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  1. Article ; Online: Non-Lethal Dose-Response Models Replace Lethal Bioassays for Predicting the Hazard of Para-Aminopropiophenone to Australian Wildlife

    Clive A. Marks / Lee Allen / Heli Lindeberg

    Animals, Vol 13, Iss 472, p

    2023  Volume 472

    Abstract: Para-aminopropiophenone (PAPP) is a potent methaemoglobin (MetHb) forming agent used for the lethal control of exotic carnivores and mustelids. To assess the sensitivity of Australian wildlife to PAPP we developed an in vivo assay that did not use death ... ...

    Abstract Para-aminopropiophenone (PAPP) is a potent methaemoglobin (MetHb) forming agent used for the lethal control of exotic carnivores and mustelids. To assess the sensitivity of Australian wildlife to PAPP we developed an in vivo assay that did not use death as an endpoint. Sub-lethal dose-response data were modelled to predict PAPP doses required to achieve an endpoint set at 80% MetHb (MetHb 80 ). The comparative sensitivity of non-target mammals referenced to this endpoint was found to be highly variable, with southern brown bandicoots ( Isoodon obesulus ) the most sensitive species (MetHb 80 = 6.3 mg kg −1 ) and bush rats ( Rattus fuscipes ) the most tolerant (MetHb 80 = 1035 mg kg −1 ). Published LD 50 estimates were highly correlated with PAPP doses modelled to achieve the MetHb 80 endpoint (r 2 = 0.99, p < 0.001). Most dose-response data for native mammals were collected in the field or in semi-natural enclosures, permitting PAPP and placebo dosed animals to be fitted with tracking transmitters and transponders and released at their point of capture. A protracted morbidity and mortality was observed only in Australian ravens ( Corvus coronoides ). The combination of sub-lethal dose-response assay and survival data collected in the field provided more relevant information about the actual hazard of pest control agents to non-target wildlife species than laboratory-based lethal-dose bioassays. We discuss the need to replace lethal-dose data with biologically meaningful insights able to define a continuum of toxicological hazards that better serve the needs of conservation and veterinary scientists and wildlife managers.
    Keywords para-aminopropiophenone ; PAPP ; methaemoglobin ; MetHb ; animal welfare ; lethal-dose bioassay ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Subject code 333
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: How to Incorporate Health Equity Training Into Gastroenterology and Hepatology Fellowships.

    Lee-Allen, Jannel / Shah, Brijen J

    Gastroenterology

    2021  Volume 160, Issue 6, Page(s) 1924–1928

    MeSH term(s) Curriculum ; Education, Medical, Graduate/methods ; Fellowships and Scholarships/methods ; Gastroenterology/education ; Health Equity ; Humans ; Quality Improvement ; Teaching Rounds
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.03.018
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  3. Article: Psychotic Symptoms in Patients With Major Neurological Diseases.

    Kim, Jong S / Hong, Seung-Bong / Park, Keun-Woo / Lee, Allen T C

    Journal of clinical neurology (Seoul, Korea)

    2024  Volume 20, Issue 2, Page(s) 153–165

    Abstract: Neurological diseases often manifest with neuropsychiatric symptoms such as depression, emotional incontinence, anger, apathy and fatigue. In addition, affected patients may also experience psychotic symptoms such as hallucinations and delusions. Various ...

    Abstract Neurological diseases often manifest with neuropsychiatric symptoms such as depression, emotional incontinence, anger, apathy and fatigue. In addition, affected patients may also experience psychotic symptoms such as hallucinations and delusions. Various factors contribute to the development of psychotic symptoms, and the mechanisms of psychosis are similar, but still differ among various neurological diseases. Although psychotic symptoms are uncommon, and have been less well investigated, they may annoy patients and their families as well as impair the patients' quality of life and increase the caregiver burden. Therefore, we need to appropriately identify and treat these psychotic symptoms in patients with neurological diseases.
    Language English
    Publishing date 2024-03-04
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2023.0501
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  4. Article ; Online: Development and validation of cognitive ageing risk score (CARS) for early detection of subtle cognitive deficits in older people.

    Fung, Ada Wai Tung / Lee, Allen Ting Chun / Ma, Suk Ling / Lam, Linda Chiu Wa

    BMC geriatrics

    2024  Volume 24, Issue 1, Page(s) 277

    Abstract: Background: Early cognitive deficits commonly seen in older people have not been well defined and managed in primary care. The objectives are (1) to develop and validate a new risk score to estimate the risk of dementia in Chinese older population; and ( ...

    Abstract Background: Early cognitive deficits commonly seen in older people have not been well defined and managed in primary care. The objectives are (1) to develop and validate a new risk score to estimate the risk of dementia in Chinese older population; and (2) to evaluate the use of risk score in conjunction with cognitive screening in detecting early cognitive deficits in community older people.
    Methods: A development cohort of 306 cognitive healthy older adults aged 60 or above were followed for 6 years. A CARS was constructed using the estimated coefficients of risk factors associated with dementia at follow up. Validation was carried out in another five-year cohort of 383 older adults. The usefulness of CARS in detecting early cognitive deficits was evaluated.
    Results: Risk factors include older age, male gender, low level of education, poorly controlled diabetes, prolonged sleep latency, fewer mind body or light exercise, loneliness, and being apolipoprotein e4 carriers. A cutoff of CARS at -1.3 had a sensitivity of 83.9% and a specificity of 75.4% to predict dementia. The area under curve was 82.5% in the development cohort. Early cognitive deficits were characterized by impaired retention (p <.001, 95% CI 0.2-0.9) and attention (p =.012, 95% CI 0.1-0.8).
    Conclusion: The CARS can be used as a standard risk assessment of dementia or in conjunction with a computerized cognitive screening to evaluate a full cognitive profile for detecting early cognitive deficits. The result put forward the integration of risk algorithm into smart healthcare system to provide personalized lifestyle interventions.
    MeSH term(s) Aged ; Humans ; Male ; Aging ; Cognition ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/complications ; Dementia/diagnosis ; Risk Factors ; Middle Aged ; Female
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article ; Validation Study
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-024-04879-5
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  5. Article ; Online: Clinical considerations when using assessment tools to identify depression in older adults with mild cognitive impairment.

    Lee, Allen Ting Chun / Chiu, Helen Fung Kum / Peisah, Carmelle

    International psychogeriatrics

    2022  Volume 34, Issue 5, Page(s) 413–416

    MeSH term(s) Aged ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Depression/diagnosis ; Humans
    Language English
    Publishing date 2022-04-25
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610222000424
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  6. Article: Philosophy and method

    Lee, Allen S

    The Routledge companion to management information systems , p. 30-46

    making interpretive research interpretive

    2018  , Page(s) 30–46

    Author's details Allen S. Lee
    Keywords Management-Informationssystem ; Philosophie
    Language English
    Publisher Routledge
    Publishing place London
    Document type Article
    ISBN 978-1-138-66645-0 ; 1-138-66645-9
    Database ECONomics Information System

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  7. Article ; Online: Use of focused intensive care echo in the diagnosis of primary cardiac angiosarcoma

    Jasmine Medhora / Graham Wilson / Andrew Ronald / Lee Allen

    Clinical Case Reports, Vol 8, Iss 12, Pp 3057-

    2020  Volume 3060

    Abstract: Abstract Focused Intensive Care Echo can aid diagnosis in complex patients where initial investigations are non‐diagnostic. FICE is an essential skill for critical care physicians, and bedside echocardiography should be a standard investigation for all ... ...

    Abstract Abstract Focused Intensive Care Echo can aid diagnosis in complex patients where initial investigations are non‐diagnostic. FICE is an essential skill for critical care physicians, and bedside echocardiography should be a standard investigation for all critical care patients.
    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
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  8. Article ; Online: Is cognitive screening useful for long-term prediction of incident dementia?

    Lam, Linda Chiu Wa / Lee, Allen T C

    The Lancet. Healthy longevity

    2021  Volume 2, Issue 7, Page(s) e387–e388

    MeSH term(s) Cognition ; Dementia/diagnosis ; Humans ; Mass Screening
    Language English
    Publishing date 2021-06-30
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2666-7568
    ISSN (online) 2666-7568
    DOI 10.1016/S2666-7568(21)00148-3
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  9. Article ; Online: Inpatient stay for older adults: a double-edged sword for cognition?

    Lee, Allen T C / Chiu, Helen F K

    International psychogeriatrics

    2021  Volume 34, Issue 11, Page(s) 953–954

    MeSH term(s) Humans ; Aged ; Inpatients ; Cognition
    Language English
    Publishing date 2021-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610221001137
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  10. Article ; Online: Gastroparesis: what is the current state-of-the-art for evaluation and medical management? What are the results?

    Lee, Allen

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2013  Volume 17, Issue 9, Page(s) 1553–1556

    Abstract: Gastroparesis is a chronic motility disorder that leads to delayed gastric emptying and negatively impacts morbidity, mortality, and quality of life. This paper provides an overview of the pathophysiology leading to symptoms in gastroparesis, discusses ... ...

    Abstract Gastroparesis is a chronic motility disorder that leads to delayed gastric emptying and negatively impacts morbidity, mortality, and quality of life. This paper provides an overview of the pathophysiology leading to symptoms in gastroparesis, discusses tests for diagnosis, and examines the evidence behind different treatment options for gastroparesis. Although delayed gastric emptying is the cardinal finding in gastroparesis, other physiologic abnormalities may contribute to the pathogenesis of symptoms. Gastric emptying scintigraphy is considered the gold standard for the diagnosis of gastroparesis but novel tests are currently available. Although metoclopramide is the only FDA approved medication to treat gastroparesis, alternative therapeutic options are available and should be tailored according to symptoms as well as physiologic abnormalities.
    MeSH term(s) Botulinum Toxins/therapeutic use ; Combined Modality Therapy ; Diet Therapy ; Domperidone/therapeutic use ; Erythromycin/therapeutic use ; Gastrointestinal Agents/therapeutic use ; Gastroparesis/diagnosis ; Gastroparesis/drug therapy ; Gastroparesis/physiopathology ; Gastroparesis/therapy ; Humans ; Metoclopramide/therapeutic use ; Smoking Cessation
    Chemical Substances Gastrointestinal Agents ; Domperidone (5587267Z69) ; Erythromycin (63937KV33D) ; Botulinum Toxins (EC 3.4.24.69) ; Metoclopramide (L4YEB44I46)
    Language English
    Publishing date 2013-06-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1007/s11605-013-2254-x
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