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Article ; Online: Impacts of ship emissions and sea-land breeze on urban air quality using chemical characterization, source contribution and dispersion model simulation of PM

Tseng, Yu-Lun / Cheng, Wen-Hsi / Yuan, Chung-Shin / Lo, Kuo-Cheng / Lin, Chitsan / Lee, Chia-Wei / Bagtasa, Gerry

Environmental pollution (Barking, Essex : 1987)

2024 Volume 347, Page(s) 123663

Abstract: Fine particulate matter ( ... ...

Abstract	Fine particulate matter (PM
MeSH term(s)	Air Pollutants/analysis ; Ships ; Vehicle Emissions/analysis ; Environmental Monitoring ; Air Pollution/analysis ; Particulate Matter/analysis ; Dust/analysis ; Aerosols/analysis
Chemical Substances	Air Pollutants ; Vehicle Emissions ; Particulate Matter ; Dust ; Aerosols
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2024.123663
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Article ; Online: Hybrid modes in gold nanoslit arrays on Bragg nanostructures and their application for sensitive biosensors.

Lo, Shu-Cheng / Lee, Chia-Wei / Chern, Ruey-Lin / Wei, Pei-Kuen

Optics express

2022 Volume 30, Issue 17, Page(s) 30494–30506

Abstract: In this work, we present high-performance surface plasmonic sensors using gold nanostructures and Bragg photonic structures. The gold film on the Bragg structure provides Tamm plasmon states (TPs). The Fano coupling between higher order TPs and Bloch- ... ...

Abstract	In this work, we present high-performance surface plasmonic sensors using gold nanostructures and Bragg photonic structures. The gold film on the Bragg structure provides Tamm plasmon states (TPs). The Fano coupling between higher order TPs and Bloch-wave surface plasmon polariton (BW-SPP) on the gold nanoslit array results in a new hybrid Tamm-plasmon mode. Using finite-difference time-domain calculations, we demonstrate that the hybrid mode has the advantages of high surface sensitivity of BW-SPP mode and high resonant quality of Tamm state. The calculated plasmonic field distribution shows that the hybrid mode has a similar evanescent distribution with BW-SPP mode on gold surface and TPs field in the Bragg structure. The experimental results verify that the hybrid mode has one hundred times higher wavelength sensitivity than the Tamm state. The figure of merit of the hybrid mode is five times better than the BW-SPP mode in conventional nanoslit arrays. The real-time sensorgram further confirms that the hybrid mode has a much higher sensitivity and better signal to noise ratios in the biomolecular interaction measurement.
MeSH term(s)	Biosensing Techniques/methods ; Gold/chemistry ; Nanostructures/chemistry ; Photons ; Surface Plasmon Resonance/methods
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2022-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.465748
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Article ; Online: Synthesis of 4-thiol-furanosidic uronate

Ma, Shih-Ting / Lee, Chia-Wei / Liu, Wei-Min

RSC advances

2021 Volume 11, Issue 30, Page(s) 18409–18416

Abstract: Uronic acids are not only important building blocks of polysaccharides and oligosaccharides but also are widely used in the food and pharmaceutical industries. Inspired by the structure of natural products, here, we disclosed base-mediated and radical- ... ...

Abstract	Uronic acids are not only important building blocks of polysaccharides and oligosaccharides but also are widely used in the food and pharmaceutical industries. Inspired by the structure of natural products, here, we disclosed base-mediated and radical-mediated hydrothiolation reactions for the preparation of thiol-contained uronates. In comparison with base-mediated reaction, radical-mediated hydrothiolation is inefficient due to the electron-withdrawing group on the ethylene group; nevertheless, the adduct had excellent stereoselectivity at both C-4 and C-5 positions. For the alkaline approach, thiols as nucleophiles can regioselectively and stereoselectively attach to the C-4 position of Δ-
Language	English
Publishing date	2021-05-21
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra02110a
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Article ; Online: Risk factors for anisometropia in schoolchildren: A population-based, longitudinal cohort study.

Lee, Chia-Wei / Chiang, Chi-Chen / Tsai, Der-Chong / Tsai, Ching-Yao / Liou, Yiing Mei

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

2023 Volume 43, Issue 6, Page(s) 1500–1509

Abstract: Purpose: To investigate the incidence rate and risk factors for anisometropia among young schoolchildren.: Methods: A population-based cohort study, the Myopia Investigation Study in Taipei, was conducted in primary schools in Taipei City. Children ... ...

Abstract	Purpose: To investigate the incidence rate and risk factors for anisometropia among young schoolchildren. Methods: A population-based cohort study, the Myopia Investigation Study in Taipei, was conducted in primary schools in Taipei City. Children were recruited for biannual comprehensive eye examinations over 2 years. Cycloplegic autorefraction and slit lamp examinations were performed biannually. Data on demographic information, parental history, lifestyle and near-work activities were collected using parent-administered questionnaires at the first and final visits. Anisometropia was defined as ≥1 D difference in the spherical equivalent (SE) refractive error. Results: A total of 7035 8-year-old children completed the 2-year follow-up evaluations. The average annual incidence of anisometropia was 3.8%. Multivariable logistic regression analysis revealed that baseline SE (odds ratio [OR]: 0.87 95% CI: 0.80-0.95) and female sex (OR: 1.24, 95% confidence interval [CI]: 1.02-1.50) were significantly associated with incident anisometropia. Among lifestyle risk factors, spending <1 h per day in after-school outdoor activities on weekdays (OR: 1.38, 95% CI: 1.08-1.76) and performing near work at a distance <30 cm (OR: 1.33, 95% CI: 1.08-1.64) were significantly associated with an increased risk of incident anisometropia. In the multiple linear regression analysis, the inter-eye difference in SE increased significantly in children performing near work at distances <30 cm (adjusted β = 0.03; p = 0.02). Conclusions: This study indicated the annual incidence of anisometropia in Taiwanese schoolchildren. Less time spent outdoors and shorter eye-to-object distances during near work increased the risk of incident anisometropia.
MeSH term(s)	Child ; Humans ; Female ; Anisometropia/epidemiology ; Longitudinal Studies ; Cohort Studies ; Myopia/epidemiology ; Myopia/complications ; Risk Factors ; Refraction, Ocular ; Prevalence
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	604564-9
ISSN	1475-1313 ; 0275-5408
ISSN (online)	1475-1313
ISSN	0275-5408
DOI	10.1111/opo.13215
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Article ; Online: Spatiotemporal variation and inter-transport of atmospheric speciated mercury between Kaohsiung Harbor and neighboring urban areas.

Tu, I-Chieh / Yuan, Chung-Shin / Tseng, Yu-Lun / Lee, Chia-Wei / Lin, Chitsan

Environmental pollution (Barking, Essex : 1987)

2023 Volume 342, Page(s) 123039

Abstract: This study investigated the spatiotemporal variation, gas-particle partition, and source resolution of atmospheric speciation mercury (ASM) in Kaohsiung Harbor and neighboring Metro Kaohsiung. Four sampling sites were selected to determine the pollution ... ...

Abstract	This study investigated the spatiotemporal variation, gas-particle partition, and source resolution of atmospheric speciation mercury (ASM) in Kaohsiung Harbor and neighboring Metro Kaohsiung. Four sampling sites were selected to determine the pollution characteristics and inter-transport of ASM between the port and urban areas. The yearly average GEM, GOM, and PBM concentrations were 7.13 ± 2.2 ng/m
MeSH term(s)	Mercury/analysis ; Environmental Monitoring/methods ; Air Pollutants/analysis ; Air Pollution/analysis ; Vehicle Emissions/analysis ; Seasons
Chemical Substances	Mercury (FXS1BY2PGL) ; Air Pollutants ; Vehicle Emissions
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.123039
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Article ; Online: Autophagy ENDing unproductive phase-separated endocytic protein deposits.

Wilfling, Florian / Lee, Chia-Wei / Erdmann, Philipp S / Baumeister, Wolfgang

Autophagy

2021 Volume 17, Issue 10, Page(s) 3264–3265

Abstract: Selective disposal of a wide range of cellular entities by macroautophagy/autophagy is achieved through a special class of proteins called autophagy receptors, which link corresponding cargo to the membrane-bound autophagosomal protein Atg8/LC3. In ... ...

Abstract	Selective disposal of a wide range of cellular entities by macroautophagy/autophagy is achieved through a special class of proteins called autophagy receptors, which link corresponding cargo to the membrane-bound autophagosomal protein Atg8/LC3. In pursuit of novel autophagy receptors and their cargo, we uncovered a previously undescribed autophagy pathway for removal of aberrant clathrin-mediated endocytosis (CME) protein condensates in
MeSH term(s)	Autophagy/physiology ; Autophagy-Related Protein 8 Family/metabolism ; Autophagy-Related Proteins/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
Chemical Substances	Autophagy-Related Protein 8 Family ; Autophagy-Related Proteins ; Saccharomyces cerevisiae Proteins
Language	English
Publishing date	2021-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2021.1957567
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Article ; Online: Epigenetic transgenerational effects of PM2.5 collected from southern Taiwan on sperm functions and DNA methylation in mouse offspring.

Lee, Chia-Wei / Chen, Kuan-Ling / Yuan, Chung-Shin / Lai, Ching-Shu / Tsai, Xiang-Yi / Wu, Ping-Hsun / Hsu, Ping-Chi

Ecotoxicology and environmental safety

2023 Volume 269, Page(s) 115802

Abstract: During respiration, particulate matter with a diameter of 2.5 µm or less ( ... ...

Abstract	During respiration, particulate matter with a diameter of 2.5 µm or less (PM
MeSH term(s)	Pregnancy ; Humans ; Female ; Mice ; Male ; Animals ; DNA Methylation ; Epigenesis, Genetic ; Prenatal Exposure Delayed Effects/metabolism ; Reactive Oxygen Species/metabolism ; Taiwan ; Semen ; Spermatozoa ; Particulate Matter/metabolism ; Water/metabolism
Chemical Substances	Reactive Oxygen Species ; Particulate Matter ; Water (059QF0KO0R)
Language	English
Publishing date	2023-12-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.115802
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Article ; Online: Association of Preoperative Prognostic Nutritional Index with Risk of Postoperative Acute Kidney Injury: A Meta-Analysis of Observational Studies.

Liu, Chien-Cheng / Liu, Ping-Hsin / Chen, Hsiao-Tien / Chen, Jui-Yi / Lee, Chia-Wei / Cheng, Wan-Jung / Chen, Jen-Yin / Hung, Kuo-Chuan

Nutrients

2023 Volume 15, Issue 13

Abstract: This meta-analysis aimed to assess the clinical association of the preoperative prognostic nutritional index (pre-PNI) with the risk of postoperative acute kidney injury. Four databases (e.g., Medline) were searched from inception to December 2022 to ... ...

Abstract	This meta-analysis aimed to assess the clinical association of the preoperative prognostic nutritional index (pre-PNI) with the risk of postoperative acute kidney injury. Four databases (e.g., Medline) were searched from inception to December 2022 to investigate the association between pre-PNI (i.e., low vs. high) and PO-PNI as well as the correlation between pre-PNI and other postoperative prognostic indices. Overall, 13 observational studies, including 9185 patients, were eligible for analysis. A low PNI was related to increased risks of PO-AKI [odd ratio (OR) = 1.65,
MeSH term(s)	Humans ; Nutrition Assessment ; Prognosis ; Retrospective Studies ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/complications
Language	English
Publishing date	2023-06-28
Publishing country	Switzerland
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15132929
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Article ; Online: Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis.

Sui, Xuewu / Wang, Kun / Song, Kangkang / Xu, Chen / Song, Jiunn / Lee, Chia-Wei / Liao, Maofu / Farese, Robert V / Walther, Tobias C

Nature communications

2023 Volume 14, Issue 1, Page(s) 3100

Abstract: Inhibitors of triacylglycerol (TG) synthesis have been developed to treat metabolism-related diseases, but we know little about their mechanisms of action. Here, we report cryo-EM structures of the TG-synthesis enzyme acyl-CoA:diacylglycerol ... ...

Abstract	Inhibitors of triacylglycerol (TG) synthesis have been developed to treat metabolism-related diseases, but we know little about their mechanisms of action. Here, we report cryo-EM structures of the TG-synthesis enzyme acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a membrane bound O-acyltransferase (MBOAT), in complex with two different inhibitors, T863 and DGAT1IN1. Each inhibitor binds DGAT1's fatty acyl-CoA substrate binding tunnel that opens to the cytoplasmic side of the ER. T863 blocks access to the tunnel entrance, whereas DGAT1IN1 extends further into the enzyme, with an amide group interacting with more deeply buried catalytic residues. A survey of DGAT1 inhibitors revealed that this amide group may serve as a common pharmacophore for inhibition of MBOATs. The inhibitors were minimally active against the related MBOAT acyl-CoA:cholesterol acyltransferase 1 (ACAT1), yet a single-residue mutation sensitized ACAT1 for inhibition. Collectively, our studies provide a structural foundation for developing DGAT1 and other MBOAT inhibitors.
MeSH term(s)	Acyltransferases/metabolism ; Diacylglycerol O-Acyltransferase/genetics ; Diacylglycerol O-Acyltransferase/metabolism ; Lipogenesis ; Sterol O-Acyltransferase/chemistry ; Triglycerides
Chemical Substances	Acyltransferases (EC 2.3.-) ; Diacylglycerol O-Acyltransferase (EC 2.3.1.20) ; Sterol O-Acyltransferase (EC 2.3.1.26) ; Triglycerides
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-38934-3
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Article ; Online: A 3D culture system for evaluating the combined effects of cisplatin and anti-fibrotic drugs on the growth and invasion of lung cancer cells co-cultured with fibroblasts.

Pan, Huei-Jyuan / Lee, Chia-Wei / Wu, Li-Yu / Hsu, Heng-Hua / Tung, Yi-Chung / Liao, Wei-Yu / Lee, Chau-Hwang

APL bioengineering

2023 Volume 7, Issue 1, Page(s) 16117

Abstract: Fibrosis and fibroblast activation usually occur in the tissues surrounding a malignant tumor; therefore, anti-fibrotic drugs are used in addition to chemotherapy. A reliable technique for evaluating the combined effects of anti-fibrotic drugs and ... ...

Abstract	Fibrosis and fibroblast activation usually occur in the tissues surrounding a malignant tumor; therefore, anti-fibrotic drugs are used in addition to chemotherapy. A reliable technique for evaluating the combined effects of anti-fibrotic drugs and anticancer drugs would be beneficial for the development of an appropriate treatment strategy. In this study, we manufactured a three-dimensional (3D) co-culture system of fibroblasts and lung cancer cell spheroids in Matrigel supplemented with fibrin (fibrin/Matrigel) that simulated the tissue microenvironment around a solid tumor. We compared the efficacy of an anticancer drug (cisplatin) with or without pretreatments of two anti-fibrotic drugs, nintedanib and pirfenidone, on the growth and invasion of cancer cells co-cultured with fibroblasts. The results showed that the addition of nintedanib improved cisplatin's effects on suppressing the growth of cancer cell spheroids and the invasion of cancer cells. In contrast, pirfenidone did not enhance the anticancer activity of cisplatin. Nintedanib also showed higher efficacy than pirfenidone in reducing the expression of four genes in fibroblasts associated with cell adhesion, invasion, and extracellular matrix degradation. This study demonstrated that the 3D co-cultures in fibrin/Matrigel would be useful for assessing the effects of drug combinations on tumor growth and invasion.
Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Journal Article
ISSN	2473-2877
ISSN (online)	2473-2877
DOI	10.1063/5.0115464
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