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  1. Book: Ultrasound in Assisted Reproduction and Early Pregnancy

    Fonda, Jane S. / Rodgers, Rachael J. / Ledger, William L.

    A Practical Guide

    2021  

    Abstract: Ultrasonography is a crucial tool in successful assisted reproduction but requires a steady hand and can often be difficult for unconfident clinicians. A comprehensive ultrasound imaging reference, this is an essential guide for trainee clinicians, ... ...

    Author's details William L. Ledger is Head of Discipline of Obstetrics and Gynaecology of the Faculty of Medicine at the University of New South Wales, Director of Reproductive Medicine and Senior Staff Specialist at the Royal Hospital for Women and Chair of the Research and Development Committee and a fertility specialist at IVFAustralia, Sydney Australia
    Abstract Ultrasonography is a crucial tool in successful assisted reproduction but requires a steady hand and can often be difficult for unconfident clinicians. A comprehensive ultrasound imaging reference, this is an essential guide for trainee clinicians, ultrasonographers, and nurses working in the field of assisted reproductive technology. Providing the reader with an overview of the process and a foundation to direct their ultrasound assessment of each patient, it contains highly practical tips a...
    Language English
    Size 84 p.
    Publisher Cambridge University Press
    Document type Book
    Note PDA Manuell_10
    Format 221 x 276 x 22
    ISBN 9781108810210 ; 1108810217
    Database PDA

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  2. Book: Controversies in assisted reproduction

    Ledger, William

    (Best practice & research. Clinical obstetrics & gynaecology ; volume 53 (November 2018))

    2018  

    Author's details Professor William Ledger, guest editor
    Series title Best practice & research. Clinical obstetrics & gynaecology ; volume 53 (November 2018)
    Best practice & research
    Collection Best practice & research
    Language English
    Size 96 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT019941551
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 1040 -53- verfügbar in Königswinter Königswinter

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  3. Book: Oxford textbook of obstetrics and gynaecology

    Arulkumaran, Sabaratnam / Ledger, William / Denny, Lynette / Doumouchtsis, Stergios K.

    2020  

    Title variant Textbook of obstetrics and gynaecology ; Obstetrics and gynaecology
    Author's details Sabaratnam Arulkumaran, William Ledger, Lynette Denny, Stergios Doumouchtsis
    Keywords Gynecology ; Obstetrics
    Subject code 618
    Language English
    Size xviii, 903 Seiten, Illustrationen, 29 cm
    Edition First edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    Note Zugang zur Online-Ausgabe über Code ; Formerly CIP.
    HBZ-ID HT020454158
    ISBN 978-0-19-876636-0 ; 9780192515230 ; 0-19-876636-X ; 0192515233
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2020 A 647 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  4. Book: Chronic pelvic pain

    Schlaff, William D. / Vancaillie, Thierry / Ledger, William

    (Cambridge medicine)

    2015  

    Author's details William Ledger ; , William D. Schlaff ; Thierry G. Vancaillie
    Series title Cambridge medicine
    Keywords Pelvic Pain ; Chronic Disease ; Pelvic Inflammatory Disease ; Pain Management
    Language English
    Size VII, 159 S. : Ill.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT018523922
    ISBN 978-1-107-63662-0 ; 1-107-63662-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 411 available for loan (reading room) Lesesaal EG

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  5. Book: Gynecological drug therapy

    Ledger, William

    2007  

    Author's details ed. by William Leigh Ledger
    Language English
    Size XI, 315 S. : Ill., graph. Darst.
    Publisher Informa Healthcare
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014891288
    ISBN 0-8247-2841-6 ; 978-0-8247-2841-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 402 order for loan Magazin

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  6. Book: The fallopian tube in infertility and IVF practice

    Ledger, William / Tan, Seang Lin / Bahathiq, Adil O. S.

    2010  

    Author's details ed. by William L. Ledger ; Seang Lin Tan ; Adil O. S. Bahathiq
    Keywords Fallopian Tube Diseases / complications ; Fallopian Tube Diseases / therapy ; Fallopian Tubes / physiopathology ; Infertility, Female ; Fertilization in Vitro
    Language English
    Size VIII, 130 S., [2] Bl. : Ill., graph. Darst., 26 cm
    Publisher Cambridge Univ. Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT016442997
    ISBN 978-0-521-87378-9 ; 0-521-87378-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 3660 order for loan Magazin

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  7. Article ; Online: A strong foundation for the next generation.

    Mihalas, Bettina P / Frost, Emily R / Kadam, Kaushiki M / Sucquart, Irene E / Sirigeri, Prakruti / Ledger, William L / Gilchrist, Robert B

    Molecular reproduction and development

    2023  Volume 90, Issue 10-11, Page(s) 773

    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Letter
    ZDB-ID 20321-x
    ISSN 1098-2795 ; 1040-452X
    ISSN (online) 1098-2795
    ISSN 1040-452X
    DOI 10.1002/mrd.23709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2759: Show issues Location:
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  8. Article ; Online: Immunocytochemical Localization of Olfactory-signaling Molecules in Human and Rat Spermatozoa.

    Makeyeva, Yuliya / Nicol, Christopher / Ledger, William L / Ryugo, David K

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2020  Volume 68, Issue 7, Page(s) 491–513

    Abstract: Expression of olfactory receptors (ORs) in non-olfactory tissues has been widely reported over the last 20 years. Olfactory marker protein (OMP) is highly expressed in mature olfactory sensory neurons (mOSNs) of the olfactory epithelium. It is involved ... ...

    Abstract Expression of olfactory receptors (ORs) in non-olfactory tissues has been widely reported over the last 20 years. Olfactory marker protein (OMP) is highly expressed in mature olfactory sensory neurons (mOSNs) of the olfactory epithelium. It is involved in the olfactory signal transduction pathway, which is mediated by well-conserved components, including ORs, olfactory G protein (Golf), and adenylyl cyclase 3 (AC3). OMP is widely expressed in non-olfactory tissues with an apparent preference for motile cells. We hypothesized that OMP is expressed in compartment-specific locations and co-localize with an OR, Golf, and AC3 in rat epididymal and human-ejaculated spermatozoa. We used immunocytochemistry to examine the expression patterns of OMP and OR6B2 (human OR, served as positive olfactory control) in experimentally induced modes of activation and determine whether there are any observable differences in proteins expression during the post-ejaculatory stages of spermatozoal functional maturation. We found that OMP was expressed in compartment-specific locations in human and rat spermatozoa. OMP was co-expressed with Golf and AC3 in rat spermatozoa and with OR6B2 in all three modes of activation (control, activated, and hyperactivated), and the mode of activation changed the co-expression pattern in acrosomal-reacted human spermatozoa. These observations suggest that OMP expression is a reliable indicator of OR-mediated chemoreception, may be used to identify ectopically expressed ORs, and could participate in second messenger signaling cascades that mediate fertility.
    MeSH term(s) Animals ; Gene Expression Regulation ; Humans ; Immunohistochemistry/methods ; Male ; Olfactory Marker Protein/metabolism ; Rats ; Spermatozoa/cytology ; Spermatozoa/metabolism
    Chemical Substances Olfactory Marker Protein
    Language English
    Publishing date 2020-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1369/0022155420939833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Implementation of the findings of a national enquiry into the misdiagnosis of miscarriage in the Republic of Ireland: impact on quality of clinical care.

    Ledger, William L / Turner, Michael J

    Fertility and sterility

    2016  Volume 105, Issue 2, Page(s) 417–422

    Abstract: Objective: To describe the findings of a national inquiry into cases of misdiagnosis of miscarriage in the Republic of Ireland and to report the results of implementation of the findings of the inquiry, including investment in new equipment and training, ...

    Abstract Objective: To describe the findings of a national inquiry into cases of misdiagnosis of miscarriage in the Republic of Ireland and to report the results of implementation of the findings of the inquiry, including investment in new equipment and training, new national guidelines, and rigorous annual audit of early pregnancy units.
    Design: Narrative description of the inquiry and its findings and results of a subsequent audit.
    Setting: Not applicable.
    Patient(s): Women with problems of bleeding and/or pain in early pregnancy who were erroneously diagnosed as having a nonviable intrauterine pregnancy.
    Intervention(s): After two cases of misdiagnosis of miscarriage that were widely reported in the Republic of Ireland in June 2010, a Miscarriage Misdiagnosis Review Team was commissioned by the Irish Health Service Executive (HSE) to undertake a national review of other possible cases of misdiagnosis of miscarriage. The Review Team made a series of recommendations that were subsequently implemented in full. The results of the implementation of the findings of the Review Team have been the subject of three annual audits across the country.
    Main outcome measure(s): The main outcome measure was the occurrence of misdiagnosis of miscarriage in the Republic of Ireland before and after implementation of the findings of the Review Team.
    Result(s): Twenty-four confirmed cases of misdiagnosis of miscarriage were identified, mostly occurring between 2005 and 2010. Analysis led to a series of recommendations by the Review Team, which were implemented in full by the HSE. Over € 3 million was provided to fund implementation; 26 high-quality gynecological ultrasound machines were purchased to reequip 19 units involved in provision of care to women with suspected miscarriage. There was further allocation of resources for new equipment and improvement in the management and staffing of early pregnancy units across Ireland, with each center now having a dedicated and properly staffed Early Pregnancy Assessment Unit. A national training program in the management of early pregnancy problems has been implemented, along with regular national meetings to discuss early pregnancy problems. National clinical guidelines on the diagnosis and management of miscarriage for implementation have been distributed to all hospitals.
    Conclusion(s): No cases of miscarriage misdiagnosis were identified in any of the three annual audits, suggesting that implementation of the findings of the review has been successful. We believe that this is the first report of national change in practice leading to improvement in clinical outcomes in the management of suspected miscarriage.
    MeSH term(s) Abortion, Spontaneous/diagnosis ; Abortion, Spontaneous/economics ; Budgets ; Diagnostic Errors/economics ; Female ; Guideline Adherence ; Health Care Costs ; Health Care Rationing ; Health Services Needs and Demand ; Humans ; Medical Audit ; National Health Programs/economics ; National Health Programs/standards ; Needs Assessment ; Northern Ireland ; Practice Guidelines as Topic ; Predictive Value of Tests ; Pregnancy ; Prenatal Care/economics ; Prenatal Care/standards ; Program Development ; Program Evaluation ; Quality Improvement/economics ; Quality Improvement/standards ; Quality Indicators, Health Care/economics ; Quality Indicators, Health Care/standards ; Time Factors ; Ultrasonography, Prenatal
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2015.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 73: Show issues Location:
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  10. Article ; Online: Four-dimensional ultrasound biometry following botulinum toxin type A injection to the pelvic floor.

    Nesbitt-Hawes, Erin M / Dietz, Hans Peter / Ledger, William L / Abbott, Jason A

    Neurourology and urodynamics

    2021  Volume 41, Issue 1, Page(s) 375–382

    Abstract: Aims: The objective of this study was to provide follow-up data on four-dimensional ultrasound (4DUS) morphometry for women having botulinum toxin type A (BoNT-A) treatment of pelvic floor tension myalgia (PFTM).: Materials and methods: A prospective ...

    Abstract Aims: The objective of this study was to provide follow-up data on four-dimensional ultrasound (4DUS) morphometry for women having botulinum toxin type A (BoNT-A) treatment of pelvic floor tension myalgia (PFTM).
    Materials and methods: A prospective cohort study was performed from October 2013 to June 2018, recruiting women scheduled for BoNT-A injection in the pelvic floor musculature. Translabial 4DUS, vaginal pressure assessment by manometry and pain visual analog scales (VAS) were performed on all women before injection and again at 4, 12, and 26 weeks. The BoNT-A injection was performed under 4DUS guidance.
    Results: Twenty-nine women had 44 injections over the course of the study. Although improvements were seen in VAS scores for dysmenorrhea, nonmenstrual pelvic pain, and dyspareunia, there were no significant differences in ultrasound biometry at either rest, Valsalva, or on contraction when comparing postinjection measurements at 4, 12, and 26 weeks with pre-injection baseline. Similarly, vaginal pressure readings at rest demonstrated a significant improvement throughout the 4, 12, and 26 week follow-up, with a reduction in maximal contraction at 4 and 12 but not 26 weeks.
    Conclusions: This study demonstrates that 4DUS biometry of the pelvic floor does not correlate with clinical pain and vaginal pressure outcomes for BoNT-A injection in the context of PFTM.
    MeSH term(s) Biometry ; Botulinum Toxins, Type A/therapeutic use ; Female ; Humans ; Pelvic Floor/diagnostic imaging ; Pelvic Pain/drug therapy ; Prospective Studies ; Treatment Outcome
    Chemical Substances Botulinum Toxins, Type A (EC 3.4.24.69)
    Language English
    Publishing date 2021-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.24833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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