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Article ; Online: Towards a replacement therapy for stimulant betel quid dependence: A proof of concept study.

Osborne, Peter G / Pasupuleti, Ragavendra Rao / Lee, Chien-Hung / Ponnusamy, Vinoth Kumar

2024 Volume 29, Issue 2, Page(s) e13371

Abstract: Stimulant betel quid (SBQ) containing Piper betle leaf (L), green unripe Areca catechu nut (AN) and the alkalizing agent, slaked lime, is an addictive, carcinogenic stimulant, with no pharmacotherapy, chewed by millions of people in the Asia/Pacific ... ...

Abstract	Stimulant betel quid (SBQ) containing Piper betle leaf (L), green unripe Areca catechu nut (AN) and the alkalizing agent, slaked lime, is an addictive, carcinogenic stimulant, with no pharmacotherapy, chewed by millions of people in the Asia/Pacific region. We compared the in vivo physiological profile of chewing (1) non-stimulant P. betle leaf+AN (LAN), (2) SBQ utilizing slaked lime and (3) a novel SBQ utilizing Mg(OH)
MeSH term(s)	Humans ; Areca ; Proof of Concept Study ; Tandem Mass Spectrometry ; Calcium Compounds ; Oxides
Chemical Substances	lime (C7X2M0VVNH) ; Calcium Compounds ; Oxides
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1324314-7
ISSN	1369-1600 ; 1355-6215
ISSN (online)	1369-1600
ISSN	1355-6215
DOI	10.1111/adb.13371
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Article: Longitudinal Assessment of Quality of Life in Nasopharyngeal Cancer Patients Treated with Intensity-Modulated Proton Therapy and Volumetric Modulated Arc Therapy at Different Time Points.

Liao, Kuan-Cho / Huang, Yu-Jie / Tsai, Wen-Ling / Lee, Chien-Hung / Fang, Fu-Min

Cancers

2024 Volume 16, Issue 6

Abstract: Purpose: This retrospective cohort study aims to compare the quality of life (QoL) in patients with nasopharyngeal cancer (NPC) treated with intensity-modulated proton therapy (IMPT) versus volumetric modulated arc therapy (VMAT) at different time ... ...

Abstract	Purpose: This retrospective cohort study aims to compare the quality of life (QoL) in patients with nasopharyngeal cancer (NPC) treated with intensity-modulated proton therapy (IMPT) versus volumetric modulated arc therapy (VMAT) at different time points. Materials and methods: We conducted a longitudinal assessment of QoL on 287 newly diagnosed NPC patients (IMPT: 41 and VMAT: 246). We collected outcomes of global QoL, functional QoL, C30 symptoms, and HN35 symptoms from EORTC QLQ-C30 and QLQ-HN35 questionnaires at pre-radiotherapy, during radiotherapy (around 40 Gy), 3 months post radiotherapy, and 12-months post radiotherapy (RT). The generalized estimating equation was utilized to interpret the group effect, originating from inherent group differences; time effect, attributed to RT effects over time; and interaction of the group and time effect. Results: IMPT demonstrated superior mean dose reductions in 12 of the 16 organs at risk compared to VMAT, including a significant (>50%) reduction in the oral cavity and larynx. Both groups exhibited improved scores of global QoL, functional QoL, and C30 symptoms at 12 months post RT compared to the pre-RT status. Regarding global QoL and C30 symptoms, there was no interaction effect of group over time. In contrast, significant interaction effects were observed on functional QoL ( Conclusions: Compared to VMAT, dose reduction attributed to IMPT could translate into better functional QoL and HN35 symptoms, but the effect is time dependent and exclusively observed during the RT phase.
Language	English
Publishing date	2024-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16061217
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Article ; Online: A Study of the Relationship between Phthalate Exposure and the Occurrence of Adult Asthma in Taiwan.

Duh, Tsai-Hui / Yang, Chih-Jen / Lee, Chien-Hung / Ko, Ying-Chin

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 13

Abstract: Although phthalate esters contribute to airway remodeling by increasing bronchial cells' migration and proliferation, the relationship between human exposure to phthalates and asthma is not understood. We measured phthalate exposure in the human body and ...

Abstract	Although phthalate esters contribute to airway remodeling by increasing bronchial cells' migration and proliferation, the relationship between human exposure to phthalates and asthma is not understood. We measured phthalate exposure in the human body and evaluated its effect on asthma. Asthma (
MeSH term(s)	Humans ; Male ; Adult ; Female ; Taiwan/epidemiology ; Phthalic Acids/toxicity ; Diethylhexyl Phthalate ; Asthma/chemically induced ; Asthma/epidemiology ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Environmental Pollutants/analysis
Chemical Substances	phthalic acid (6O7F7IX66E) ; mono-(2-ethylhexyl)phthalate (FU2EWB60RT) ; monobutyl phthalate (ZI46LWZ45G) ; Phthalic Acids ; Diethylhexyl Phthalate (C42K0PH13C) ; Environmental Pollutants
Language	English
Publishing date	2023-07-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28135230
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Article ; Online: Linking metabolic syndrome with low bone mass through insights from BMI and health behaviors.

Lee, Chun-Ying / Chuang, Yun-Shiuan / Lee, Chien-Hung / Wu, Ming-Tsang

Scientific reports

2023 Volume 13, Issue 1, Page(s) 14393

Abstract: The objective of this study is to investigate the relationship between metabolic syndrome (MetS), and bone density in a 30- to 50-year-old Taiwanese population, and to explore the combined effects of BMI and health behaviors on this association. A total ... ...

Abstract	The objective of this study is to investigate the relationship between metabolic syndrome (MetS), and bone density in a 30- to 50-year-old Taiwanese population, and to explore the combined effects of BMI and health behaviors on this association. A total of 52,912 individuals aged 30-50 years from the Taiwan Biobank were included in this cross-sectional study. Bone density status was assessed using quantitative ultrasound (QUS). The joint effect was assessed by including an interaction term in the multi-logistic regression models to test the association between MetS, BMI, and bone density while controlling for potential confounders. MetS was associated with reduced bone density, with the risk of severe low bone density (SLBD) higher among BMI < 24 kg/m
MeSH term(s)	Humans ; Adult ; Middle Aged ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Body Mass Index ; Cross-Sectional Studies ; Health Behavior ; Bone Diseases, Metabolic
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41513-7
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Article ; Online: Impact of Vitiligo on Life Quality of Patients: Assessment of Currently Available Tools.

Yang, Ting-Ting / Lee, Chien-Hung / Lan, Cheng-Che E

International journal of environmental research and public health

2022 Volume 19, Issue 22

Abstract: Background: How different tools for evaluating health-related quality of life (QoL) reflect the burden of vitiligo has rarely been compared. In this study, we aim to evaluate the impact of vitiligo on QoL using currently available tools.: Methods: A ... ...

Abstract	Background: How different tools for evaluating health-related quality of life (QoL) reflect the burden of vitiligo has rarely been compared. In this study, we aim to evaluate the impact of vitiligo on QoL using currently available tools. Methods: A single-center, cross-sectional study of vitiligo patients was performed. QoL was evaluated using the dermatology life quality index (DLQI), short form-36 (SF-36), and willingness to pay (WTP). As the original DLQI cutoff score (>10) indicating aginificantly impated QoL was found to underestimate QoL, receiver operating characteristic (ROC) curve was use to determine a new cutoff point discriminating vitiligo patients with positive mental stress (SF-36 mental health ≤ 52). Results: Of the 143 patients enrolled, 24.5% were identified having significant mental stress by SF-36 mental health domain score ≤ 52 while there were only 13.3% patients with significantly hampered QoL indicated by DLQI >10. Using ROC analysis, DLQI ≥ 7 was found to be a more appropriate DLQI cutoff value for identifying mental stress in vitiligo patients. Additionally, the median WTP for treating vitiligo was comparable to other inflammatory skin diseases. Conclusions: There exist discrepancies in the outcomes identifying significant disease burden of vitiligo using DLQI and SF-36, making the current DLQI cutoff score (>10) for identifying significantly affected QoL inappropriate for these patients.
MeSH term(s)	Humans ; Quality of Life/psychology ; Vitiligo ; Surveys and Questionnaires ; Cross-Sectional Studies ; Cost of Illness
Language	English
Publishing date	2022-11-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192214943
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Article ; Online: Betel quid-associated cancer: Prevention strategies and targeted treatment.

Ko, Albert Min-Shan / Lee, Chien-Hung / Ko, Ying-Chin

Cancer letters

2020 Volume 477, Page(s) 60–69

Abstract: Betel quid (BQ) and areca nut use are at risk of cancer. This review includes the latest evidence of carcinogenesis caused by BQ exposure, suggests possible prevention strategies. We conducted a systematic literature search in the PubMed and Web of ... ...

Abstract	Betel quid (BQ) and areca nut use are at risk of cancer. This review includes the latest evidence of carcinogenesis caused by BQ exposure, suggests possible prevention strategies. We conducted a systematic literature search in the PubMed and Web of Science databases to identify relevant articles published in the past 10 years according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Arecoline N-oxide, a metabolite of areca nut, is likely an initiator in carcinogenesis and is detoxified by N-acetylcysteine. Oral potentially malignant disorder and reactive oxygen species involved in carcinogenesis pathways may be treatable using antioxidants. Screening programs conducted by trained physicians are useful for identifying patients with early stages of oral cancer in high-risk groups. Anti-inflammatory medications may be used as chemopreventive agents in the disease-free stage after surgery. The association between survival and tumor somatic mutations in patients who chew BQ should be addressed in cancer studies. Current evidence on the natural course from BQ exposure to cancer occurrence and development provides information for developing primary, secondary, and tertiary prevention strategies against BQ-associated cancer at clinical or translational levels.
MeSH term(s)	Acetylcysteine/metabolism ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Areca/adverse effects ; Areca/toxicity ; Arecoline/analogs & derivatives ; Arecoline/toxicity ; Carcinogens/toxicity ; Cyclic N-Oxides/toxicity ; Humans ; Inactivation, Metabolic ; Mass Screening ; Mouth Neoplasms/etiology ; Mouth Neoplasms/mortality ; Mouth Neoplasms/prevention & control ; Mouth Neoplasms/therapy ; Mutation
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Carcinogens ; Cyclic N-Oxides ; arecoline 1-oxide ; Arecoline (4ALN5933BH) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2020-02-26
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2020.02.030
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Zs.A 1177: Show issues

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Article: Temporal Clustering of Skin Sympathetic Nerve Activity Bursts in Acute Myocardial Infarction Patients.

Liu, Chun / Lee, Chien-Hung / Lin, Shien-Fong / Tsai, Wei-Chung

Frontiers in neuroscience

2021 Volume 15, Page(s) 720827

Abstract: Backgrounds: ...

Abstract	Backgrounds:
Language	English
Publishing date	2021-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2021.720827
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Article ; Online: Betel Quid Dependence Effects on Working Memory and Remote Memory in Chewers with Concurrent Use of Cigarette and Alcohol.

Lee, Chih-Ying / Wang, Wei-Han / Lee, Chien-Hung / Ho, Ming-Chou

Substance use & misuse

2021 Volume 57, Issue 1, Page(s) 105–113

Abstract: Objective: The current study asked whether BQ dependence level could affect working memory (WM) and remote memory for the chewers with concurrent use of cigarettes and alcohol, a common phenomenon in Taiwan.: Methods: The standardized ... ...

Abstract	Objective: The current study asked whether BQ dependence level could affect working memory (WM) and remote memory for the chewers with concurrent use of cigarettes and alcohol, a common phenomenon in Taiwan. Methods: The standardized neuropsychological tests (Wechsler Memory Scale III (WMS-III) and Remote Memory Test) were adopted to address the BQ chewers' verbal WM, spatial WM and remote memory. The Spatial Span Test and the Digit Span Test from WMS-III and the Remote Memory Test were adopted. The Betel Nut Dependency Scale (BNDS), the Fagerstrom Test for Nicotine Dependence (FTND), and the Alcohol Use Disorders Identification Test (AUDIT) were adopted to measure the dependence levels. Results: The BQ dependence level and Last BQ did not affect spatial WM, verbal WM, and remote memory. Last Cigarette is critical in affecting WM; namely, longer interval led to worse performance. Finally, higher alcohol dependence level could lead to better remote memory. Conclusions: To our knowledge, there are no BQ studies addressing the effects of concurrent use of cigarettes and alcohol on memory.
MeSH term(s)	Alcoholism ; Areca ; Humans ; Mastication ; Memory, Long-Term ; Memory, Short-Term ; Taiwan ; Tobacco Products
Language	English
Publishing date	2021-10-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2021.1990338
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Article ; Online: Body composition modify the association between ambient particulate matter and lung function among asthma patients.

Lin, Fang-Chi / Chen, Pei-Shih / Lin, Yuan-Chung / Lin, Meng-Chih / Wu, Chao-Chien / Chen, Kang-Shin / Lee, Chien-Hung / Wang, Tsu-Nai

Environmental science and pollution research international

2023 Volume 30, Issue 37, Page(s) 88060–88071

Abstract: The effect of ambient ... ...

Abstract	The effect of ambient PM
MeSH term(s)	Humans ; Particulate Matter/analysis ; Air Pollution/analysis ; Cross-Sectional Studies ; Environmental Exposure/analysis ; Air Pollutants/analysis ; Asthma/epidemiology ; Asthma/chemically induced ; Obesity/chemically induced ; Body Composition ; Lung/chemistry
Chemical Substances	Particulate Matter ; Air Pollutants
Language	English
Publishing date	2023-07-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-28597-4
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Article: LC-MS/MS measurement of alkaloids in alkaline extracts of Areca nut preparations and their physiological effects

Osborne, Peter G. / Pasupuleti, Raghavendra Rao / Wu, Ming-Tsang / Lee, Chien-Hung / Ponnusamy, Vinoth Kumar

Process biochemistry. 2022 July, v. 118

2022

Abstract: Betel quid (BQ) containing Piper betle leaf (L), green unripe Areca catechu nut (AN) and slaked lime (Ca(OH)₂) is an addictive carcinogenic stimulant, with no pharmacotherapy, chewed by millions of people in Asia. We measured the effect of the ... ...

Abstract	Betel quid (BQ) containing Piper betle leaf (L), green unripe Areca catechu nut (AN) and slaked lime (Ca(OH)₂) is an addictive carcinogenic stimulant, with no pharmacotherapy, chewed by millions of people in Asia. We measured the effect of the constituents of slaked lime, NaOH and Ca(OH)₂, on the levels of endogenous alkaloids in aqueous extracts of AN alone and L+AN (LAN) using UHPLC-MS/MS. Alkaloid levels in AN and LAN extracts were arecoline> >guvacoline>arecaidine>guvacine. In vitro hydrolyzation of extracts of AN and LAN by NaOH or Ca(OH)₂, as occurs in vivo when BQ is chewed, dose-dependently decreased levels of muscarinic esters, arecoline (maximum 65%↓) and guvacoline (maximum 69%↓), and increased carboxylic acid GABA uptake inhibitors, arecaidine (maximum 275%↑) and guvacine (maximum 18%↑). In five volunteers, chewing BQ but not LAN, increased heart rate (maximum 19b/min), forehead temperature (maximum 1 °C), facial flushing and sweating, all symptoms of BQ stimulation. Hydrolysis of compounds in LAN is necessary to induce stimulant effects. Levels of arecoline, considered to mediate stimulant and addictive properties of BQ, negatively correlate with the physiological stimulant effects while levels of GABA uptake inhibitors positively correlate. Unripe, green AN warrants investigation as replacement therapy in the treatment of BQ substance use disorder.
Keywords	Areca catechu ; Piper betle ; arecoline ; betel ; betel nut ; calcium hydroxide ; carcinogenicity ; drug therapy ; heart rate ; hydrolysis ; leaves ; temperature ; Asia
Language	English
Dates of publication	2022-07
Size	p. 65-73.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	1359-5113
DOI	10.1016/j.procbio.2022.04.018
Database	NAL-Catalogue (AGRICOLA)

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