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  1. Article: Elucidation of the di-c-glycosylation steps during biosynthesis of the antitumor antibiotic, kidamycin.

    Heo, Kyung Taek / Lee, Byeongsan / Jang, Jae-Hyuk / Hong, Young-Soo

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 985696

    Abstract: Kidamycins belong to the pluramycin family of antitumor antibiotics that contain di-C-glycosylated angucycline. Owing to its interesting biological activity, several synthetic derivatives of kidamycins are currently being developed. However, the ... ...

    Abstract Kidamycins belong to the pluramycin family of antitumor antibiotics that contain di-C-glycosylated angucycline. Owing to its interesting biological activity, several synthetic derivatives of kidamycins are currently being developed. However, the synthesis of these complex structural compounds with unusual C-glycosylated residues is difficult. In the kidamycin-producing
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.985696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway.

    Roh, Jongtae / Jang, Jun-Pil / Oh, Taehoon / Kim, Jihong / Lee, Byeongsan / Hong, Young-Soo / Jang, Jae-Hyuk / Ko, Sung-Kyun

    Pharmacological reports : PR

    2024  Volume 76, Issue 2, Page(s) 435–438

    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2186248-5
    ISSN 2299-5684 ; 1734-1140
    ISSN (online) 2299-5684
    ISSN 1734-1140
    DOI 10.1007/s43440-024-00591-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 861: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway.

    Roh, Jongtae / Jang, Jun-Pil / Oh, Taehoon / Kim, Jihong / Lee, Byeongsan / Hong, Young-Soo / Jang, Jae-Hyuk / Ko, Sung-Kyun

    Pharmacological reports : PR

    2024  Volume 76, Issue 2, Page(s) 368–378

    Abstract: Background: Excessive stress, a major problem in modern societies, affects people of all ages worldwide. Corticosterone is one of the most abundant hormones secreted during stressful conditions and is associated with various dysfunctions in the body. In ...

    Abstract Background: Excessive stress, a major problem in modern societies, affects people of all ages worldwide. Corticosterone is one of the most abundant hormones secreted during stressful conditions and is associated with various dysfunctions in the body. In particular, we aimed to investigate the protective effects of hygrolansamycin C (HYGC) against corticosterone-induced cellular stress, a manifestation of excessive stress prevalent in contemporary societies.
    Methods: We isolated HYGC from Streptomyces sp. KCB17JA11 and subjected PC12 cells to corticosterone-induced stress. The effects of HYGC were assessed by measuring autophagy and the expression of mitogen-activated protein kinase (MAPK) phosphorylation-related genes. We used established cellular and molecular techniques to analyze protein levels and pathways.
    Results: HYGC effectively protected cells against corticosterone-induced injury. Specifically, it significantly reduced corticosterone-induced oxidative stress and inhibited the expression of autophagy-related proteins induced by corticosterone, which provided mechanistic insight into the protective effects of HYGC. At the signaling level, HYGC suppressed c-Jun N-terminal kinase and extracellular signal-regulated kinase phosphorylation and p38 activation.
    Conclusions: HYGC is a promising candidate to counteract corticosterone-induced apoptosis and oxidative stress. Autophagy and MAPK pathway inhibition contribute to the protective effects of HYGC. Our findings highlight the potential of HYGC as a therapeutic agent for stress-related disorders and serve as a stepping stone for further exploration and development of stress management strategies.
    MeSH term(s) Rats ; Animals ; Humans ; Corticosterone/toxicity ; p38 Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Signaling System ; Oxidative Stress ; Signal Transduction ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Apoptosis ; Autophagy
    Chemical Substances Corticosterone (W980KJ009P) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2186248-5
    ISSN 2299-5684 ; 1734-1140
    ISSN (online) 2299-5684
    ISSN 1734-1140
    DOI 10.1007/s43440-024-00572-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 861: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: A unique dual acyltransferase system shared in the polyketide chain initiation of kidamycinone and rubiflavinone biosynthesis.

    Heo, Kyung Taek / Lee, Byeongsan / Hwang, Gwi Ja / Park, Beomcheol / Jang, Jun-Pil / Hwang, Bang Yeon / Jang, Jae-Hyuk / Hong, Young-Soo

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1274358

    Abstract: The pluramycin family of natural products has diverse substituents at the C2 position, which are closely related to their biological activity. Therefore, it is important to understand the biosynthesis of C2 substituents. In this study, we describe the ... ...

    Abstract The pluramycin family of natural products has diverse substituents at the C2 position, which are closely related to their biological activity. Therefore, it is important to understand the biosynthesis of C2 substituents. In this study, we describe the biosynthesis of C2 moieties in
    Language English
    Publishing date 2023-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1274358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Construction of an Artificial Biosynthetic Pathway for the Styrylpyrone Compound 11-Methoxy-Bisnoryangonin Produced in Engineered

    Heo, Kyung Taek / Lee, Byeongsan / Jang, Jae-Hyuk / Ahn, Jung-Oh / Hong, Young-Soo

    Frontiers in microbiology

    2021  Volume 12, Page(s) 714335

    Abstract: A cDNA clone ( ... ...

    Abstract A cDNA clone (named
    Language English
    Publishing date 2021-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.714335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Induction of Fungal Secondary Metabolites by Co-Culture with Actinomycete Producing HDAC Inhibitor Trichostatins.

    Hwang, Gwi Ja / Roh, Jongtae / Son, Sangkeun / Lee, Byeongsan / Jang, Jun-Pil / Hur, Jae-Seoun / Hong, Young-Soo / Ahn, Jong Seog / Ko, Sung-Kyun / Jang, Jae-Hyuk

    Journal of microbiology and biotechnology

    2023  Volume 33, Issue 11, Page(s) 1437–1447

    Abstract: A recently bioinformatic analysis of genomic sequences of fungi indicated that fungi are able to produce more secondary metabolites than expected. Despite their potency, many biosynthetic pathways are silent in the absence of specific culture conditions ... ...

    Abstract A recently bioinformatic analysis of genomic sequences of fungi indicated that fungi are able to produce more secondary metabolites than expected. Despite their potency, many biosynthetic pathways are silent in the absence of specific culture conditions or chemical cues. To access cryptic metabolism, 108 fungal strains isolated from various sites were cultured with or without
    MeSH term(s) Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/metabolism ; Coculture Techniques ; Actinobacteria/genetics ; Actinobacteria/metabolism ; Fungi/metabolism ; Metabolome ; Secondary Metabolism/genetics
    Chemical Substances Histone Deacetylase Inhibitors
    Language English
    Publishing date 2023-07-26
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2412195-2
    ISSN 1738-8872 ; 1738-8872
    ISSN (online) 1738-8872
    ISSN 1738-8872
    DOI 10.4014/jmb.2301.01017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Targeted Isolation of

    Kim, Jun Gu / Lee, Byeongsan / Han, Jae Sang / Oh, Taehoon / Park, Beomcheol / Cho, Yong Beom / An, Beom Kyun / Choi, Jin Won / Ko, Sung-Kyun / Lee, Mi Kyeong / Hong, Young-Soo / Hwang, Bang Yeon

    ACS omega

    2023  Volume 8, Issue 41, Page(s) 38263–38271

    Abstract: Liquid chromatography-mass spectrometry (LC-MS/MS)-based molecular networking analysis was applied ... ...

    Abstract Liquid chromatography-mass spectrometry (LC-MS/MS)-based molecular networking analysis was applied to
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c04647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Rubiflavin G, photorubiflavin G, and photorubiflavin E: Novel pluramycin derivatives from Streptomyces sp. W2061 and their anticancer activity against breast cancer cells.

    Lee, Byeongsan / Lee, Ga-Eun / Hwang, Gwi Ja / Heo, Kyung Taek / Lee, Jae Kyoung / Jang, Jun-Pil / Hwang, Bang Yeon / Jang, Jae-Hyuk / Cho, Yong-Yeon / Hong, Young-Soo

    The Journal of antibiotics

    2023  Volume 76, Issue 10, Page(s) 585–591

    Abstract: The pluramycin family of antibiotics comprises angucycline compounds derived from actinomycetes that possess anticancer and antibacterial properties. Pluramycins are structurally characterized by two aminoglycosides linked by a carbon-carbon bond next to ...

    Abstract The pluramycin family of antibiotics comprises angucycline compounds derived from actinomycetes that possess anticancer and antibacterial properties. Pluramycins are structurally characterized by two aminoglycosides linked by a carbon-carbon bond next to the γ-pyrone angucycline backbone. Kidamycins (3, 4) and rubiflavins (6-9) were screened through liquid chromatography-mass spectrometry analysis of the crude extracts of Streptomyces sp. W2061, which was cultured in complex media under phosphate-limiting conditions. Newly isolated rubiflavin G (7) and photoactivated compounds (8, 9) were characterized using exhaustive 1D and 2D nuclear magnetic resonance analysis. The cytotoxicity of kidamycin (3), photokidamycin (4), and photorubiflavin G (8) was determined using two human breast cancer cell lines-MCF7 and MDA-MB-231. Compared to MCF7 cells, MDA-MB-231 cells were more sensitive to the active compounds, and photokidamycin (4) considerably inhibited MCF7 and MDA-MB-231 cell growth (IC
    MeSH term(s) Humans ; Female ; Streptomyces/chemistry ; Breast Neoplasms/drug therapy ; Aminoglycosides ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Carbon ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry
    Chemical Substances rubiflavin (11016-71-0) ; pluramycin (11016-27-6) ; Aminoglycosides ; Anti-Bacterial Agents ; Carbon (7440-44-0) ; Antineoplastic Agents
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390800-8
    ISSN 1881-1469 ; 0021-8820 ; 0368-3532
    ISSN (online) 1881-1469
    ISSN 0021-8820 ; 0368-3532
    DOI 10.1038/s41429-023-00643-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Construction of an Artificial Biosynthetic Pathway for Zingerone Production in

    Heo, Kyung Taek / Park, Kyung Won / Won, Juhee / Lee, Byeongsan / Jang, Jae-Hyuk / Ahn, Jung-Oh / Hwang, Bang Yeon / Hong, Young-Soo

    Journal of agricultural and food chemistry

    2021  Volume 69, Issue 48, Page(s) 14620–14629

    Abstract: Zingerone (vanillylacetone; 4-hydroxy-3-methoxyphenylethyl methyl ketone) is a key component responsible for the pungency of ginger ( ...

    Abstract Zingerone (vanillylacetone; 4-hydroxy-3-methoxyphenylethyl methyl ketone) is a key component responsible for the pungency of ginger (
    MeSH term(s) Biosynthetic Pathways ; Butanones ; Escherichia coli/genetics ; Guaiacol/analogs & derivatives ; Kava
    Chemical Substances Butanones ; zingerone (4MMW850892) ; Guaiacol (6JKA7MAH9C) ; benzylideneacetone (B03X40BMT5)
    Language English
    Publishing date 2021-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.1c05534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: Construction of an Artificial Biosynthetic Pathway for Zingerone Production in Escherichia coli Using Benzalacetone Synthase from Piper methysticum

    Heo, Kyung Taek / Park, Kyung Won / Won, Juhee / Lee, Byeongsan / Jang, Jae-Hyuk / Ahn, Jung-Oh / Hwang, Bang Yeon / Hong, Young-Soo

    Journal of agricultural and food chemistry. 2021 Nov. 23, v. 69, no. 48

    2021  

    Abstract: Zingerone (vanillylacetone; 4-hydroxy-3-methoxyphenylethyl methyl ketone) is a key component responsible for the pungency of ginger (Zingiber officinale). In this study, it was confirmed that a type III polyketide synthase (PKS) gene (pmpks) from Piper ... ...

    Abstract Zingerone (vanillylacetone; 4-hydroxy-3-methoxyphenylethyl methyl ketone) is a key component responsible for the pungency of ginger (Zingiber officinale). In this study, it was confirmed that a type III polyketide synthase (PKS) gene (pmpks) from Piper methysticum exhibits feruloyl-CoA-preferred benzalacetone synthase (BAS) activity. Based on these results, we constructed an artificial biosynthetic pathway for zingerone production from supplemented ferulic acid with 4-coumarate CoA ligase (4CL), PmPKS, and benzalacetone reductase (BAR). Furthermore, a de novo pathway for the production of zingerone was assembled using six heterologous genes, encoding tyrosine ammonia-lyase (optal), cinnamate-4-hydroxlase (sam5), caffeic acid O-methyltransferase (com), 4CL (4cl2nt), BAS (pmpks), and BAR (rzs1), in Escherichia coli. Using the engineered l-tyrosine-overproducing E. coli ΔCOS4 strain as a host, a maximum yield of 24.03 ± 2.53 mg/L zingerone was achieved by complete de novo synthesis.
    Keywords Escherichia coli ; Piper methysticum ; Zingiber officinale ; biochemical pathways ; caffeate O-methyltransferase ; ferulic acid ; food chemistry ; genes ; ginger ; ligases ; oxidoreductases ; polyketide synthases ; tyrosine ammonia-lyase
    Language English
    Dates of publication 2021-1123
    Size p. 14620-14629.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.1c05534
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 1185: Show issues

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