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  1. Article ; Online: Don't let D-dimer fool you: Elevated D-dimer plasma levels should not imply 'hyperfibrinolysis'.

    Hardy, M / Bareille, M / Lecompte, T / Mullier, F

    Thrombosis research

    2022  Volume 214, Page(s) 63–64

    MeSH term(s) Blood Coagulation Disorders ; Fibrin Fibrinogen Degradation Products ; Fibrinolysis ; Humans ; Plasma
    Chemical Substances Fibrin Fibrinogen Degradation Products ; fibrin fragment D
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2022.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 863: Show issues Location:
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  2. Article ; Online: "Defining Heparin Resistance: Communication from the ISTH SSC Subcommittee of Perioperative and Critical Care Thrombosis and Hemostasis": comment from Gouin-Thibault et al.

    Gouin-Thibault, Isabelle / Mullier, François / Lecompte, Thomas

    Journal of thrombosis and haemostasis : JTH

    2024  Volume 22, Issue 2, Page(s) 572–574

    MeSH term(s) Humans ; Communication ; Hemostasis ; Heparin/pharmacology ; Thrombosis
    Chemical Substances Heparin (9005-49-6)
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Letter
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.10.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  3. Article ; Online: Ten considerations about viscoelastometric tests.

    Mansour, Alexandre / Godier, Anne / Lecompte, Thomas / Roullet, Stéphanie

    Anaesthesia, critical care & pain medicine

    2024  Volume 43, Issue 3, Page(s) 101366

    Language English
    Publishing date 2024-03-07
    Publishing country France
    Document type Letter
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2024.101366
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  4. Article ; Online: Prothrombin conversion and thrombin decay in patients with cirrhosis-role of prothrombin and antithrombin deficiencies.

    Sinegre, Thomas / Abergel, Armand / Lecompte, Thomas / Lebreton, Aurélien

    Journal of thrombosis and haemostasis : JTH

    2024  Volume 22, Issue 5, Page(s) 1347–1357

    Abstract: Background: Thrombin generation (TG) in the presence of thrombomodulin (TG-TM) in the plasma of patients with cirrhosis (PWC) is tilted toward a hypercoagulable phenotype. Low protein C and elevated factor VIII levels play a role, but other determinants, ...

    Abstract Background: Thrombin generation (TG) in the presence of thrombomodulin (TG-TM) in the plasma of patients with cirrhosis (PWC) is tilted toward a hypercoagulable phenotype. Low protein C and elevated factor VIII levels play a role, but other determinants, such as the prothrombin/antithrombin pair, must also be studied.
    Objectives: The objectives were (i) to quantitatively assess the subprocesses (prothrombin conversion and thrombin decay) and (ii) to understand the underlying mechanism by studying TG dynamics after prothrombin and antithrombin plasma level correction in PWC.
    Methods: We studied TG-TM in plasma samples of 36 healthy controls (HCs) and 41 PWC with prothrombin and antithrombin levels of <70% and after their correction. We initiated coagulation with an intermediate picomolar concentration of tissue factor. We determined the overall thrombin potential, prothrombin conversion, and thrombin decay.
    Results: TG-TM was increased in PWC compared with HC due to impaired thrombin inhibition. Indeed, thrombin decay capacity (min
    Conclusion: Our results highlight that in PWC, hypercoagulability (evidenced in the presence of TM) is due to impaired thrombin decay, whereas low prothrombin levels do not translate into decreased prothrombin conversion, likely due to altered TM-activated protein C negative feedback.
    MeSH term(s) Humans ; Prothrombin ; Thrombin/metabolism ; Male ; Female ; Middle Aged ; Case-Control Studies ; Blood Coagulation ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnosis ; Aged ; Thrombomodulin/blood ; Adult ; Antithrombins/blood ; Blood Coagulation Tests ; Phenotype ; Thromboplastin/metabolism
    Chemical Substances Prothrombin (9001-26-7) ; Thrombin (EC 3.4.21.5) ; Thrombomodulin ; Antithrombins ; Thromboplastin (9035-58-9) ; THBD protein, human
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2024.01.016
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  5. Article ; Online: Vaccination-induced thrombocytopenia and thrombosis (VITT) and pre-VITT: Do not miss (or misdiagnose) the new member of the thrombotic thrombocytopenias family.

    Noyé, Mickaël / Lecompte, Thomas

    European heart journal open

    2022  Volume 2, Issue 5, Page(s) oeac056

    Language English
    Publishing date 2022-09-07
    Publishing country England
    Document type Editorial
    ISSN 2752-4191
    ISSN (online) 2752-4191
    DOI 10.1093/ehjopen/oeac056
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  6. Article ; Online: Laboratory Monitoring of Heparin Anticoagulation in Hemodialysis: Rationale and Strategies.

    Chiasakul, Thita / Mullier, François / Lecompte, Thomas / Nguyen, Philippe / Cuker, Adam

    Seminars in nephrology

    2024  , Page(s) 151477

    Abstract: Unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs) are commonly used to prevent clotting of the hemodialysis extracorporeal circuit and optimize hemodialysis adequacy. There is no consensus on the optimal dosing for UFH and LMWHs ... ...

    Abstract Unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs) are commonly used to prevent clotting of the hemodialysis extracorporeal circuit and optimize hemodialysis adequacy. There is no consensus on the optimal dosing for UFH and LMWHs during hemodialysis. In clinical practice, semiquantitative clotting scoring of the dialyzer and venous chamber may help to guide UFH and LMWH dose adjustment. Laboratory monitoring has not been shown to improve clinical outcomes and is therefore not routinely indicated in most hemodialysis patients. It might, however, be considered in select patients, such as those with extremes of body weight or history of repeated clotting or bleeding. Methods for laboratory monitoring include the activated partial thromboplastin time, activated clotting time, and antifactor Xa assays for UFH and antifactor Xa assay for LMWHs. Target ranges for anticoagulation in hemodialysis have been suggested but not clearly defined. When utilizing these tests, issues such as availability, standardization, interfering factors, and interpretation must be considered. In this narrative review, we discuss the rationale and methods of monitoring anticoagulation in hemodialysis.
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2023.151477
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    Se 784: Show issues Location:
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  7. Article ; Online: Assessment of the individual determinants of two fibrinolysis assays, GFC and ECLT in platelet-depleted plasma and derived euglobulin fraction respectively.

    Bareille, Marion / Lecompte, Thomas / Mullier, François

    Thrombosis research

    2023  Volume 230, Page(s) 33–36

    Language English
    Publishing date 2023-08-13
    Publishing country United States
    Document type Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2023.08.008
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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Are Viscoelastometric Assays of Old Generation Ready for Disposal? Comment on Volod et al. Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices.

    Bareille, Marion / Lecompte, Thomas / Mullier, François / Roullet, Stéphanie

    Journal of clinical medicine

    2023  Volume 12, Issue 2

    Abstract: With the advent of new viscoelastometric hemostatic assay (VHA) devices, with ready-to-use cartridge reagents allowing for their use by people without special laboratory skills, the appreciation of the actual clinical value of VHAs in settings such as ... ...

    Abstract With the advent of new viscoelastometric hemostatic assay (VHA) devices, with ready-to-use cartridge reagents allowing for their use by people without special laboratory skills, the appreciation of the actual clinical value of VHAs in settings such as severe trauma, post-partum hemorrhage, cardiac surgery and liver transplantation still needs to be fully validated. While two of the newest versions remain based on a 'cup and pin' system (ROTEM
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020477
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  9. Article ; Online: Clinical studies on platelet transfusion: Time to consider methodological issues related to platelet counting.

    Mullier, François / Baccini, Véronique / Lippi, Giuseppe / Lecompte, Thomas

    Transfusion

    2023  Volume 63, Issue 11, Page(s) 2198–2200

    MeSH term(s) Humans ; Platelet Transfusion ; Blood Platelets ; Thrombocytopenia
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Letter
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17550
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  10. Article ; Online: Erratum to: Glomerular filtration rate estimated by Cockcroft-Gault formula better predicts anti-Xa levels than Modification of the diet in renal disease equation in older patients with prophylactic enoxaparin.

    Dufour, B / Toussaint-Hacquard, M / Kearney-Schwartz, A / Manckoundia, M D P / Laurain, M-C / Joly, L / Deibener, J / Wahl, D / Lecompte, T / Benetos, A / Perret-Guillaume, Christine

    The journal of nutrition, health & aging

    2024  Volume 27, Issue 12, Page(s) 1289

    Language English
    Publishing date 2024-01-04
    Publishing country France
    Document type Published Erratum
    ZDB-ID 2081921-3
    ISSN 1760-4788 ; 1279-7707
    ISSN (online) 1760-4788
    ISSN 1279-7707
    DOI 10.1007/s12603-012-0380-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7466: Show issues

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