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  1. Article ; Online: Self-Organization via Dewetting in Polymeric Assemblies.

    Nam, Kibeom / Lee, Dong Yun

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2400255

    Abstract: Dewetting is a spontaneous process involving a thin liquid film that minimizes interfacial energy by reducing the surface area via the generation of defects on the film. In industry, dewetting is regarded as a problem that results in defects or a ... ...

    Abstract Dewetting is a spontaneous process involving a thin liquid film that minimizes interfacial energy by reducing the surface area via the generation of defects on the film. In industry, dewetting is regarded as a problem that results in defects or a heterogeneous surface; however, in this study, dewetting is intentionally induced to create various patterns at intended positions spontaneously with polymeric materials and nanoparticles. The dewetting-induced patterning process is conducted by controlling the capillary force and evaporation ratio through an evaporative self-assembly system. The linear-polymeric arrays on the substrate played an important role in modifying the surface geometry and treatment for a heterogeneous surface, and an additional patterning process is performed on patterned arrays to create dewetting-induced self-organizing patterns. Here, this method is used to introduce material arrays with specific shapes such as dots, dumbbells, potbellies, Vs, and trapezoids.
    Language English
    Publishing date 2024-04-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202400255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Need for Prospective Cohort Study of the Association between Lower Urinary Tract Symptoms and Cognitive Decline in Elderly Individuals.

    Lee, Dong Yun / Kam, Sung Chul

    The world journal of men's health

    2023  Volume 41, Issue 4, Page(s) 974–975

    Language English
    Publishing date 2023-01-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2719786-4
    ISSN 2287-4690 ; 2287-4208
    ISSN (online) 2287-4690
    ISSN 2287-4208
    DOI 10.5534/wjmh.220187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Should Psychiatric Symptoms Be Evaluated in Elderly Males With Lower Urinary Tract Symptoms?

    Lee, Dong Yun / Kam, Sung Chul

    International neurourology journal

    2023  Volume 27, Issue 2, Page(s) 155–156

    Language English
    Publishing date 2023-06-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2584447-7
    ISSN 2093-6931 ; 2093-4777
    ISSN (online) 2093-6931
    ISSN 2093-4777
    DOI 10.5213/inj.2346038.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Tissue-Selective Estrogen Complex and Breast.

    Lee, Dong Yun

    Journal of menopausal medicine

    2020  Volume 26, Issue 2, Page(s) 99–103

    Abstract: Although estrogen-progestin therapy has traditionally been standard care for postmenopausal women with an intact uterus experiencing bothersome menopausal symptoms, concerns about side effects related to menopausal hormone therapy (MHT) have led to a ... ...

    Abstract Although estrogen-progestin therapy has traditionally been standard care for postmenopausal women with an intact uterus experiencing bothersome menopausal symptoms, concerns about side effects related to menopausal hormone therapy (MHT) have led to a dramatic decrease in MHT use over recent decades. As many MHT side effects are now believed to be associated with the progestin component of MHT, efforts have been made to develop a progestin-free alternative to conventional MHT. Recently, a tissue-selective estrogen complex (TSEC), a combination of conjugated estrogen and bazedoxifene, was developed as a progestin-free MHT and is now approved and used worldwide for the relief of vasomotor symptoms and the prevention of bone loss in postmenopausal women. Replacement of synthetic progestin with bazedoxifene could allow more favorable safety profiles, such as those for pain or tenderness, mammographic density, and cancer incidence, for the breast. This review examined the effects of the TSEC on breasts and demonstrated evidence from preclinical and clinical studies supporting TSEC use in clinical practice.
    Language English
    Publishing date 2020-09-06
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 3021719-2
    ISSN 2288-6761 ; 2288-6478
    ISSN (online) 2288-6761
    ISSN 2288-6478
    DOI 10.6118/jmm.20015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Engineered Aurotherapy for the Multimodal Treatment of Glioblastoma.

    Kim, Hyung Shik / Lee, Dong Yun

    Brain tumor research and treatment

    2022  Volume 10, Issue 4, Page(s) 215–220

    Abstract: Glioblastoma multiforme (GBM) is the most aggressive brain tumor, characterized by fatal prognosis and high rates of recurrence. Although there are various treatment strategies such as surgical resection, radiotherapy, and chemotherapy, these traditional ...

    Abstract Glioblastoma multiforme (GBM) is the most aggressive brain tumor, characterized by fatal prognosis and high rates of recurrence. Although there are various treatment strategies such as surgical resection, radiotherapy, and chemotherapy, these traditional approaches still have not improved the survival rates and prolongation. Therefore, there is a pressing requirement for developing novel technologies to combat GBM. Nanoparticle-based GBM therapy can be considered a promising approach to precisely treat tumors with minimal side effects. Among various nanoparticles, gold nanoparticle (AuNP) has been demonstrated to be effective in treating GBM because of its advantages such as easy functionalization due to self-assembled monolayers of thiols, surface plasmon resonance effect on its surface, and relatively low toxicity issues. By using nanoscale (5-100 nm) and facile functionalization with a targeting ligand, AuNP can overcome the obstacles caused by blood-brain barrier, which selectively inhibits AuNP penetration into the brain tumor mass. AuNPs delivered into brain tissue and targeted with GBM have been mostly explored for photothermal therapy and photodynamic therapy, but also investigated in the development of complex therapies including radiotherapy, chemotherapy, and immunotherapy using AuNP-based nanoplatforms. Therefore, the aim of this mini review is to summarize recent works on the AuNPs-based nanoplatforms for treating GBM with a multimodal approach.
    Language English
    Publishing date 2022-11-08
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 3018737-0
    ISSN 2288-2413 ; 2288-2405
    ISSN (online) 2288-2413
    ISSN 2288-2405
    DOI 10.14791/btrt.2022.0032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors.

    Kim, Hyung Shik / Lee, Dong Yun

    Biomedicines

    2022  Volume 10, Issue 1

    Abstract: The current treatment for malignant brain tumors includes surgical resection, radiotherapy, and chemotherapy. Nevertheless, the survival rate for patients with glioblastoma multiforme (GBM) with a high grade of malignancy is less than one year. From a ... ...

    Abstract The current treatment for malignant brain tumors includes surgical resection, radiotherapy, and chemotherapy. Nevertheless, the survival rate for patients with glioblastoma multiforme (GBM) with a high grade of malignancy is less than one year. From a clinical point of view, effective treatment of GBM is limited by several challenges. First, the anatomical complexity of the brain influences the extent of resection because a fine balance must be struck between maximal removal of malignant tissue and minimal surgical risk. Second, the central nervous system has a distinct microenvironment that is protected by the blood-brain barrier, restricting systemically delivered drugs from accessing the brain. Additionally, GBM is characterized by high intra-tumor and inter-tumor heterogeneity at cellular and histological levels. This peculiarity of GBM-constituent tissues induces different responses to therapeutic agents, leading to failure of targeted therapies. Unlike surgical resection and radiotherapy, photodynamic therapy (PDT) can treat micro-invasive areas while protecting sensitive brain regions. PDT involves photoactivation of photosensitizers (PSs) that are selectively incorporated into tumor cells. Photo-irradiation activates the PS by transfer of energy, resulting in production of reactive oxygen species to induce cell death. Clinical outcomes of PDT-treated GBM can be advanced in terms of nanomedicine. This review discusses clinical PDT applications of nanomedicine for the treatment of GBM.
    Language English
    Publishing date 2022-01-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10010096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Quality of life and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women.

    Lee, Dong-Yun / Chung, Yoon-Sok

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 7142

    Abstract: This study was performed to evaluate quality of life (QOL) and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women with low bone mass. This multicenter, prospective, noninterventional observational study ... ...

    Abstract This study was performed to evaluate quality of life (QOL) and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women with low bone mass. This multicenter, prospective, noninterventional observational study included 3907 postmenopausal women who received a combination of raloxifene 60 mg and cholecalciferol 800 IU daily to treat or prevent osteoporosis. Changes in QOL and patient satisfaction were evaluated after 3 and 6 months of treatment. In addition, the safety profile was assessed. Mean age was 67.7 ± 9.3 years old. QOL, assessed by European Quality of life instrument 5 Dimensions (EQ-5D) index, improved significantly after 3 months (0.81 ± 0.11, P < 0.001) and 6 months (0.82 ± 0.11, P < 0.001) of treatment compared to the baseline (0.78 ± 0.14). Improvement in QOL was also significant regardless of previous regimens both in women who were switched from other drugs (bisphosphonates or selective estrogen receptor modulators) and in women who received the study drug for the first time (P < 0.001 for all comparisons). Percentage of women satisfied with the effects (from 37.3 to 67.7%, P < 0.001) and convenience (from 42.8 to 74.1%, P < 0.001) of treatment compared to previous medication significantly increased after 6 months of treatment. In addition, serious adverse drug reactions did not occur, and hot flushes were observed only in 12 women (0.3%). Combination therapy with raloxifene and cholecalciferol significantly improves quality of life with no serious adverse events and high patient satisfaction at 6 months. Our real-world data suggest that this regimen is a promising option for postmenopausal women with low bone mass.
    MeSH term(s) Aged ; Cholecalciferol/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Osteoporosis, Postmenopausal/drug therapy ; Patient Satisfaction ; Postmenopause ; Prospective Studies ; Quality of Life ; Raloxifene Hydrochloride/adverse effects
    Chemical Substances Cholecalciferol (1C6V77QF41) ; Raloxifene Hydrochloride (4F86W47BR6)
    Language English
    Publishing date 2022-05-03
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-11298-2
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  8. Article ; Online: Prediction Models for Readmission Using Home Healthcare Notes and OMOP-CDM.

    Gan, Sujin / Kim, Chungsoo / Lee, Dong Yun / Park, Rae Woong

    Studies in health technology and informatics

    2024  Volume 310, Page(s) 1438–1439

    Abstract: This study developed readmission prediction models using Home Healthcare (HHC) documents via natural language processing (NLP). An electronic health record of Ajou University Hospital was used to develop prediction models (A reference model using only ... ...

    Abstract This study developed readmission prediction models using Home Healthcare (HHC) documents via natural language processing (NLP). An electronic health record of Ajou University Hospital was used to develop prediction models (A reference model using only structured data, and an NLP-enriched model with structured and unstructured data). Among 573 patients, 63 were readmitted to the hospital. Five topics were extracted from HHC documents and improved the model performance (AUROC 0.740).
    MeSH term(s) Humans ; Patient Readmission ; Medicine ; Home Care Services ; Hospitals, University ; Delivery of Health Care
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI231233
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  9. Article ; Online: Enhanced Mechanical Properties of Polylactic Acid/Poly(Butylene Adipate-co-Terephthalate) Modified with Maleic Anhydride.

    Nam, Kibeom / Kim, Sang Gu / Kim, Do Young / Lee, Dong Yun

    Polymers

    2024  Volume 16, Issue 4

    Abstract: An increase in plastic waste pollution and the strengthening of global environmental policies have heightened the need for research on biodegradable plastics. In this regard, polylactic acid (PLA) and poly(butylene adipate-co-terephthalate) (PBAT) are ... ...

    Abstract An increase in plastic waste pollution and the strengthening of global environmental policies have heightened the need for research on biodegradable plastics. In this regard, polylactic acid (PLA) and poly(butylene adipate-co-terephthalate) (PBAT) are notable examples, serving as alternatives to traditional plastics. In this study, the compatibility and mechanical properties of PLA/PBAT blends were improved by the chemical grafting of maleic anhydride (MAH). In addition, qualitative analyses were conducted, dynamic mechanical properties were investigated, and the structure and mechanical characteristics of the blends were analyzed. With an increase in the MAH concentration, the grafting yield of the blends increased, and significantly improved the compatibility of the PLA/PBAT blend, with an ~2 and 2.9 times increase in the tensile strength and elongation at break, respectively. These findings indicate that the modified PLA/PBAT blend demonstrates potential for applications that require sustainable plastic materials, thereby contributing to the development of environmentally friendly alternatives in the plastics industry.
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16040518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Characterization of sacral chordoma and differential diagnosis from other sacral malignancy using [18F]FDG PET/CT.

    Lee, Dong Yun / Kim, Yong-Il / Ryu, Jin-Sook / Kim, Wanlim

    Medicine

    2024  Volume 103, Issue 14, Page(s) e37678

    Abstract: 2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/computed tomography (CT) is known to be a helpful imaging modality for sacral chordoma, but its detailed characteristics have not been fully described. The purpose of our study ...

    Abstract 2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/computed tomography (CT) is known to be a helpful imaging modality for sacral chordoma, but its detailed characteristics have not been fully described. The purpose of our study was to identify the [18F]FDG PET/CT imaging characteristics of sacral chordoma and compare them with other sacral malignancy. This retrospective study included patients who underwent [18F]FDG PET/CT because of a mass involving the sacrum. Investigated visual findings included visual score and distribution, and semiquantitative parameters measured included standardized uptake values (SUVmax, SUVpeak, SUVmean), tumor-to-liver ratio (TLR), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and tumor size. Comparison studies and receiver operating characteristics (ROC) curve analysis were performed to differentiate between sacral chordoma and other sacral malignancy. Ten patients with sacral chordoma were finally included (M:F = 6:4, median age = 67 yr). On [18F]FDG PET/CT, sacral chordomas presented as a mass with minimal-moderate uptake with a usually heterogenous distribution. Compared with 12 patients with other sacral malignancies (M:F = 4:8, median age 42 yr), sacral chordoma showed a significantly lower TLR (median value 2.1 vs 6.3, P = .021). In ROC curve analysis, TLR showed the largest area under the curve (AUC) of 0.79 (cutoff ≤ 4.0; sensitivity 100.0%, specificity 58.3%; P = .004), and SUVmax showed the second largest AUC of 0.73 (cutoff ≤ 6.9; sensitivity 80.0%, specificity 66.7%; P = .034). [18F]FDG PET/CT of sacral chordoma showed minimal-moderate uptake. The TLR of [18F]FDG PET/CT was significantly lower than that of other sacral malignancy and was the most useful parameter for differentiating sacral chordoma, with the largest AUC. SUVmax could be another helpful semiquantitative parameter.
    MeSH term(s) Humans ; Aged ; Adult ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18 ; Chordoma/diagnostic imaging ; Diagnosis, Differential ; Sacrum/diagnostic imaging ; Retrospective Studies ; Tumor Burden ; Radiopharmaceuticals
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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