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  1. Article ; Online: Man with swollen arm.

    Yang, Shih-Chia / Lee, Chi-Wei

    Emergency medicine journal : EMJ

    2024  Volume 41, Issue 2, Page(s) 82–102

    MeSH term(s) Humans ; Male ; Arm
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2023-213072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1941: Show issues Location:
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  2. Article: Physiological effects of N95 respirators on rescuers during cardiopulmonary resuscitation.

    Yang, Shih-Chia / Lee, Chi-Wei

    Heliyon

    2023  Volume 9, Issue 8, Page(s) e18970

    Abstract: Objectives: There is a lack of evidence in the medical literature reporting the physiological stress imposed by the wearing of N95 respirators during cardiopulmonary resuscitation (CPR) in healthcare providers. The aim of this study is to monitor the ... ...

    Abstract Objectives: There is a lack of evidence in the medical literature reporting the physiological stress imposed by the wearing of N95 respirators during cardiopulmonary resuscitation (CPR) in healthcare providers. The aim of this study is to monitor the changes in hemodynamics and blood gas profiles in rescuers during the performance of CPR while wearing N95 respirators.
    Methods: Thirty-two healthy healthcare workers performed standard CPR on manikins, each participant conducted 2 min of chest compression followed by 2 min of rest for 3 cycles. A non-invasive blood gas measuring device via a fingertip detector was used to collect arterial blood gas and hemodynamic data. Student t-test was used for comparison of various physiologic parameters before and after each session of chest compression.
    Results: There were no significant differences in arterial blood gas profiles including partial pressure of arterial carbon dioxide and partial pressure of arterial oxygen before and after each session of chest compression (p > 0.05 for all). Heart rate and cardiac output were significantly higher after CPR (p < 0.05 for all), but no significant changes were found on blood pressure.
    Conclusions: Our data suggest that healthcare providers wearing N95 respirators during provision of CPR in a short period of time does not cause any significant abnormalities in blood gas profiles and blood pressure. This may provide evidence to reassure the safe use of N95 respirator during performance of CPR.
    Language English
    Publishing date 2023-08-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e18970
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  3. Article: A deadly needle-tract: Inward exsanguination.

    Lin, Chin-Shen / Lee, Chi-Wei

    World journal of emergency medicine

    2021  Volume 13, Issue 1, Page(s) 74

    Language English
    Publishing date 2021-12-30
    Publishing country China
    Document type Journal Article
    ZDB-ID 2753264-1
    ISSN 1920-8642
    ISSN 1920-8642
    DOI 10.5847/wjem.j.1920-8642.2022.007
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  4. Article ; Online: Man with swollen eye.

    Yang, Shih-Chia / Lee, Chi-Wei

    Emergency medicine journal : EMJ

    2021  Volume 38, Issue 7, Page(s) 494–510

    MeSH term(s) Aged ; Carotid-Cavernous Sinus Fistula/complications ; Carotid-Cavernous Sinus Fistula/diagnosis ; Carotid-Cavernous Sinus Fistula/surgery ; Conjunctival Diseases/etiology ; Exophthalmos/etiology ; Humans ; Lymphoma/complications ; Lymphoma/diagnosis ; Lymphoma/surgery ; Male ; Orbital Neoplasms/complications ; Orbital Neoplasms/diagnosis ; Orbital Neoplasms/surgery ; Pain ; Prefrontal Cortex ; Vision Disorders
    Language English
    Publishing date 2021-08-27
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2020-210058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Potential applications and challenges of novel ambient ionization mass spectrometric techniques in the emergency care for acute poisoning

    Lee, Chi-Wei / Su, Hung / Shiea, Jentaie

    Trends in analytical chemistry. 2022 July 15,

    2022  

    Abstract: Rapid identification of the offending toxicants remains the most important part of the emergency care for acute poisoning. Nonetheless, most contemporary methods of laboratory confirmation are not timely enough and/or too technically-demanding to attain ... ...

    Abstract Rapid identification of the offending toxicants remains the most important part of the emergency care for acute poisoning. Nonetheless, most contemporary methods of laboratory confirmation are not timely enough and/or too technically-demanding to attain this goal. For more than half a decade, two ambient ionization mass spectrometric platforms, namely, (a) thermal desorption-electrospray ionization-mass spectrometry (TD-ESI-MS), and (b) Electrospray-assisted laser desorption ionization-mass spectrometry (ELDI-MS) have been applied to rapidly provide qualitative and semi-quantitative analyses of various toxicants and toxins found in different types of clinical specimen collected under different scenarios of emergency care. The ultimate goal of these studies is to meet the prerequisite that the end user of an ambient ionization mass spectrometry (AIMS) could eventually be a nurse or an emergency physician rather than an analytical chemist. Therefore, the design of the analytical system should be capable of taking biofluids automatically with minimal, if not without, pretreatment and generating analytical reports understandable to the end users, instead of mass spectra or chromatograms. In this article, a comprehensive account of (i) the potential clinical applications of two ambient ionization mass spectrometric platforms in the emergency care for acute poisoning and (ii) the challenges confronted by these cutting-edge technologies is unveiled.
    Keywords analytical chemistry ; desorption ; ionization
    Language English
    Dates of publication 2022-0715
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 2014041-1
    ISSN 0165-9936
    ISSN 0165-9936
    DOI 10.1016/j.trac.2022.116742
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: An Unusual Cause of Lower Gastrointestinal Bleeding.

    Yang, Shih-Chia / Lee, Chi-Wei

    The Journal of emergency medicine

    2020  Volume 59, Issue 3, Page(s) e95–e96

    MeSH term(s) Gastrointestinal Hemorrhage/etiology ; Humans
    Language English
    Publishing date 2020-07-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2020.06.029
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1895: Show issues Location:
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  7. Article ; Online: Thermal desorption ambient ionization mass spectrometry for emergency toxicology.

    Su, Hung / Huang, Min-Zong / Shiea, Jentaie / Lee, Chi-Wei

    Mass spectrometry reviews

    2022  Volume 42, Issue 5, Page(s) 1828–1847

    Abstract: In the emergency department, it is important to rapidly identify the toxic substances that have led to acute poisoning because different toxicants or toxins cause poisoning through different mechanisms, requiring disparate therapeutic strategies and ... ...

    Abstract In the emergency department, it is important to rapidly identify the toxic substances that have led to acute poisoning because different toxicants or toxins cause poisoning through different mechanisms, requiring disparate therapeutic strategies and precautions against contraindicating actions, and diverse directions of clinical course monitoring and prediction of prognosis. Ambient ionization mass spectrometry, a state-of-the-art technology, has been proved to be a fast, accurate, and user-friendly tool for rapidly identifying toxicants like residual pesticides on fruits and vegetables. In view of this, developing an analytical platform that explores the application of such a cutting-edge technology in a novel direction has been initiated a research program, namely, the rapid identification of toxic substances which might have caused acute poisoning in patients who visit the emergency department and requires an accurate diagnosis for correct clinical decision-making to bring about corresponding data-guided management. This review includes (i) a narrative account of the breakthrough in emergency toxicology brought about by the advent of ambient ionization mass spectrometry and (ii) a thorough discussion about the clinical implications and technical limitations of such a promising innovation for promoting toxicological tests from tier two-level to tier one level.
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1491946-1
    ISSN 1098-2787 ; 0277-7037
    ISSN (online) 1098-2787
    ISSN 0277-7037
    DOI 10.1002/mas.21784
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  8. Article: Chronic Sore Throat Mandates Re-Thinking.

    Yang, Shih-Chia / Lo, Shih-Hao / Lee, Chi-Wei

    The Journal of emergency medicine

    2021  Volume 62, Issue 1, Page(s) e11–e12

    MeSH term(s) Humans ; Intubation, Intratracheal ; Pharyngitis/etiology
    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2021.10.024
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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Rapid Characterization of Undeclared Pharmaceuticals in Herbal Preparations by Ambient Ionization Mass Spectrometry for Emergency Care.

    Lee, Chi-Wei / Su, Hung / Hsu, Yi-Wen / Su, Lin-Zhen / Wu, Yen-Hung / Hou, Chia-Yi / Shih, Shu-Yu / Shiea, Jentaie

    Journal of the American Society for Mass Spectrometry

    2024  Volume 35, Issue 5, Page(s) 960–971

    Abstract: In Asia, some herbal preparations have been found to be adulterated with undeclared synthetic medicines to increase their therapeutic efficiency. Many of these adulterants were found to be toxic when overdosed and have been documented to bring about ... ...

    Abstract In Asia, some herbal preparations have been found to be adulterated with undeclared synthetic medicines to increase their therapeutic efficiency. Many of these adulterants were found to be toxic when overdosed and have been documented to bring about severe, even life-threatening acute poisoning events. The objective of this study is to develop a rapid and sensitive ambient ionization mass spectrometric platform to characterize the undeclared toxic adulterated ingredients in herbal preparations. Several common adulterants were spiked into different herbal preparations and human sera to simulate the clinical conditions of acute poisoning. They were then sampled with a metallic probe and analyzed by the thermal desorption-electrospray ionization mass spectrometry. The experimental parameters including sensitivity, specificity, accuracy, and turnaround time were prudently optimized in this study. Since tedious and time-consuming pretreatment of the sample is unnecessary, the toxic adulterants could be characterized within 60 s. The results can help emergency physicians to make clinical judgments and prescribe appropriate antidotes or supportive treatment in a time-sensitive manner.
    MeSH term(s) Spectrometry, Mass, Electrospray Ionization/methods ; Humans ; Drug Contamination ; Plant Preparations/analysis ; Plant Preparations/chemistry ; Emergency Medical Services/methods
    Chemical Substances Plant Preparations
    Language English
    Publishing date 2024-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1073671-2
    ISSN 1879-1123 ; 1044-0305
    ISSN (online) 1879-1123
    ISSN 1044-0305
    DOI 10.1021/jasms.4c00016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 241: Show issues

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  10. Article ; Online: Rapid identification of mushroom toxins by direct electrospray probe mass spectrometry for emergency care.

    Su, Hung / Jiang, Zong-Han / Hsu, Yi-Wen / Wang, Yu-Chi / Chen, Yun-Yi / Wu, Deng-Chyang / Shiea, Jentaie / Lee, Chi-Wei

    Analytica chimica acta

    2024  Volume 1296, Page(s) 342343

    Abstract: Mushroom poisoning occurs frequently after the ingestion of toxic wild mushrooms misidentified as edible species. The goal of this study is to develop a mass spectrometric platform to bypass the need for morphological recognition of poisonous mushrooms ... ...

    Abstract Mushroom poisoning occurs frequently after the ingestion of toxic wild mushrooms misidentified as edible species. The goal of this study is to develop a mass spectrometric platform to bypass the need for morphological recognition of poisonous mushrooms by experts and rapidly identify the toxins in the mushrooms for emergency care. Trace mushroom toxins were collected by penetrating and removing the mushrooms surface for 3 mm with a direct electrospray probe (DEP). The analytes on the DEP were then dissolved in the solution (70% isopropanol containing 0.1% acetic acid) flowing out of a solvent reservoir on the DEP. Electrospray ionization was induced from the sample solution as a high electric field was generated between the DEP and MS inlet. The obtaining mass spectrometric results were further analyzed with principal component analysis (PCA) to classify mushroom toxins. The mass spectrometric platform for detecting mushroom toxins was assessed for its sensitivity, precision, and efficiency by determining its limit-of-detection (LOD), repeatability, and turnaround time, respectively. As a result, the LODs of the mushroom toxins in pure methanol and spiked in human vomitus by DEP/MS were within 0.001-0.5 ng/μL and 0.01-1 ng/μL, respectively. Linear responses of the mushroom toxins in pure methanol with concentrations between 0.01 and 5 ng/μL (R
    MeSH term(s) Humans ; Methanol ; Mass Spectrometry ; Mycotoxins ; Emergency Medical Services ; Agaricales
    Chemical Substances Methanol (Y4S76JWI15) ; Mycotoxins
    Language English
    Publishing date 2024-02-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2024.342343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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