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Article: Unravelling the landscape of skin cancer through single-cell transcriptomics.

Srivastava, Ankit / Bencomo, Tomas / Das, Ishani / Lee, Carolyn S

2022 Volume 27, Page(s) 101557

Abstract: The human skin is a complex organ that forms the first line of defense against pathogens and external injury. It is composed of a wide variety of cells that work together to maintain homeostasis and prevent disease, such as skin cancer. The exponentially ...

Abstract	The human skin is a complex organ that forms the first line of defense against pathogens and external injury. It is composed of a wide variety of cells that work together to maintain homeostasis and prevent disease, such as skin cancer. The exponentially rising incidence of skin malignancies poses a growing public health challenge, particularly when the disease course is complicated by metastasis and therapeutic resistance. Recent advances in single-cell transcriptomics have provided a high-resolution view of gene expression heterogeneity that can be applied to skin cancers to define cell types and states, understand disease evolution, and develop new therapeutic concepts. This approach has been particularly valuable in characterizing the contribution of immune cells in skin cancer, an area of great clinical importance given the increasing use of immunotherapy in this setting. In this review, we highlight recent skin cancer studies utilizing bulk RNA sequencing, introduce various single-cell transcriptomics approaches, and summarize key findings obtained by applying single-cell transcriptomics to skin cancer.
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2443840-6
ISSN	1936-5233
ISSN	1936-5233
DOI	10.1016/j.tranon.2022.101557
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Article ; Online: Relationship between the EULAR/ACR classification criteria and organ damage in systemic lupus erythematosus.

Mok, Chi Chiu / Chung, Yuen Kwan / Lee, Carolyn / Ho, Ling Yin / To, Chi Hung

Lupus

2023 Volume 32, Issue 3, Page(s) 424–430

Abstract: Objectives: To study the relationship between the 2019 EULAR/ACR classification criteria and organ damage in patients with systemic lupus erythematosus (SLE).: Methods: Patients involved in a cross-sectional validation study of the EULAR/ACR criteria ...

Abstract	Objectives: To study the relationship between the 2019 EULAR/ACR classification criteria and organ damage in patients with systemic lupus erythematosus (SLE). Methods: Patients involved in a cross-sectional validation study of the EULAR/ACR criteria and judged by a panel of rheumatologists to be clinical SLE were studied. Those who fulfilled the EULAR/ACR criteria at their last clinic visit were stratified into 2 groups based on a cutoff score of 20. The last SLE International Collaborating Clinic (SLICC) Organ Damage Index (SDI) was compared between these two groups. Relationship among the domains of the EULAR/ACR criteria and SDI in all patients was studied by using Spearman's rank correlation. Results: A total of Conclusion: In addition to disease classification, the EULAR/ACR SLE criteria may have value in predicting prognosis.
MeSH term(s)	Humans ; Female ; Young Adult ; Adult ; Middle Aged ; Male ; Lupus Erythematosus, Systemic ; Cross-Sectional Studies ; Antibodies, Antiphospholipid ; Leukopenia ; Prognosis
Chemical Substances	Antibodies, Antiphospholipid
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1154407-7
ISSN	1477-0962 ; 0961-2033
ISSN (online)	1477-0962
ISSN	0961-2033
DOI	10.1177/09612033231153791
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Zs.A 3717: Show issues

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Article ; Online: Use of student photography to explore nursing.

Lee, Carolyn J

Nurse educator

2014 Volume 39, Issue 4, Page(s) 192

MeSH term(s)	Creativity ; Education, Nursing/methods ; Humans ; Interprofessional Relations ; Learning ; Nursing Education Research ; Nursing Evaluation Research ; Nursing Methodology Research ; Photography ; Students, Nursing/psychology ; Teaching/methods
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1034267-9
ISSN	1538-9855 ; 0363-3624
ISSN (online)	1538-9855
ISSN	0363-3624
DOI	10.1097/NNE.0000000000000055
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Zs.A 2904: Show issues

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Article: Very early antepartum pregnancy-associated spontaneous coronary artery dissection case report.

Lee, Carolyn / Saw, Jacqueline

Cardiovascular diagnosis and therapy

2018 Volume 8, Issue 4, Page(s) 512–515

Abstract: Spontaneous coronary artery dissection (SCAD) is an elusive cardiovascular disease that is increasingly recognized. Classically, pregnancy had been perceived as a notable risk factor for SCAD. However, modern studies had revealed that pregnancy- ... ...

Abstract	Spontaneous coronary artery dissection (SCAD) is an elusive cardiovascular disease that is increasingly recognized. Classically, pregnancy had been perceived as a notable risk factor for SCAD. However, modern studies had revealed that pregnancy-associated SCAD (PASCAD) accounted for fewer cases than previously thought. The majority of PASCAD cases occur in women post-partum. We describe a case of a 30-year-old woman who presented with SCAD while 10 days pregnant, which is the earliest PASCAD case reported in the literature.
Language	English
Publishing date	2018-09-05
Publishing country	China (Republic : 1949- )
Document type	Case Reports
ZDB-ID	2685043-6
ISSN	2223-3660 ; 2223-3652
ISSN (online)	2223-3660
ISSN	2223-3652
DOI	10.21037/cdt.2018.06.02
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Article ; Online: The creation of a White Coat Ceremony.

Mitchell, Kathleen / Phillips, Kelly / Pocotte, Susan / Lee, Carolyn

Journal of professional nursing : official journal of the American Association of Colleges of Nursing

2020 Volume 36, Issue 4, Page(s) 218–222

Abstract: Historically, the White Coat Ceremony has had a medical school connotation. While not exclusive to the discipline of medicine, the White Coat Ceremony is a recently adopted ritual embraced by a variety of health care professions. The white coat serves as ...

Abstract	Historically, the White Coat Ceremony has had a medical school connotation. While not exclusive to the discipline of medicine, the White Coat Ceremony is a recently adopted ritual embraced by a variety of health care professions. The white coat serves as a symbol of achievement into one's professional program. The purpose of this article is to provide an overview of the White Coat Ceremony as an emblematic transition into professional nursing education, to provide context of the use of symbolic ceremony in nursing, to describe the details of a White Coat Ceremony currently in place in a nursing college, and to discuss suggestions for replication. A survey to elicit student responses to the ceremonial event was achieved through an IRB study. Results obtained through a student survey were strongly favorable to the personal meaning as to participating in a White Coat Ceremony. The authors endorse the use of such a ceremony in professional nursing education settings.
MeSH term(s)	Ceremonial Behavior ; Humans ; Nursing
Language	English
Publishing date	2020-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	632951-2
ISSN	1532-8481 ; 8755-7223
ISSN (online)	1532-8481
ISSN	8755-7223
DOI	10.1016/j.profnurs.2020.01.004
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Article: Validation of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in ANA-positive Chinese patients.

Chung, Yuen Kwan / Ho, Ling Yin / Lee, Carolyn / To, Chi Hung / Mok, Chi Chiu

Therapeutic advances in musculoskeletal disease

2022 Volume 14, Page(s) 1759720X221100300

Abstract: Background: The aim of this study was to validate the 2019 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for systemic lupus erythematosus (SLE) in antinuclear antibody (ANA)-positive Chinese ... ...

Abstract	Background: The aim of this study was to validate the 2019 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for systemic lupus erythematosus (SLE) in antinuclear antibody (ANA)-positive Chinese patients. Methods: Medical records of all adult patients who attended the rheumatology out-patient clinics between May and September 2019 were reviewed. Patients with ever ANA positive (titre ⩾1:80) were included and evaluated for the fulfilment of the 2019 EULAR/ACR, 2012 Systemic Lupus International Collaborating Clinics (SLICC) and 1997 ACR criteria for SLE classification. The performance of these criteria in predicting a clinical diagnosis of SLE as judged by an independent panel of rheumatologists was studied and compared in different subgroups. Results: A total of 1533 patients (88.2% women; age at first clinic attendance 45.5 ± 15.6 years) were studied and 562 patients were judged to be clinical SLE. The sensitivity and specificity of the EULAR/ACR (⩾10 points), SLICC and ACR criteria for a clinical diagnosis of SLE was 96.1%, 97.9% and 86.1%; and 85.8%, 86.3% and 94.3%, respectively. Applying the attribution rule to the non-SLE controls, the specificity of the three criteria increased to 95.0%, 92.5% and 98.8%, respectively. The specificity of the EULAR/ACR criteria was higher in male patients (97.9%), those aged >50 years (97.0%) and disease duration of ⩽3 years (97.6%). Using a cut-off of 12 points, the specificity of the EULAR/ACR criteria was further increased (96.6%) while a high sensitivity (95.0%) was maintained. Conclusion: In Chinese patients with a positive ANA, the EULAR/ACR criteria for clinical SLE perform equally well to the SLICC criteria. Both the EULAR/ACR and SLICC are more sensitive but less specific than the ACR criteria. The specificity of all the three criteria is enhanced by applying the attribution rule to controls. The specificity of the EULAR/ACR criteria is higher in certain patient subgroups or when the cut-off score is raised.
Language	English
Publishing date	2022-05-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2516075-8
ISSN	1759-7218 ; 1759-720X
ISSN (online)	1759-7218
ISSN	1759-720X
DOI	10.1177/1759720X221100300
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Article ; Online: Multidisciplinary collaboration on exoskeleton development adopting user-centered design: a systematic integrative review.

Cheng, Clio Yuen Man / Lee, Carolyn Chi Ying / Chen, Coco Ke / Lou, Vivian W Q

Disability and rehabilitation. Assistive technology

2022 Volume 19, Issue 3, Page(s) 909–937

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Humans ; Aged ; User-Centered Design ; Exoskeleton Device ; Activities of Daily Living ; Aging ; Delivery of Health Care
Language	English
Publishing date	2022-10-24
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2221782-4
ISSN	1748-3115 ; 1748-3107
ISSN (online)	1748-3115
ISSN	1748-3107
DOI	10.1080/17483107.2022.2134470
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Zs.A 6301: Show issues

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Article ; Online: Promoting Faculty Education on Needs and Resources for Military-Active and Veteran Students.

Gibbs, Catherine E / Lee, Carolyn J / Ghanbari, Haraz

The Journal of nursing education

2019 Volume 58, Issue 6, Page(s) 347–353

Abstract: Background: The numbers of post-9/11 service members transitioning out of the military are escalating. Our diverse nursing student population will increasingly include Veterans or those engaged in military service.: Method: This article describes an ... ...

Abstract	Background: The numbers of post-9/11 service members transitioning out of the military are escalating. Our diverse nursing student population will increasingly include Veterans or those engaged in military service. Method: This article describes an educational session directed at nurse faculty about the needs of these students. The event focused on the array of experiences and issues experienced by active military students or Veterans as they are deployed, transition back into civilian life, or return to college. Results: This educational forum was well attended and praised by nurse faculty who reported increased levels of awareness, knowledge, and resources pertinent to this student population. Conclusion: Student-centeredness is valued in nursing education. Compliance with pertinent policies, engagement with community resources, and conveying personal interest in our students is especially valuable for students engaged in military service. Other nursing programs are encouraged to adopt a similarly designed event. [J Nurs Educ. 2019;58(6):347-353.].
MeSH term(s)	Education, Nursing ; Faculty, Nursing/education ; Health Resources ; Health Services Needs and Demand ; Humans ; Military Personnel ; Self Report ; Students, Nursing ; Veterans
Language	English
Publishing date	2019-06-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	410686-6
ISSN	1938-2421 ; 0148-4834
ISSN (online)	1938-2421
ISSN	0148-4834
DOI	10.3928/01484834-20190521-05
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Zs.B 616: Show issues

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Article ; Online: Outcomes of Percutaneous Coronary Intervention in Patients with Spontaneous Coronary Artery Dissection.

Hassan, Saber / Samuel, Rohit / Starovoytov, Andrew / Lee, Carolyn / Aymong, Eve / Saw, Jacqueline

Journal of interventional cardiology

2021 Volume 2021, Page(s) 6686230

Abstract: Objectives: To compare outcomes of percutaneous coronary intervention (PCI) in spontaneous coronary artery dissection (SCAD) patients versus conservative therapy.: Background: SCAD is an important cause of myocardial infarction (MI) in young-to- ... ...

Abstract	Objectives: To compare outcomes of percutaneous coronary intervention (PCI) in spontaneous coronary artery dissection (SCAD) patients versus conservative therapy. Background: SCAD is an important cause of myocardial infarction (MI) in young-to-middle-aged women. Percutaneous coronary intervention (PCI) is often pursued, but outcomes compared to conservative therapy are unclear. Methods: 403 nonatherosclerotic SCAD patients were enrolled between 2011 and 2017 and prospectively followed up in our Vancouver General Hospital registries. Detailed baseline, hospital, PCI, and outcomes were recorded. We explored the outcomes of SCAD patients who underwent PCI during their initial presentation. Results: PCI was performed in 75 patients, the average age was 48.9 ± 10.1 yrs, and 94.7% were women. All presented with MI; 50.7% STEMI, 49.3% NSTEMI, and 13.3% had VT/VF. PCI was successful in 34.7%, partially successful in 37.3%, and unsuccessful in 28.0%. Stents were deployed in 73.3%, 16.0% had balloon angioplasty alone, 10.7% had wiring attempts only, and 5.3% required bailout surgery. Major adverse cardiovascular event rates (MACE) were significantly higher with the PCI group in hospital (29.3% versus 2.8%, Conclusion: PCI in SCAD patients was associated with high failure rate and MACE in hospital and at long-term follow-up. These findings support the recommendation of conservative therapy as first-line management unless high-risk features are present.
MeSH term(s)	Coronary Vessel Anomalies/diagnosis ; Coronary Vessel Anomalies/surgery ; Female ; Humans ; Long Term Adverse Effects/diagnosis ; Long Term Adverse Effects/epidemiology ; Male ; Middle Aged ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/instrumentation ; Percutaneous Coronary Intervention/methods ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Risk Adjustment ; Risk Assessment ; Risk Factors ; Sex Factors ; Stents ; Treatment Outcome ; Vascular Diseases/congenital ; Vascular Diseases/diagnosis ; Vascular Diseases/surgery
Language	English
Publishing date	2021-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036325-7
ISSN	1540-8183 ; 0896-4327
ISSN (online)	1540-8183
ISSN	0896-4327
DOI	10.1155/2021/6686230
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Zs.A 2719: Show issues

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Article ; Online: Case reports of coronary fibromuscular dysplasia and spontaneous coronary artery dissections.

Lee, Carolyn / Starovoytov, Andrew / Saw, Jacqueline

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2018 Volume 93, Issue 4, Page(s) 631–634

Abstract: Spontaneous coronary artery dissection (SCAD) is an important cause of acute coronary syndrome especially in women. The most common underlying predisposing cause of SCAD is fibromuscular dysplasia (FMD), a non-inflammatory arteriopathy that results in ... ...

Abstract	Spontaneous coronary artery dissection (SCAD) is an important cause of acute coronary syndrome especially in women. The most common underlying predisposing cause of SCAD is fibromuscular dysplasia (FMD), a non-inflammatory arteriopathy that results in weakening of the affected arteries, and can cause dissection or aneurysm. Coronary FMD (CFMD) was described as rare, and was shown to cause SCAD in histopathological case reports. Unfortunately, CFMD is challenging to diagnose on coronary angiography, as the findings can be similar to other causes of coronary artery disease. Therefore, we illustrate two case examples of CFMD on coronary angiography, and highlight findings on optical coherence tomography to aid diagnosis.
MeSH term(s)	Adult ; Aged ; Coronary Angiography ; Coronary Vessel Anomalies/diagnostic imaging ; Coronary Vessel Anomalies/etiology ; Coronary Vessel Anomalies/pathology ; Coronary Vessel Anomalies/therapy ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/pathology ; Female ; Fibromuscular Dysplasia/complications ; Fibromuscular Dysplasia/diagnostic imaging ; Fibromuscular Dysplasia/pathology ; Fibromuscular Dysplasia/therapy ; Humans ; Male ; Predictive Value of Tests ; Tomography, Optical Coherence ; Vascular Diseases/congenital ; Vascular Diseases/diagnostic imaging ; Vascular Diseases/etiology ; Vascular Diseases/pathology ; Vascular Diseases/therapy
Language	English
Publishing date	2018-11-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.27982
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