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  1. Article ; Online: Author response to: Comment on: Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries.

    Ledda, Virginia / Bhangu, Aneel / Nepogodiev, Dmitri

    The British journal of surgery

    2023  Volume 110, Issue 9, Page(s) 1241

    MeSH term(s) Humans ; Environment ; Health Personnel
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad183
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  2. Article ; Online: Radiolucent foreign bodies presenting as inflammatory bowel disease: the case of an ingested plastic straw disguising as Crohn's.

    Wadham, B / Connolly, T / Ledda, V / Satchidanand, R Y

    Annals of the Royal College of Surgeons of England

    2021  Volume 104, Issue 5, Page(s) e147–e149

    Abstract: More than 80% of ingested foreign bodies are thought to pass spontaneously in the faeces, with fewer than 1% requiring surgical intervention. 'Missed' gastrointestinal foreign bodies are rare and often due to the lack of an obtainable history in patients ...

    Abstract More than 80% of ingested foreign bodies are thought to pass spontaneously in the faeces, with fewer than 1% requiring surgical intervention. 'Missed' gastrointestinal foreign bodies are rare and often due to the lack of an obtainable history in patients with communication difficulties or radiolucent foreign bodies. We present the rare case of a 27-year-old woman with severe learning difficulties and a complex surgical history who presented with a 2-year history of increasing abdominal discomfort due to a 'missed' foreign body. Initially diagnosed as Crohn's disease, this case highlights the value of oral contrast enhancement imaging in patients who do not fit a 'classical' inflammatory bowel disease presentation.
    MeSH term(s) Adult ; Chronic Disease ; Crohn Disease/diagnosis ; Crohn Disease/diagnostic imaging ; Female ; Foreign Bodies/complications ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Humans ; Plastics
    Chemical Substances Plastics
    Language English
    Publishing date 2021-12-23
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2021.0204
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  3. Article ; Online: Uncertainties and opportunities in delivering environmentally sustainable surgery: the surgeons' view.

    Ledda, V / George, C / Glasbey, J / Labib, P / Li, E / Lu, A / Kudrna, L / Nepogodiev, D / Picciochi, M / Williams, I / Bhangu, A

    Anaesthesia

    2024  Volume 79, Issue 3, Page(s) 293–300

    Abstract: Surgery is a carbon-heavy activity and creates a high volume of waste. Surgical teams around the world want to deliver more environmentally sustainable surgery but are unsure what to do and how to create change. There are many interventions available, ... ...

    Abstract Surgery is a carbon-heavy activity and creates a high volume of waste. Surgical teams around the world want to deliver more environmentally sustainable surgery but are unsure what to do and how to create change. There are many interventions available, but resources and time are limited. Capital investment into healthcare and engagement of senior management are challenging. However, frontline teams can change behaviours and drive wider change. Patients have a voice here too, as they would like to ensure their surgery does not harm their local community but are concerned about the effects on them when changes are made. Environmentally sustainable surgery is at the start of its journey. Surgeons need to rapidly upskill their generic knowledge base, identify which measures they can implement locally and take part in national research programmes. Surgical teams in the NHS have the chance to create a world-leading programme that can bring change to hospitals around the world. This article provides an overview of how surgeons see the surgical team being involved in environmentally sustainable surgery.
    MeSH term(s) Humans ; Surgeons ; Hospitals ; Delivery of Health Care ; Uncertainty
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.16195
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  4. Article ; Online: Parotid Masson's tumor: case report.

    Carta, Filippo / Sionis, Sara / Ledda, Valeria / Gerosa, Clara / Puxeddu, Roberto

    Brazilian journal of otorhinolaryngology

    2016  Volume 84, Issue 4, Page(s) 523–525

    MeSH term(s) Adult ; Facial Nerve/pathology ; Female ; Hemangioendothelioma/diagnostic imaging ; Hemangioendothelioma/pathology ; Hemangioendothelioma/surgery ; Humans ; Magnetic Resonance Imaging ; Parotid Neoplasms/diagnostic imaging ; Parotid Neoplasms/pathology ; Parotid Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2016-03-29
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 2428110-4
    ISSN 1808-8686 ; 1808-8694
    ISSN (online) 1808-8686
    ISSN 1808-8694
    DOI 10.1016/j.bjorl.2016.01.003
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  5. Article ; Online: The timing of COVID-19 transmission

    Ferretti, L. / Ledda, A. / Wymant, C. / Zhao, L. / Ledda, V. / Abeler- Dorner, L. / Kendall, M. / Nurtay, A. / Cheng, H.-Y. / Ng, T.-C. / Lin, H.-H. / Hinch, R. / Masel, J. / Kilpatrick, A. M. / Fraser, C.

    Abstract: The timing of SARS-CoV-2 transmission is a critical factor to understand the epidemic trajectory and the impact of isolation, contact tracing and other non- pharmaceutical interventions on the spread of COVID-19 epidemics. We examined the distribution of ...

    Abstract The timing of SARS-CoV-2 transmission is a critical factor to understand the epidemic trajectory and the impact of isolation, contact tracing and other non- pharmaceutical interventions on the spread of COVID-19 epidemics. We examined the distribution of transmission events with respect to exposure and onset of symptoms. We show that for symptomatic individuals, the timing of transmission of SARS-CoV-2 is more strongly linked to the onset of clinical symptoms of COVID-19 than to the time since infection. We found that it was approximately centered and symmetric around the onset of symptoms, with three quarters of events occurring in the window from 2-3 days before to 2-3 days after. However, we caution against overinterpretation of the right tail of the distribution, due to its dependence on behavioural factors and interventions. We also found that the pre-symptomatic infectious period extended further back in time for individuals with longer incubation periods. This strongly suggests that information about when a case was infected should be collected where possible, in order to assess how far into the past their contacts should be traced. Overall, the fraction of transmission from strictly pre-symptomatic infections was high (41%; 95%CI 31-50%), which limits the efficacy of symptom-based interventions, and the large fraction of transmissions (35%; 95%CI 26-45%) that occur on the same day or the day after onset of symptoms underlines the critical importance of individuals distancing themselves from others as soon as they notice any symptoms, even if they are mild. Rapid or at-home testing and contextual risk information would greatly facilitate efficient early isolation.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.09.04.20188516
    Database COVID19

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  6. Article ; Online: Megacities, migration and an evolutionary approach to bipolar disorder: a study of Sardinian immigrants in Latin America.

    Carta, Mauro G / Moro, Maria F / Piras, Martina / Ledda, Vanessa / Prina, Eleonora / Stocchino, Serena / Orrù, Germano / Romano, Ferdinando / Brasesco, Maria V / Freire, Rafael C / Nardi, Antonio E / Tondo, Leonardo

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2019  Volume 42, Issue 1, Page(s) 63–67

    Abstract: Objective: To determine whether people with a Sardinian genetic background who live in the megacities of South America have a higher frequency of hypomania than residents of Sardinia.: Methods: A community survey of Sardinian immigrants was carried ... ...

    Abstract Objective: To determine whether people with a Sardinian genetic background who live in the megacities of South America have a higher frequency of hypomania than residents of Sardinia.
    Methods: A community survey of Sardinian immigrants was carried out in four Brazilian metropoles (n=218) and Buenos Aires (n=306). The results were compared with those of a study involving a similar methodology (Mood Disorder Questionnaire [MDQ] as a screening tool) conducted in seven Italian regions, including a sub-sample from Sardinia.
    Results: There was a higher prevalence of lifetime hypomania among Sardinians living in the Brazilian metropoles than among those living in Sardinia. This result was also consistent with Sardinian immigrants in Buenos Aires. After stratification by sex and age, the lifetime prevalence of MDQ scores ≥ 8 among Sardinians in South-American megacities and Sardinia was 8.6% vs. 2.9%, respectively (p < 0.0001).
    Conclusions: The higher frequency of hypomania in migrant populations appears to favor an evolutionary view in which mood disorders may be a maladaptive aspect of a genetic background with adaptive characteristics.
    MeSH term(s) Adult ; Age Distribution ; Argentina/epidemiology ; Bipolar Disorder/epidemiology ; Brazil/epidemiology ; Cities/epidemiology ; Cross-Cultural Comparison ; Female ; Humans ; Italy/ethnology ; Male ; Prevalence ; Risk Factors ; Sex Distribution ; Surveys and Questionnaires ; Transients and Migrants/psychology
    Language English
    Publishing date 2019-07-01
    Publishing country Brazil
    Document type Journal Article
    ISSN 1809-452X
    ISSN (online) 1809-452X
    DOI 10.1590/1516-4446-2018-0338
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  7. Article ; Online: The timing of COVID-19 transmission

    Ferretti, Luca / Ledda, Alice / Wymant, Chris / Zhao, Lele / Ledda, Virginia / Abeler- Dorner, Lucie / Kendall, Michelle / Nurtay, Anel / Cheng, Hao-Yuan / Ng, Ta-Chou / Lin, Hsien-Ho / Hinch, Rob / Masel, Joanna / Kilpatrick, A. Marm / Fraser, Christophe

    medRxiv

    Abstract: The timing of SARS-CoV-2 transmission is a critical factor to understand the epidemic trajectory and the impact of isolation, contact tracing and other non- pharmaceutical interventions on the spread of COVID-19 epidemics. We examined the distribution of ...

    Abstract The timing of SARS-CoV-2 transmission is a critical factor to understand the epidemic trajectory and the impact of isolation, contact tracing and other non- pharmaceutical interventions on the spread of COVID-19 epidemics. We examined the distribution of transmission events with respect to exposure and onset of symptoms. We show that for symptomatic individuals, the timing of transmission of SARS-CoV-2 is more strongly linked to the onset of clinical symptoms of COVID-19 than to the time since infection. We found that it was approximately centered and symmetric around the onset of symptoms, with three quarters of events occurring in the window from 2-3 days before to 2-3 days after. However, we caution against overinterpretation of the right tail of the distribution, due to its dependence on behavioural factors and interventions. We also found that the pre-symptomatic infectious period extended further back in time for individuals with longer incubation periods. This strongly suggests that information about when a case was infected should be collected where possible, in order to assess how far into the past their contacts should be traced. Overall, the fraction of transmission from strictly pre-symptomatic infections was high (41%; 95%CI 31-50%), which limits the efficacy of symptom-based interventions, and the large fraction of transmissions (35%; 95%CI 26-45%) that occur on the same day or the day after onset of symptoms underlines the critical importance of individuals distancing themselves from others as soon as they notice any symptoms, even if they are mild. Rapid or at-home testing and contextual risk information would greatly facilitate efficient early isolation.
    Keywords covid19
    Language English
    Publishing date 2020-09-07
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.09.04.20188516
    Database COVID19

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  8. Article ; Online: The Timing of COVID-19 Transmission

    Ferretti, Luca / Ledda, Alice / Wymant, Chris / Zhao, Lele / Ledda, Virginia / Abeler- Dörner, Lucie / Kendall, Michelle / Nurtay, Anel / Cheng, Hao-Yuan / Ng, Ta-Chou / Lin, Hsien-Ho / Hinch, Rob / Masel, Joanna / Kilpatrick, A. Marm / Fraser, Christophe

    SSRN Electronic Journal ; ISSN 1556-5068

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3716879
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Association of the Careggi Collateral Score with 3-month modified Rankin Scale score after thrombectomy for stroke with occlusion of the middle cerebral artery.

    Cappellari, Manuel / Saia, Valentina / Pracucci, Giovanni / Enrico, Fainardi / Consoli, Arturo / Nappini, Sergio / Castellan, Lucio / Bracco, Sandra / Bergui, Mauro / Cosottini, Mirco / Vangosa, Alessandra Briatico / Vinci, Sergio / Ruggiero, Maria / Puglielli, Edoardo / Chiumarulo, Luigi / Cester, Giacomo / Comelli, Chiara / Silvagni, Umberto / Morosetti, Daniele /
    Caldiera, Valentina / Cavasin, Nicola / Ledda, Valeria / Sanfilippo, Giuseppina / Saletti, Andrea / Filauri, Pietro / Gallesio, Ivan / Nuzzi, Nunzio Paolo / Amistá, Pitero / Zivelonghi, Cecilia / Plebani, Mauro / Pavia, Marco / Romano, Daniele / Biraschi, Francesco / Menozzi, Roberto / Gasparotti, Roberto / Giorgianni, Andrea / Zini, Andrea / Inzitari, Domenico / Toni, Danilo / Mangiafico, Salvatore

    Journal of neurology

    2021  Volume 269, Issue 2, Page(s) 1013–1023

    Abstract: Background: The Careggi Collateral Score (CCS) (qualitative-quantitative evaluation) was developed from a single-centre cohort as an angiographic score to describe both the extension and effectiveness of the pial collateral circulation in stroke ... ...

    Abstract Background: The Careggi Collateral Score (CCS) (qualitative-quantitative evaluation) was developed from a single-centre cohort as an angiographic score to describe both the extension and effectiveness of the pial collateral circulation in stroke patients with occlusion of the anterior circulation. We aimed to examine the association between CCS (quantitative evaluation) and 3-month modified Rankin Scale (mRS) score in a large multi-center cohort of patients receiving thrombectomy for stroke with occlusion of middle cerebral artery (MCA).
    Methods: We conducted a study on prospectively collected data from 1284 patients enrolled in the Italian Registry of Endovascular Treatment in Acute Stroke. According to the extension of the retrograde reperfusion in the cortical anterior cerebral artery (ACA)-MCA territories, CCS ranges from 0 (absence of retrograde filling) to 4 (visualization of collaterals until the alar segment of the MCA).
    Results: Using CCS of 4 as reference, CCS grades were associated in the direction of unfavourable outcome on 3-month mRS shift (0 to 6); significant difference was found between CCS of 0 and CCS of 1 and between CCS of 3 and CCS of 4. CCS ≥ 3 was the optimal cut-off for predicting 3-month excellent outcome, while CCS ≥ 1 was the optimal cut-off for predicting 3-month survival. CCS of 0 and CCS < 3 were associated in the direction of unfavourable recanalization on TICI shift (0 to 3) compared with CCS ≥ 1 and CCS ≥ 3, respectively. Compared with CCS ≥ 3 as reference, CCS of 0 and CCS 1 to 2 were associated in the direction of unfavourable recanalization on TICI shift. There was no evidence of heterogeneity of effects of successful recanalization and procedure time ≤ 60 min on 3-month mRS shift across CCS categories.
    Conclusion: The CCS could provide a future advantage for improving the prognosis in patients receiving thrombectomy for stroke with M1 or M1-M2 segment of the MCA occlusion.
    MeSH term(s) Cerebral Angiography ; Endovascular Procedures ; Humans ; Infarction, Middle Cerebral Artery/diagnostic imaging ; Infarction, Middle Cerebral Artery/surgery ; Middle Cerebral Artery/diagnostic imaging ; Middle Cerebral Artery/surgery ; Retrospective Studies ; Stroke/diagnostic imaging ; Stroke/surgery ; Thrombectomy ; Treatment Outcome
    Language English
    Publishing date 2021-11-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-021-10898-8
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  10. Article ; Online: Correction to: Association of the Careggi Collateral Score with 3-month modified Rankin Scale score after thrombectomy for stroke with occlusion of the middle cerebral artery.

    Cappellari, Manuel / Saia, Valentina / Pracucci, Giovanni / Fainardi, Enrico / Consoli, Arturo / Nappini, Sergio / Castellan, Lucio / Bracco, Sandra / Bergui, Mauro / Cosottini, Mirco / Vangosa, Alessandra Briatico / Vinci, Sergio / Ruggiero, Maria / Puglielli, Edoardo / Chiumarulo, Luigi / Cester, Giacomo / Comelli, Chiara / Silvagni, Umberto / Morosetti, Daniele /
    Caldiera, Valentina / Cavasin, Nicola / Ledda, Valeria / Sanfilippo, Giuseppina / Saletti, Andrea / Filauri, Pietro / Gallesio, Ivan / Nuzzi, Nunzio Paolo / Amistá, Pitero / Zivelonghi, Cecilia / Plebani, Mauro / Pavia, Marco / Romano, Daniele / Biraschi, Francesco / Menozzi, Roberto / Gasparotti, Roberto / Giorgianni, Andrea / Zini, Andrea / Inzitari, Domenico / Toni, Danilo / Mangiafico, Salvatore

    Journal of neurology

    2021  Volume 269, Issue 2, Page(s) 1024–1025

    Language English
    Publishing date 2021-12-24
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-021-10941-8
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