) e12076

Abstract: To evaluate the prevalence of sarcopenia in patients undergoing pancreatic surgery and to examine its impact on the surgical outcomes and survival of patients.Skeletal muscle index (SMI) was measured on preoperative CT. A patient was considered ... ...

Abstract	To evaluate the prevalence of sarcopenia in patients undergoing pancreatic surgery and to examine its impact on the surgical outcomes and survival of patients.Skeletal muscle index (SMI) was measured on preoperative CT. A patient was considered sarcopenic if SMI was <38.5 cm/m for a female or <52.4 cm/m for a male. Postoperative pancreatic fistula (POPF) and severe morbidity (Clavien≥3) were analyzed. Survival of patients with cancer was calculated using the Kaplan-Meier method.In total, 107 consecutive patients were included. Among them, 50 (47%) patients were sarcopenic and 65 (60%) were undernourished. The rates of severe morbidity and mortality were comparable between sarcopenic and nonsarcopenic groups. However, all POPF grade B or C and deaths occurred in the sarcopenic or nonsarcopenic overweight group (BMI > 25) with significantly lengthened hospital stays (P = .003). After pancreatectomy for cancer, 31 (40.2%) patients showed postoperative recurrence and 23 (29.9%) died after a median follow-up of 15 ± 13.5 months. Despite comparable histological types and stages, the median overall and disease-free survivals were lower in sarcopenic patients (16 months vs not reached, P = .02 and 11.1 months vs 22.5 months; P = .04, respectively). The multivariate analysis revealed that, sarcopenia trended to increase the risk of death (HR = 2.04, P = .07).Sarcopenia negatively impacted short- and long-term outcomes in patients undergoing pancreatectomy.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Muscle, Skeletal/pathology ; Pancreatectomy/adverse effects ; Pancreatic Diseases/surgery ; Postoperative Complications/epidemiology ; Prevalence ; Retrospective Studies ; Risk Factors ; Sarcopenia/complications ; Sarcopenia/epidemiology ; Sarcopenia/mortality ; Survival Analysis
Language	English
Publishing date	2018-07-12
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000012076
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Article ; Online: Liver Venous Deprivation or Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy?: A Retrospective Multicentric Study.

Annals of surgery

2021 Volume 274, Issue 5, Page(s) 874–880

Abstract: Objective: To compare 2 techniques of remnant liver hypertrophy in candidates for extended hepatectomy: radiological simultaneous portal vein embolization and hepatic vein embolization (HVE); namely LVD, and ALPPS.: Background: Recent advances in ... ...

Abstract	Objective: To compare 2 techniques of remnant liver hypertrophy in candidates for extended hepatectomy: radiological simultaneous portal vein embolization and hepatic vein embolization (HVE); namely LVD, and ALPPS. Background: Recent advances in chemotherapy and surgical techniques have widened indications for extended hepatectomy, before which remnant liver augmentation is mandatory. ALPPS and LVD typically show higher hypertrophy rates than portal vein embolization, but their respective places in patient management remain unclear. Methods: All consecutive ALPPS and LVD procedures performed in 8 French centers between 2011 and 2020 were included. The main endpoint was the successful resection rate (resection rate without 90-day mortality) analyzed according to an intention-to-treat principle. Secondary endpoints were hypertrophy rates, intra and postoperative outcomes. Results: Among 209 patients, 124 had LVD 37 [13,1015] days before surgery, whereas 85 underwent ALPPS with an inter-stages period of 10 [6, 69] days. ALPPS was mostly-performed for colorectal liver metastases (CRLM), LVD for CRLM and perihilar cholangiocarcinoma. Hypertrophy was faster for ALPPS. Successful resection rates were 72.6% for LVD ± rescue ALPPS (n = 6) versus 90.6% for ALPPS (P < 0.001). Operative duration, blood losses and length-of-stay were lower for LVD, whereas 90-day major complications and mortality were comparable. Results were globally unchanged for CRLM patients, or after excluding the early 2 years of experience (learning-curve effect). Conclusions: This study is the first 1 comparing LVD versus ALPPS in the largest cohort so far. Despite its retrospective design, it yields original results that may serve as the basis for a prospective study.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/therapy ; Embolization, Therapeutic/methods ; Feasibility Studies ; Female ; Hepatectomy/methods ; Hepatic Veins/surgery ; Humans ; Intention to Treat Analysis/methods ; Ligation/methods ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Portal Vein/surgery ; Retrospective Studies ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2021-08-22
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000005121
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Article ; Online: Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.

Dujardin, Simon / Lécolle, Katia / Caillierez, Raphaëlle / Bégard, Séverine / Zommer, Nadège / Lachaud, Cédrick / Carrier, Sébastien / Dufour, Noëlle / Aurégan, Gwennaëlle / Winderickx, Joris / Hantraye, Philippe / Déglon, Nicole / Colin, Morvane / Buée, Luc

Acta neuropathologica communications

2014 Volume 2, Page(s) 14

Abstract: Background: In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain, the hierarchical pathways of this neurodegeneration have been well established in ... ...

Abstract	Background: In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain, the hierarchical pathways of this neurodegeneration have been well established in Alzheimer's disease (AD) and other sporadic tauopathies such as argyrophilic grain disorder and progressive supranuclear palsy but the molecular and cellular mechanisms supporting this progression are yet not known. These pathways appear to be associated with the intercellular transmission of pathology, as recently suggested in Tau transgenic mice. However, these conclusions remain ill-defined due to a lack of toxicity data and difficulties associated with the use of mutant Tau. Results: Using a lentiviral-mediated rat model of hippocampal NFD, we demonstrated that wild-type human Tau protein is axonally transferred from ventral hippocampus neurons to connected secondary neurons even at distant brain areas such as olfactory and limbic systems indicating a trans-synaptic protein transfer. Using different immunological tools to follow phospho-Tau species, it was clear that Tau pathology generated using mutated Tau remains near the IS whereas it spreads much further using the wild-type one. Conclusion: Taken together, these results support a novel mechanism for Tau protein transfer compared to previous reports based on transgenic models with mutant cDNA. It also demonstrates that mutant Tau proteins are not suitable for the development of experimental models helpful to validate therapeutic intervention interfering with Tau spreading.
MeSH term(s)	Animals ; Brain/pathology ; Cell Differentiation/genetics ; Cells, Cultured ; Disease Models, Animal ; Disease Progression ; Embryo, Mammalian ; Gene Transfer Techniques ; Humans ; Microfluidic Analytical Techniques ; Microscopy, Confocal ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Mutation/genetics ; Neurons/metabolism ; Protein Transport/physiology ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Tauopathies/pathology ; tau Proteins/metabolism
Chemical Substances	Microtubule-Associated Proteins ; RNA, Messenger ; tau Proteins
Language	English
Publishing date	2014-01-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/2051-5960-2-14
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Article ; Online: Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.

Caillierez, Raphaëlle / Bégard, Séverine / Lécolle, Katia / Deramecourt, Vincent / Zommer, Nadège / Dujardin, Simon / Loyens, Anne / Dufour, Noëlle / Aurégan, Gwennaëlle / Winderickx, Joris / Hantraye, Philippe / Déglon, Nicole / Buée, Luc / Colin, Morvane

Molecular therapy : the journal of the American Society of Gene Therapy

2013 Volume 21, Issue 7, Page(s) 1358–1368

Abstract: Most models for tauopathy use a mutated form of the Tau gene, MAPT, that is found in frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) and that leads to rapid neurofibrillary degeneration (NFD). Use of a wild-type (WT) form of ... ...

Abstract	Most models for tauopathy use a mutated form of the Tau gene, MAPT, that is found in frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) and that leads to rapid neurofibrillary degeneration (NFD). Use of a wild-type (WT) form of human Tau protein to model the aggregation and associated neurodegenerative processes of Tau in the mouse brain has thus far been unsuccessful. In the present study, we generated an original "sporadic tauopathy-like" model in the rat hippocampus, encoding six Tau isoforms as found in humans, using lentiviral vectors (LVs) for the delivery of a human WT Tau. The overexpression of human WT Tau in pyramidal neurons resulted in NFD, the morphological characteristics and kinetics of which reflected the slow and sporadic neurodegenerative processes observed in sporadic tauopathies, unlike the rapid neurodegenerative processes leading to cell death and ghost tangles triggered by the FTDP-17 mutant Tau P301L. This new model highlights differences in the molecular and cellular mechanisms underlying the pathological processes induced by WT and mutant Tau and suggests that preference should be given to animal models using WT Tau in the quest to understand sporadic tauopathies.
MeSH term(s)	Animals ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Humans ; Lentivirus/genetics ; Male ; Mice, Inbred C57BL ; Rats ; Rats, Wistar ; Tauopathies/genetics ; Tauopathies/metabolism ; tau Proteins/genetics ; tau Proteins/metabolism
Chemical Substances	tau Proteins
Language	English
Publishing date	2013-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1038/mt.2013.66
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Article ; Online: A fiber-modified adenoviral vector interacts with immunoevasion molecules of the B7 family at the surface of murine leukemia cells derived from dormant tumors

Rogée Sophie / Lécolle Katia / Grellier Elodie / Couturier Cyril / D'Halluin Jean-Claude / Hong Saw-See / Fender Pascal / Boulanger Pierre / Quesnel Bruno / Colin Morvane

Molecular Cancer, Vol 10, Iss 1, p

2011 Volume 105

Abstract: Abstract Tumor cells can escape the immune system by overexpressing molecules of the B7 family, e.g. B7-H1 (PD-L1 or CD86), which suppresses the anti-tumor T-cell responses through binding to the PD-1 receptor, and similarly for B7.1 (CD80), through ... ...

Abstract	Abstract Tumor cells can escape the immune system by overexpressing molecules of the B7 family, e.g. B7-H1 (PD-L1 or CD86), which suppresses the anti-tumor T-cell responses through binding to the PD-1 receptor, and similarly for B7.1 (CD80), through binding to CTLA-4. Moreover, direct interactions between B7-H1 and B7.1 molecules are also likely to participate in the immunoevasion mechanism. In this study, we used a mouse model of tumor dormancy, DA1-3b leukemia cells. We previously showed that a minor population of DA1-3b cells persists in equilibrium with the immune system for long periods of time, and that the levels of surface expression of B7-H1 and B7.1 molecules correlates with the dormancy time. We found that leukemia cells DA1-3b/d365 cells, which derived from long-term dormant tumors and overexpressed B7-H1 and B7.1 molecules, were highly permissive to Ad5FB4, a human adenovirus serotype 5 (Ad5) vector pseudotyped with chimeric human-bovine fibers. Both B7-H1 and B7.1 were required for Ad5FB4-cell binding and entry, since (i) siRNA silencing of one or the other B7 gene transcript resulted in a net decrease in the cell binding and Ad5FB4-mediated transduction of DA1-3b/d365; and (ii) plasmid-directed expression of B7.1 and B7-H1 proteins conferred to Ad5FB4-refractory human cells a full permissiveness to this vector. Binding data and flow cytometry analysis suggested that B7.1 and B7-H1 molecules played different roles in Ad5FB4-mediated transduction of DA1-3b/d365, with B7.1 involved in cell attachment of Ad5FB4, and B7-H1 in Ad5FB4 internalization. BRET analysis showed that B7.1 and B7-H1 formed heterodimeric complexes at the cell surface, and that Ad5FB4 penton, the viral capsomere carrying the fiber projection, could negatively interfere with the formation of B7.1/B7-H1 heterodimers, or modify their conformation. As interactors of B7-H1/B7.1 molecules, Ad5FB4 particles and/or their penton capsomeres represent potential therapeutic agents targeting cancer cells that had developed immunoevasion mechanisms.
Keywords	B7-H1 ; B7.1 ; dormant leukemia cells ; adenovirus ; adenovirus vector ; atadenovirus ; chimeric fiber ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	570
Language	English
Publishing date	2011-08-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
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Article ; Online: A fiber-modified adenoviral vector interacts with immunoevasion molecules of the B7 family at the surface of murine leukemia cells derived from dormant tumors.

Grellier, Elodie / Lécolle, Katia / Rogée, Sophie / Couturier, Cyril / D'Halluin, Jean-Claude / Hong, Saw-See / Fender, Pascal / Boulanger, Pierre / Quesnel, Bruno / Colin, Morvane

Molecular cancer

2011 Volume 10, Page(s) 105

Abstract: Tumor cells can escape the immune system by overexpressing molecules of the B7 family, e.g. B7-H1 (PD-L1 or CD86), which suppresses the anti-tumor T-cell responses through binding to the PD-1 receptor, and similarly for B7.1 (CD80), through binding to ... ...

Abstract	Tumor cells can escape the immune system by overexpressing molecules of the B7 family, e.g. B7-H1 (PD-L1 or CD86), which suppresses the anti-tumor T-cell responses through binding to the PD-1 receptor, and similarly for B7.1 (CD80), through binding to CTLA-4. Moreover, direct interactions between B7-H1 and B7.1 molecules are also likely to participate in the immunoevasion mechanism. In this study, we used a mouse model of tumor dormancy, DA1-3b leukemia cells. We previously showed that a minor population of DA1-3b cells persists in equilibrium with the immune system for long periods of time, and that the levels of surface expression of B7-H1 and B7.1 molecules correlates with the dormancy time. We found that leukemia cells DA1-3b/d365 cells, which derived from long-term dormant tumors and overexpressed B7-H1 and B7.1 molecules, were highly permissive to Ad5FB4, a human adenovirus serotype 5 (Ad5) vector pseudotyped with chimeric human-bovine fibers. Both B7-H1 and B7.1 were required for Ad5FB4-cell binding and entry, since (i) siRNA silencing of one or the other B7 gene transcript resulted in a net decrease in the cell binding and Ad5FB4-mediated transduction of DA1-3b/d365; and (ii) plasmid-directed expression of B7.1 and B7-H1 proteins conferred to Ad5FB4-refractory human cells a full permissiveness to this vector. Binding data and flow cytometry analysis suggested that B7.1 and B7-H1 molecules played different roles in Ad5FB4-mediated transduction of DA1-3b/d365, with B7.1 involved in cell attachment of Ad5FB4, and B7-H1 in Ad5FB4 internalization. BRET analysis showed that B7.1 and B7-H1 formed heterodimeric complexes at the cell surface, and that Ad5FB4 penton, the viral capsomere carrying the fiber projection, could negatively interfere with the formation of B7.1/B7-H1 heterodimers, or modify their conformation. As interactors of B7-H1/B7.1 molecules, Ad5FB4 particles and/or their penton capsomeres represent potential therapeutic agents targeting cancer cells that had developed immunoevasion mechanisms.
MeSH term(s)	Adenoviridae/genetics ; Animals ; B7-1 Antigen/genetics ; B7-1 Antigen/metabolism ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Capsid Proteins/metabolism ; Cell Line, Tumor ; Gene Knockdown Techniques ; Gene Transfer Techniques ; Genetic Vectors ; Humans ; Leukemia ; Mice ; Protein Binding ; Protein Multimerization ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Surface Plasmon Resonance ; Tumor Escape ; Viral Tail Proteins/metabolism ; Virus Attachment ; Virus Internalization
Chemical Substances	B7-1 Antigen ; B7-H1 Antigen ; Capsid Proteins ; Recombinant Proteins ; Viral Tail Proteins
Language	English
Publishing date	2011-08-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1476-4598
ISSN (online)	1476-4598
DOI	10.1186/1476-4598-10-105
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Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

Salomone, / Saverio, Di / Griffiths, / Ewen, A / Gujjuri, Rohan R / Hutchinson, Peter J / Kaafarani, Haytham MA / Lederhuber, Hans / Löffler, Markus W / Mashbari, Hassan N / Minaya-Bravo, Ana / Morton, Dion G / Moszkowicz, David / Pata, Francesco / Tsoulfas, George / Venn, Mary L / Cox, Daniel / Roslani, April C / Alakaloko, Felix /

de Vries, Jean-Paul PM / Aaraj, Mahmoud A / Abbott, Tom EF / Abbott, Sarah J / Abdalla, Mutwakil OM / Abdelaal, Ahmed S / Ademuyiwa, Adesoji O / Aherne, Thomas M / Ali, Osman M / Alkadeeki, Ghadah Z / Almeida, Ana C / Alrahawy, Mahmoud M / Ambler, Graeme K / Alameer, Ehab / Andreani, Stefano M / De Andrés-Asenjo, Beatriz / Antonanzas, Leyre Lopez / Aoun, Salah G / Ashoush, Fouad M / Augestad, Knut Magne / Avellana, Rocio B / Ayeni, Funbi A / Ayorinde, John OO / Babu, Bheemanakone H / Baig, Mirza MAS / Bajomo, Oreoluwa M / Baker, Olivia J / Baker, Markus P / Baldwin, Alexander J / Ban, Vin Shen / Baron, Ryan D / Barranquero, Alberto G / Barry, Conor P / DI Bartolomeo, Alessandro / Bass, Gary A / Bath, Michael F / Batjer, H Hunt / Beamish, Andrew J / Belgaumkar, Ajay P / Bence, Matthew N / Benson, Ruth A / Bernal-Sprekelsen, Juan Carlos / Bhama, Anuradha R / Bhavaraju, Avi V / Biffl, Walter L / Blundell, Chris M / Boddy, Alexander P / Borgstein, Alexander BJ / Bosanquet, David C / Bosch, Karen D / Bouhuwaish, Ahmad EM / Bozkurt, Mehmet A / Brathwaite, Collin EM / Brown, Benjamin C / Brown, Oliver D / Brown, Allison K / Buarque, Igor Lima / Bueno-Cañones, Alejandro D / Bulugma, Mustafa R / Burke, Joshua R / Byrne, Matthew HV / Cagigal-Ortega, Elima P / Callcut, Rachael A / DI Candido, Francesca / Canova, Michaela E / Carlos, William J / Caruana, Edward J / Cato, Liam D / Catton, Andrew B / Ceretti, Andrea Pisani / Chase, Thomas JG / Chiara, Francesco Di / Chowdhury, Abeed H / Chung, Eric A / Cicerchia, Pierfranco M / Clough, Ethan CS / Coleman, Natasha L / Collins, Chris G / Collins, Michelle L / Colonna, Emily T / Comini, Lara V / Coughlin, Patrick A / Cruzado, Laura Fernández-Gomez / Davidson, Brian R / Davies, Richard J / Davies, Emma J / Davis, Niall F / Dawson, Brett E / Dean, Benjamin JF / Delgado, Maria Garcia-Conde / Diaz, Jose J / Dickson, Kathryn E / Diez-Alonso, Manuel M / Dixon, Jan R / Doe, Matthew J / Drake, Thomas D / Drake, Frederick T / Duffy, John P / Dunne, Declan FJ / Dunne, Naomi JM / Durán-Muñoz-Cruzado, Virginia M / Durst, Alexander ZE / Eardley, Nicola J / Edwards, John G / Elfallal, Ahmed H / Elfiky, Mahmoud MA / Elliott, Jessie A / Emile, Sameh H / Emslie, Katy M / Endorf, Frederick W / Engel, Jamie L / Enjuto, Diego T / Etchill, Eric W / Evans, Jonathan P / Fahey, Brian A / Faria, Carlos S / Feo, Carlo V / Ferguson, Henry JM / Fernandez, Beatriz Dieguez / Fernandez, Andres Garcia / Fernández, Antonio J / Fernández-Pacheco, Borja Camacho / Fitzgerald, J Edward / Fonsi, Giovanni B / Font, Roser Farré / Fowler, Amy L / Fretwell, Kenneth R / Fructuoso, Lorena Sanchon / Fusai, Giuseppe K / Garcia, Miguel Hernandez / Garcia-Ureña, Miguel Angel / Gill, Charn K / Gisbertz, Suzanne S / Del Giudice, Roberto / Giuffrida, Maria Carmela / Di Giuseppe, Matteo / Gómez, María Fanjul / Griffiths, Ewen A / Guariglia, Claudio A / Hainsworth, Alison J / Hall, Bria J / Hall, James RW / Hammond, John S / Haqqani, Maha H / Harrison, Ewen M / Hazelton, Joshua P / van Heinsbergen, Maarten / Hill, Arnold DK / Hing, Caroline B / Hirji, Sameer A / Ho, Michael WS / Holbrook, Charlotte M / Holme, Thomas J / Hopkins, James C / Hopkinson, David N / Hossain, Fahad S / Hudson, Victoria E / Hughes, Jane L / Hwang, E. Shelley / Ibrahim, Mohamed AH / Isolani, Simone M / Jenkinson, Michael D / Jenny, Hillary E / Jeyaretna, Deva S / Jones, Robert P / Jones, Andrew P / Jonker, Pascal KC / Jönsson, Maria L / Joyce, Doireann P / Kalkwarf, Kyle J / Kamarajah, Sivesh K / El Kassas, Mohamed / Kavanagh, Dara O / Keatley, James M / Khalefa, Mohamed A / Khan, Jim S / Kirmani, Bilal H / Kisiel, Aaron P / Kouris, Spyros Marinos / Kowal, Mikolaj R / Labib, Peter L / Larkin, John O / Lauscher, Johannes C / Leclercq, Wouter KG / Ledesma, Frances SJ / Leite-Moreira, André M / Leung, Elaine YL / Lewis, Sophia E / Lima, Maria João / Lin, Daniel J / Liu, Helen H / Lowery, Aoife J / Lozano, Saida Martel / Luney, Catriona R / Maia, Mariana Magalhães / Mariani, Nicolò M / Marino, Marco V / Marra, Angelo A / Marsh, Christopher L / Martin, Robert CG / McCluney, Simon J / McIntyre, Robert C / Mckay, Siobhan C / McKevitt, Kevin L / Meagher, Ashley D / Mehdi, Mohammad Q / Mehigan, Brian J / Gonzalez-De Miguel, Melania / De Miguel-Ardevines, Maria-Carmen / Mills, Sarah J / Mohan, Helen M / Moir, John AG / Monson, John RT / Monteiro, Joana M / Montella, Maria T / Montesinos, Cristina Soto / Morgom, Marwa M / Moura, Francisco S / Muguerza, Jose M / Murphy, Suzanne H / De Nardi, Paola / Naumann, David N / Neary, Paul C / Neely, David TA / Ng-Kamstra, Joshua S / Ngu, Albert WT / Nguyen, Truong A / Nita, George E / Nunes, Quentin M / Nygaard, Rachel M / O'Meara, Lindsay B / O'Neill, John R / Okafor, Barbara U / Olson, Steven A / Oo, Aung Y / Ormazabal, Pablo Collera / Osorio, Alexander L / Pachl, Max J / Parry, James T / Patel, Panna K / Pérez-Sánchez, Luis E / Pevidal, Ana Nogues / Pezzuto, Anna P / Philp, Matthew M / Pinkney, Thomas D / Pollok, Joerg M / Povey, Meical G / Poza, Alfredo Alonso / Rajgor, Amarkumar D / Rao, Jagan N / Raptis, Dimitri A / Rice, Henry E / Ridgway, Paul F / Rivas, Ana Munoz / Rodriguez-Sanjuan, Juan C / Rogers, Luke J / Da Roit, Anna / Rollett, Rebecca A / Romera, Jose L / Rooney, Siobhan M / Roxo, Vanessa I / Le Roy, Bertrand / Rubio, Eduardo E / Ruiz, Carolina Castro / Ruiz, Manuel Losada / Ryan, Éanna J / Saad, Abdel Rahman / Saeed, Samerah A / Salama, Hiba A / Salamah, Abdulrauf A / Sampietro, Gianluca M / Sarma, Diwakar R / Schaffer, Kathryn B / Schnitzbauer, Andreas A / Scurrah, Rachel J / Serevina, Olivia L / Serralheiro, Pedro A / Sewards, Joseph M / Shackcloth, Michael J / Shaw, Abigail V / Sheel, Andrea RG / Sica, Giuseppe S / De Simone, Veronica / Singh, Aminder A / Singh, Rabindra P / Skelly, Brendan L / Smith, Henry G / Sohail, Amir H / Spalding, Duncan R / Springford, Laurie R / Ssentongo, Anna E / Steinkamp, Pieter J / Stevens, Kent A / Stewart, Grant D / Stylianides, Nicholas A / Sullivan, Tom BB / Taher, Ahmed SA / Tamimy, Muhammad S / Tang, Alethea M / Tebala, Giovanni D / Tejero-Pintor, Francisco J / Thaha, Mohamed A / Thomas, Amy J / De Toma, Giorgio / La Torre, Filippo / Torres, Antonio J / Townshend, David N / Trout, Isobel M / Tucker, Sarah C / Ubhi, Harmony K / Vega, Viviana A / Velmahos, George C / Velopulos, Catherine G / Viswanath, Yirupaiahgari KS / Vivas, Alfredo A / Wade, Ryckie G / Wadley, Martin S / Wall, Joshua JS / Walters, Andrew M / Warren, Oliver J / Weerasinghe, Chamindri K / Wilkin, Richard JW / Williams, Katherine J / Winter, Stuart C / Wormald, Justin CR / Wright, Franklin L / Xyda, Souzana E / Young, Alastair L / Youssef, Mina MG / Yousuf, Farhat B / El Youzouri, Hanan / Zappa, Marco A / Abate, Emmanuele / Abdalaziz, Hossam / Abdelkarim, Mostafa / Abdou, Hossam / Aboelkassem-Ibrahim, Ahmad / Abuown, Ala / Acebes-Garcia, Fernando / Acharya, Metesh / Adamina, Michel / Addae-Boateng, Emmanuel / Aftab, Raiyyan / Agarwal, Arnav / Aguilar, José / Ahmed, Yousra / Aitken, Emma / Al-Azzawi, Marwa / Al-Embideen, Somya / Al-Masri, Mahmoud / Al-Najjar, Hani / Al-Sukaini, Ahmad / Alam, Ruhina / Alderson, Derek / Aliyeva, Zumrud / Aljanadi, Firas / Almasri, Murad / Alonso-Ortuño, Paula / Altintoprak, Fatih / Amira, Gamal / Amjad, Rabbia / Anania, Gabriele / Andabaka, Tatjana / Angelou, Dimitrios / Annamalai, Seethalakshmi / Annessi, Valerio / Anthoney, James / Anwar, Sibtain / Anwer, Mariyah / Aragon-Chamizo, Juan / Ardito, Antonella / Arigoni, Michele / Armao, Teodora / Arminio, Armando / Armstrong, Lara / Arnaud, Alexis / Asaad, Peter / Ashcroft, James / Ashmore, Christopher / Asqalan, Ahmad / Asti, Emanuele / Aubry, Emmanuelle / Aytac, Erman / Ayuso-Herrera, Esther / Baeza, Melody / Bailon-Cuadrado, Martin / Bakmaz, Bernarda / Baldi, Caterina / Baldini, Edoardo / Baldo, Stefano / Ballabio, Michele / Baloyiannis, Ioannis / Baltazar, Gerard / Bàmbina, Fabrizio / Bandiera, Alessandro / Barlow, Emma / Barmasse, Roberto / Barmpagianni, Christina / Baronio, Gianluca / Barra, Fabio / Bartsch, Anne-Marie / Basgaran, Amedra / Basha, Amr / Bashkirova, Varvara / Bastazza, Marco / Baumber, Rachel / Belcher, Elizabeth / Belvedere, Angela / Benítez-Linero, Inmaculada / Bergeat, Damien / Bernasconi, Matteo / Bhalla, Ashish / Bhutiani, Neal / Bianco, Federica / Bisagni, Pietro / Blake, Iain / Blanco-Colino, Ruth / Blazquez-Martin, Alma / Boal, Matthew / Bonavina, Luigi / Bonavina, Giulia / Bond-Smith, Giles / Booth, Karen / Borges, Filipe / Borghi, Felice / Bouchagier, Konstantinos / Bourke, Grainne / Boyle, Emily / Brachini, Gioia / Brain, Jessie / Brar, Amanpreet / Breckles, Lisa / Bretagnol, Frédéric / Brixton, Genevieve / Bruzzaniti, Placido / Bueser, Teofila / Burnside, Nathan / Caballero, Albert / Calcerrada-Alises, Enrique / Callahan, Miriam / Camarero, Enrique / Campagnaro, Tommaso / Campanelli, Michela / Candiani, Massimo / Cantalejo-Diaz, Miguel / Cao, Han / Capelli, Patrizio / Capizzi, Vita / Carcano, Giulio / Carissimi, Francesca / Carlini, Massimo / Carlucci, Michele / Carmichael, Heather / Carrasco, Milagros / Carrillo, Mariana / Carvello, Michele / Casati, Massimiliano / Castoro, Carlo / Catalan, Vanesa / Cavaleiro, Salomé / Cellerino, Paola / Centinaio, Giovanna / Cernei, Cristina / Cerro, Cristina / Cervellera, Maurizio / Chakrabortee, Sohini / Chamberlain, Stephanie / Chan, Jeffrey / Chang, Grace / Chaudhry, Dauod / Chebaro, Alexandre / Chen, David / Chetty, Govind / Chia, Zoe / Chiappini, Ambra / Chiarugi, Massimo / Chidambaram, Swathikan / Chiozza, Matteo / Cholewa, Hanna / Chong, Clara / Choolani-Bhojwani, Ekta / Christoforidis, Dimitri / Chui, Karen / Chung, Choyin / Cirillo, Bruno / Citterio, Davide / Clermidi, Pauline / Coccolini, Federico / Colletti, Gaia / Compagnoni, Bruno / Concepción-Martín, Vanesa / Confalonieri, Marco / Connolly, Hannah / Conso, Christel / Conti, Luigi / Cooper, Zara / Cordera, Fernando / Corral, Javier / Costa, Marta / Costanzi, Andrea / Cotsoglou, Christian / Cozza, Valerio / Cuming, Tamzin / Curtis, Miles / Cuschieri, Joseph / D'Agruma, Michele / D'Andrea, Giancarlo / Daliya, Prita / Dare, Oliver / Darko, Ebenezer / Day, Andrew / Dehal, Ahmed / Dehart, Dustin / Delgado-Oliver, Eduardo / Denning, Max / Desai, Anant / Desender, Liesbeth / Dester, Sara / Díaz-García, Alberto / Diaz-Peña, Patricia / Dousset, Bertrand / Doussot, Alexandre / Duchateau, Nicolas / Duff, Sarah / Dunning, Joel / Duque-Mallen, Victoria / Dziakova, Jana / Egan, Bridget / Egan, Richard / El-Ali, Abess / Elfeki, Hossam / Elhadi, Muhammed / Eljareh, Mohammed / Elkady, Ramy / Elkhafeefi, Fatimah / Elmore, Ugo / Elmoslemany, Tarek / Emmerson, Oliver / Enemosah, Ibrahim / English, Camilla / English, William / Escartin, Jorge / Estaire-Gomez, Mercedes / Evans, Luke / Evans, Jessica / Exley, Rebecca / Fabbri, Nicoló / Falco, Giuseppe / Familiari, Pietro / Fancellu, Alessandro / Farik, Shebani / Farrell, Tony / Fehervari, Matyas / Fell, Adam / Fernandez-Camuñas, Angel / Fernández-Marín, Reyes / Fernández-Martínez, María / Ferrara, Francesco / Ferrari, Guglielmo / Ferrero, Simone / Findlay, Laura / Fiore, Marco / Fiori, Enrico / Flatman, Michael / Flindall, Ian / Flor, Blas / Fontana, Tommaso / Ford, Samuel / Ford, David / Forlani, Stefano / Francone, Elisa / Frattaruolo, Colomba / Frio, Federico / Gagliano, Annalisa / Gagliardi, Filippo / Gahunia, Sukhpreet / Gaino, Francesca / Gala, Tanzeela / Galfrascoli, Elisa / Galimberti, Luca / Gallagher, Phoebe / Galleano, Raffaele / Galván-Pérez, Armando / Gammeri, Emanuele / Ganau, Mario / Garcés-García, Raúl / Garulli, Gianluca / Gascon-Ferrer, Isabel / Gattolin, Andrea / Gaujoux, Sebastien / Gentilli, Sergio / Georgiades, Fanourios / Ghanbari, Amir / Ghosh, Dhruv / Giacometti, Marco / Giblin, Anna-Victoria / Gilbert, Catherine / Giménez, Clara / Giorgakis, Emmanouil / Gipponi, Manuel / Glen, Paul / Goatly, Giles / Gobatti, Davide / Godbole, Chintamani / Gohil, Kajal / Gómez, Marcos / Gomez-Rosado, Juan-Carlos / Gonullu, Emre / Gonzalez-Gonzalez, Enrique / Gordini, Luca / Gracia, Isabel / Gracia-Roche, Carlos / Granieri, Stefano / Green, Susanna / Grivon, Manuela / Grove, Thomas / Guaglio, Marcello / Guaitoli, Eleonora / Guglielmi, Alfredo / Guha, Soumya / Gustavino, Claudio / Habeeb, Amir / Hagger, Robert / Hakmi, Hazim / Halkias, Constantine / Hall, Claire / Hampton, Matthew / Handa, Siddhartha / Hansen, Laura / Haq, Iram / Harky, Amer / Harries, Rhiannon / Harrison, Joseph / Hasan, Raashad / Hawari, Mohammad / Hawkin, Paul / Hebblethwaite, Bethany / Henriques, Susana / Heritage, Emily / Hernandez-Juara, Pilar / Herrero-Lopez, Maria / Hervieux, Erik / Heyd, Bruno / Higgs, Simon / Hitchman, Louise / Ho, Beatrice / Hogan, Aisling / Hölzle, Frank / Hossain, Tanvir / Hurt, Libor / Hutchinson, Peter / Iacob, Giulio / Iannone, Immacolata / Ibrahim, Sherif / Iovino, Domenico / Isik, Arda / Jafarova, Sevda / Jamil, Tahir / Jayaraju, Ullas / Jenner, Edward / Jimenez-Higuera, Elisa / Jimeno, Jaime / Jones, Mark / Judkins, Nicholas / Kalavrezos, Nicholas / Kalidindi, Venugopala / Kalkat, Maninder / Kamal, Mona / Kamphues, Carsten / Kang, Chong / Kara, Yasin / Karam, Edward / Karim, Ahmed / Kashora, Florence / Kearney, David / Khajuria, Apoorva / Khan, Umul / Khan, Azam / Khatri, Chetan / Kinnaman, Gabriel / Kinross, James / Kler, Aaron / Klimopoulos, Serafeim / Kocataş, Ali / Kolias, Angelos / Königsrainer, Alfred / Konsten, Joop / Kontovounisios, Christos / Kourdouli, Amar / Krishnan, Emily / Kristinsson, Sverrir / Kruijff, Schelto / Kudsk-Iversen, Søren / Kufeji, Dorothy / Kugler, Nadav / Kulkarni, Rugved / Kurihara, Hayato / Laface, Letizia / Lakkis, Zaher / Lami, Mariam / Landaluce-Olavarria, Aitor / Lapolla, Pierfrancesco / Lawani, Ismail / Lawday, Samuel / Lázaro, André / Lecolle, Katia / Leventoglu, Sezai / Li, Zoe / Liew, Ignatius / Lisi, Giorgio / Lizzi, Vincenzo / Lo, Terence / Lomiento, Daniele / Longhi, Marco / Lostis, Emilie / Lostoridis, Eftychios / Loubani, Mahmoud / Lowy-Benoliel, Alejandro / Lucianetti, Alessandro / Luke, Louis / Lunevicius, Raimundas / Luraghi, Marco / Lye, George / Mabrouk, Islam / Macchi, Alberto / MacDonald, Luisa / Machairas, Nikolaos / Madonini, Marco / Magowan, Drew / Maisonneuve, Emeline / Majkowska, Agata / Majkowski, Lawrence / Mak, Jason / Malabarba, Stefano / Malerba, Michele / Mannan, Syed / Manson, Joanna / Mansuri, Ahmer / Mantoglu, Baris / Manu, Nichola / Maqsood, Afnan / Marano, Alessandra / Marchbank, Adrian / Marcos-Santos, Pablo / Marrano, Enrico / Martin, Janet / Martin, Emmeline / Martin, Guy / Martin-Albo, Lorena / Martín-Román, Lorena / Martinelli, Fabio / Martínez-dePaz, Fernando / Martinez-German, Antonio / Martinez-Pinedo, Carlos / Martins, Ricardo / Marwan, Hisham / Marzi, Federica / Mathieu, Pierre / Matute-Najarro, Maria-Soledad / Maw, Andrew / Mazingi, Dennis / Mazzaferro, Vincenzo / McCanny, Andrew / McKenzie, Katherine / McLarty, Nicola / McPherson, Iain / Medina, Esther / Mediratta, Saniya / Medone, Marzia / Mehra, Gautam / Mele, Simone / Melero-Cortés, Lidia / Mendoza-Moreno, Fernando / Meneghini, Simona / Mercante, Giuseppe / Merdrignac, Aude / Merola, Stephen / Metallidis, Symeon / Michel, Martin / Migliore, Marco / Mihanovic, Jakov / Miller, Douglas / Mingoli, Andrea / Minto, Gary / Mirabella, Antonello / Misra, Nikhil / Mitrasinovic, Stefan / Miu, Victor / Moawad, Nader / Mochet, Sylvie / Modabber, Ali / Mohammad, Adam / Mohan, Midhun / Moliner-Sánchez, Carmen / Mongelli, Francesco / Monteleone, Michela / Montuori, Mauro / Moore, Rachel / Mora-Guzmán, Ismael / Morales, Xavier / Morales, Dieter / Morelli, Luca / Morelli, Lucia / Morgan, Richard / Morris, Chris / Mortini, Pietro / Mosca, Angelo / Motter, Dema / Moug, Susan / Mukherjee, Samrat / Najdy, Manhal / Nakas, Apostolos / Namazov, Ilgar / Naredla, Pradyumna / Nasef, Emmhamed / Nassa, Heeam / Nath, Rahul / Navarro-Sánchez, Antonio / Nazarian, Scarlet / Negri, Giampiero / Nehra, Deepika / Neil-Dwyer, Jason / Neri, Jacopo / Newton, Katy / Nikaj, Herald / Niquen, Milagros / Nobile, Sara / Nogueiro, Jorge / Ntirenganya, Faustin / Nugent, Michael / Núñez, Jordi / Ocaña, Juan / Okechukwu, Valentine / Oliva-Mompean, Fernando / Oliveira, Ana / Ollat, Didier / Onos, Lavinia / Osagie-Clouard, Liza / Osman, Khabab / Ottolina, Jessica / Ourieff, Jared / Outani, Oumaima / Oyewole, Bankole / Ozben, Volkan / Pacheco-Sanchez, David / Padilla-Valverde, David / Pai, Madhava / Paiella, Salvatore / Paisley, Samuel / Palini, Gianmarco / Palmeri, Matteo / Panahi, Pedram / Parente, Alessandro / Parlanti, Daniele / Parmar, Chetan / Pascual, Angela / Patel, Mahul / Pathak, Abhijit / Patil, Sangram / Pattyn, Piet / Peckham-Cooper, Adam / Pedrazzani, Corrado / Pellino, Gianluca / Peluso, Chiara / Pereira, André / Pereira-Neves, António / Perez-Diaz, Md / Pérez-González, Marta

an international cohort study

2020

Keywords	covid19
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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